Sarcopenia
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  • ||||||||||  Review, Journal:  Extracellular matrix/mitochondria pathway: a novel potential target for sarcopenia. (Pubmed Central) -  Feb 24, 2021   
    Thus, it remains important to be able to offer less cumbersome but equally effective alternatives such as pharmacological approaches to help elderly patients. In this review, we discuss the involvement of mitochondria dysfunction as well as the ECM remodeling in sarcopenia and we suggest that the future of sarcopenia drug development may be targeting ECM/mitochondria pathway.
  • ||||||||||  calcifediol / Generic mfg.
    Clinical, Review, Journal:  Vitamin D supplementation: upper limit for safety revisited? (Pubmed Central) -  Feb 24, 2021   
    The prevention and/or correction of vitamin D deficiency/insufficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected.
  • ||||||||||  Review, Journal:  Impact of Mitophagy and Mitochondrial Unfolded Protein Response as New Adaptive Mechanisms Underlying Old Pathologies: Sarcopenia and Non-Alcoholic Fatty Liver Disease. (Pubmed Central) -  Feb 24, 2021   
    Nevertheless, the role of the integrated stress response (ISR) involving UPR and mitophagy in the development and progression of these illnesses is still a matter of debate, considering that some studies indicate that the prolonged exposure to low levels of stress may trigger these mechanisms to maintain mitohormesis, whereas others sustain that chronic activation of them could lead to cell death. In this review, we discuss the available research that contributes to unveil the role of the mitochondrial UPR in the development of sarcopenia, in an attempt to describe changes prior to the manifestation of severe symptoms; and in NAFLD, in order to prevent or reverse fat accumulation and its progression by means of suitable protocols to be addressed in future studies.
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS
    Clinical, Journal, Tumor Mutational Burden, PD(L)-1 Biomarker, IO biomarker:  Association between skeletal muscle loss and the response to nivolumab immunotherapy in advanced gastric cancer patients. (Pubmed Central) -  Feb 24, 2021   
    In this review, we discuss the available research that contributes to unveil the role of the mitochondrial UPR in the development of sarcopenia, in an attempt to describe changes prior to the manifestation of severe symptoms; and in NAFLD, in order to prevent or reverse fat accumulation and its progression by means of suitable protocols to be addressed in future studies. As a surrogate marker for skeletal muscle loss, the PMI may be useful for predicting the response to nivolumab among patients with advanced GC.
  • ||||||||||  Clinical, Journal:  Association between Dietary Habits and Physical Function in Brazilian and Italian Older Women. (Pubmed Central) -  Feb 23, 2021   
    Our findings indicate that Brazilian and Italian community-dwelling older women show different patterns of protein intake, with higher consumption of plant-based protein in the Brazilian sample and higher ingestion of animal-derived protein in the Italian subgroup. These dietary patterns may differentially impact the relationship between physical function and protein intake observed in Brazilian and Italian older women.
  • ||||||||||  Review, Journal:  Nutrition and Sarcopenia-What Do We Know? (Pubmed Central) -  Feb 23, 2021   
    Selenium, magnesium, and omega 3 fatty acids have been studied as supplements in clinical trials and in the diet, and they appear to demonstrate a potential association with physical activity and muscle performance in older individuals. Following the Mediterranean diet and higher consumption of fruits and vegetables have been associated with improved physical performance and protection against muscle wasting, sarcopenia, and frailty.
  • ||||||||||  Journal:  Sarcopenia is Associated with Nonunion of Open Tibia and Ankle Fractures. (Pubmed Central) -  Feb 23, 2021   
    Diagnosing sarcopenia in these individuals can inform medical decision making and patient counseling regarding risk for nonunion. Further work is needed to identify effective interventions to improve outcomes in these patients.Level of Evidence: III.
  • ||||||||||  Review, Journal:  New understanding of the pathogenesis and treatment of stroke-related sarcopenia. (Pubmed Central) -  Feb 23, 2021   
    At present, there is still no particularly effective way to stop its progress,however, the combination of rehabilitation exercise, nutrition supply and drugs may delay or even prevent the development of stroke-related sarcopenia. This article reviews the latest progress in the pathogenesis, screening, evaluation and treatment of stroke-related sarcopenia to provide reference for clinical treatment and rehabilitation of stroke.
  • ||||||||||  Journal:  Submental Muscle Activity and Its Role in Diagnosing Sarcopenic Dysphagia. (Pubmed Central) -  Feb 23, 2021   
    Patients with sarcopenic dysphagia had longer submental muscle activity duration and higher amplitude during swallowing as assessed using sEMG. The findings of this study can be useful in elucidating the underlying pathophysiology of sarcopenic dysphagia and in diagnosing sarcopenic dysphagia.
  • ||||||||||  Review, Journal:  NAD metabolism and its roles in cellular processes during ageing. (Pubmed Central) -  Feb 23, 2021   
    However, much remains to be learnt about how NAD influences human health and ageing biology. This includes a deeper understanding of the molecular mechanisms that regulate NAD levels, how to effectively restore NAD levels during ageing, whether doing so is safe and whether NAD repletion will have beneficial effects in ageing humans.
  • ||||||||||  Retrospective data, Journal:  Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. (Pubmed Central) -  Feb 23, 2021   
    Using Mendelian randomization we report possible overlapping causal pathways, including diabetes susceptibility, haematological parameters, and the immune system. We conclude that muscle weakness in older adults has distinct mechanisms from continuous strength, including several pathways considered to be hallmarks of ageing.
  • ||||||||||  Clinical, Review, Journal:  Late-onset hypogonadism: clinical evidence, biological aspects and evolutionary considerations. (Pubmed Central) -  Feb 23, 2021   
    In this manuscript, we apply key principles of evolutionary medicine to testosterone biology and LOH to provide a novel perspective on these two fields. Additionally, we discuss insightful data derived from the animal kingdom to illustrate the plasticity of individual testosterone trajectories across the lifespan, outline cost-benefit-considerations of TRT in LOH and highlight potential caveats of such therapies.
  • ||||||||||  Clinical, Journal:  Frailty, sarcopenia and health related outcomes among elderly patients in Saudi Arabia. (Pubmed Central) -  Feb 23, 2021   
    In conclusion, this research highlights the high prevalence of sarcopenia among elderly patients and the increasing percentage of frail patients in Saudi Arabia. In addition, significant difference and association were found with sarcopenia and frailty with many sociodemographic and clinical components of elderly patients in Saudi Arabia.
  • ||||||||||  Clinical, Journal, HEOR:  Burden of Disease in Patients With Tumor-Induced Osteomalacia. (Pubmed Central) -  Feb 23, 2021   
    © 2020 American Society for Bone and Mineral Research © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research
  • ||||||||||  Trial completion date, Trial primary completion date:  Dietary Behaviour Change Intervention Among Older People With Sarcopenic Obesity (clinicaltrials.gov) -  Feb 20, 2021   
    P=N/A,  N=60, Recruiting, 
    JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research Trial completion date: Apr 2021 --> Sep 2021 | Trial primary completion date: Apr 2021 --> Sep 2021
  • ||||||||||  Journal:  The ultrasonographic measurement of muscle thickness in sarcopenia. A prediction study. (Pubmed Central) -  Feb 20, 2021   
    The prevalence of sarcopenia in the geriatric population and the rehabilitation wards is reported to be high. Therefore, an easy, fast, low cost and with no risk, widely available method such as ultrasonography could be an extremely valuable tool for the screening and follow-up of sarcopenia.
  • ||||||||||  Journal:  Amount of laryngeal upward movement and pharyngeal area as indicators of decreased swallowing muscle function in sarcopenia. (Pubmed Central) -  Feb 20, 2021   
    In a recent article in the Journal of Oral Rehabilitation, Miyashita and colleagues suggested the usefulness of measuring the amount of laryngeal upward movement and pharyngeal area by the videofluoroscopic swallowing study to determine decreased swallowing muscle function in sarcopenia (1). Although a small number of patients were included making it hard to perform extensive multivariable analyses and to draw firm conclusions, the study suggests a novel, single procedure to diagnose sarcopenic dysphagia.
  • ||||||||||  Review, Journal:  Signaling Pathways That Control Muscle Mass. (Pubmed Central) -  Feb 20, 2021   
    Although modulating muscle function to prevent and treat disease is an enticing concept that has intrigued research teams for decades, a lack of thorough understanding of the molecular mechanisms and signaling pathways that control muscle mass, in addition to poor transferability of findings from rodents to humans, has obstructed efforts to develop effective treatments. Here, we review the progress made in unraveling the molecular mechanisms responsible for the regulation of muscle mass, as this continues to be an intensive area of research.
  • ||||||||||  Biomarker, Review, Journal:  Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place? (Pubmed Central) -  Feb 20, 2021   
    The adoption of multi-marker approaches (combined with multivariate modeling) has shown great potential for addressing the complexity of PF&S pathophysiology and identifying candidate biological markers. Well-designed longitudinal studies are necessary for the incorporation of reliable biomarkers into clinical practice and for unveiling novel targets that are amenable to interventions.
  • ||||||||||  Review, Journal:  Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review. (Pubmed Central) -  Feb 20, 2021   
    In addition, we cover the pathogenesis and treatment of sarcopenia in autoimmune and rheumatic diseases. This review provides a comprehensive understanding of sarcopenia in various autoimmune diseases and highlights the need for a consistent definition of sarcopenia.
  • ||||||||||  Trial primary completion date:  A Cross-sectional Study of Sarcopenia in Patients With Parkinson ' s Disease (clinicaltrials.gov) -  Feb 19, 2021   
    P=N/A,  N=908, Recruiting, 
    This study shows that measuring muscle health (the patient's muscle volume and how much fat they have in their muscles) could help identify the more vulnerable patients and enable early prevention of severe liver disease. Trial primary completion date: Jan 2021 --> Dec 2021