Sarcopenia
Welcome,         Profile    Billing    Logout  
 46 Companies   12 Products   12 Products   17 Mechanisms of Action   756 Trials   22406 News 


«12...295296297298299300301302303304305...401402»
  • ||||||||||  Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
    Clinical, Journal:  SGLT2 inhibitor and sarcopenia in a lean elderly adult with type 2 diabetes: A case report. (Pubmed Central) -  Feb 18, 2021   
    Insulin therapy was discontinued and oral antidiabetes drugs, including sodium-glucose cotransporter 2 inhibitor dapagliflozin, were initiated at age 69 years...She also lost substantial body weight and developed sarcopenia. The current case indicates the importance of patient assessment before SGLT2i initiation in the elderly.
  • ||||||||||  Review, Journal:  Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis. (Pubmed Central) -  Feb 18, 2021   
    The severe disturbance of intestinal barrier in LC can result in dysbiosis, several bacterial infections, LC-related complications, and sarcopenia. Here in this review, we will summarize the current knowledge of the relationship between sarcopenia and dysbiosis in patients with LC.
  • ||||||||||  Clinical, Review, Journal:  Molecular Mechanism Contributing to Malnutrition and Sarcopenia in Patients with Liver Cirrhosis. (Pubmed Central) -  Feb 18, 2021   
    This review summarizes known and proposed molecular mechanisms contributing to malnutrition and sarcopenia in liver cirrhosis and highlights remaining knowledge gaps. Since, in the prevention and treatment of DRM and sarcopenia in cirrhotic patients, more research is needed to identify potential biomarkers for diagnosis and development of targeted therapeutic strategies.
  • ||||||||||  Journal:  Sarcopenia and Cardiac Dysfunction. (Pubmed Central) -  Feb 17, 2021   
    Future research must explore other therapeutic interventions in randomized, double-blind clinical trials, which may help to supplement exercise regimens. Sarcopenia shows promise as an easily measured predictor of outcomes after transcatheter aortic valve replacement.
  • ||||||||||  Clinical, Journal:  Glucocorticoid use is an independent risk factor for developing sarcopenia in patients with rheumatoid arthritis: from the CHIKARA study. (Pubmed Central) -  Feb 17, 2021   
    RA patients using GCs at an average dose ≥ 3.25 mg/day over 1 year were at higher risk for developing sarcopenia. Reduction or withdrawal of GCs may prevent sarcopenia.Key Points• Patients with RA are at higher risk of sarcopenia.• Predictors or risk factors for developing sarcopenia over 1 year in RA patients were investigated using the prospective observational CHIKARA database.• RA patients using GCs at an average dose ≥ 3.25 mg/day over 1 year were at higher risk for developing sarcopenia.• Reduction or withdrawal of GCs may be essential to prevent sarcopenia.
  • ||||||||||  Clinical, Review, Journal:  Sarcopenia: A Contemporary Health Problem among Older Adult Populations. (Pubmed Central) -  Feb 17, 2021   
    Physical activity and nutrition are the main studied ways to prevent sarcopenia, and they also offer better outcomes. This review aims to report the prevalence of sarcopenia in older adults, its etiology, prevention, and treatment techniques.
  • ||||||||||  Review, Journal:  Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications. (Pubmed Central) -  Feb 17, 2021   
    Myokines are protagonists in the complex condition of sarcopenia, which is associated with adverse clinical outcomes in patients with CVD. The discovery of new pathways and the link between myokines and CVD remain a cornerstone toward multifaceted interventions and perhaps the minimization of the damage resulting from muscle loss induced by factors such as atherosclerosis.
  • ||||||||||  Review, Journal:  Role of Age-Related Mitochondrial Dysfunction in Sarcopenia. (Pubmed Central) -  Feb 17, 2021   
    It has been largely proven that the modulation of mitochondrial functions can induce the death of senescent cells and that removal of senescent cells improves musculoskeletal health, quality, and function. In this review, the crosstalk among mitochondria, cellular senescence, and sarcopenia will be discussed with the aim to elucidate the role that the musculoskeletal cellular senescence may play in the onset of sarcopenia through the mediation of mitochondria.
  • ||||||||||  Journal:  Basic Science of Frailty-Biological Mechanisms of Age-Related Sarcopenia. (Pubmed Central) -  Feb 17, 2021   
    The pathophysiologic underpinnings of sarcopenia are complex and multifactorial. In this review, the causes of sarcopenia are surveyed at the systems, cell, subcellular, and molecular levels with emphasis on the interplay between these various causes of this degenerative disease process.
  • ||||||||||  Journal:  Association between Reproductive Span and Sarcopenia. (Pubmed Central) -  Feb 17, 2021   
    Multiple logistic regression analysis was performed using weighted populations. After adjusting for covariates, reproductive span was found to be inversely associated with the risk of sarcopenia [Tertile 1 = 1 (reference); Tertile 2, odds ratio (OR) = 0.927, 95% confidence interval (CI) = 0.863-0.995; Tertile 3, OR = 0.854, 95% CI = 0.793-0.915].
  • ||||||||||  Journal:  Skeletal Muscle Mass by Bioelectrical Impedance Analysis and Calf Circumference for Sarcopenia Diagnosis. (Pubmed Central) -  Feb 17, 2021   
    This suggests that CC could be used as a marker of sarcopenia for older adults in settings in lower-middle-income countries where no other methods of diagnosing muscle mass are available. Although the CC is not the unique parameter to the diagnosis of sarcopenia, it could be a useful procedure in the clinic to identify patients at risk of sarcopenia.
  • ||||||||||  Clinical, Review, Journal:  Shifting perspectives - interplay between non-alcoholic fatty liver disease and insulin resistance in lean individuals. (Pubmed Central) -  Feb 17, 2021   
    The development of NAFLD in lean subjects seems to be interconnected with metabolic phenotype, precisely visceral fat tissue, sarcopenia, and insulin resistance. Here, we summarize available data focusing on the co-dependent relationship between metabolic phenotype, insulin resistance, and development of NAFLD in lean individuals, suggesting more appropriate tools for measuring body fat distribution for the screening of patients at risk.
  • ||||||||||  Clinical, Journal:  Low thoracic skeletal muscle area is not associated with negative outcomes in patients with COVID-19. (Pubmed Central) -  Feb 16, 2021   
    Moreover, in order to implement a diet that follows the right recommendations, another tables shows nutritional composition of breakfast, lunch and dinner (that each provide 3 grams of leucine and 25 grams of protein) for seven days. SMI determined by CT at the level of twelfth thoracic vertebra (T12) was not associated with negative outcomes in hospitalized patients with COVID-19.
  • ||||||||||  Clinical, Journal:  Association of an Overhydrated State With the Liver Fibrosis and Prognosis of Cirrhotic Patients. (Pubmed Central) -  Feb 13, 2021   
    Because preoperative abdominal imaging with either modality is common for patients with CD, SMI could be a reliable and largely available tool to stratify the risk of postoperative complications. An increased ECW/TBW value was associated with progressive liver fibrosis and malnutrition and related to the prognosis of cirrhotic patients.
  • ||||||||||  Journal:  Is There a Correlation Between Sarcopenia and Aortic Aneurysm Morphometry? (Pubmed Central) -  Feb 13, 2021   
    Further high quality RCTs with physiological doses of micronutrients in people with low baseline intakes or circulating concentrations, using robust methodology, are required to assess effects of supplementation adequately. No abstract available
  • ||||||||||  Review, Journal:  Resistance Training in Hypoxia as a New Therapeutic Modality for Sarcopenia-A Narrative Review. (Pubmed Central) -  Feb 13, 2021   
    It should also be acknowledged that a number of mechanisms proposed to facilitate the augmented response to RTH remain poorly understood, particularly the role of metabolic, hormonal, and intracellular signaling pathways. Further RTH intervention studies considering various exercise parameters (e.g., load, recovery time between sets, hypoxic dose, and intervention period) are strongly recommended to reinforce knowledge about the adaptational processes and the effects of this type of resistance training for sarcopenia in older people.
  • ||||||||||  Journal:  Editorial: Sarcopenia: 2020. (Pubmed Central) -  Feb 13, 2021   
    Further RTH intervention studies considering various exercise parameters (e.g., load, recovery time between sets, hypoxic dose, and intervention period) are strongly recommended to reinforce knowledge about the adaptational processes and the effects of this type of resistance training for sarcopenia in older people. No abstract available
  • ||||||||||  Clinical, Journal:  Evidence-Based Optimal Cutoff Values with the Validation of Criterion-Referenced Standards for Sarcopenic Elderly Fitness Improvement. (Pubmed Central) -  Feb 12, 2021   
    Based on these scientific evidences, we determined cutoff values from our reserved DB and realized that 75 years for men and 70 years for women are the transitional period during which there are large declines in muscle and fat mass (p < 0.01), which reflects physical function tests (p < 0.01) in both genders. Using the six factors with ideal cutoff thresholds, an individual exercise program can be designed for alleviating symptoms of frailty caused by sarcopenia for the elderly.
  • ||||||||||  Enrollment open:  Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty (clinicaltrials.gov) -  Feb 11, 2021   
    P=N/A,  N=250, Recruiting, 
    The combined assessment of those factors may have potential prognostic value for EC. Not yet recruiting --> Recruiting