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|||||||||| Clinical, Journal: Relationship Between Sarcopenia and Electrocardiographic Abnormalities in Older People: The Bushehr Elderly Health Program. (Pubmed Central) - May 25, 2021
Although some older adults have higher cardiovascular risk factors, these data showed that further factors such as sarcopenia may be identified as a particular risk factor for future cardiovascular events. Therefore, sarcopenia could be added to the screening of the older population to reduce the risk of cardiovascular events.

|||||||||| Review, Journal: Anabolic Resistance of Muscle Protein Turnover Comes in Various Shapes and Sizes. (Pubmed Central) - May 25, 2021
Namely, we discuss the fact that anabolic resistance exists as a dimmer switch, capable of varying from higher to lower levels of resistance, to the main anabolic stimuli of feeding and exercise depending on the population. Moreover, we review the evidence on whether increased physical activity and targeted exercise can be leveraged to restore the sensitivity of skeletal muscle tissue to dietary amino acids regardless of the population.

|||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Clinical, Journal: Prognostic Impact of Muscle Quantity and Quality and Fat Distribution in Diffuse Large B-Cell Lymphoma Patients. (Pubmed Central) - May 25, 2021
Reduced muscle quality (SMD) and increased intermuscular fat (IMAT), rather than low muscle quantity (SMI), are associated with poor prognosis in DLBCL, when measured at the L3 level, and particularly at the level of the proximal thigh. The proximal thigh represents a novel radiological landmark to study body composition.

|||||||||| Clinical: Pruritus has impact on QOL of patient. HE affects both the patient and caregivers QOL. Best way to overcome is to develop a score based on QOL of patient and caregivers. Along with sarcopenia and gender of patient. ( just a thought!) (Twitter) - May 24, 2021

|||||||||| Review: 🙏@LTxjournal for inviting us to review #Hepaticencephalopathy ✴️Why? HE is🚫in MELD, so⬇️LT access,🌀of readmissions, falls, sarcopenia ✴️What's needed? #Equity in LT ✴️ How? Extra points/#LDLT for 🏥recurrences despite Rx/🚫shunts or dementia ⤵️ https://t.co/FQ1HkmkChb (Twitter) - May 24, 2021

|||||||||| New trial: PANGeA_MM: PANGeA - Physical Activity and Nutrition for Quality Ageing (clinicaltrials.gov) - May 23, 2021
P, N=950, Recruiting, Sponsor: Science and Research Centre Koper

|||||||||| Hey doc, I’m always confused by NSAID advice: reducing systemic inflammation lessens sarcopenia , but isn’t local acute inflammation necessary for hypertrophic response? NSAIDS don’t differentiate…? What route makes more sense? 😕 (Twitter) - May 23, 2021

|||||||||| Clinical, Journal: Impact of sarcopenia on survival of pancreatic cancer patients treated with concurrent chemoradiotherapy. (Pubmed Central) - May 22, 2021
Although sarcopenia was not a significant factor for OS (p = 0.121) in multivariate analysis, long-term survivors were observed only in the no sarcopenia group (OS at 60 months: 9.5% vs 0%, p < 0.001). In patients undergoing CCRT for LAPC, sarcopenia is an independent factor for adverse prognosis.

|||||||||| Journal: Reply to Ata and colleagues' Letter to the Editor: Adjustments for Anterior Thigh Muscle Measuremets in Sarcopenia. (Pubmed Central) - May 22, 2021
In patients undergoing CCRT for LAPC, sarcopenia is an independent factor for adverse prognosis. No abstract available

|||||||||| sirolimus / Generic mfg.
Preclinical, Journal: Water Extract of Lotus Leaf Alleviates Dexamethasone-Induced Muscle Atrophy via Regulating Protein Metabolism-Related Pathways in Mice. (Pubmed Central) - May 22, 2021
The AKT-mammalian target of the rapamycin (mTOR) signal pathway, which is important for muscle protein synthesis, was increased in LL-administered groups...Q3G is predicted to be one of the major active phenolic components in LL. Therefore, we propose LL as a supplement or therapeutic agent to prevent or treat muscle wasting, such as sarcopenia.

|||||||||| Review, Journal: Harnessing Muscle-Liver Crosstalk to Treat Nonalcoholic Steatohepatitis. (Pubmed Central) - May 22, 2021
In this perspective review, we discuss key pathophysiological processes driving sarcopenia in NAFLD: anabolic resistance, insulin resistance, metabolic inflexibility and systemic inflammation. Interventions that modify muscle quantity (mass), muscle quality (fat), and physical function by simultaneously engaging multiple targets and pathways implicated in muscle-liver crosstalk may be required to address the multifactorial pathogenesis of NAFLD/NASH and provide effective and durable therapies.

|||||||||| Clinical, Journal: The Burdens of Orthopedic Patients and the Value of the HEPAS Approach (Healthy Eating, Physical Activity, and Sleep Hygiene). (Pubmed Central) - May 22, 2021
Interventions that modify muscle quantity (mass), muscle quality (fat), and physical function by simultaneously engaging multiple targets and pathways implicated in muscle-liver crosstalk may be required to address the multifactorial pathogenesis of NAFLD/NASH and provide effective and durable therapies. No abstract available

|||||||||| Clinical, Journal: Approach to Obesity in the Elderly. (Pubmed Central) - May 22, 2021
Risk-benefit issues should be considered with extreme care and disclosed to candidates. The selection process requires good presurgical functional status, individualized consideration of the sequels of obesity and reliance on centers which are highly experienced in the surgical procedure as well as short and long term subsequent comprehensive care and support.

|||||||||| [VIRTUAL] DEVELOPING SARCOPENIA IS A RISK FACTOR FOR FRACTURES IN PATIENTS WITH RHEUMATOID ARTHRITIS: 4-YEAR DATA FROM THE CHIKARA STUDY () - May 21, 2021 - Abstract #EULAR2021EULAR_3805;
Overall, 7.8% of RA patients developed sarcopenia during the 4-year follow-up period, and they developed fractures more frequently. Evaluation of sarcopenia is important for risk assessment of fractures.

|||||||||| [VIRTUAL] THE ASSOCIATION BETWEEN PRESARCOPENIA AND BONE MINERAL DENSITY IN ADULT PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_3652;
Evaluation of sarcopenia is important for risk assessment of fractures. The BMD in the region of total hip, femoral neck, ultra-distal radius, and total body in patients with decreased muscle mass was significantly lower than in patients without low lean mass.

|||||||||| [VIRTUAL] SARCOPENIA RATE IN COVID-19 SURVIVORS () - May 21, 2021 - Abstract #EULAR2021EULAR_3470;
We here highlighted a sarcopenia prevalence at 3 and 6 months following a hospitalization for COVID-19 of 13% and 3% respectively, occurring mainly in patients with comorbidities. Sarcopenia was not associated to worse cardio-pulmonary results in comparison with non-sarcopenic patients.

|||||||||| [VIRTUAL] FRAILTY IN THE PATIENTS WITH OSTEOARTHRITIS OF THE KNEE WAS NOT CAUSED BY SARCOPENIA () - May 21, 2021 - Abstract #EULAR2021EULAR_3363;
Sarcopenia was not associated to worse cardio-pulmonary results in comparison with non-sarcopenic patients. In the patients with knee OA immediately before arthroplasty, frailty was not caused by sarcopenia.

|||||||||| [VIRTUAL] PREVALENCE OF SARCOPENIA AND CLINICAL IMPLICATIONS IN NEWLY DIAGNOSED RHEUMATOID ARTHRITIS PATIENTS () - May 21, 2021 - Abstract #EULAR2021EULAR_3037;
With treatment, sarcopenia improved significantly. RA patients should be evaluated in terms of sarcopenia besides evaluating joint and extra-articular findings at the time of diagnosis.

|||||||||| [VIRTUAL] USAGE OF THE SARC-F QUESTIONNAIRE FOR SARCOPENIA SCREENING IN PATIENTS WITH RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_3035;
The SARC-F questionnaire alone is not adequate for screening of SP in RA patient. It is necessary to develop other simple screening methods that can easily be carried out in real clinical practice to identify individuals with possible SP for further diagnostic tests.

|||||||||| [VIRTUAL] PATHOLOGICAL PHENOTYPES OF BODY COMPOSITION IN PATIENTS WITH RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_3013;
The overall frequency of pathological phenotypes of body composition was high and amounted to 96.2% in women with RA. The most common pathological phenotype was an osteopenic obesity characterized by a decrease in BMD and an increase in fat mass.

|||||||||| [VIRTUAL] ADHERENCE TO MEDITERRANEAN DIET AND NUTRITIONAL STATE IN ITALIAN WOMEN WITH ISOLATED SJÖGREN’S SYNDROME () - May 21, 2021 - Abstract #EULAR2021EULAR_2560;
SS patients have an unbalanced diet because of a higher intake of fat foods, likely for their lubricating effect. Despite the absence of correlation with objective parameters, the increased dryness in patients with a reduced intake of PUFA arouses our interest in a future study including omega-3 supplementation.

|||||||||| [VIRTUAL] VERIFICATION OF MANIFESTATIONS OF SARCOPENIA IN OBESE PATIENTS WITH THREE METHODS FOR BODY COMPOSITION ASSESSMENT (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3618;
From methods of body composition assessment, air-replacement bodyplatismography (BodPod) is the most sensitive in the verification of skeletal muscle mass reduction in obese patients. This method shows that patients with obesity have a significantly reduced muscle mass compared with normal weight or overweight subjects.

|||||||||| [VIRTUAL] DIAGNOSTIC VALUE OF MUSCLE STRENGTH TESTS FOR THE DIAGNOSIS OF SARCOPENIA IN RHEUMATOID ARTHRITIS PATIENTS (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3134;
This method shows that patients with obesity have a significantly reduced muscle mass compared with normal weight or overweight subjects. Muscle strength tests proposed by the European Working Group on Sarcopenia in Older People have a low specificity, diagnostic accuracy and positive predictive values for detecting SP in RA patients, which requires the development of other methods of the first step of diagnosis of SP in RA patients.

|||||||||| [VIRTUAL] A LONGITUDINAL STUDY OF SARCOPENIA, LOCOMOTIVE SYNDROME, AND FRAILTY IN PATIENTS WITH RHEUMATOID ARTHRITIS: FROM THE CHIKARA STUDY (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3133;
The new onset rates at 2 years were 4.4% for sarcopenia, 15.4% for locomotive syndrome, and 13.3% for frailty. In the new onset sarcopenia and locomotive syndrome groups, both GC use and dosage were significantly higher.

|||||||||| [VIRTUAL] IMPORTANCE OF BODY MASS MEASUREMENT AND THE GRIP STRENGTH TEST TO PREDICT FALLS IN PATIENTS WITH RHEUMATOID ARTHRITIS (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3130;
RA patients with both low leg muscle score and low grip strength at baseline were at high risk for falls during the four-year follow-up period. Evaluation of muscle mass and function can predict falls in RA patients.

|||||||||| [VIRTUAL] BODY COMPOSITION AND FREQUENCY OF SARCOPENIA IN PATIENTS WITH SYSTEMIC SCLEROSIS (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_2777;
Healthy BC was found only in 11,3% cases, while overfat - in 72,7% and low ALM – in 34,1% SSc patients. SP was detected in 22.7% of women, among them in half of cases - severe SP, without any differences between the limited and diffuse subtypes of the disease.

|||||||||| [VIRTUAL] SARCOPENIA IN MYOSITIS PATIENTS: A MARKER OF MUSCLE DAMAGE ASSOCIATED WITH HANDICAP (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_2764;
Muscle mass measured by DXA is a relevant parameter for muscle damage and disability in myositis patients. Sarcopenic myositis patients represent a subgroup with important muscle damage and handicap.

|||||||||| [VIRTUAL] RHEUMATOID ARTHRITIS PER SE IS NOT RISK FACTOR FOR CLINICAL FRACTURES: NINE-YEAR FINDINGS OF THE TOMORROW STUDY (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_2352;
RA per se was not a risk factor for clinical fractures in this cohort. Low BMD at the thoracic vertebrae and the use of GC with even low dose at entry were apparently significant risk factors for the incidence of clinical fractures among patients with RA.

|||||||||| Preclinical, Journal: Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats. (Pubmed Central) - May 21, 2021
The fish oil supplement also alters protein expression in an age-specific manner, but the relationship between proteomic and contractile responses remains unclear. Further investigation to better understand the magnitude and mechanisms muscular effects of DFO in aged populations is warranted.

|||||||||| cisplatin / Generic mfg.
Clinical, Journal: Sarcopenia predicts a poor treatment outcome in patients with head and neck squamous cell carcinoma receiving concurrent chemoradiotherapy. (Pubmed Central) - May 21, 2021
The prevalence of sarcopenia in HNC patients receiving CCRT was 27%. Its presence before treatment was a significant predictor of incomplete CCRT and poor DSS rate in HNC patients.

|||||||||| temozolomide / Generic mfg.
Clinical, Journal: Prognostic relevance of temporal muscle thickness as a marker of sarcopenia in patients with glioblastoma at diagnosis. (Pubmed Central) - May 21, 2021
• We appraised the correlation among TMT and survival, sex, age at surgery, and performance status, measured on brain MRIs of patients affected by glioblastoma at diagnosis. • TMT did not show any significant correlation with prognosis, age at surgery, or performance status, and its usefulness might be restricted only to patients with brain metastases and recurrent or treated glioblastoma.

|||||||||| Journal: Skeletal muscle mass and sarcopenia can be determined with 1.5-T and 3-T neck MRI scans, in the event that no neck CT scan is performed. (Pubmed Central) - May 21, 2021
• We found that skeletal muscle mass and sarcopenia determined on CT and 1.5-T and 3-T MRI neck scans at the C3 level can be used interchangeably. • When CT imaging of the neck is missing for skeletal muscle mass analysis, patients can be assessed with 1.5-T or 3-T neck MRIs.

|||||||||| Clinical, Journal: Malnutrition and Alcohol in Patients Presenting with Severe Complications of Cirrhosis After Laparoscopic Bariatric Surgery. (Pubmed Central) - May 21, 2021
However, thirteen patients achieved stabilization or full re-compensation with medical therapy and nutritional support. Our cases underline the risk of alcohol intake and malnutrition after laparoscopic bariatric surgery as causes of severe liver decompensation and underline the need for careful interdisciplinary care of these patients after surgery to early identify and treat alcohol misuse, malnutrition, and liver disease.

|||||||||| Observational data, Retrospective data, Journal: Progressive muscle loss is an independent predictor for survival in locally advanced oral cavity cancer: A longitudinal study. (Pubmed Central) - May 21, 2021
Progressive muscle loss was independently associated with worse survival outcomes in patients with stage III-IVB OSCC. Muscle loss might not be detected by changes in BMI.

|||||||||| Review, Journal: Sarcopenia in Inflammatory Bowel Disease: A Narrative Overview. (Pubmed Central) - May 21, 2021
There is evolving research in many chronic inflammatory states, such as chronic liver disease and rheumatoid arthritis, whereby interventions have begun to be developed to counteract sarcopenia. The purpose of this review is to evaluate the current literature regarding the impact of sarcopenia in the management of IBD, from mechanistic drivers through to assessment and management.

|||||||||| Clinical, Review, Journal: Body Composition Methods in Adults with Type 2 Diabetes or at Risk for T2D: a Clinical Review. (Pubmed Central) - May 21, 2021
Review findings indicate that these methods were capable of identifying clinically relevant T2D disease-related complications such as sarcopenia and T2D risk factors such as obesity or regional adiposity. However, estimates were often sex and race/ethnicity specific warranting cross-validation of these methods in broader populations with T2D or risk for T2D prior to clinical implementation.

|||||||||| docetaxel / Generic mfg.
Clinical, Retrospective data, Journal: Body Composition Changes in Gastric Cancer Patients during Preoperative FLOT Therapy: Preliminary Results of an Italian Cohort Study. (Pubmed Central) - May 21, 2021
Preoperative FLOT was associated with a further reduction in SMI, BMI, and VAI. These changes were not associated with short-term outcomes.

|||||||||| Clinical, Journal: Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical-surgical procedures: the PROADAPT pilot study protocol. (Pubmed Central) - May 21, 2021
P=N/A
NCT03659123. Pre-results of the trial.

|||||||||| Review, Journal: Age-related changes in muscle architecture and metabolism in humans: the likely contribution of physical inactivity to age-related functional decline. (Pubmed Central) - May 21, 2021
It is imperative therefore that research examining interactions between ageing, physical activity and muscle mass and metabolic health is prioritised so that it can inform on the "normal" muscle ageing process and on strategies for improving health span and well-being. This review will focus on important changes in muscle architecture and metabolism that accompany ageing and highlight the likely contribution of physical inactivity to these changes.

|||||||||| Clinical, Observational data, Journal: Intensity Matters for Musculoskeletal Health: A Cross-Sectional Study on Movement Behaviors of Older Adults from High-Income Scottish and Low-Income South African Communities. (Pubmed Central) - May 21, 2021
Conversely, more time spent in MVPA was associated with faster gait speed (p < 0.001) and greater hip bone mineral density (p = 0.011) in the South African cohort. Our findings confirm the beneficial role of MVPA in both high- and low-income cohorts, however, the relationship MVPA had with components of musculoskeletal health in older adults differed between settings.

|||||||||| Clinical, Journal: The association between TP53 rs1625895 polymorphism and the risk of sarcopenic obesity in Iranian older adults: a case-control study. (Pubmed Central) - May 21, 2021
Our findings confirm the beneficial role of MVPA in both high- and low-income cohorts, however, the relationship MVPA had with components of musculoskeletal health in older adults differed between settings. We suggested that TP53 rs1625895 polymorphism may increase the risk of sarcopenic obesity in Iranian population.

|||||||||| Clinical, Journal: Association between dietary energy and protein intake and sarcopenia among the elderly in 8 cities across China (Pubmed Central) - May 21, 2021
We suggested that TP53 rs1625895 polymorphism may increase the risk of sarcopenic obesity in Iranian population. The level of protein intake is associated with the grip strength and gait speed of the elderly in China, but has no significant effect on the detection rate of sarcopenia.

|||||||||| Clinical, Journal: Prognostic value and association of sarcopenic obesity and systemic inflammatory indexes in patients with hepatocellular carcinoma following hepatectomy and the establishment of novel predictive nomograms. (Pubmed Central) - May 21, 2021
The LMR was an independent factor of SO. The novel nomograms developed from the SOLMR grading system combining SO with the LMR provide good prognostic estimates of the outcomes of HCC patients.

|||||||||| Enrollment open: Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics (clinicaltrials.gov) - May 20, 2021
P=N/A, N=30, Recruiting, Sponsor: University of Arkansas
The novel nomograms developed from the SOLMR grading system combining SO with the LMR provide good prognostic estimates of the outcomes of HCC patients. Not yet recruiting --> Recruiting

|||||||||| New trial: RENAMUS 19: FGF19 and Chronic Kidney Disease (clinicaltrials.gov) - May 20, 2021
P=N/A, N=170, Not yet recruiting, Sponsor: Hospices Civils de Lyon

|||||||||| Biomarker, Review, Journal: MRI-Derived Biomarkers Related to Sarcopenia: A Systematic Review. (Pubmed Central) - May 20, 2021
Future studies should test and compare the performance of proposed MRI biomarkers for sarcopenia characterization and quantification using a standardized experimental setup. 1 Technical Efficacy Stage: 2.

|||||||||| Review, Journal: Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments. (Pubmed Central) - May 20, 2021
Healthy diet and physical activity are beneficial to both sarcopenic obesity and diabetes, but there are only recommended drugs for diabetes. This review consolidates and discusses the latest research in pathogenesis, diagnosis, and treatments of diabetes and sarcopenic obesity.

|||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Clinical, Journal: Prognostic impact of the psoas muscle index, a parameter of sarcopenia, in patients with diffuse large B-cell lymphoma treated with rituximab-based chemoimmunotherapy. (Pubmed Central) - May 20, 2021
In a multivariate analysis, sarcopenia remained predictive of outcomes for overall survival (p = .009), progression free survival (p = .028), and response to treatment (p = .006). Sarcopenia defined by evaluating PMI is a simple and routinely applicable method that can predict poor outcomes in patients with DLBCL.

|||||||||| Journal: Time gap between the onset and diagnosis in Werner syndrome: a nationwide survey and the 2020 registry in Japan. (Pubmed Central) - May 20, 2021
The average grip strength, walking speed, and skeletal muscle mass index met the diagnostic criteria for sarcopenia. The registry revealed that there are opportunities for early diagnosis and intervention; therefore, sensitization about the disease is needed.

|||||||||| Clinical, Journal: Sarcopenia in Children With End-Stage Liver Disease on the Transplant Waiting List. (Pubmed Central) - May 20, 2021
Post-LT PICU duration was increased in children with sarcopenia, reflecting adverse outcomes associated with muscle loss. Further studies are needed to elucidate the underlying mechanisms of sarcopenia in children with ESLD.



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