Sarcopenia
Welcome,         Profile    Billing    Logout  
 46 Companies   12 Products   12 Products   17 Mechanisms of Action   756 Trials   22406 News 


«12...291292293294295296297298299300301...401402»
  • ||||||||||  [VIRTUAL] Changes in Quality of Life in Lung Cancer Survivors: Trend and Predictors () -  Mar 14, 2021 - Abstract #ATS2021ATS_2049;    
    These associations affirm that treatment type impacts QoL, and survivorship care should address performance status and comorbidity management. Our findings additionally suggest that future studies should examine body composition (i.e., sarcopenia) and leisure time activities as additional targets to optimize QoL.
  • ||||||||||  Clinical, Journal:  GLIM Criteria for Malnutrition in Surgical IBD Patients: A Pilot Study. (Pubmed Central) -  Mar 13, 2021   
    GLIM has a higher rate of malnutrition detection than ESPEN 2015, as malnutrition in IBD seems linked to inflammation and secondary malabsorption even without a reduction of food intake. The sensitivity of the screening tools is lower than the specificity when compared with GLIM criteria for malnutrition diagnosis.
  • ||||||||||  Journal:  Impact of whole dairy matrix on musculoskeletal health and aging-current knowledge and research gaps. (Pubmed Central) -  Mar 12, 2021   
    We conclude that the dairy matrix exerts an effect on bone and muscle health that is more than the sum of its nutrients, and we suggest that whole foods, not only single nutrients, need to be assessed in future observational and intervention studies of health outcomes. Furthermore, the importance of the matrix effect on health outcomes argues in favor of making future dietary guidelines food based.
  • ||||||||||  Clinical, Journal:  Repurposing a fracture risk calculator (FRAX) as a screening tool for women at risk for sarcopenia. (Pubmed Central) -  Mar 12, 2021   
    Here we provide preliminary evidence to suggest that FRAX probabilities without BMD might predict sarcopenia with high sensitivity and reasonable specificity. Given that FRAX clinical risk factors are identified without equipment, there is potential to use this or a modified version of the FRAX tool to screen for individuals at risk of sarcopenia.
  • ||||||||||  Review, Journal:  Muscle Wasting and Sarcopenia in Heart Failure-The Current State of Science. (Pubmed Central) -  Mar 12, 2021   
    In the last decades, many advances have been accomplished but sarcopenia remains an underdiagnosed pathology and more efforts are needed to find an efficacious therapeutic plan. The purpose of this review is to illustrate the current knowledge in terms of pathogenesis, diagnosis, and treatment of sarcopenia in order to provide a better understanding of wasting disorders occurring in chronic heart failure.
  • ||||||||||  Clinical, Review, Journal:  Myoprotective Whole Foods, Muscle Health and Sarcopenia: A Systematic Review of Observational and Intervention Studies in Older Adults. (Pubmed Central) -  Mar 11, 2021   
    There was moderate evidence for the role of these foods in muscle strength and sarcopenia, and limited or inconclusive evidence for the benefits of other whole foods (e.g., fish, eggs) for muscle health in older adults. Although current nutritional recommendations are often based on a single nutrient approach, further research about the role of protein-rich and other foods in muscle health will allow for the development of guidelines that are based on whole foods, also highlighting the potential importance of non-protein nutrients within these foods for myoprotection in older adults.
  • ||||||||||  Trial completion:  Vitality Acupunch Exercise Program for Sarcopenia Older Adults (clinicaltrials.gov) -  Mar 10, 2021   
    P=N/A,  N=114, Completed, 
    Nutrition support to restore muscle mass would prolong survival for higher-risk patients. Recruiting --> Completed
  • ||||||||||  Journal:  Indicators of Sarcopenia: Sex Differences in Competitive Runners Prior to Peak Muscle Mass. (Pubmed Central) -  Mar 10, 2021   
    Female runners displayed the highest muscle quality (T1=15.3±1.7; T3=15.7±2.0) compared to male runners (T1=13.7±1.4, p < 0.001; T3=14.2±1.6, p < 0.001) and male non-runners (T1=12.4±1.8, p=0.001; T3=13.2±1.6, p < 0.001), while female non-runners (T1=14.6±2.5, p=0.154; T3=15.1 ±2.2, p=0.124) showed higher muscle quality than male non-runners. Higher muscle quality in low-body-mass index females persists over one-year during young-adulthood and while running contributes to whole-body muscle mass accrual, it does not appear to be significantly associated with improvements in the most commonly used upper-body diagnostic indicator of sarcopenia.
  • ||||||||||  Desferal (deferoxamine) / Kermanshah University of Medical Sciences, Novartis
    Journal:  Iron deficiency attenuates protein synthesis stimulated by branched-chain amino acids and insulin in myotubes. (Pubmed Central) -  Mar 10, 2021   
    Differentiated C2C12 myotubes were incubated with an iron chelator, deferoxamine mesylate, and then stimulated with BCAA or insulin to activate protein synthesis...We suggest that low iron availability attenuates BCAA- and insulin-stimulated protein synthesis, possibly via activation of AMPK in myotubes. The present findings advance the understanding of the importance of iron to skeletal muscle protein synthesis and, thus, may contribute to the prevention of sarcopenia and frailty.
  • ||||||||||  Review, Journal:  The Interplay between Mitochondrial Morphology and Myomitokines in Aging Sarcopenia. (Pubmed Central) -  Mar 10, 2021   
    The resulting mitochondrial dysfunction in sarcopenic muscles feedbacks systemically by releasing the myomitokines fibroblast growth factor 21 (FGF21) and growth and differentiation factor 15 (GDF15), influencing the whole-body homeostasis and dictating healthy or unhealthy aging. This review describes the principal pathways controlling mitochondrial quality, many of which are potential therapeutic targets against muscle aging, and the connection between mitochondrial dysfunction and the myomitokines FGF21 and GDF15 in the pathogenesis of aging sarcopenia.
  • ||||||||||  Biomarker, Journal:  The Impact of New Biomarkers and Drug Targets on Age-Related Disorders. (Pubmed Central) -  Mar 9, 2021   
    There are now considerable efforts underway to address these deficits in preclinical and clinical studies, which include the use of better study cohorts, longitudinal designs, improved translation of data from preclinical models, multi-omics profiling, identification of new biomarker candidates and refinement of computational tools and databases containing relevant information. Such efforts will support future interdisciplinary studies and help to identify potential new targets that are amenable to therapeutic approaches such as pharmacological interventions to increase the human healthspan in parallel with the lifespan.
  • ||||||||||  Journal:  Vitamin D and Muscle Sarcopenia in Aging. (Pubmed Central) -  Mar 9, 2021   
    Vitamin D inadequacy or deficiency is related to muscle fiber atrophy, elevated risk of chronic musculoskeletal pain, sarcopenia, and falls. This review describes the effect of vitamin D in skeletal muscle tissue function and metabolism and includes discussion of possible mechanisms in skeletal muscle.
  • ||||||||||  Preclinical, Journal:  Multiplex Analysis of Circulating Hormone Levels in Rat Models of Age-Related Diseases. (Pubmed Central) -  Mar 9, 2021   
    As an example, we have analyzed serum from 12-week-old rats using multiplexes for the hormones insulin, leptin, growth hormone, corticosterone, and testosterone, which have been implicated in sarcopenia. The same technique can be used in the investigation of other sarcopenia biomarkers as well as in other disease cases involving both clinical and preclinical biomarker studies.
  • ||||||||||  Biomarker, Journal:  Ultrasound Biomarkers for Sarcopenia: What Can We Tell So Far? (Pubmed Central) -  Mar 9, 2021   
    The article also describes representative examples that reflect modern practice in the field. Imaging is routinely used in clinical practice, and radiologists can play an important role in the evaluation of geriatric patients, providing an unprecedented opportunity to improve decision support in sarcopenia prevention and treatment.
  • ||||||||||  Biomarker, Journal:  Future Ultrasound Biomarkers for Sarcopenia: Elastography, Contrast-Enhanced Ultrasound, and Speed of Sound Ultrasound Imaging. (Pubmed Central) -  Mar 9, 2021   
    Different features of muscle quality, including muscle elasticity, microcirculation and muscle perfusion during rest and physical activity, and the content of intramuscular adipose tissue can be measured using emerging and promising ultrasound techniques such as elastography, contrast-enhanced imaging, and speed of sound ultrasound technology. This article reviews the recent evidence on the use of ultrasound techniques in the assessment of muscle quality and the possibilities for the future evaluation of sarcopenia.
  • ||||||||||  Review, Journal:  Nutritional Supplements to Support Resistance Exercise in Countering the Sarcopenia of Aging. (Pubmed Central) -  Mar 9, 2021   
    The purpose of this review is to provide an up-to-date, evidence-based account of nutritional strategies to enhance resistance training-induced adaptations in an attempt to combat age-related muscle mass loss. In addition, we provide insight on how to incorporate the aforementioned nutritional strategies that may support the growth or maintenance of skeletal muscle and subsequently extend the healthspan of older individuals.