Sarcopenia
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  • ||||||||||  Review, Journal:  Protein Intake and Frailty: A Matter of Quantity, Quality, and Timing. (Pubmed Central) -  Apr 13, 2021   
    Here, we provide a narrative review of the current literature regarding the association between protein intake (amount (how much?), quality (what type?), and distribution across meals (when?)) and frailty-related parameters. The ultimate aim of this work is to offer practical, evidence-based indications to healthcare professionals responsible for the care of frail older adults.
  • ||||||||||  Clinical, Journal:  Lower Serum n-3 Fatty Acid Level in Older Adults with Sarcopenia. (Pubmed Central) -  Apr 13, 2021   
    These findings suggest a possible protective effect of n-3 FA on human muscle homeostasis. Further well-designed large-scale longitudinal studies are necessary to understand the definite role of circulating n-3 FA level in sarcopenia risk assessment.
  • ||||||||||  Clinical, Journal:  Sarcopenia Severity Based on Computed Tomography Image Analysis in Patients with Cirrhosis. (Pubmed Central) -  Apr 13, 2021   
    The frequency of alcohol-induced cirrhosis, refractory ascites, hepatic encephalopathy, CRP > 20 mg/mL, and severe malnutrition was also higher in severe-sarcopenic patients. The interval between sarcopenia and severe sarcopenia may reflect a window of opportunity in which to intervene and mitigate muscle wasting to improve patient outcomes.
  • ||||||||||  Journal:  Coronavirus disease 2019 pandemic and alterations of body composition. (Pubmed Central) -  Apr 13, 2021   
    Further studies are needed to assess whether these simplified algorithms are applicable to older Asian adults with functional and/or cognitive impairment and nursing home residents. Individuals with malnutrition, sarcopenia, obesity, sarcopenic obesity and older adults with abnormal body composition or malnutrition risk may require tailored medical nutrition therapy to improve short and long-term COVID-19 outcomes.
  • ||||||||||  Journal:  Prognostic value of interim PET/CT in non-hodgkin lymphoma (Pubmed Central) -  Apr 13, 2021   
    It is necessary to explore the mechanism of sarcopenia and optimal intervention, such as exercise, nutrition, or drug therapy. Early treatment response assessed by interim PET/CT is the strongest prognostic factor in NHL patients.
  • ||||||||||  [VIRTUAL] THE ROLE OF DIET AND LIFESTYLE IN CHRONIC INFLAMMATION (HALL F) -  Apr 11, 2021 - Abstract #AUTO2021AUTO_135;    
    Of relevance, several environmental factors are suspected of aggravating or perpetuating the inflammatory state.MethodsMedline, Embase, Amed, and CINAHL databases were searched for studies reporting on the role of diet and lifestyle in chronic inflammation.ResultsTobacco smoking, pollution, chronic psychological stress, circadian disruption (caused by shift work, social jet lag, or exposure to artificial light at night), physical inactivity, and the typical hypercaloric, western-type diet (which is high in sugar, refined grains, salt, trans fatty acids, oxidized lipids, and advanced glycation end-products, and low in various micronutrients, fiber, prebiotics, omega-3 fatty acids and phytochemicals), coupled with visceral obesity, increased intestinal permeability and a reduction in microbiota diversity (as a result of increased sanitation, overuse of antibiotics, less time spent in natural spaces and adoption of western-like diets) can promote or exacerbate inflammation. Conversely, various lifestyle and dietary interventions can decrease, inhibit, or resolve inflammation.ConclusionsWe argue that every patient diagnosed with an autoimmune disease should be given lifestyle and dietary recommendations that specifically address inflammation.
  • ||||||||||  Clinical, Clinical data, Review, Journal:  Undernutrition, Sarcopenia, and Frailty in Fragility Hip Fracture: Advanced Strategies for Improving Clinical Outcomes. (Pubmed Central) -  Apr 10, 2021   
    We searched PubMed (MEDLINE) and Cochrane Central Register of Controlled Trials (CENTRAL) for relevant literature published over the last 10 years and found that advanced interventions targeting the aforementioned conditions helped to significantly improve postoperative outcomes among these patients. Going forward, protocols from advanced interventions for detecting, diagnosing, and treating nutrition problems in geriatric patients with hip fractures should become standard practice in healthcare settings.
  • ||||||||||  Retrospective data, Review, Journal:  Exercise, Nutrition, and Combined Exercise and Nutrition in Older Adults with Sarcopenia: A Systematic Review and Network Meta-analysis. (Pubmed Central) -  Apr 10, 2021   
    Compared with the control group, exercise alone and the combination of exercise and nutrition significantly increased handgrip strength (1.12 kg, 95% CI: 0.12, 2.11; 2.03 kg, 95% CI: 1.10, 2.97) and improved dynamic balance (-1.76 seconds, 95% CI: -2.24, -1.28; -1.02 seconds, 95% CI: -1.64, -0.39). Both exercise alone and the combination of exercise and nutrition have beneficial effects on muscle strength and physical performance in older adults with sarcopenia.
  • ||||||||||  Review, Journal:  Rehabilitation Nutrition and Exercise Therapy for Sarcopenia. (Pubmed Central) -  Apr 10, 2021   
    Nutritional and exercise therapy should be started very early after admission and adjusted to the level of inflammation and disease status. Repeated assessment, diagnosis, goal setting, interventions, and monitoring using the rehabilitation nutrition care process is important to maximize treatment effectiveness and improve patients' functional recovery and quality of life.
  • ||||||||||  [VIRTUAL] Association between sarcopenic obesity and nonalcoholic fatty liver disease and fibrosis detected by fibroscan (Poster area) -  Apr 9, 2021 - Abstract #EASLILC2021EASL_ILC_756;    
    Targeted interventions to improve Table:(Poster Session33): Univariate and Multivariate Odds Ratio of Risk Factors for NAFLD, NAFLD-associated Fibrosis and Cirrhosis based on the Prevalence of Sarcopenic Obesity Sarcopenic Obesity Sarcopenic Obesity OR (95% CI) P value OR (95% CI) P value NAFLD (CAP≥ 263 dB/m) NAFLD (CAP≥ 285 dB/m) Age, sex, ethnicity-adjusted 2.88 (1.82–4.57) <0.001 3.71 (2.24–6.14) <0.001 Multivariate model 1 2.69 (1.57–4.60) 0.001 3.37 (1.88–6.01) <0.001 Multivariate model 2 2.61 (1.51–4.50) 0.002 3.31 (1.85–5.96) 0.001 Significant fibrosis Cirrhosis Age, gender, ethnicity-adjusted 2.60 (1.24–5.46) <0.001 3.15 (0.56–17.75) 0.178 Multivariate model 1 2.28 (1.09–4.75) 0.030 3.31 (0.63–17.28) 0.144 Multivariate model 2 2.22 (1.03–4.80) 0.043 3.89 (0.69–21.94) 0.115 The multivariate model 1 included age, gender, race/ethnicity, education status, marital status, diabetes, smoking status, hypertension, and total cholesterol. The multivariate model 2 includes physical activity, total calorie intake, and alcohol consumption in addition to the variables in model 1.
  • ||||||||||  [VIRTUAL] prognostic impacts of the change in muscle mass on patients with cirrhosis (Poster area) -  Apr 9, 2021 - Abstract #EASLILC2021EASL_ILC_470;    
    Myostatin was proved to be an important emerging biomarker independently associated with sarcopenia, and in com- bination with CPK or albumin can be used as a screening tool for sarcopenia in clinical practice. ΔSMI/yr was significantly associated with prognosis of patients with cirrhosis independent of baseline Child-Pugh and MELD scores.
  • ||||||||||  Enrollment open:  NSMH: Nutritional Strategies for Metabolic Health in Aging (clinicaltrials.gov) -  Apr 8, 2021   
    P1/2,  N=48, Recruiting, 
    As confirmed for sarcopenia and myosteatosis, the improvement of subcutaneous adipose tissue was associated to the amelioration of cognitive impairment independently of liver function probably suggesting an active role of the adipose tissue in the inter‐ organ ammonia trafficking. Not yet recruiting --> Recruiting
  • ||||||||||  stavudine / Generic mfg., didanosine / Generic mfg.
    Clinical, Journal:  Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV. (Pubmed Central) -  Apr 7, 2021   
    Among ART-treated PWH, mtDNA haplogroup H was independently associated with weak grip and frailty. This association could represent a mechanism of weakness and frailty in the setting of HIV and ART.
  • ||||||||||  Clinical, Review, Journal:  Maldigestion Versus Malabsorption in the Elderly. (Pubmed Central) -  Apr 7, 2021   
    Diagnostic testing for maldigestion and malabsorption generally is similar to that used in younger patients. Maldigestion and malabsorption occur in older individuals and require a high level of suspicion, especially when weight loss, sarcopenia, or nutrient deficiencies are present.