Sarcopenia
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  • ||||||||||  Review, Journal:  Late-onset Systemic Lupus Erythematosus. (Pubmed Central) -  Jan 16, 2025   
    Measures to minimize the exposure to long-term exposure to high-dose steroids are crucial. Beyond this, it is of essence to adopt non-pharmacological interventions as an adjunct to traditional immunosuppression to improve pain, fatigue, depression, and anxiety, improve cardiovascular health and overall better quality of life with favourable long-term outcomes.
  • ||||||||||  Journal:  Energy Expenditure in Chronic Kidney Disease: Affecting Factors and Evaluation Methods. (Pubmed Central) -  Jan 16, 2025   
    Many health problems can accompany CKD, such as protein-energy malnutrition, sarcopenia, etc, and increase the mortality rate. This study aims to present the specific factors affecting energy expenditure specific to CKD in line with the current literature, to discuss the methods used to determine energy expenditure, and to examine these methods according to groups receiving and not receiving renal replacement therapy (hemodialysis, peritoneal dialysis, and renal transplantation).
  • ||||||||||  Review, Journal:  From molecular to physical function: The aging trajectory. (Pubmed Central) -  Jan 16, 2025   
    Finally, a pro-inflammatory state associated with age has detrimental impacts on the muscle. The purpose of this review is to highlight the physiological adaptations driving muscle aging and their potential mitigation with exercise/physical activity and nutrition.
  • ||||||||||  Preclinical, Journal:  Feruloylacetone and Its Analog Demethoxyferuloylacetone Mitigate Obesity-Related Muscle Atrophy and Insulin Resistance in Mice. (Pubmed Central) -  Jan 16, 2025   
    The supplements also promoted the formation of a gut microbial consortium comprising Blautia intestinalis, Dubosiella newyorkensis, Faecalicatena fissicatena, Waltera intestinalis, Clostridium viride, and Caproiciproducens galactitolivorans, which contributed to the reduction of obesity-induced chronic inflammation. These findings suggest, for the first time, that FER and DFER may prevent obesity-related complications, including muscle atrophy and insulin resistance, thereby warranting further research into their long-term efficacy and safety.
  • ||||||||||  LY294002 / Eli Lilly
    Journal:  Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway. (Pubmed Central) -  Jan 15, 2025   
    PSP exhibits significant ameliorative effects on skeletal muscle aging and atrophy, as well as mitochondrial dysfunction by activating the PI3K/Akt/mTOR signaling pathway. Our study uniquely investigates the effects of PSP on skeletal muscle aging and mitochondrial dysfunction with a specific focus on the PI3K/Akt/mTOR signaling pathway, which highlights the potential of PSP as a novel therapeutic agent for sarcopenia, offering an alternative to current treatment strategies.
  • ||||||||||  Trial completion date, Trial primary completion date:  MIMOSA: Maintaining Immune and Mitochondrial Functions in Old Adults with SAfe Nutrition. (clinicaltrials.gov) -  Jan 15, 2025   
    P=N/A,  N=240, Not yet recruiting, 
    Our study uniquely investigates the effects of PSP on skeletal muscle aging and mitochondrial dysfunction with a specific focus on the PI3K/Akt/mTOR signaling pathway, which highlights the potential of PSP as a novel therapeutic agent for sarcopenia, offering an alternative to current treatment strategies. Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Jun 2026 --> Jun 2027
  • ||||||||||  Observational data, Journal:  Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study. (Pubmed Central) -  Jan 14, 2025   
    The findings of this study may greatly aid in understanding the relationship between blood biomarkers, lifestyle and sarcopenia progression in older adults, and may help in SII is significantly associated with sarcopenia in a geriatric outpatient population, and a population-specific SII cut-off may serve as a novel, simple, and practical biomarker for diagnosing sarcopenia.
  • ||||||||||  Journal:  Frailty or sarcopenia: which is a better indicator of mortality risk in older adults? (Pubmed Central) -  Jan 13, 2025   
    The study was pioneering in establishing a negative association between SVR and depression within the US population. Sarcopenia using <36?kg for men and <23?kg for women as cut-off points seems to be better than the frailty phenotype for identifying the risk of mortality in older adults.
  • ||||||||||  Journal:  Evaluating the Impact of Phosphatidylethanol Testing on Hospital Outcomes. (Pubmed Central) -  Jan 13, 2025   
    This study highlights the association between recent alcohol use, as identified by PEth testing, and severe hospital outcomes. While PEth testing provides an objective measure of recent alcohol consumption, further research is needed to explore its role in improving clinical outcomes and guiding interventions for patients with alcohol use.
  • ||||||||||  Journal:  Quinine inhibits myogenic differentiation by disrupting AKT signaling pathway. (Pubmed Central) -  Jan 13, 2025   
    Quinine reduced muscle protein and gene expression by modulating AKT signaling and inhibiting myogenic differentiation and muscle regeneration. Therefore, quinine may cause sarcopenia, and this risk should be considered when using quinine for treatment.
  • ||||||||||  Journal:  The association between sarcopenic obesity, sarcopenia and functional dependence, malnutrition, and mortality: the phenomenon of obesity paradox in sarcopenic obesity. (Pubmed Central) -  Jan 12, 2025   
    In the final-adjusted model, compared to patients with non-sarcopenic non-obesity phenotype, sarcopenic obesity is significantly associated with functional dependence (odds ratio [OR]: 3.83, 95% CI 1.47-9.97; P?=?0.006), malnutrition (OR: 0.48, 95% CI 0.24-0.99; P?=?0.047), and all-cause mortality (hazard ratio[HR]: 2.78, 95% CI 1.57-4.94; P?=?0.001); sarcopenia is significantly associated with malnutrition (OR: 2.48, 95% CI 1.09-5.65; P?=?0.030), and all-cause mortality (HR:3.06, 95% CI 1.69-5.56; P?<?0.001); obesity is significantly associated with malnutrition (OR:0.11, 95% CI 0.05-0.22; P?<?0.001). Consequently, it is advisable to incorporate sarcopenia and sarcopenic obesity into the screening and treatment protocols for older adults in the community to effectively mitigate the adverse health consequences.
  • ||||||||||  Biomarker, Journal:  The mediating role of inflammatory biomarkers in the association between serum copper and sarcopenia. (Pubmed Central) -  Jan 12, 2025   
    Furthermore, white blood cell (WBC) count, neutrophil count, and systemic inflammation index (SII) were identified as significant mediators in the relationship between serum Cu and the risk of sarcopenia, with mediation proportions of 6.34%, 6.20%, and 4.37%, respectively (all P?<?0.05). Therefore, balancing essential trace metals is crucial for maintaining muscle health.
  • ||||||||||  Review, Journal:  Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR). (Pubmed Central) -  Jan 12, 2025   
    Particular attention is paid to the need for personalized medicine as it applies to exercise and geroscience, given the inter-individual variability in adaptation to exercise demonstrated in older adult cohorts. Overall, this consensus provides a foundation for applying and extending the current knowledge base of exercise as medicine for an aging population to optimize health span and quality of life.
  • ||||||||||  Review, Journal:  Can We Maintain Muscle Mass on a Plant-Based Diet? (Pubmed Central) -  Jan 12, 2025   
    Although animal-based proteins remain highly effective in preserving muscle mass, plant-based proteins can serve as a viable alternative in many scenarios. Future research should focus on well-designed, large-scale studies across diverse populations to refine guidelines for optimizing plant-based protein intake in sarcopenia prevention and management.
  • ||||||||||  Review, Journal:  Sarcopenia in MASLD-Eat to Beat Steatosis, Move to Prove Strength. (Pubmed Central) -  Jan 12, 2025   
    BS induces weight loss and stabilizes metabolic imbalances, but its impact on sarcopenia is nuanced, underscoring the need for further research. Our aim is to provide a comprehensive review of the interplay between sarcopenia and MASLD and offer insight into the most recent therapeutic challenges and discoveries, as sarcopenia is often overlooked or unrecognized and poses significant challenges for managing these patients.