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|||||||||| Very excited to present my basic science research at #ats2021 on intermittent hypoxia and sarcopenia this coming May! (Twitter) - Mar 17, 2021

|||||||||| Clinical, Journal: Myosteatosis to predict inferior perioperative outcome in patients undergoing orthotopic liver transplantation. (Pubmed Central) - Mar 17, 2021
Adding myosteatosis to the well-established Balance-of-Risk-(BAR)-score resulted in an increased prognostic value compared to the original BAR-score. Myosteatosis may be a useful parameter to predict perioperative outcome in patients undergoing OLT, supporting the role of muscle quality (myosteatosis) over quantity (muscle mass) in this setting.

|||||||||| Clinical, Journal: Measuring sarcopenia on pre-operative CT in older adults undergoing emergency laparotomy: a comparison of three different calculations. (Pubmed Central) - Mar 17, 2021
PML3 is superior to PMI or PBSA and should be considered the method of calculation of choice. Additionally, PML3 compares favourably to ASA and P-POSSUM.

|||||||||| Journal: Key Components of Human Myofibre Denervation and Neuromuscular Junction Stability are Modulated by Age and Exercise. (Pubmed Central) - Mar 17, 2021
These data support the role of exercise in maintaining NMJ stability, even in elderly inactive individuals. Furthermore, the cell culture findings suggest that the transcriptional capacity of satellite cells for AChR subunit genes is negatively affected by ageing.

|||||||||| Clinical, Journal: Calf Circumference as a Case-Finding Tool for Sarcopenia: Influence of Obesity on Diagnostic Performance. (Pubmed Central) - Mar 17, 2021
Furthermore, the cell culture findings suggest that the transcriptional capacity of satellite cells for AChR subunit genes is negatively affected by ageing. No abstract available

|||||||||| Retrospective data, Review, Journal: Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials. (Pubmed Central) - Mar 17, 2021
The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement.

|||||||||| Clinical, Journal: Commentary: Euthyroid Sick Syndrome in Patients With COVID-19. (Pubmed Central) - Mar 17, 2021
Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement. No abstract available

|||||||||| Review, Journal: Pharmacological targeting of age-related changes in skeletal muscle tissue. (Pubmed Central) - Mar 16, 2021
However, other treatment options are still scarce. In this review, we explore currently applied nutritional and pharmacological approaches to mitigate age- related muscle wasting, and discuss potential future therapeutic avenues.

|||||||||| Enrollment open, Trial completion date, Trial primary completion date: Sarcopenia in Older Patients in the Acute Hospital Setting (clinicaltrials.gov) - Mar 16, 2021
P=N/A, N=50, Recruiting, Sponsor: Rambam Health Care Campus
In this review, we explore currently applied nutritional and pharmacological approaches to mitigate age- related muscle wasting, and discuss potential future therapeutic avenues. Not yet recruiting --> Recruiting | Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Dec 2021 --> Dec 2022

|||||||||| Journal: Effect of muscle depletion on survival in peripheral arterial occlusive disease: quality over quantity. (Pubmed Central) - Mar 16, 2021
Myosteatosis is a stronger predictor than sarcopenia, which indicates that quality is more important than quantity. Results should be interpreted with caution due to missing data on medication usage.

|||||||||| Clinical, Journal: Sarcopenia in patients with cardiovascular disease. (Pubmed Central) - Mar 16, 2021
Results should be interpreted with caution due to missing data on medication usage. No abstract available

|||||||||| Journal: Vitamin D Inhibits Myogenic Cell Fusion and Expression of Fusogenic Genes. (Pubmed Central) - Mar 16, 2021
Elderly individuals face a higher risk of falling and suffering fractures; hence, administration of vitamin D for treating fractures in the elderly could actually promote fusion impairment and, consequently, severe defects in muscle regeneration. Therefore, our results suggest that vitamin D replacement therapy should be used for prevention of age-related muscle loss, rather than for treatment of sarcopenia.

|||||||||| Clinical, Review, Journal: Impact of Protein Intake in Older Adults with Sarcopenia and Obesity: A Gut Microbiota Perspective. (Pubmed Central) - Mar 16, 2021
This could counteract the development of sarcopenia and obesity and, therefore, represent a novel approach for dietary recommendations based on the gut microbiota profile. However, more human trials utilizing advanced metabolomic techniques to investigate the microbiome and its relationship with macronutrient intake, especially protein, are warranted.

|||||||||| Journal: Author's reply. (Pubmed Central) - Mar 16, 2021
However, more human trials utilizing advanced metabolomic techniques to investigate the microbiome and its relationship with macronutrient intake, especially protein, are warranted. No abstract available

|||||||||| Clinical, Journal: Clinical and predictive value of simplified creatinine index used as muscle mass surrogate in end-stage kidney disease haemodialysis patients-results from the international MONitoring Dialysis Outcome initiative. (Pubmed Central) - Mar 16, 2021
No abstract available SCI is a simple, easily obtainable and clinically relevant surrogate marker of MM in HD patients.

|||||||||| Clinical, Observational data, Journal: Prognostic Value of Psoas Muscle Mass Index in Patients With Non‒ST-Segment‒Elevation Myocardial Infarction: A Prospective Observational Study. (Pubmed Central) - Mar 16, 2021
Conclusions Muscle wasting defined as PMI is a simple and useful objective marker to predict future cardiovascular outcome in patients with non‒ST-segment‒elevation myocardial infarction. Registration Information URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN000013445.

|||||||||| Clinical, Journal: Highlighting sarcopenia management for promoting surgical outcomes in esophageal cancers: evidence from a prospective cohort study. (Pubmed Central) - Mar 16, 2021
Registration Information URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN000013445. Sarcopenia was associated with poor metabolic stress and immune responses surrounding esophagectomy and was a potential target for reducing complications and promoting recovery of QOL.

|||||||||| Clinical, Journal: Prevalence and risk factors of sarcopenia in community-dwelling older adults visiting regional medical institutions from the Kadoma Sarcopenia Study. (Pubmed Central) - Mar 16, 2021
The prevalence of sarcopenia in this study was 22.3%. Besides traditional risk factors for sarcopenia, the number of daily conversations was an independent factor.

|||||||||| Journal: Associations of changes in fat free mass with risk for type 2 diabetes: Hispanic Community Health Study/Study of Latinos. (Pubmed Central) - Mar 16, 2021
Besides traditional risk factors for sarcopenia, the number of daily conversations was an independent factor. Reducing loss of FFM during adulthood may reduce prediabetes risk (primarily insulin resistance), particularly among individuals with overweight/obesity.

|||||||||| Clinical, Journal: SARC-F as a Screening Tool for Sarcopenia and Possible Sarcopenia Proposed by AWGS 2019 in Hospitalized Older Adults. (Pubmed Central) - Mar 16, 2021
SARC-F≥4 is suitable as a screening tool for sarcopenia in hospitalized older adults. SARC-F assessment could facilitate the detection and exclusion of sarcopenia at hospitalization and may lead to early adoption of a therapeutic and preventive approach.

|||||||||| Clinical, Journal: Effectiveness of a Short-Term Mixed Exercise Program for Treating Sarcopenia in Hospitalized Patients Aged 80 Years and Older: A Prospective Clinical Trial. (Pubmed Central) - Mar 16, 2021
Very old inpatients with sarcopenia can benefit from a mixed exercise program (even as short as two weeks) by improving their ADL and gait speed. However, the long-term effects of exercise on important clinical outcomes need to be further evaluated.

|||||||||| Clinical, Journal: Oral Management in Rehabilitation Medicine: Oral Frailty, Oral Sarcopenia, and Hospital-Associated Oral Problems. (Pubmed Central) - Mar 16, 2021
Oral health management provided by dental hygienists improves not only oral status and function, swallowing function, and nutritional status but also activities of daily living, discharge home, and in-hospital mortality in post-acute rehabilitation. Oral rehabilitation, promotion, education, and medical-dental collaboration can be effective interventions for oral problems and therefore are necessary to improve rehabilitation outcomes.

|||||||||| Journal: Screening for Sarcopenia with a Self-Reported Cartoon Questionnaire: Combining SARC-F with Finger-Ring Test. (Pubmed Central) - Mar 16, 2021
The cSARC-CalF showed a better overall diagnostic accuracy than the SARC-F and a similar overall diagnostic accuracy as the SARC-CalF in Chinese community-dwelling older adults. It may serve as a new tool for screening sarcopenia; however, it needs to be validated in other populations.

|||||||||| Clinical, Journal: Validation of the Danish SARC-F in Hospitalized, Geriatric Medical Patients. (Pubmed Central) - Mar 16, 2021
SARC-F does not seem to be a suitable screening tool for identifying and excluding non-sarcopenic geriatric patients. Furthermore, the SARC-F score was more strongly correlated with reduced muscle strength and physical function than with low muscle mass.

|||||||||| Clinical, Journal: Correlation between SARC-F Score and Ultrasound-Measured Thigh Muscle Thickness in Older Hospitalized Cancer Patients. (Pubmed Central) - Mar 16, 2021
Approximately, 46.3% of older hospitalized cancer patients presented sarcopenia. Additionally, we found a moderate inverse correlation and no systematic bias risk between SARC-F and ultrasound-measured muscle thickness.

|||||||||| Clinical, Journal: Reply to "Letter to the Editor: Sarcopenia in Pediatrics? To be reconsidered…". (Pubmed Central) - Mar 16, 2021
We would like to thank Razaq et al for their comments regarding our manuscript titled "Sarcopenia in Children with End Stage Liver Disease on the Transplant Waiting list". We appreciate their comments regarding the application of sarcopenia in children.

|||||||||| Journal: Sarcopenia: a geriatric giant facing a huge transition. (Pubmed Central) - Mar 16, 2021
We appreciate their comments regarding the application of sarcopenia in children. No abstract available

|||||||||| Journal: Prognostic significance of radiodensity-based skeletal muscle quantification using preoperative CT in resected non-small cell lung cancer. (Pubmed Central) - Mar 16, 2021
The proportion of low attenuation muscle was associated with DFS in resected lung cancer patients. Further investigation is needed to establish whether radiodensity-based detailed skeletal muscle quantification could be early biomarker to predict prognosis in NSCLC.

|||||||||| Clinical, Journal: Sarcopenia after induction therapy is associated with reduced survival in patients undergoing esophagectomy for locally-advanced esophageal cancer. (Pubmed Central) - Mar 16, 2021
With a median follow-up of 24.9 months, patients with sarcopenia at the time of esophagectomy had worse OS [median 24.3 (IQR, 9.9-34.5) vs. 50.9 (IQR, 25.6-50.9) months, P=0.0292] and DFS [median 11.7 (IQR, 6.4-25.8) vs. 29.4 (IQR, 12.8-26.7) months, P=0.0387] compared to non-sarcopenic patients. Sarcopenia is associated with reduced overall and DFS in patients undergoing esophagectomy for LAEC.

|||||||||| Journal: Sarcopenia in older people with chronic airway diseases: the Rotterdam study. (Pubmed Central) - Mar 16, 2021
Sarcopenia was prevalent and associated with chronic airway diseases among older population. These results suggest the need for early diagnosis of sarcopenia in older people with chronic airway diseases by applying EWGSOP2 recommendations.

|||||||||| cisplatin / Generic mfg.
[VIRTUAL] MUSCLE ATROPHY AFTER CHEMOTHERAPY IS INDUCED BY MITOCHONDRIAL DAMAGE AND PROLONGED BY MYOBLAST DETERMINATION PROTEIN-1 DOWNREGULATION IN MICE (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_4568;
Mitochondrial damage may be involved in the onset of cisplatin-induced muscle atrophy, and MyoD downregulation may have prevented recovery from atrophy. Our results suggest that mitochondria protection/activation may be a useful treatment strategy against muscle wasting resultant from chemotherapy.

|||||||||| [VIRTUAL] CT EVALUATION OF SKELETAL MUSCLE MASS DYNAMICS FOLLOWING SUSTAINED VIROLOGICAL RESPONSE IN PATIENTS WITH HCV-RELATED COMPENSATED CIRRHOSIS TREATED WITH DIRECT ACTING ANTIVIRALS (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_4370;
Following SVR achievement, the skeletal muscle mass increased in more than a quarter of patients, as showed by CT quantification. Underweight patients aged 65 or older, with pretreatment hypoalbuminemia had no muscle mass improvement, remaining the most vulnerable among liver cirrhosis patients, so that particular adapted care should be considered.

|||||||||| [VIRTUAL] ASSOCIATION OF SARCOPENIA, FATIGUE, AND SERUM MYOKINES IN PATIENTS WITH CHRONIC LIVER DISEASE (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_4334;
All secondary sarcopenia criteria measures were moderately to strongly correlated with distinct groupings of serum myokines. Two sarcopenia criteria (AAS METs, % lean mass) were individually associated with BMI.

|||||||||| [VIRTUAL] OBESITY IS ASSOCIATED WITH ALTERED PSOAS MUSCLE COMPOSITION AND PSOAS MUSCLE COMPOSITION PREDICTS ADVERSE OUTCOMES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_4173;
This observational study found obese IBD patients to have higher LDM, as compared to non-obese. Those with higher LDM had worse IBD-related outcomes at 6-months.

|||||||||| [VIRTUAL] PRINCIPAL COMPONENTS ANALYSIS (PCA) IN CHRONIC LIVER DISEASE (CLD) REVEALS THREE COMPONENT MODEL HIGHLIGHTING DISCRETE CONTRIBUTIONS BY SARCOPENIA CRITERIA MEASURES AND SERUM MYOKINES (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_3861;
Criteria measures for possible sarcopenia define discrete model components and contribute independent fatigue and myokine associations. Possible sarcopenia is highly significantly associated with the % lean mass.

|||||||||| [VIRTUAL] THE EFFECT OF MALNUTRITION ON THE POSTOPERATIVE OUTCOMES OF PATIENTS UNDERGOING ESOPHAGEAL RESECTION: ANALYSIS OF 2011-2017 US HOSPITALS (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_3668;
This study shows the presence of malnutrition increases the risk of postoperative death in this cohort of patients undergoing esophageal resection. Given this finding, it is important that these patients are identified early and provided aggressive nutritional therapies pre-procedure, followed by close surveillance and treatment of postoperative complications following esophagectomy.

|||||||||| [VIRTUAL] THE IMPACT OF MALNUTRITION ON THE POSTOPERATIVE OUTCOMES OF PATIENTS UNDERGOING SMALL BOWEL RESECTION FOR CROHN’S DISEASE (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_3649;
This study demonstrates that the presence of malnutrition is associated with postoperative death and complications following small intestinal resection in patients with Crohn’s disease. Given this finding, it is important for Crohn’s patients who suffer from extensive small intestinal involvement and malnutrition to undergo preprocedural nutrition-repletion therapy in order to improve postsurgical outcomes.

|||||||||| [VIRTUAL] THE CLINICAL IMPACT OF MALNUTRITION ON THE POSTSURGICAL OUTCOMES OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE UNDERGOING COLECTOMY: ANALYSIS OF 2011-2017 US HOSPITALS (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_3644;
This study shows that malnutrition is an independent risk factor of postoperative mortality and complication in IBD patients undergoing large bowel resection. Given this finding, it is important that these patients are provided aggressive pre-procedural nutritional therapy and are closely followed for early recognition/treatment of postoperative complications.

|||||||||| [VIRTUAL] THE RELATIONSHIP BETWEEN ADIPOSITY/SARCOPENIA AND DEATH AMONG PATIENTS WITH COVID-19 DIFFERS BASED ON THE PRESENCE OF GASTROINTESTINAL SYMPTOMS (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_3523;
Given this finding, it is important that these patients are provided aggressive pre-procedural nutritional therapy and are closely followed for early recognition/treatment of postoperative complications. Among patients with COVID-19, the relationship between measures of adiposity/sarcopenia and death differs in patients with and without GI symptoms.

|||||||||| [VIRTUAL] SEMAGLUTIDE IN ASSOCIATION TO ENDOSCOPIC SLEEVE GASTROPLASTY: TAKING ENDOSCOPIC BATRIATRIC PROCEDURES OUTCOMES TO THE NEXT LEVEL (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_3050;
Great decrease in BFM preventing sarcopenic obesity. Adhesion to treatment was significant as well as changes in Hb1Ac.

|||||||||| [VIRTUAL] SARCOPENIA ASSESSED BY PSOAS MUSCLE INDEX IS NOT ASSOCIATED WITH PORTOSYSTEMIC GRADIENT AND PORTAL HYPERTENSION IN PATIENTS WITH CIRRHOSIS. (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_3044;
There was no correlation between Psoas muscle index and portosystemic gradient in the cohort (r= 0.015), Figure 1.ConclusionSarcopenia and sarcopenic obesity is common in patients with cirrhosis who undergo TIPS placement. Although sarcopenia assessed by psoas muscle index has been shown to prognosticate survival in patients with cirrhosis, it is not associated with portosystemic gradient/ portal hypertension in these patients.

|||||||||| [VIRTUAL] ASSESSMENT OF SECONDARY SARCOPENIA IN CHRONIC LIVER DISEASE (CLD): HOW GOOD ARE OUR CRITERIA MEASURES? (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_2918;
%LM is best predictor of PSS as compared to AAS METs and GS. Myokines did not seem to improve the model.

|||||||||| [VIRTUAL] EFFECTS OF SARCOPENIA ON POST-ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY ADVERSE EVENTS IN PATIENTS WITH BILIARY TRACT CANCER (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_2806;
Multivariate logistic analysis showed that sarcopenia was a significant risk factor for post-ERCP adverse events (odds ratio [OR], 4.64, 95% confidence interval [CI] 1.23–17.4, p = 0.02). We used propensity score matching for further analysis owing to a significant intergroup difference in patients’ Background: s. After matching, both groups included 59 patients, and no significant difference was observed in patients’ Background: s. Multivariate logistic analysis confirmed that sarcopenia was a significant risk factor for post-ERCP adverse events (OR 5.98, 95% CI 1.23–29.1, p = 0.03).ConclusionsSarcopenia in patients with biliary tract cancer could suggest a high risk of post-ERCP adverse events.

|||||||||| [VIRTUAL] FACTORS ASSOCIATED WITH EARLY AND LATE MORTALITY AFTER ENDOSCOPIC RESECTION FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_2784;
ECOG-PS and CCI were associated with both mortality after endoscopic resection for ESCC, while age was associated with only late mortality. ECOG-PS and CCI, rather than age, should be regarded as indices for a relatively shorter life expectancy.

|||||||||| [VIRTUAL] THE ROLE OF SARCOPENIA IN PREDICTING THE POST-OPERATIVE MORBIDITY AND PERI-OPERATIVE MORTALITY IN PATIENTS UNDERGOING ELECTIVE SURGERY FOR GASTRIC CANCER (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_2422;
However, it did not adversely affect the post-operative outcome. Among the variables considered, only esophagojejunostomy was associated with a poor post-operative outcome.

|||||||||| [VIRTUAL] THE CLINICAL IMPACT OF MALNUTRITION ON THE POSTOPERATIVE OUTCOMES OF PATIENTS UNDERGOING PANCREATIC RESECTION: ANALYSIS OF 2011-2017 US HOSPITAL (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_2371;
As evidenced by this study, the presence of malnutrition results in increased postoperative death and complications following pancreatic resection. Therefore, these patients require early involvement by pancreatic and nutritional specialists, followed by aggressive nutrition repletion therapies and close peri and post-operative surveillance of surgical complications.

|||||||||| [VIRTUAL] LIFR-α/JAK/STAT3-DEPENDENT ADIPOCYTE INFLAMMATION INDUCES LIPOLYSIS AND ANOREXIA CONTRIBUTING TO GASTROINTESTINAL CANCER CACHEXIA. (DDW Virtual) - Mar 15, 2021 - Abstract #DDW2021DDW_688;
JCI Insight 3(14):e121221.3 Arora, G.K., Gupta, A.,… Iyengar, P., and Infante, R.E. (2020). J Cachexia, Sarcopenia, Muscle Rapid Communications 3, 115-128.

|||||||||| there's also the question of whether low calorie is a good thing --- ppl with excess adipose often start with sarcopenia and osteopenia ... when there is body recomp at a higher intake that's better for incr muscle & bone density than a course of persistent undereating (Twitter) - Mar 14, 2021

|||||||||| [VIRTUAL] Quantitative CT Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in COPD () - Mar 14, 2021 - Abstract #ATS2021ATS_5166;
Future studies are needed including interventional studies targeting sarcopenia to improve clinical outcomes in patients with severe COPD. Figure 1:

|||||||||| [VIRTUAL] Longitudinal Association Between Skeletal Muscle Mass and All-Cause Mortality in Ever-Smokers () - Mar 14, 2021 - Abstract #ATS2021ATS_4994;
Loss of muscle mass is associated with an increased risk of all-cause mortality, independent of BMI or disease severity, even in persons with normal muscle mass. Prevention of muscle loss or therapies to build muscle mass may be beneficial in an ever-smoker population.



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