Sarcopenia
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  • ||||||||||  Journal:  Identification of a Sesquiterpene Lactone from Arctium lappa Leaves with Antioxidant Activity in Primary Human Muscle Cells. (Pubmed Central) -  May 20, 2021   
    By using siRNA, we demonstrated that the inhibition of the expression of Nrf2 reduced the protective effect of onopordopicrin, indicating that the activation of the Nrf2/HO-1 signaling pathway mediates the antioxidant effect of onopordopicrin in primary human muscle cells. Therefore, our results suggest that onopordopicrin may be a potential therapeutic molecule to fight against oxidative stress in pathological specific muscle disorders.
  • ||||||||||  Journal:  Additive effect of low skeletal muscle mass and abdominal obesity on coronary artery calcification. (Pubmed Central) -  May 20, 2021   
    Pre-sarcopenic obesity significantly increased CAC incidence and progression compared to either pre-sarcopenia or abdominal obesity alone. Conclusion Pre-sarcopenia and abdominal obesity together were significantly associated with a higher CAC presence and increased risk of CAC incidence and progression, independent of traditional CVD risk factors.
  • ||||||||||  Journal:  The Effects of Muscle Cell Aging on Myogenesis. (Pubmed Central) -  May 20, 2021   
    Moreover, aged myoblasts showed a reduction in the expression of MRFs and metabolic/anabolic factors, along with an increased expression of apoptotic, atrophy and inflammatory factors. A diminished differentiation capacity characterized the aged myoblasts which, in combination with the induction of apoptotic and atrophy factors, indicated a disrupted myogenic lineage in the senescent muscle cells.
  • ||||||||||  Journal:  Relationship between mental and physical disorders in old age and senility. (Pubmed Central) -  May 20, 2021   
    The most frequent mental and physical disorders were the cognitive and depressive disorders presence, a high risk of malnutrition syndrome, sarcopenia and falls syndrome, reduced functional capabilities, while senile patients had significantly more pronounced disorders. It has been shown that the cognitive and depressive disorders presence in the elderly and senile increases the falling syndrome risk and reduced functional capabilities, and in old age - sarcopenia syndrome.
  • ||||||||||  Retrospective data, Review, Journal:  Systematic review and meta-analysis of lean mass and mortality: Rationale and study description. (Pubmed Central) -  May 20, 2021   
    The meta-analysis can be further conducted in subgroups based on measurement modalities, site of measurements, definition of low lean mass adopted, and types of cancer for studies conducted in cancer patients. This series of meta-analysis provided insight and evidence on the relationship between lean mass and mortality in all directions, which may be useful for further study and guideline development.
  • ||||||||||  Retrospective data, Journal:  Sarcopenia and mortality in cancer: A meta-analysis. (Pubmed Central) -  May 20, 2021   
    The robust association of decreased lean mass with increased mortality further justified the importance of developing clinical guidelines for managing sarcopenia in cancer patients. Public health initiatives aiming at promoting awareness of muscle health in susceptible individuals are urgently needed.
  • ||||||||||  Retrospective data, Journal:  Different definition of sarcopenia and mortality in cancer: A meta-analysis. (Pubmed Central) -  May 20, 2021   
    The association of low lean mass with increased mortality was consistent across different definitions; this provides further evidence on the poorer survival in cancer patients with sarcopenia. However, further studies evaluating the performance of each definition are warranted.
  • ||||||||||  Clinical, Journal:  Sarcopenic Characteristics of Active Older Adults: a Cross-Sectional Exploration. (Pubmed Central) -  May 20, 2021   
    Contributions of age, physical activity, daily protein intake, and biological sex can explain the individual variation in outcomes related to changes in body composition, strength, power, and/or cardiorespiratory fitness in a cohort of active older adults. The preprint version of this work is available on Research Square: https://www.researchsquare.com/article/rs-51873/v1 .
  • ||||||||||  Niagen (nicotinamide riboside) / ChromaDex
    Trial completion date, Trial initiation date, Trial primary completion date:  NR-VET: Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans (clinicaltrials.gov) -  May 19, 2021   
    P=N/A,  N=144, Not yet recruiting, 
    The preprint version of this work is available on Research Square: https://www.researchsquare.com/article/rs-51873/v1 . Trial completion date: Mar 2025 --> Jun 2025 | Initiation date: May 2021 --> Aug 2021 | Trial primary completion date: Dec 2024 --> Mar 2025
  • ||||||||||  Trial initiation date:  Impact of Fish Oil Dose on Tissue Content and Function (clinicaltrials.gov) -  May 19, 2021   
    P=N/A,  N=40, Not yet recruiting, 
    Trial completion date: Mar 2025 --> Jun 2025 | Initiation date: May 2021 --> Aug 2021 | Trial primary completion date: Dec 2024 --> Mar 2025 Initiation date: Apr 2021 --> Sep 2021
  • ||||||||||  Trial completion:  GERKO: Whole-body Electromyostimulation in Inpatient Rehabilitation (clinicaltrials.gov) -  May 17, 2021   
    P=N/A,  N=134, Completed, 
    Given the negative impact of end stage renal disease on body composition, it is important to ensure adequate nutritional intake begins in the acute post-transplantation phase to help support both recovery from surgery and prevention of long-term metabolic complications. Not yet recruiting --> Completed
  • ||||||||||  Clinical, Journal:  Anthropometric indicators as screening tools for sarcopenia in older adult women. (Pubmed Central) -  May 15, 2021   
    To this end body mass index exhibited better sensitivity and calf circumference better specificity. The results of the study may improve nursing practice and that of other healthcare professionals, enabling sarcopenia screening in older adult women from simple and low-cost anthropometric indicators.
  • ||||||||||  Journal:  Sarcopenia increases 1-year mortality after surgical resection of hepatocellular carcinoma. (Pubmed Central) -  May 15, 2021   
    The results of the study may improve nursing practice and that of other healthcare professionals, enabling sarcopenia screening in older adult women from simple and low-cost anthropometric indicators. Sarcopenia diagnosed using L3 SMI is an independent prognostic factor for 1-year deaths in cases with hepatic malignancy with Child-Turcotte-Pugh score A undergoing surgical resection.
  • ||||||||||  Journal:  Potential health effects of dietary nitrate supplementation in aging and chronic degenerative disease. (Pubmed Central) -  May 15, 2021   
    This, in turn, presents a practical opportunity for susceptible populations to support ease of movement and exercise tolerance, both of which may promote free-living physical activity. A theoretical rationale details the potential health effects of dietary nitrate supplementation, wherein a working framework hypothesizes beetroot juice consumption prior to structured exercise training may offer synergistic benefits to aid healthy aging and independent-living among older adults.
  • ||||||||||  Review, Journal:  Nutrition in alcohol-related liver disease: Physiopathology and management. (Pubmed Central) -  May 15, 2021   
    Prompt recognition of at-risk individuals, early diagnosis and treatment of malnutrition remains a key component of ArLD management. In this review, we describe the pathophysiology of malnutrition in ArLD, review the screening tools available for nutritional assessment and discuss nutritional management strategies relevant to the different stages of ArLD, ranging from acute alcoholic hepatitis through to decompensated end stage liver disease.
  • ||||||||||  Clinical, Review, Journal:  Treatment of sarcopenia in nursing home residents: a scoping review protocol. (Pubmed Central) -  May 15, 2021   
    The results will be disseminated to researchers in the field by submitting the review to a peer-reviewed international journal and by presenting our findings at relevant conferences. We expect that the results of the final review will help to guide future research in the field of sarcopenia treatment for nursing home residents.
  • ||||||||||  Journal:  1,25-Dihydroxyvitamin D Inhibits Lipopolysaccharide-Induced Interleukin-6 Production by C2C12 Myotubes. (Pubmed Central) -  May 15, 2021   
    The TNFα protein content could not be measured, and MHC was not decreased despite LPS stimulation of C2C12 myotubes. Further studies are needed to examine the effects of higher doses of LPS stimulation on muscle cells and use more sensitive methods for measuring TNFα protein to investigate the preventive effects of 1,25(OH)D on increased TNFα and muscle proteolysis.
  • ||||||||||  Journal:  Sarcopenia in cirrhosis: A practical overview. (Pubmed Central) -  May 15, 2021   
    Early recognition and tailored management incorporating high protein diets and combination aerobic/resistance exercise can ameliorate the complications associated with sarcopenia in cirrhosis. This review provides an overview of the epidemiology, pathogenesis, assessment tools and management of sarcopenia in cirrhosis.