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- || Clinical, Journal: Muscle wasting associated co-morbidities, rather than sarcopenia are risk factors for hospital mortality in critical illness. (Pubmed Central) - Mar 2, 2021
In critically ill patients with abdominal sepsis, muscle wasting associated co-morbidities rather than sarcopenia were risk factors for hospital mortality.
- || Clinical, Journal: Comparison of revised EWGSOP criteria and four other diagnostic criteria of sarcopenia in Chinese community-dwelling elderly residents. (Pubmed Central) - Mar 2, 2021
Risk factors associated with the EWGSOP2-defined sarcopenia have no consistent patterns with the EWGSOP1, AWGS, IWGA, and FNIH criteria. Therefore, the validity of the EWGSOP2 consensus needs to be confirmed in further prospective studies.
- | Preclinical, Journal: Anabolic Properties of Mixed Wheat-Legume Pasta Products in Old Rats: Impact on Whole-Body Protein Retention and Skeletal Muscle Protein Synthesis. (Pubmed Central) - Mar 2, 2021
After legume-enriched pasta intake, muscle mass, and protein accretion were in the same range as in the casein and SMP groups. Mixed wheat-legume pasta could be a nutritional strategy for enhancing the protein content and improving the protein quality, i.e., amino acid profile, of this staple food that is more adequate for maintaining muscle mass, especially for older individuals.
- || Clinical, Review, Journal: Uremic Sarcopenia: Clinical Evidence and Basic Experimental Approach. (Pubmed Central) - Mar 2, 2021
This review highlights molecular mechanisms and promising interventions for uremic sarcopenia that were revealed through basic research. Extensive study is still needed to cast light on the many aspects of locomotive organ impairments in CKD and explore the ways that diet and exercise therapies can improve both outcomes and quality of life at every level.
- || Clinical, Journal: Leucine-Enriched Protein Supplementation Increases Lean Body Mass in Healthy Korean Adults Aged 50 Years and Older: A Randomized, Double-Blind, Placebo-Controlled Trial. (Pubmed Central) - Mar 2, 2021
In subgroup analyses, significant differences remained only in subjects between 50 and 64 years of age. We concluded that leucine-enriched protein supplementation can have beneficial effects by preventing muscle loss, mainly for late middle-aged adults.
- | Journal: Comparison between Appendicular Skeletal Muscle Index DXA Defined by EWGSOP1 and 2 versus BIA Tengvall Criteria among Older People Admitted to the Post-Acute Geriatric Care Unit in Italy. (Pubmed Central) - Mar 2, 2021
Moreover, in females, the prevalence was comparable among the three diagnostic criteria, while in males, it was significantly higher under Tengvall than the other two criteria. The application of the Tengvall formula with a single frequency BIA should be revised in terms of application for assessing low ASMI in elderly patients.
- | Biomarker, Retrospective data, Journal: Sarcopenia as a Prognostic Factor for 90-Day and Overall Mortality in Patients Undergoing Spine Surgery for Metastatic Tumors: A Multicenter Retrospective Cohort Study. (Pubmed Central) - Mar 2, 2021
The frailty/sarcopenia paradigm is a stronger predictor of survival at these time points than other standards. PS can be used in clinical decision-making to select which patients with metastatic spine tumors are appropriate surgical candidates.
- | Journal: The effect of sarcopenia on perioperative complications in abdominally based free-flap breast reconstruction. (Pubmed Central) - Mar 2, 2021
PS can be used in clinical decision-making to select which patients with metastatic spine tumors are appropriate surgical candidates. Sarcopenia does not predispose to minor or major surgical complications in patients who undergo abdominally based microsurgical breast reconstruction.
- | Preclinical, Journal: Sarcopenia Detection System Using RGB-D Camera and Ultrasound Probe: System Development and Preclinical In-Vitro Test. (Pubmed Central) - Mar 2, 2021
The proposed method was validated by in-vitro test with a human thigh mimicked ham-gelatin phantom. The result showed the ham tissue thickness was maintained within approximately 26.01 ± 1.0 mm during 82° scanning with a 2.5 N radial force setting and the radial force between probe and surface of the phantom was maintained within 2.50 ± 0.1 N.
- || Clinical, Journal: Metabolic syndrome-related sarcopenia is associated with worse prognosis in patients with gastric cancer: A prospective study. (Pubmed Central) - Mar 2, 2021
The long-term prognoses of patients with sarcopenia were impaired by preoperative MetS, while patients without sarcopenia benefited. Thus, patients with both sarcopenia and MetS require more medical interventions.
- || Clinical, Observational data, Journal: Body composition and bone mineral density in craniopharyngioma patients: a longitudinal study over 10 years. (Pubmed Central) - Mar 2, 2021
Z-scores of BMI, fat percentage and FMI remained stable in patients with craniopharyngioma over time, while Z-scores of FFMI and BMD increased. Higher glucocorticoid dose and radiotherapy were associated with BMD loss and GHRT with increase.
- | Journal: Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5. (Pubmed Central) - Mar 2, 2021
UPS overactivation, indicated by increased atrogin-1/MAFbx (atrogin-1) and muscle RING-finger protein-1 (MuRF-1) protein levels and oxidative stress, was abolished in tibialis anterior muscles from TGR5 mice. Our results collectively suggest that all sarcopenia features induced by the DDC-supplemented diet in mice are dependent on TGR5 receptor expression.
- || Clinical, Journal: Isometric Strength Measures are Superior to the Timed Up and Go Test for Fall Prediction in Older Adults: Results from a Prospective Cohort Study. (Pubmed Central) - Mar 2, 2021
Fallers showed a significantly lower handgrip strength (-5.7 kg, 95% confidence interval: -10.4 to -1.1, p=0.019) and knee extension strength (-4.9 kg, -9.6 to -0.2, p=0.042) at follow-up, while no significant differences were found for any TUG variation. Handgrip and knee extension strength measures - particularly when assessed regularly over time - have the potential to serve as a simple and easy tool for detecting individuals at risk of falling as compared to functional mobility measures (ie, TUG test).
- || Review, Journal: Cardiac Cachexia: A Well-Known but Challenging Complication of Heart Failure. (Pubmed Central) - Mar 2, 2021
Understanding its background is crucial in the development of treatment strategies to prevent and treat tissue wasting. There are currently no specific European guidelines or recommended therapy for cachexia treatment in HF ("cardiac cachexia").
- | Journal: Exercise Intolerance in Kidney Diseases: Physiological Contributors and Therapeutic Strategies. (Pubmed Central) - Mar 2, 2021
Current and prospective pharmaceutical and nutraceutical strategies to improve exertional fatigue are also broached. An extensive understanding of the pathophysiological mechanisms of exercise intolerance will allow for the development of more targeted therapeutic approached to improve exertional fatigue and health related quality of life in CKD and ESRD.
- | New trial, HEOR: Physical Exercise, Nutrition Supplement and Frailty of Older Population (clinicaltrials.gov) - Mar 1, 2021
P=N/A, N=120, Enrolling by invitation, Sponsor: Taipei Medical University
- [VIRTUAL] Low Muscle Mass at Admission Predicts Poor Walking Function at Discharge in Patients With Anterior Circulation Stroke Not in Posterior Circulation Stroke [Board No. LBP20] () - Feb 28, 2021 - Abstract #ISC2021ISC_1109;
LMM at admission is associated with poor walking function at discharge only in ACS. ADDIN EN.REFLIST
- [VIRTUAL] Short-Term Outcome of Post-Stroke Fatigue During the Transition From Hospital to Home () - Feb 28, 2021 - Abstract #ISC2021ISC_924;
In this study, PSF during hospitalization can affect sleep status and QOL after discharge, and which is consistent with previous studies. It is worth noting that patients with PSF at admission had higher SARC-F scores after discharged home.
- | Journal: "Zooming" in the Anterior Thigh Muscle for the Diagnosis of Sarcopenia. (Pubmed Central) - Feb 27, 2021
It is worth noting that patients with PSF at admission had higher SARC-F scores after discharged home. No abstract available
- | Journal: Reply to: "Zooming" in the Anterior Thigh Muscle for the Diagnosis of Sarcopenia. (Pubmed Central) - Feb 27, 2021
No abstract available No abstract available
- || Clinical, Journal: Supplementation with Whey Protein, Omega-3 Fatty Acids and Polyphenols Combined with Electrical Muscle Stimulation Increases Muscle Strength in Elderly Adults with Limited Mobility: A Randomized Controlled Trial. (Pubmed Central) - Feb 27, 2021
The combination of EMS and this specific nutritional intervention could be considered as a new approach for the prevention of sarcopenia but more work is needed before this approach should be recommended. This trial was registered at the Japanese University Hospital Medical Information Network (UMIN) clinical trial registry (UMIN000008382).
- || Clinical, Journal: Persisting muscle dysfunction in Cushing's syndrome despite biochemical remission. (Pubmed Central) - Feb 27, 2021
This study shows that Cushing's syndrome associated myopathy does not spontaneously resolve during remission. This calls for action to identify effective interventions to improve muscle dysfunction in this setting.
- | Journal: Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. (Pubmed Central) - Feb 27, 2021
These physiological benefits arise from rejuvenated PGE2 levels which augment mitochondrial function and autophagy and decrease TGF-beta and ubiquitin-proteasome pathways. Our studies demonstrate a previously unrecognized role for PGE2 signaling in countering muscle atrophy and identify 15-PGDH as a promising therapeutic target to counter sarcopenia.
- | Journal: Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium. (Pubmed Central) - Feb 26, 2021
These position statements offer a rational basis for an evidence-based definition of sarcopenia. The analyses that informed these position statements are summarized in this article and discussed in accompanying articles in this issue of the journal.
- | Journal: Thyroid Function and Sarcopenia: Results from the ELSA-Brasil Study. (Pubmed Central) - Feb 26, 2021
The analyses that informed these position statements are summarized in this article and discussed in accompanying articles in this issue of the journal. Subtle thyroid hormone alterations are associated with sarcopenia or its defining components in middle-aged and older adults without overt thyroid dysfunction.
- || Clinical, Journal: Comparing Longitudinal Sarcopenia Trends by Definitions Across Men and Women After Hip Fracture. (Pubmed Central) - Feb 26, 2021
Overall, there appeared to be no reduction in sarcopenia over the year after hip fracture, regardless of definition. Future research should examine the relationship between sarcopenia prevalence and functional recovery.
- | Journal: Nrf2 deficiency promotes the increasing trend of autophagy during aging in skeletal muscle: a potential mechanism for the development of sarcopenia. (Pubmed Central) - Feb 26, 2021
Autophagy flux was measured in young WT, young KO, old WT, old KO mice, using colchicine as autophagy inhibitor...Nrf2 KO and increasing age caused decreased cross-sectional area of extensor digitorum longus and soleus muscles. We concluded that Nrf2 deficiency and increasing age may activate AMPK and ROS signals to cause excessive autophagy activation in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.
- || Clinical, Journal: Malnutrition as Key Predictor of Physical Frailty among Malaysian Older Adults. (Pubmed Central) - Feb 26, 2021
Results suggested that frailty and malnutrition shared considerable overlap, which emphasised the interrelated but discrete concepts. Therefore, the assessment of malnutrition is imperative and could be used as a practical implication in assessing frailty syndrome.
- | Journal: Usefulness of Carnitine Supplementation for the Complications of Liver Cirrhosis. (Pubmed Central) - Feb 26, 2021
In conclusion, carnitine deficiency is not always rare in liver cirrhosis, and it requires constant attention in the daily medical care of this disease. Carnitine supplementation might be an important strategy for improving the quality of life of patients with liver cirrhosis.
- || Clinical, Journal: Correlation of Body Composition and Nutritional Status with Functional Recovery in Stroke Rehabilitation Patients. (Pubmed Central) - Feb 26, 2021
Multiple regression analysis revealed that a high muscle rate (skeletal muscle mass/body weight) (odds ratio OR = 2.43), high phase angle (OR = 3.32), and high GNRI (OR = 2.57) were significantly associated with motor FIM items at four weeks in male and female patients. Muscle mass maintenance through nutritional management and early rehabilitation in the acute period of stroke is essential for functional recovery in stroke patients.
- ||| Journal, Adverse events, HEOR: Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis. (Pubmed Central) - Feb 26, 2021
Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia.
- || Clinical, Journal: Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross-Sectional, Population-Based Cohorts. (Pubmed Central) - Feb 26, 2021
These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia. The prevalence of muscle weakness, defined by the putative SDOC grip strength constructs, depends on the construct of weakness used.
- | Journal: Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis. (Pubmed Central) - Feb 26, 2021
CART models did not select DXA-based lean mass as a primary discriminator of slowness. These results were presented to an SDOC Consensus Panel, who used them and other information to develop the SDOC Position Statements.
- || Clinical, Journal: Application of Cut-Points for Low Muscle Strength and Lean Mass in Mobility-Limited Older Adults. (Pubmed Central) - Feb 26, 2021
A greater number of individuals fall below SDOC Grip max cut-points compared with previous recommendations. Clinicians and researchers working with older adults may consider these thresholds as an inclusive means to identify candidates for low-risk lifestyle promyogenic and function-promoting therapies.
- || Clinical, Review, Journal: The Association Between Computed Tomography-Defined Sarcopenia and Outcomes in Adult Patients Undergoing Radiotherapy of Curative Intent for Head and Neck Cancer: A Systematic Review. (Pubmed Central) - Feb 26, 2021
The certainty of the evidence requires strengthening with further research. Understanding the impact sarcopenia has on outcomes for these patients has implications for informing potential nutrition interventions and facilitating individualized care.
- | Journal: Evaluating body composition by combining quantitative spectral detector computed tomography and deep learning-based image segmentation. (Pubmed Central) - Feb 26, 2021
Understanding the impact sarcopenia has on outcomes for these patients has implications for informing potential nutrition interventions and facilitating individualized care. We describe a software toolkit allowing for an accurate analysis of body composition utilizing a combination of DCNN- and threshold-based segmentations from spectral detector computed tomography.
- || Biomarker, Clinical, Journal: Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischaemic stroke, with focus on (co)-morbidity and ageing/cellular senescence (SASKit): protocol for a prospective cohort study. (Pubmed Central) - Feb 26, 2021
We anticipate that our detailed study protocol and data analysis plan may also guide other biomarker exploration trials. The study was approved by the local ethics committee (Ethikkommission an der Medizinischen Fakultät der Universität Rostock, A2019-0174), registered at the German Clinical Trials Register (DRKS00021184), and results will be published following standard guidelines.
- | Journal: Dreadful Consequences of Sarcopenia and Osteoporosis due to COVID-19 Containment. (Pubmed Central) - Feb 26, 2021
The study was approved by the local ethics committee (Ethikkommission an der Medizinischen Fakultät der Universität Rostock, A2019-0174), registered at the German Clinical Trials Register (DRKS00021184), and results will be published following standard guidelines. No abstract available
- ||| New trial: Impact of Fish Oil Dose on Tissue Content and Function (clinicaltrials.gov) - Feb 25, 2021
P=N/A, N=40, Not yet recruiting, Sponsor: University of Stirling
No abstract available .
- | New trial: SARCO-V: Sarcopenia and Mechanical Ventilation in Older Patients Admitted Due to COVID-19 (clinicaltrials.gov) - Feb 25, 2021
P, N=120, Recruiting, Sponsor: Brugmann University Hospital
- || Clinical, Journal: ASO Author Reflections: The Significance of Limited Surgery Among Patients with Sarcopenia. (Pubmed Central) - Feb 25, 2021
. No abstract available
- || Clinical, Journal: Decline in muscle strength and performance predicts fracture risk in elderly women and men. (Pubmed Central) - Feb 25, 2021
5xSTS and GS were the tests most consistently associated with fractures. Further studies are required to determine whether muscle strength/performance improve the predictive accuracy of fracture prediction models.
- || Clinical, Clinical data, Journal: Association between temporal muscle thickness and clinical outcomes in patients with newly diagnosed glioblastoma. (Pubmed Central) - Feb 25, 2021
Our findings suggest that TMT can be a useful prognostic biomarker for clinical outcomes in GBM patients. Further preclinical and clinical studies could help elucidate this association of sarcopenia with clinical outcomes in GBM patients.
- || Review, Journal: Regulation of microRNAs in Satellite Cell Renewal, Muscle Function, Sarcopenia and the Role of Exercise. (Pubmed Central) - Feb 25, 2021
miRNAs modulate key steps of skeletal myogenesis including satellite cells renewal, skeletal muscle plasticity, and regeneration. Here, we provide an overview of the general aspects of muscle regeneration and miRNAs role in skeletal mass homeostasis and plasticity with a special interest in their expression in sarcopenia and skeletal muscle adaptation to exercise in the elderly.
- |||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Reimbursement, Medicare: My pre-TIPS evaluation includes MHE assesment (critical flicker and Stroop), sarcopenia evaulation (at least hand grip), nutrition assessment, ECHO and radiology discussion. Rifaximin in high risk groups but funding/medicare issues. Any news on the planned AUS TIPS consortium? (Twitter) - Feb 25, 2021
- ||| Clinical: Should be BCAA be a part of nutritional regime in these patients especially those who have sarcopenia prior to TIPS for preventing post tips HE (Twitter) - Feb 25, 2021
- | New trial: Effectiveness of Interactive Exergame in Older Adults With Sarcopenia (clinicaltrials.gov) - Feb 25, 2021
P=N/A, N=60, Not yet recruiting, Sponsor: Taipei Medical University
- ||| New trial, Surgery, Bariatric surgery: SarcoFit: Effect of Protein Supplementation and a Structured Exercise Program on Muscle in Women After Bariatric Surgery. (clinicaltrials.gov) - Feb 25, 2021
P=N/A, N=75, Recruiting, Sponsor: Hospital Clinic of Barcelona
- metformin / Generic mfg.
[VIRTUAL] EVALUATION OF THE INCIDENCE OF FRACTURE IN AN OSTEOPOROTIC ELDERLY POPULATION ACCORDING TO THE PRESENCE OF DIABETES. ROLE OF SARCOPENIA ASSESSED USING THE SARC-F QUESTIONNAIRE. () - Feb 24, 2021 - Abstract #ICE2021ICE_355;
However, practically all of the patients were under treatment for OP and were 25OHD sufficient. The percentage of sarcopenic patients in our population of older adults assessed by SARC-F questionnaire was 11% and it did not correlate with the incidence of fx.