Sarcopenia
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  • ||||||||||  Journal:  Age- and sex-specific changes in lower-limb muscle power throughout the lifespan. (Pubmed Central) -  Feb 11, 2021   
    MFI and FFMV combined provides a more complete, muscle-specific description linked to function enabling objective sarcopenia detection. Relative power decreased i) above 40 years by the loss in absolute power (specific power only) and the increase in body mass, and ii) above ̴ 70 years by the loss in absolute power (both specific power and leg lean mass).
  • ||||||||||  Preclinical, Journal:  Effect of Dietary Silk Peptide on Obesity, Hyperglycemia, and Skeletal Muscle Regeneration in High-Fat Diet-Fed Mice. (Pubmed Central) -  Feb 11, 2021   
    SP also had an anti-diabetic effect in VAT and skeletal muscle because it upregulated glucose transporter type 4 (GLUT4) and uncoupling protein 3 (UCP3) expression. Furthermore, SP reduced ubiquitin proteasome and promoted myoblast determination protein 1 (MyoD)/myogenic factor 4 (myogenin) expression, implying that it may have potential for the treatment of obesity-induced hyperglycemia and obesity-associated sarcopenia.
  • ||||||||||  Journal:  Application of SDOC Cut-points for Low Muscle Strength for Recovery of Walking Speed After Hip Fracture. (Pubmed Central) -  Feb 11, 2021   
    Taken together, these results suggest that the intrinsic trophic differences between EOMs-derived myogenic progenitors and their counterparts from other muscles could explain why those cells show higher proliferative and fusion rates, as well as better regenerative properties. SDOC cut-points for grip strength standardized to weight provided consistent indication of poor walking speed performance post hip fracture.
  • ||||||||||  Journal:  Dietary Intake, D3Cr Muscle Mass, and Appendicular Lean Mass in a Cohort of Older Men. (Pubmed Central) -  Feb 11, 2021   
    When an accurate assessment of muscle mass (rather than lean mass) is used, reduced muscle mass is highly associated with important outcomes and the negative effects of adiposity are minimal, suggesting that obesity has little relevance for the understanding of important adverse health outcomes of sarcopenia in older men. Nondairy animal protein intake (within a Western dietary pattern and alone) was positively associated with D3Cr muscle mass in older men.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Phase classification, Trial completion date, Trial primary completion date:  PSSMAR: Postacute Sarcopenia: Supplementation With ?-hydroxyMethylbutyrate After Resistance Training (clinicaltrials.gov) -  Feb 10, 2021   
    P=N/A,  N=32, Completed, 
    No abstract available Recruiting --> Completed | Phase classification: P2 --> PN/A | Trial completion date: Aug 2021 --> Feb 2021 | Trial primary completion date: Aug 2021 --> Feb 2021
  • ||||||||||  Trial primary completion date:  Dietary Nitrate and Muscle Power With Aging (clinicaltrials.gov) -  Feb 10, 2021   
    P1,  N=20, Recruiting, 
    Recruiting --> Completed | Phase classification: P2 --> PN/A | Trial completion date: Aug 2021 --> Feb 2021 | Trial primary completion date: Aug 2021 --> Feb 2021 Trial primary completion date: Aug 2020 --> Aug 2021
  • ||||||||||  Trial completion date, Trial primary completion date:  Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals (clinicaltrials.gov) -  Feb 10, 2021   
    P1,  N=10, Suspended, 
    Trial primary completion date: Aug 2020 --> Aug 2021 Trial completion date: Jul 2020 --> Jul 2021 | Trial primary completion date: Jul 2020 --> Jul 2021
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Effects of the Combination of β-Hydroxy-β-Methyl Butyrate and R(+) Lipoic Acid in a Cellular Model of Sarcopenia. (Pubmed Central) -  Feb 10, 2021   
    The C2C12 cell line is used as myoblasts or is differentiated in myotubes, sarcopenia is induced by dexamethasone (DEX)...During the early phase of myotube formation, the mixture preserves the number of myogenin-positive cells, whereas it completely prevents the DEX-dependent damage in a later phase of myotube differentiation (7 days), as evaluated by cell diameter and percentage of multinucleated cells. R(+)LA in association with HMB is suggested for sarcopenia therapy.
  • ||||||||||  Review, Journal:  Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease-The Union of Two Culprits. (Pubmed Central) -  Feb 10, 2021   
    Therefore, it is imperative to continue shining the light on this topic and better understand the underlying mechanism as well as treatment options. In this review article, we aimed to address the pathophysiology, impact, and outcomes of sarcopenic obesity on NAFLD.
  • ||||||||||  Clinical, Journal:  Association Between Length of Stay in the Intensive Care Unit and Sarcopenia Among Hemiplegic Stroke Patients. (Pubmed Central) -  Feb 10, 2021   
    Additionally, patients with sarcopenia had a longer length of stay in the ICU, and univariate and multivariate analyses confirmed that the ICU length of stay was significantly related to sarcopenia (adjusted odds ratio=1.187; 95% confidence interval, 1.019-1.382; p=0.028). The length of stay in the ICU was significantly associated with sarcopenia in hemiplegic stroke patients.
  • ||||||||||  Retrospective data, Review, Journal:  Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis. (Pubmed Central) -  Feb 9, 2021   
    Such information may help to improve anti-aging strategies by countering age-specific muscle function deficiencies and may improve mid-life adults' ability to transition better functionally into old age. Sarcopenia is highly prevalent in individuals with CVD, dementia, diabetes mellitus and respiratory disease.
  • ||||||||||  Review, Journal:  The intersection of exercise and aging on mitochondrial protein quality control. (Pubmed Central) -  Feb 9, 2021   
    Although not yet completely elucidated, numerous molecular processes involved in mitochondrial biogenesis and turnover are affected with age. The contrasting and often opposite consequences of exercise and age suggest that exercise can serve as non-pharmacological "mitochondrial medicine" for aging muscle to ameliorate mitochondrial content and function, via pathways that implicate organelle protein quality control mechanisms.
  • ||||||||||  Journal:  Handgrip Strength Is an Independent Predictor of Cardiovascular Outcomes in Diabetes Mellitus. (Pubmed Central) -  Feb 9, 2021   
    Multivariate Cox hazard analysis identified the cardio-ankle vascular index (CAVI) and handgrip strength as independent predictors of MACE (hazard ratio [HR] = 1.18, P = 0.039; and HR = 0.70, P = 0.016, respectively).Handgrip strength is an indicator of sarcopenia in diabetic patients, and together with CAVI it was independently associated with the incidence of MACE. This suggests that the handgrip strength test might be useful in the management of patients with DM at high risk of cardiovascular outcomes.
  • ||||||||||  Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date:  EXERSARCO: Physical Activity Program for Counteracting Sarcopenia (clinicaltrials.gov) -  Feb 9, 2021   
    P=N/A,  N=16, Active, not recruiting, 
    This suggests that the handgrip strength test might be useful in the management of patients with DM at high risk of cardiovascular outcomes. Recruiting --> Active, not recruiting | N=36 --> 16 | Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  Clinical, Review, Journal:  Frailty, sarcopenia and cachexia in heart failure patients: Different clinical entities of the same painting. (Pubmed Central) -  Feb 9, 2021   
    However, the treatment of all these conditions still remain debated and only a profound knowledge of the specific mechanisms and patterns of disease progression will allow to use the appropriate therapy in a given clinical setting. For all these reasons we briefly review current knowledge on frailty, sarcopenia and cachexia in HF patients with the attempt to define clinically significant degrees of multiorgan dysfunction, specific "red alert" thresholds in clinical practice and therapeutic approach.
  • ||||||||||  Review, Journal:  Nonalcoholic Steatohepatitis, Sarcopenia, and Liver Transplantation. (Pubmed Central) -  Feb 9, 2021   
    For all these reasons we briefly review current knowledge on frailty, sarcopenia and cachexia in HF patients with the attempt to define clinically significant degrees of multiorgan dysfunction, specific "red alert" thresholds in clinical practice and therapeutic approach. Watch a video presentation of this article Watch an interview with the author.