|
46 Companies |
|
12 Products |
|
12 Products |
|
17 Mechanisms of Action |
|
756 Trials |
|
22406 News |
|
| «12...304305306307308309310311312313314...401402» |
- || Clinical, Journal: Effects of combining exercise with long-chain polyunsaturated fatty acid supplementation on cognitive function in the elderly: a randomised controlled trial. (Pubmed Central) - Dec 16, 2020
Subgroup analysis for participants with low skeletal muscle mass index (SMI) corresponding to sarcopenia cut-off value showed changes in selective attention, while working memory in the exercise with LCPUFA group was better than in the control group. These findings suggest that exercise with LCPUFA supplementation potentially improves attention and working memory in the elderly with low SMI.
- | Journal: The ALIOS diet in male and female rodents recapitulates the clinical and transcriptomic features of NAFLD and NASH. (Pubmed Central) - Dec 16, 2020
These findings suggest that exercise with LCPUFA supplementation potentially improves attention and working memory in the elderly with low SMI. The ALIOS diet in mice recapitulates many of the clinical features of NAFLD and therefore represents a robust and reproducible model for investigating the pathogenesis of NAFLD and its progression.
- | Journal: Prediction Equations of the Multifrequency Standing and Supine Bioimpedance for Appendicular Skeletal Muscle Mass in Korean Older People. (Pubmed Central) - Dec 16, 2020
The new standing and supine MF-BIA prediction equation are useful for epidemiological and field settings as well as a clinical diagnosis of sarcopenia. Future research is needed to improve the sensitivity of diagnosis of sarcopenia using MF-BIA.
- || Clinical, Journal: Effect of collagen peptides on skeletal muscle mass in the elderly: An interventional study examining oral nutrition support for patients in a recovery-phase rehabilitation ward (Pubmed Central) - Dec 16, 2020
Future research is needed to improve the sensitivity of diagnosis of sarcopenia using MF-BIA. Our results suggest that the oral intake of collagen peptides increases the skeletal muscle mass in patients in recovery-phase rehabilitation wards.
- | Journal: Association of Body Shape Index (ABSI) with Hand Grip Strength. (Pubmed Central) - Dec 16, 2020
Transforming the grip strength, ABSI, and BMI by taking their logarithm prior to standardization did not meaningfully change the associations seen. These findings suggest that combining anthropometrics (ABSI, BMI) with grip strength may better identify individual mortality hazard in research studies and clinical practice.
- || Clinical, Observational data, Retrospective data, Journal: Low Muscle Mass is Associated with Walking Function in Patients with Acute Ischemic Stroke. (Pubmed Central) - Dec 15, 2020
Low skeletal muscle mass at the onset of ischemic stroke is an independent predictor of walking function at discharge during the acute phase. Our findings highlight the importance of detecting skeletal muscle mass in patients with acute ischemic stroke.
- | New trial: Sarcopenia and Physical Performance in Hemodialysis Patients (clinicaltrials.gov) - Dec 15, 2020
P, N=26, Not yet recruiting, Sponsor: Hacettepe University
- || Clinical, Retrospective data, Journal: Sarcopenia Does Not Worsen Survival in Patients With Cirrhosis Undergoing Transjugular Intrahepatic Portosystemic Shunt for Refractory Ascites. (Pubmed Central) - Dec 15, 2020
Our findings highlight the importance of detecting skeletal muscle mass in patients with acute ischemic stroke. Sarcopenia should not be considered as a contraindication to TIPSS insertion in refractory ascites because it is not associated with de novo HE or increased mortality.
- | Biomarker, Retrospective data, Journal: Body mass index and skeletal muscle index are useful prognostic factors for overall survival after gastrectomy for gastric cancer: Retrospective cohort study. (Pubmed Central) - Dec 15, 2020
High and low BMI, and low SMI, were independent prognostic factors for OS (hazard ratio [HR] = 2.355, 1.736, and 1.607, respectively; P = .009, .023, and .033, respectively).SMI and BMI did not impact perioperative morbidity in patients undergoing gastrectomy for gastric cancer. Both SMI and BMI are useful prognostic factors for OS in gastric cancer patients after gastrectomy.
- | Journal: Evaluation of the Hungarian-language SARC-F sarcopenia-screening questionnaire (Pubmed Central) - Dec 15, 2020
Orv Hetil. 2020; 161(47): 2000-2005.
- || Clinical, Journal: Self-Reported Impact of the COVID-19 Pandemic on Nutrition and Physical Activity Behaviour in Dutch Older Adults Living Independently. (Pubmed Central) - Dec 15, 2020
Subgroups with higher risk of impact could be identified. This study shows a negative impact of the COVID-19 pandemic on nutrition and physical activity behaviour of many older adults, which may increase their risk of malnutrition, frailty, sarcopenia and disability.
- | Adlumiz (anamorelin) / Helsinn, Ono Pharma
Journal: Cachexia and Sarcopenia Associated with Lung Cancer (Pubmed Central) - Dec 15, 2020
Anamorelin, a novel selective ghrelin receptor agonist, is under development for treating cancer cachexia...The trial for early induction of multimodal intervention, Nutrition and Exercise Treatment for Advanced Cancer(NEXTAC)program, showed excellent feasibility and safety in elderly patients with advanced NSCLC and pancreatic cancer. These trials can develop a novel method for the treatment of cancer cachexia.
- | Journal: Sarcopenia and Nutrition Support in the Treatment of Gastric Cancer (Pubmed Central) - Dec 15, 2020
In this article, firstly, we summarised the impact of sarcopenia in resectable stage, and then in advanced gastric cancer receiving chemotherapy. Finally, we discussed the nutrition support for advanced gastric cancer.
- | Journal: Sarcopenia and Cancer Cachexia in the Treatment of Colorectal Cancer (Pubmed Central) - Dec 15, 2020
Sarcopenia and cancer cachexia may coexist, and it is important to recognize them. We report the latest findings on the relationship between colorectal cancer and sarcopenia/cancer cachexia.
- | Journal: Nutritional Management in Cancer Chemotherapy Based on Pathophysiology of Sarcopenia (Pubmed Central) - Dec 15, 2020
Additionally, we showed the new topic about assessment for malnutrition, such as GLIM criteria, which is the global nutritional assessment formula for malnutrition including weight loss, low BMI and reduce of muscle mass. Now, we can recommend to use the global nutritional assessment and nutritional therapies even for cancer patients.
- || Clinical, Journal: Anemia in the elderly: influence on physical, functional status and prognosis. (Pubmed Central) - Dec 15, 2020
This is the basis for the administration of iron preparations, among which two- and threevalent ones are isolated. Trivalent iron preparations are most preferred in older patients because they have better tolerance and less frequency of side effects with comparable efficacy with divalent preparations.
- |||| Botox (onabotulinumtoxin A) / GSK, AbbVie
Clinical: @ShaliniShahMD - thanks for fascinating ideas about Elimination diet, role of Vit D and #sarcopenia. Botox as the saviour for headache patients during #Covid_19 . Food for thought (pun) about role of diet in pain and how to manage. Thanks Raj and Ketan fr steering it abt. (Twitter) - Dec 13, 2020
- || So directly increases contractile strength? What are the effects on skeletal muscle? Potentially useful in sarcopenia/skeletal atrophy? (Twitter) - Dec 13, 2020
- || Clinical, Journal: Predictive Value of Temporal Muscle Thickness Measurements on Cranial Magnetic Resonance Images in the Prognosis of Patients With Primary Glioblastoma. (Pubmed Central) - Dec 12, 2020
In the multivariate survival analysis using a Cox regression model, TMT (HR 0.863; 95% CI 0.748-0.996; P = 0.044), age at the diagnosis of GBM (HR 1.042; 95% CI 1.024-1.060; P < 0.001), and concurrent chemoradiotherapy (HR 0.510; 95% CI 0.336-0.775; P = 0.002) were significantly associated with survival time. TMT as an independent predictor is sensitive to the survival prognosis of primary GBM patients, which has potential to predict the survival time.
- || Clinical, Journal: Treatment on the Spleen Prevents the Progression of Secondary Sarcopenia in Patients With Liver Cirrhosis. (Pubmed Central) - Dec 12, 2020
Both splenectomy and PSE were associated with the prevention of secondary sarcopenia in patients with LC. Moreover, it can be expected that muscle volume loss is reduced by splenectomy or PSE in patients with hyperammonemia.
- A new diagnostic index of sarcopenia for predicting short-term postoperative complications in patients undergoing surgery for gastric cancer () - Dec 12, 2020 - Abstract #IDDF2020IDDF_240;
Patients with low CCR had a higher incidence of overall complications (P<0.001), including mild complications (P<0.001) and major complications (P<0.001). Conclusions The preoperative CCR was identified as a reliable nutrition and sarcopenia assessment tool for predicting short-term prognosis for patients with gastric cancer after surgery.
- ||| Clinical: There's evidence from transplant and other surgical areas that sarcopenia / myopenia is a marker of frailty and associated with poor outcomes. Probably can see in other muscles, but psoas is easy to measure, and now there's normative pediatric data. https://t.co/t7Yryldon1 (Twitter) - Dec 11, 2020
- || Delighted to be presenting with expert colleagues Professor @RobertMakMDPhD and Professor @KamKalantar on sarcopenia and cachexia in renal disease, at the Virtual 13th Cachexia Conference (11-13 December 2020). @QUBSONM (Twitter) - Dec 11, 2020
- | Trial initiation date: PROMOTe: Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome (clinicaltrials.gov) - Dec 11, 2020
P=N/A, N=70, Not yet recruiting, Sponsor: King's College London
Conclusions The preoperative CCR was identified as a reliable nutrition and sarcopenia assessment tool for predicting short-term prognosis for patients with gastric cancer after surgery. Initiation date: Sep 2020 --> Jan 2021
- | #SarcopeniaSucks 😢 (Twitter) - Dec 10, 2020
- || Clinical, Journal: Daily lifestyle behaviors and risks of sarcopenia among older adults. (Pubmed Central) - Dec 10, 2020
The results of this study highlight that, among health behaviors, an unbalanced food selection (six nutrients), not meeting physical activity recommendations (150 min/week), and a higher sitting time (≥7 h/day) were risk factors for sarcopenia among older adults. Intervention programs for sarcopenia prevention in older adults should focus on promoting balanced food selection, sufficient physical activity, and reduced sitting time.
- || Clinical, Review, Journal: The Effect of MicroRNA-Mediated Exercise on Delaying Sarcopenia in Elderly Individuals. (Pubmed Central) - Dec 10, 2020
Therefore, exercise may delay sarcopenia in elderly individuals by regulating miRNAs in skeletal muscle. In future miRNA-focused treatment strategies, these studies will provide valuable information for the formulation of exercise methods and will provide useful and targeted exercise programs for elderly individuals with sarcopenia.
- || Clinical, Journal: The risk of sarcopenia 24 months after bariatric surgery - assessment by dual energy X-ray absorptiometry (DEXA): a prospective study. (Pubmed Central) - Dec 10, 2020
As such, patients after B/M surgery are at risk of sarcopenia. A low level of physical activity may also play a negative role.
- || Clinical, Journal: Prevalence of Sarcopenia in Older South African Patients Following Surgery for Fragility Fractures of the Hip. (Pubmed Central) - Dec 10, 2020
Sarcopenia is associated with poor patient outcomes following surgical intervention. Orthopaedic surgeons should therefore be cognizant of the presentation and associated risk of sarcopenia as our patient populations age.
- | New trial: A Randomized-Control Study of Gym Tonic's Community Based Strength Training Intervention. (clinicaltrials.gov) - Dec 10, 2020
P=N/A, N=318, Completed, Sponsor: PulseSync Pte Ltd
- || Clinical, Journal: Protein Intake, Protein Mealtime Distribution and Seafood Consumption in Elderly Norwegians: Associations with Physical Function and Strength. (Pubmed Central) - Dec 9, 2020
Mean gait speed was 1.0 ± 0.3 m/s. The interaction analysis suggests that there might be gender differences in the effect of seafood consumption on gait speed.
- || Clinical, Journal: The Asian working group for sarcopenia's new criteria updated in 2019 causing a change in sarcopenia prevalence in Japanese older adults requiring long-term care/support. (Pubmed Central) - Dec 8, 2020
Conversely, the sarcopenia diagnosis in females statistically remained unchanged. Thus, a mismatch might exist between the two criteria regarding sarcopenia prevalence in males.
- || Clinical, Journal: Association between skeletal muscle mass index and lung function/respiratory muscle strength in older adults requiring long-term care or support. (Pubmed Central) - Dec 8, 2020
[Conclusion] Therefore, the findings of this study suggested that compared with lung function tests, maximum expiratory pressure, which is an indicator of respiratory muscle strength, is related to muscle mass. Maximum expiratory pressure might be the most useful indicator for sarcopenia.
- || Clinical, Journal: The Prevalence of Sarcopenic Obesity in Postmenopausal Women with a History of Breast Cancer Depending on Adopted Methodology - A Case-Control Study. (Pubmed Central) - Dec 8, 2020
SO diagnosis based on the percentage of fatty tissue mass in the body of >38% and SMI value were associated with a higher detection rate of SO in each study group, regardless of the adopted cut-off value. Similar results were obtained in each analyzed group when using the remaining diagnostic criteria for obesity and SMI value, regardless of the cut-off value.
- || Review, Journal: Flavonoids: nutraceutical potential for counteracting muscle atrophy. (Pubmed Central) - Dec 8, 2020
The effects of flavonoids on muscle atrophy have been investigated by monitoring molecular mechanisms involved in protein turnover, mitochondrial activity, and myogenesis. This review summarizes the reported effects of flavonoids on sarcopenia, cachexia, and disuse muscle atrophy, thus, providing an insight into the understanding of the associated molecular mechanisms.
- || Clinical, Journal: Current Status of Sarcopenia in the Disabled Elderly of Chinese Communities in Shanghai: Based on the Updated EWGSOP Consensus for Sarcopenia. (Pubmed Central) - Dec 8, 2020
The elderly participants with a physical disability had a higher prevalence of low hand handgrip strength than those with a visual disability. More studies with a larger sample size and longitudinal follow-up are needed to confirm our findings.
- ||| Clinical: Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins https://t.co/uFjE60Us2f @mackinprof @nclarkrd @lesliebonci @Roaxana (Twitter) - Dec 7, 2020
- || RCT of BCAA supplementation in cirrhosis with sarcopenia with primary end point of improving muscle mass just completed at our centre. (CTRI/2019/05/019269). Awaiting results. @Srikant_274 @Sam_ogre . #livertwitter (Twitter) - Dec 7, 2020
- ||| Clinical: ✅This has been poorly studied ✅ Data suggests that improving sarcopenia is useful regarding HE, that BCAA may help ▶️ Can ve improve sarcopenia by nutrition rapidly enough in pts with RA needing TIPS? ▶️ Are all BCAA preparations equal? #livertwitter (Twitter) - Dec 7, 2020
- || Does BCAA supplementation improve sarcopenia at all on top of exercise and diet? @Srikant_274 . #livertwitter. (Twitter) - Dec 7, 2020
- | New trial: Feasibility of Estimating the Prevalence of Malnutrition, Frailty and Sarcopenia in Older People in UK Biobank, Cross-sectional Study: A Study Protocol (clinicaltrials.gov) - Dec 7, 2020
P, N=381000, Completed, Sponsor: University of Manchester
- | dexamethasone / Generic mfg.
Journal: COVID-19 and Acute Sarcopenia. (Pubmed Central) - Dec 5, 2020
At the same time, clinicians need to be increasingly aware of the condition, and measurements of muscle strength, quantity, and physical performance should be embedded into clinical practice. Clinicians should consider the risks of acute sarcopenia when weighing up the risks and benefits of treatment (e.g. dexamethasone), and instigate multidisciplinary treatment including dietetics input.
- || So that’s for net + protein synthesis for those who are looking to maintain/ build muscle. Especially in middle age when Sarcopenia starts to become an issue. @mackinprof work is brilliant in this area. (Twitter) - Dec 5, 2020
- | Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date: ALTIS: Innovative Functional Food Based on Apulian Lens Culinaris for Contrasting Sarcopenia in Dialysis Patients (clinicaltrials.gov) - Dec 3, 2020
P=N/A, N=20, Recruiting, Sponsor: Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Clinicians should consider the risks of acute sarcopenia when weighing up the risks and benefits of treatment (e.g. dexamethasone), and instigate multidisciplinary treatment including dietetics input. Not yet recruiting --> Recruiting | Trial completion date: Sep 2020 --> Mar 2021 | Initiation date: Feb 2020 --> Dec 2020 | Trial primary completion date: Jun 2020 --> Jan 2021
- | New trial: Impact of Sarcopenia Index on Postoperative Pulmonary Complication in Elderly Patients Undergoing OPCAB (clinicaltrials.gov) - Dec 3, 2020
P, N=600, Not yet recruiting, Sponsor: Yonsei University
- || Clinical, Journal: Preoperatively Identified Sarcopenia Leads to Increased Postoperative Complications, Hospital and ICU Length of Stay in Autologous Microsurgical Breast Reconstruction. (Pubmed Central) - Dec 3, 2020
Sarcopenia is significantly associated with increased complications in patients undergoing free flap breast reconstruction. Further investigation into the biochemical and physiologic changes associated with sarcopenia is needed.
- || Clinical, Journal: Physical activity and sarcopenia in older adults. (Pubmed Central) - Dec 3, 2020
Further investigation into the biochemical and physiologic changes associated with sarcopenia is needed. Therefore, older adults who are physically active, maintain higher levels of cardiorespiratory fitness, upper and lower body strength, and avoid sedentary time may have significantly lower odds of sarcopenia.