Sarcopenia
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  • ||||||||||  Clinical, Journal:  Skeletal Muscle Gene Expression in Long-Term Endurance and Resistance Trained Elderly. (Pubmed Central) -  Mar 31, 2021   
    Other pathways affected by exercise training increased the efficiency of the proteostatic mechanisms, consolidated the cytoskeletal organization, lowered the inflammation level, and contrasted cellular senescence. This study on extraordinary individuals who trained at high level for at least thirty years suggests that aging processes and exercise training travel the same paths in the opposite direction.
  • ||||||||||  Clinical, Review, Journal:  The Effects of Cow-Milk Protein Supplementation in Elderly Population: Systematic Review and Narrative Synthesis. (Pubmed Central) -  Mar 31, 2021   
    Active surveillance and early detection of asymptomatic HTLV-1 infection might be beneficial to reinforce countermeasures to inhibit the progress of HTLV infection-associated sarcopenia. The beneficial effects of CPS in achieving aged-related nutritional goals, in preserving muscle mass and in recovering after hospitalization may be particularly relevant in the elderly.
  • ||||||||||  Clinical, Review, Journal:  Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition. (Pubmed Central) -  Mar 30, 2021   
    However, it is important to note that data on the effects of omega-3 LCPUFAs are still inconsistent in many areas (e.g., cognitive decline) due to a range of factors that vary amongst the trials performed to date; these factors include dose, timing and duration; baseline omega-3 LCPUFA status; and intake of other nutrients. Well-designed intervention studies are required to optimize the effects of DHA and EPA in specific patient populations and to develop more personalized strategies for their use.
  • ||||||||||  Preclinical, Journal:  Restoration of Sarcoplasmic Reticulum Ca ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice. (Pubmed Central) -  Mar 30, 2021   
    Transcriptomic analysis revealed that these effects are at least in part mediated by enhanced cellular energetics by activation of PGC1-α, UCP1, HSF1, and APMK and increased regenerative capacity by suppression of MEF2C and p38 MAPK signaling. Together, these exciting findings are the first to support that pharmacological targeting of SERCA can be an effective therapy to counter age-related muscle dysfunction.
  • ||||||||||  Biomarker, Review, Journal:  Skeletal Muscle Health and Cognitive Function: A Narrative Review. (Pubmed Central) -  Mar 30, 2021   
    Ageing plays a role in both skeletal muscle deterioration and cognitive decline. Furthermore, lifestyle risk factors, such as physical inactivity, poor diet and smoking, are common to both disorders, so their potential role in the muscle-brain relationship warrants investigation.
  • ||||||||||  Journal:  Sarcopenia: An underlying treatment target during the COVID-19 pandemic. (Pubmed Central) -  Mar 30, 2021   
    The provision of at-home physical activities together with protein supplementation is anticipated to reverse sarcopenia and promote the prevention and treatment of COVID-19. The recommended protocols on nutritional support and physical activities are provided in detail.
  • ||||||||||  Review, Journal:  Rehabilitative Good Practices in the Treatment of Sarcopenia: A Narrative Review. (Pubmed Central) -  Mar 30, 2021   
    Based on the data obtained, the rehabilitation management of the patient with sarcopenia must be personalized and must include exercise and nutritional supplementation. These factors are important in increasing the autonomy of the elderly essential for safe walking without neglecting stretching exercises that are important for flexibility and balance and coordination exercises.
  • ||||||||||  NN1213 / Novo Nordisk
    Biomarker, Trial completion, Trial completion date:  HAPPY: A Prospective Cohort Study of Aged People for Chronic Diseases (clinicaltrials.gov) -  Mar 30, 2021   
    P=N/A,  N=1000, Completed, 
    However, further studies are required before clinical adoption. Active, not recruiting --> Completed | Trial completion date: Dec 2020 --> Mar 2021
  • ||||||||||  Journal:  Stroke and sarcopenia. (Pubmed Central) -  Mar 30, 2021   
    Clinicians should be aware of this to better identify and treat stroke-related sarcopenia. Future research should focus on larger population studies to more accurately establish correlation between stroke and sarcopenia.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion:  Preventive Effects of Cetylpyridinium Chloride on SarcopeniaStudy (clinicaltrials.gov) -  Mar 29, 2021   
    P1,  N=65, Completed, 
    Thus, these proteomic approaches on young and aged rats provide insights into the development of protein targets in the treatment of sarcopenia (muscle loss). Enrolling by invitation --> Completed
  • ||||||||||  cisplatin / Generic mfg.
    Journal:  Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation. (Pubmed Central) -  Mar 27, 2021   
    This effect was also observed in bone marrow-derived macrophages upon magnolol treatment. Taken together, magnolol may be a promising chemoprotective agent for the prevention of muscle atrophy through the upregulating M2c macrophages, which are a major source of IGF-1.
  • ||||||||||  Journal:  New insights into muscle function in chronic kidney disease and metabolic acidosis. (Pubmed Central) -  Mar 27, 2021   
    MA augments insulin resistance perpetuating the catabolic state underlying muscle wasting in CKD. Further studies are needed to investigate if targeting of MA improves muscle mitochondrial function and insulin resistance translating into meaningful improvements in physical endurance.
  • ||||||||||  Retrospective data, Review, Journal:  The association between sarcopenia and bladder cancer-specific mortality and all-cause mortality after radical cystectomy: A systematic review and meta-analysis. (Pubmed Central) -  Mar 26, 2021   
    Further studies are required to evaluate targeted interventions in patients with sarcopenia to improve clinical outcomes. Abbreviations: ACM: all-cause mortality; ASA: American Association of Anesthesiologists; BMI: body mass index; CCI: Charlson Comorbidity Index; CSM: cancer-specific mortality; CSS: cancer-specific survival; ECOG: Eastern Cooperative Oncology Group; HR: hazard ratio; NAC: neoadjuvant chemotherapy; NIH: National Institutes of Health; OS: overall survival; RC: radical cystectomy; RCT: randomised controlled trial; SMI: Skeletal Muscle Index.
  • ||||||||||  Journal:  Age-related myocardial remodeling: myth or reality? (Pubmed Central) -  Mar 24, 2021   
    These changes can lead to the development of heart failure, reduce the quality of life and thus increase the morbidity and mortality of patients. It is a process that can be negatively affected by risk factors for cardiovascular disease, many comorbidities, on the contrary, this process can be significantly positively influenced by lifestyle changes, early detection of risk factors and consistent treatment of all comorbidities.
  • ||||||||||  Clinical, Journal:  Post-exercise provision of 40 g of protein during whole body resistance training further augments strength adaptations in elderly males. (Pubmed Central) -  Mar 23, 2021   
    Participants continued their normal dietary intake and were allocated into two matched groups, then randomly assigned to either a 20 g or 40 g dose intervention. Following determination of 1 repetition maximum (1RM), participants completed 10 x 3d wk resistance training and consumed protein supplements immediately following exercise.  Significant improvements in chest press (p = 0.014, ɳp 0.34) shoulder press (p = 0.005, ɳp 0.43) and leg extension strength (p = 0.014, ɳp 0.34), were observed following the 40 g dose, resulting in performance improvements of 19.1, 21.1, and 16.1% respectively, compared to the 20 g dose. Findings suggest that ingesting 40 g of protein following resistance exercise, produces greater responses to training and may be an important nutritional strategy when prescribing resistance exercise in the elderly.