Sarcopenia
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  • ||||||||||  Whole-Body Composition Features by Computed Tomography in Ovarian Cancer: Pilot Data on Survival Correlations () -  Sep 24, 2024 - Abstract #ESUR2024ESUR_385;    
    Patient characteristics Conclusions In conclusion, in this exploratory assessment of whole-body composition profiling based on computed tomography, in EOC patients, we found significant associations between skeletal muscle volume and OS and PFS, as well as between intramuscular fat, epicardial fat and paracardial fat and PFS. Our results, although preliminary and needing further exploration, open a window to the concrete possibility of performing direct body composition profiling, with no further need for approximate estimations.
  • ||||||||||  Preclinical, Journal:  Age-induced changes in skeletal muscle mitochondrial DNA synthesis, quantity, and quality in genetically unique rats. (Pubmed Central) -  Sep 23, 2024   
    These data reveal several key findings: (1) mtDNA turnover in rat skeletal muscle decreases with age, (2) mtDNA half-lives in skeletal muscle are approximately an order of magnitude longer than what is reported for other tissues, and (3) muscle mtDNA turnover differs significantly from the turnover of other mitochondrial macromolecules including components of the mitochondrial nucleoid. These findings provide insight into the factors driving age-induced mtDNA mutation accumulation, which contribute to losses of mitochondrial genomic integrity and may play a role in skeletal muscle dysfunction.
  • ||||||||||  Review, Journal:  Amyotrophic lateral sclerosis as a disease model of sarcopenia. (Pubmed Central) -  Sep 23, 2024   
    However, some agents targeting the muscle, like myostatin and mammalian target of rapamycin inhibitors, are under investigation both in the sarcopenia and ALS context. The development of new therapeutic agents targeting the skeletal muscle may indeed be beneficial to both ALS patients and older people with sarcopenia.
  • ||||||||||  A Needs Assessment of HIV Providers in the Evaluation of Kidney Function in People Living with HIV (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3186;    
    In this pilot survey, HIV providers reported high uncertainty regarding kidney function measurement and the identification of kidney disease. HIV providers may benefit from targeted education to reduce medication errors related to drug dosing as well as appropriate nephrology referrals.
  • ||||||||||  CT-Defined Sarcopenia and Performance of GFR-Estimating Equations in Patients with Cancer (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2485;    
    This is the first study to demonstrate large bias and poor accuracy for eGFRcr and eGFRcrcys in patients with CT-defined sarcopenia, demanding other instruments such as Scys or mGFR to assess GFR more accurately in this population. Overweight and obese patients might benefit from body composition analysis to unveil underlying sarcopenia.
  • ||||||||||  Evaluation of Glucocorticoid Metabolism in CKD as a Therapeutic Target against Sarcopenia (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2371;    
    However, renal impairment by itself does not alter 11?HSD1 function in muscle, and 11?HSD1 suppression does not prevent muscle atrophy in a mouse model of CKD. Future studies may explore to what extent glucocorticoids contribute to sarcopenia in human CKD through alternative mechanisms, or whether 11?HSD1 is significant for sarcopenia development in settings unrelated to CKD.
  • ||||||||||  Skeletal Muscle Structural Adaptation to Exercise Training in CKD (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2314;    
    Exercise induced muscle fiber size and type distribution changes indicate CKD being responsive to an exercise program. This supports exercise as a powerful tool to study muscle plasticity in CKD.
  • ||||||||||  Muscle Density Changes in CKD and Clinical Outcomes (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2273;    
    Greater declines in muscle density were associated with baseline diabetes and low muscle mass. These observations suggest loss of muscle density in CKD occurs in the context of metabolic obesity as well as sarcopenia.
  • ||||||||||  Health Trajectories of Adults with ESKD and Obesity Who Are Trying to Lose Weight (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2024;    
    Those who lost weight had similar baseline dietary quality and health literacy but were more likely to lose waist circumference than those who did not lose weight. Fat free mass and functional status changes were observed with and without weight loss.
  • ||||||||||  Sarcopenia in Patients on Hemodialysis in Brazil: Results of the SARC-HD Study (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2006;    
    Male sex, older age, white ethnicity, hemodiafiltration treatment, and catheter access were risk factors for presenting sarcopenia. Our findings enhance the understanding of sarcopenia in patients on hemodialysis in Brazil.
  • ||||||||||  Association between Electrical Impedance Vectors and Sarcopenia in Patients with CKD (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2004;    
    The results suggest that VIBE, phase angle, and IR could be helpful tools for identifying sarcopenia in patients with CKD and HD. These measurements could provide valuable information for the early detection and management of sarcopenia in this population.
  • ||||||||||  Association of CKD with Sarcopenia: A Population-Wide Study (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1971;    
    Our results show that CKD is associated with sarcopenia and leads to more rapid declines in appendicular lean mass over time. These findings further validate our central DXA based measurement of eALMi and sarcopenia and highlight the importance preservation of muscle mass in individuals with CKD, especially in those with reduced eGFR.
  • ||||||||||  Low Muscle Mass Is Associated with Low Bone Mineral Density in Patients with CKD Stages G4-5 (Exhibit Hall, Convention Center) -  Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1213;    
    In patients with CKD G4-5, low appendicular skeletal muscle mass was associated with low bone mineral density in the hip and spine. The increased fracture risk in patients with CKD may be due to the co-occurrence of osteoporosis and sarcopenia, i.e., osteosarcopenia, although this requires further investigation.
  • ||||||||||  Retrospective data, Review, Journal, Surgery:  Impact of sarcopenia on outcomes following lumbar spine surgery for degenerative disease: an updated systematic review and meta-analysis. (Pubmed Central) -  Sep 21, 2024   
    Standardized clinical algorithms are essential for reliable sarcopenia diagnosis in people living with HIV in order to promote intervention strategies and to prevent adverse health outcomes. As compared to patients without sarcopenia, those with sarcopenia undergoing lumbar spine surgery for degenerative diseases have lower improvements in functional ability, quality of life, physical health, pain relief and extended hospitalization compared to those without sarcopenia.
  • ||||||||||  Journal:  Postmenopausal osteoporosis: a bioinformatics-integrated experimental study the pathogenesis. (Pubmed Central) -  Sep 21, 2024   
    Bioinformatics analysis results showed that the osteoporosis caused by ovariectomized rats was mainly related to muscle contraction, calcium signaling pathway, etc. Results of qRT-PCR were consistent with transcriptome analysis. These results reveal the pathogenesis of PMOP in ovariectomized rats and also offer a possibility for elucidating the relevance of action between PMOP and sarcopenia.
  • ||||||||||  Journal:  Thyroid dysfunction and sarcopenia: a two-sample Mendelian randomization study. (Pubmed Central) -  Sep 21, 2024   
    There was a significant association between subclinical hyperthyroidism and a reduced walking pace (OR = 1.00; 95% CI = 0.99 to 1.00; P = 0.041). This study provides evidence that hyperthyroidism, hypothyroidism, and subclinical hyperthyroidism can all increase the risk of sarcopenia.