Sarcopenia
Welcome,         Profile    Billing    Logout  
 46 Companies   12 Products   12 Products   17 Mechanisms of Action   756 Trials   22406 News 


«12...2425262728293031323334...401402»
  • ||||||||||  Journal:  Physical Performance and Telomere Length in Older Adults. (Pubmed Central) -  Sep 17, 2024   
    Decreased physical function is associated with shorter telomere length. Absolute telomere length presents a promising biomarker for distinguishing between healthy and unhealthy aging, warranting further investigation.
  • ||||||||||  Journal:  Diet to maintain adequate muscle and bone health (Pubmed Central) -  Sep 16, 2024   
    Moreover, our study revealed a nonlinear relationship between dietary vitamin K intake and handgrip strength, highlighting an optimal intake range. nutrition is crucial for muscle and bone health.
  • ||||||||||  Review, Journal:  Age-related sarcopenia and altered gut microbiota: a systematic Review. (Pubmed Central) -  Sep 15, 2024   
    Short-chain fatty acid metabolism, urolithin A, and bile acid production may be pivotal factors in the gut-muscle axis pathway. Supplementation with beneficial metabolite-associated microorganisms could enhance muscle function, mitigate muscle atrophy, and decelerate sarcopenia progression.
  • ||||||||||  Journal:  Effect of Aging on the Vocal Muscle. (Pubmed Central) -  Sep 15, 2024   
    We demonstrated that the vocal muscle is affected in the presbylarynx, with a reduction of its muscle fibers, corresponding to muscle atrophy. However, these findings may not be directly related to vocal symptoms because the patient may develop muscle compensatory mechanisms capable of reducing glottic insufficiency.
  • ||||||||||  Observational data, Journal:  Nutritional Assessment in Outpatients with Heart Failure. (Pubmed Central) -  Sep 14, 2024   
    There is a high prevalence of malnutrition among outpatients with HF, which is associated with worse prognosis, increased risk of sarcopenia, and greater frailty. These findings underscore the importance of early nutritional and functional assessments in this population to improve clinical outcomes.
  • ||||||||||  Preclinical, Journal:  Hyperphosphatemia Contributes to Skeletal Muscle Atrophy in Mice. (Pubmed Central) -  Sep 14, 2024   
    To determine the potential direct actions of phosphate on skeletal muscle, we cultured primary mouse myotubes in high phosphate concentrations, and we detected the induction of atrophy. We conclude that in experimental mouse models, hyperphosphatemia is sufficient to induce skeletal muscle atrophy and that, among various other factors, elevated phosphate levels might contribute to skeletal muscle injury in CKD.
  • ||||||||||  Review, Journal:  Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging. (Pubmed Central) -  Sep 14, 2024   
    and other factors may also be protective in diabetic retinopathy and age-related macular degeneration (AMD). This review examines Klotho functions especially as related to inflammation and potential applications.
  • ||||||||||  Journal:  Ultrasound Assessment of Sarcopenia in Alcoholic Liver Disease. (Pubmed Central) -  Sep 14, 2024   
    Patients with AH had more severe US muscle abnormalities compared to AC (RFMS 1.78 m/s vs. 1.35 m/s, p = 0.001) and the highest prevalence of RFE (?2 = 8.652, p = 0.003). Rectus Femoris US assessment could represent a reliable tool in the diagnosis and severity stratification of ALD-induced sarcopenia.
  • ||||||||||  Biomarker, Journal:  Pleiotropic effects on Sarcopenia subphenotypes point to potential molecular markers for the disease. (Pubmed Central) -  Sep 14, 2024   
    Lastly, using a gene-based GWAS approach three candidate genes were identified in the overlap of the three Sarcopenia subphenotypes: FTO, RPS10 and CALCR. The current study provides evidence of genetic overlap and pleiotropy among sarcopenia subphenotypes and highlights novel candidate genes and molecular markers associated with the risk of sarcopenia.
  • ||||||||||  Journal:  Sarcopenia, frailty prevalence, and related factors in patients with stroke: A cross-sectional analytical study from Turkey. (Pubmed Central) -  Sep 13, 2024   
    EAT-10 scores and dysphagia presence (p= 0.026), the presence of malnutrition (p< 0.021) and Nottingham Health Profile score (p< 0.001) were higher in the sarcopenic group. Sarcopenia and frailty frequently develop in patients with chronic stroke, with low lymphocyte counts, physical performance, muscle strength, and mobility and balance scores, and it is associated with poor prognostic factors including high disease severity, dysphagia, malnutrition, risk of falling, and poor quality of life.
  • ||||||||||  Journal:  Measuring computed tomography-assessed sarcopenic indices in hemodialysis patients. (Pubmed Central) -  Sep 13, 2024   
    Sarcopenia and frailty frequently develop in patients with chronic stroke, with low lymphocyte counts, physical performance, muscle strength, and mobility and balance scores, and it is associated with poor prognostic factors including high disease severity, dysphagia, malnutrition, risk of falling, and poor quality of life. No abstract available
  • ||||||||||  MitoQ (mitoquinone) / Antipodean
    Review, Journal:  Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing. (Pubmed Central) -  Sep 12, 2024   
    While there is evidence that some nicotinamide adenine dinucleotide precursors can improve physical function in older individuals, such an outcome seems unrelated to and independent of changes in skeletal muscle mitochondrial function. Future research should investigate the safety and efficacy of compounds that can improve skeletal muscle health in preclinical models through mechanisms involving mitochondria, such as mitochondrial-derived peptides and mitochondrial uncouplers, with a view to extending the human health-span.
  • ||||||||||  Clinical, Clinical data, Retrospective data, Journal:  Myosteatosis and the clinical outcomes of patients with liver cirrhosis: A meta-analysis. (Pubmed Central) -  Sep 12, 2024   
    The presence of myosteatosis in individuals diagnosed with liver cirrhosis may potentially be linked to a poor TFS prognosis. Further investigations are required to ascertain whether enhancing myosteatosis could potentially yield a survival advantage for this particular patient population.
  • ||||||||||  Review, Journal:  Adipose tissue in older individuals: a contributing factor to sarcopenia. (Pubmed Central) -  Sep 11, 2024   
    On the basis of these findings, we propose that age-related adipose tissue and sarcopenia are disorders characterized by chronic inflammation and metabolic dysregulation. Finally, we explore new potential therapeutic strategies involving specialized proresolving mediator (SPM) G protein-coupled receptor (GPCR) agonists, non-SPM GPCR agonists, transient receptor potential (TRP) channels, antidiabetic drugs in conjunction with probiotics and prebiotics, and compounds designed to target senescent cells and mitigate their pro-inflammatory activity.
  • ||||||||||  Journal:  Visual Analysis of Hot Topics and Trends in Nutrition for Decompensated Cirrhosis Between 1994 and 2024. (Pubmed Central) -  Sep 10, 2024   
    Over the past three decades, the focus of research on nutrition in decompensated cirrhosis has shifted from "hepatic encephalopathy, intestinal failure, metabolic syndrome, and alcoholic hepatitis" to "sarcopenia and nutritional assessment." In the future, nutritional interventions for sarcopenia should be based on a multimodal approach to address various causative factors. Its targeted treatment is an emerging area that warrants further in-depth research.