Sarcopenia
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  • ||||||||||  Journal:  The Influence of Pretherapeutic and Preoperative Sarcopenia on Short-Term Outcome after Esophagectomy. (Pubmed Central) -  Nov 22, 2020   
    Our findings suggest that a low preoperative SMI does not necessarily predict a poor postoperative outcome in esophageal cancer patients after esophagectomy but that there are many factors that influence the nutritional status of cancer patients. To improve nutritional status, cancer patients at our clinic receive specialized nutritional counselling during neoadjuvant treatment as well as after surgery.
  • ||||||||||  Review, Journal:  Bone Control of Muscle Function. (Pubmed Central) -  Nov 22, 2020   
    Indeed, the features of this bone-related hormone were used to test a new therapeutic approach for sarcopenia, since injection of osteocalcin in older mice induces the acquirement of physical abilities of younger animals. Even if this approach should be tested in humans, osteocalcin represents the most surprising molecule in endocrine regulation by the skeleton.
  • ||||||||||  Journal:  Cancer Therapy with Cell Sheets (Pubmed Central) -  Nov 22, 2020   
    We succeeded in clinical translation and large animal model experiments of cell sheet-based regenerative medicine to treat various complications of cancer therapy including esophageal stricture after esophageal early cancer endoscopic submucosal dissection(ESD)and lung air leaks. We would like to continue development of cell sheet-based regenerative medicine to treat frail, sarcopenia, and cancer cachexia after surgery, chemotherapy, and radio therapy by supplying stem cells and paracrine effects.
  • ||||||||||  Review, Journal:  Going to the roots of reduced magnesium dietary intake: A tradeoff between climate changes and sources. (Pubmed Central) -  Nov 21, 2020   
    As a consequence, a large percentage of people all over the world does not meet the minimum daily magnesium requirement. In this scoping review, we summarize how agronomic and environmental factors, including global warming, affect magnesium content and availability in the soil and, consequently, in the food chain, with the aim of attracting the interest of botanists, agronomists, animal and human nutritionists and physicians to work on a strategy that grants adequate magnesium intake for everybody.
  • ||||||||||  Preclinical, Journal:  Improved Calcium Homeostasis and Force by Selenium Treatment and Training in Aged Mouse Skeletal Muscle. (Pubmed Central) -  Nov 21, 2020   
    Selenium supplementation was also able to significantly enhance the Selenoprotein N levels in aged mice. Our results describe, for the first time, the beneficial effects of selenium supplementation on calcium release from the SR and muscle force in old age while point out that increased muscle mass does not improve physical performance with aging.
  • ||||||||||  Review, Journal:  Nutritional Aspects in Inflammatory Bowel Diseases. (Pubmed Central) -  Nov 21, 2020   
    Poor nutritional status, as well as selective malnutrition or sarcopenia, is associated with poor clinical outcomes, response to therapy and, therefore, quality of life. The nutritional assessment should include a dietetic evaluation with the assessment of daily caloric intake and energy expenditure, radiological assessment, and measurement of functional capacity.
  • ||||||||||  Journal:  Value-Added Opportunistic CT: Insights Into Osteoporosis and Sarcopenia. (Pubmed Central) -  Nov 21, 2020   
    Although body composition measurements are not routinely obtained using CT, quantitative assessment of bone and muscle biomarkers on CT can add value to patient care. Automated bone and muscle measurements promise to transform the everyday practice of radiology without resulting in additional cost or radiation exposure for patients.
  • ||||||||||  [VIRTUAL] Osteopenia Predicts Posttransplant Survival among Living Donor Liver Transplant Recipients () -  Nov 21, 2020 - Abstract #IHPBA2020IHPBA_1464;    
    Therefore, FABP3 drives membrane lipid composition-mediated ER stress to regulate muscle homeostasis during aging and is a valuable target for sarcopenia. Preoperative osteopenia was independently associated with post-LDLT mortality among patients with decompensated liver cirrhosis.Improving osteopenia with preoperative rehabilitation or medical therapy may improve post-LDLT survival.
  • ||||||||||  [VIRTUAL] SARCOPENIA: A MARKER OF COMORBID DISEASE BURDEN IN AN OBESE PENILE CANCER PATIENT COHORT () -  Nov 20, 2020 - Abstract #SUO2020SUO_277;    
    With standardized surgical technique, biliary complications can be minimized and donor biliary anatomy should not be considered a contraindication to right lobe liver donation. Our data demonstrates that sarcopenia can be readily assessed through the free web-based software CoreSlicer and serves as a potential marker for chronic comorbid condition burden.Funding: N/A
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  ExPrEs: Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes (clinicaltrials.gov) -  Nov 20, 2020   
    P=N/A,  N=60, Active, not recruiting, 
    This may have implications for prognostication and treatment decisions for urologists and medical oncologists, both for surgical planning and for clinical trial enrollment stratification for neoadjuvant and adjuvant RCC therapies.Funding: N/A Trial completion date: Jun 2020 --> Apr 2021 | Trial primary completion date: Jun 2020 --> Feb 2021
  • ||||||||||  Journal:  Vitamin D Supplementation for Extraskeletal Indications in Older Persons. (Pubmed Central) -  Nov 19, 2020   
    For patients with depression or cognitive disorders, we recommend screening for vitamin D deficiency, treating with oral cholecalciferol if present, and monitoring periodically to target a level of >30 ng/mL as an adjunct to usual care. The level of evidence certainly would not justify the use of vitamin D in place of more evidence-based therapies, but given the burden of these conditions in the geriatric population, we believe the potential benefit justifies the minimal risk.
  • ||||||||||  Review, Journal:  Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis? (Pubmed Central) -  Nov 19, 2020   
    Yet, several studies have shown that omega 3 fatty acids (FA) could prevent the development of RA, improve muscle metabolism and limit muscle atrophy in obese and insulin-resistant subjects. Thereby, dietary supplementation with omega 3 FA should be a promising strategy to counteract muscle lipotoxicity and for the prevention of comorbidities in RA patients.
  • ||||||||||  Journal:  Spatio-temporal gait variables predicted incident disability. (Pubmed Central) -  Nov 19, 2020   
    This study revealed that spatio-temporal gait variables had a significant predictive value for incident disability. Multifaceted and quantitative gait analysis can contribute to disability risk assessment.
  • ||||||||||  Clinical, Review, Journal:  Milk for Skeletal Muscle Health and Sarcopenia in Older Adults: A Narrative Review. (Pubmed Central) -  Nov 18, 2020   
    This could be due to high habitual protein intakes (>1.0 g/kg BW/d) in study participants, differences in the type of milk (low-fat vs whole) and timing of milk consumption, length of interventions, as well as differences in the sarcopenia status of participants in trials. Adequately powered intervention studies of individuals likely to benefit are needed to test the effectiveness of a whole food approach, including milk, for healthy muscle aging.