Sarcopenia
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  • ||||||||||  Clinical, Journal:  Associations of sleep and depression with obesity and sarcopenia in middle-aged and older adults. (Pubmed Central) -  Jan 6, 2021   
    Our findings of positive associations, of both dietary and circulating vitamin C with measures of skeletal muscle mass in middle- and older-aged men and women, suggest that dietary vitamin C intake may be useful for reducing age-related muscle loss. Among Spanish middle-aged and older adults, after adjusting for potential confounding variables, depression was uniquely associated with sarcopenia, while short sleep duration was related to general and sarcopenic obesity, and poor sleep quality was linked to general and abdominal obesity.
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date:  UNITS: The Urinary Incontinence Treatment Study (clinicaltrials.gov) -  Jan 6, 2021   
    P=N/A,  N=71, Completed, 
    Nevertheless, the low effect size warrants further studies. Recruiting --> Completed | Trial completion date: Jan 2021 --> Jan 2020 | Trial primary completion date: Jan 2021 --> Jan 2020
  • ||||||||||  Clinical, Journal:  Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial. (Pubmed Central) -  Jan 6, 2021   
    P1
    No significant effects on functional impairment, cognitive function or nutritional assessment, inflammatory cytokines IL-6, TNF-alpha were observed after leucine administration compared to the placebo. The use of l-leucine supplementation can have some beneficial effects on sarcopenia and could be considered for the treatment of sarcopenia in older individuals.
  • ||||||||||  Clinical, Review, Journal:  Stay Home: Role of Physical Exercise Training in Elderly Individuals' Ability to Face the COVID-19 Infection. (Pubmed Central) -  Jan 5, 2021   
    Additionally, immunity biomarkers were optimistically demonstrated in older adults following physical exercise training, thereby reducing mortality and morbidity rates. Finally, in accordance with recommendations to stay home and perform self-isolation to prevent the spread of COVID-19, all populations are strongly recommended to practice regular home exercise training at home to promote immune system functioning.
  • ||||||||||  Journal:  Effects of Aging on Angiogenic and Muscle Growth-Related Factors in Naturally Aged Rat Skeletal Muscles. (Pubmed Central) -  Jan 5, 2021   
    Finally, in accordance with recommendations to stay home and perform self-isolation to prevent the spread of COVID-19, all populations are strongly recommended to practice regular home exercise training at home to promote immune system functioning. Conclusion These data suggest different regulation of indices of angiogenic and muscle growth with aging in different muscle types.
  • ||||||||||  Clinical, Journal:  Analysis of epidemiological trends in chronic diseases of Chinese residents. (Pubmed Central) -  Jan 5, 2021   
    Chronic diseases in the elderly have ranked first in the spectrum of diseases among Chinese residents. Therefore, understanding the trends of main chronic diseases among Chinese residents and developing proactive countermeasures have become a major public health issue for China.
  • ||||||||||  Clinical, Journal, HEOR:  Impacts of combined osteopenia/osteoporosis and sarcopenia on balance and quality of life in older adults. (Pubmed Central) -  Jan 3, 2021   
    Therefore, understanding the trends of main chronic diseases among Chinese residents and developing proactive countermeasures have become a major public health issue for China. Our study suggests that the joint occurrence of osteoporosis with sarcopenia is associated with a risk of balance loss, a decrease in quality of life, and a potentially increased fracture risk in older adults.
  • ||||||||||  Journal:  Sarcopenia in cancer: Risking more than muscle loss. (Pubmed Central) -  Jan 2, 2021   
    Various interventions, such as resistance exercise, nutritional support, and amino acid and vitamin supplementation have shown promise in the management of sarcopenia. However, further insight into novel interventions and indeed, assessment of the benefits of management of sarcopenia in terms of survival, are required to better support cancer patients.
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    Review, Journal:  PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging. (Pubmed Central) -  Dec 31, 2020   
    This review focuses on nutritional and pharmacological interventions that target PGC-1α and related Sirtuin 1 (SIRT1) and 5' AMP-activated protein kinase (AMPKα) signaling in muscle and thus may be rapidly translated to prevent muscle disuse atrophy and promote recovery. In this review, we present several therapeutics that target PGC-1α in skeletal muscle such as leucine, β-hydroxy-β-methylbuyrate (HMB), arginine, resveratrol, metformin and combination therapies that may have future application to conditions of disuse and recovery in humans.
  • ||||||||||  Clinical, Review, Journal:  Epidemiology of weight loss, malnutrition and sarcopenia: a transatlantic view. (Pubmed Central) -  Dec 30, 2020   
    The recent Global Leadership Initiative on Malnutrition has become a consensus alternative to standardize how malnutrition may be diagnosed based on etiologic and phenotypic criteria available everywhere, from rich to poor countries. This will lead to an easier diagnosis of cancer malnutrition that itself will help us speak the same language worldwide.
  • ||||||||||  Preclinical, Journal:  Diaphragm muscle sarcopenia into very old age in mice. (Pubmed Central) -  Dec 30, 2020   
    Type IIx and/or IIb fiber CSA and proportions did not change into very old age. The results of the study support a critical threshold for the reduction in DIAm force and Pdi such that survival into very old age is not associated with evidence of progression of DIAm sarcopenia or impairment in ventilation.
  • ||||||||||  Journal:  Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy. (Pubmed Central) -  Dec 30, 2020   
    Our data showed a critical role for tryptophan in regulating skeletal muscle mass. Thus, the tryptophan metabolism pathway may be a promising target for preventing or treating skeletal muscle atrophies.
  • ||||||||||  Journal:  Obesity After Successful Kidney Transplantation. (Pubmed Central) -  Dec 30, 2020   
    Successful transplantation was associated with weight gain with increase of body fat without increase in lean body mass (sarcopenic obesity). Results suggest the need for routine assessment of body composition and nutritional education that could prevent the consequences of adipose tissue accumulation in kidney transplant recipients.
  • ||||||||||  Journal:  The impact of sarcopenia on oncologic abdominal wall reconstruction. (Pubmed Central) -  Dec 30, 2020   
    Sarcopenia, as defined by TPI, is correlated with hernia occurrence, but not SSO. These findings emphasize the importance of preoperative fitness and nutritional optimization and provide useful information for preoperative counseling and risk stratification.
  • ||||||||||  Journal:  Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments. (Pubmed Central) -  Dec 30, 2020   
    The purpose of the present paper is to present the current research around the affiliation of cirrhosis and IR, discuss potential mechanisms explaining the association between cirrhosis and IR (i.e. endocrine perturbation, liver inflammation, altered muscle mass and composition, altered gut microbiota and permeability), complications that can arise as well as treatment options, through a critical review of the literature surrounding this subject. This research will also be investigating the beneficial impact, if there is any, of identifying and curing IR in patients with cirrhosis.
  • ||||||||||  Journal:  Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss. (Pubmed Central) -  Dec 30, 2020   
    By offering a number of home-based strategies including resistance exercise, higher protein intakes and supplementation, we can potentially guide public health authorities to avoid a lifestyle disease and rehabilitation crisis post-COVID-19. Such strategies may also serve as useful preventative measures for reducing the likelihood of sarcopenia in general and in the event of future periods of isolation.
  • ||||||||||  Review, Journal:  Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: An overview. (Pubmed Central) -  Dec 30, 2020   
    Overall, evaluation of the patient's nutritional status is not negligible for its implications on susceptibility, course, severity, and responsiveness to therapies, in order to perform a tailored nutritional intervention as an integral part of the treatment of patients with COVID-19. The aim of this study was to review the current data on the relevance of nutritional status, including trace elements and vitamin status, in influencing the course and outcome of the disease 3 mo after the World Health Organization's declaration of COVID-19 as a pandemic.
  • ||||||||||  Review, Journal:  Bone and Muscle Crosstalk in Aging. (Pubmed Central) -  Dec 29, 2020   
    Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.
  • ||||||||||  Clinical, Journal:  Sarcopenia in open heart surgery patients: A cohort study. (Pubmed Central) -  Dec 29, 2020   
    Participants with sarcopenia who underwent OHS had a history of DM, longer length of hospital stays, and prolonged mechanical ventilation times, compared with patients without sarcopenia. TCTR20190509003.