Sarcopenia
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  • ||||||||||  Preclinical, Journal:  TNF receptor-associated factor 6 mediates TNFα-induced skeletal muscle atrophy in mice during aging. (Pubmed Central) -  Jul 30, 2021   
    Haplo-deficiency of TRAF6 prevents muscle atrophy and the decrease in numbers of satellite cells, Type IIA myofibers, and myogenic regeneration in TRAF6 ;TNF-Tg mice. Our findings suggest that pharmacologic inhibition of TRAF6 signaling in skeletal muscles during aging could treat/prevent age- and RA-related sarcopenia by preventing TNFα-induced proteolysis and inhibition of muscle fiber regeneration.
  • ||||||||||  Preclinical, Journal:  Functional effects of muscle PGC-1alpha in aged animals. (Pubmed Central) -  Jul 30, 2021   
    Protection from sarcopenia is seen in male animals with overexpression of PGC-1alpha in skeletal muscle but not in female animals. In summary, muscle-specific expression of PGC-1alpha into old age has beneficial effects on muscle fatigability and may protect from sarcopenia in males, but does not improve whole-body metabolism and appears to worsen age-related trabecular bone loss.
  • ||||||||||  Journal:  Relationship between sarcopenia and orthostatic hypotension. (Pubmed Central) -  Jul 30, 2021   
    There is a close relationship between sarcopenia and severe sarcopenia and OH in older adults. Therefore, when a healthcare practitioner is evaluating an older patient with sarcopenia, OH should also be evaluated, and vice versa.
  • ||||||||||  Clinical, Journal:  Micronutrient deficits in patients with chronic pancreatitis: prevalence, risk factors and pitfalls. (Pubmed Central) -  Jul 30, 2021   
    Various micronutrient deficits were observed in CP outpatients, and associated risk factors were diverse and distinct for the individual nutrients. Taken together, our findings highlight the complexity of micronutrient assessment in patients with CP and emphasise the importance of simultaneous evaluation of plasma protein levels, inflammatory activity and macro-nutritional status.
  • ||||||||||  Clinical, Journal:  Sarcopenia (and sarcopenic obesity) in older patients with gynecological malignancies. (Pubmed Central) -  Jul 30, 2021   
    We demonstrated that obesity can mask sarcopenia, taking into consideration a sample of older patient with cancer, unless body composition evaluation and comprehensive geriatric assessment, including measures of muscle strength and performance, is executed. Our work underlines the importance of a multidisciplinary approach to older patients with cancer to optimize their management.
  • ||||||||||  Clinical, Journal:  Is Sarcopenia a Risk factor for Rotator Cuff Tears? (Pubmed Central) -  Jul 30, 2021   
    The prevalence of sarcopenia in patients with rotator cuff tears was similar to an age- and sex-matched control population. Thus, with these results, we are not able to consider sarcopenia as an independent risk factor for rotator cuff tears.
  • ||||||||||  Journal, Adverse events:  Sarcopenia Predicts Perioperative Adverse Events Following Complex Revision Surgery for the Thoracolumbar Spine. (Pubmed Central) -  Jul 30, 2021   
    Thus, with these results, we are not able to consider sarcopenia as an independent risk factor for rotator cuff tears. Sarcopenia measured by PMI is associated with higher perioperative AEs, 30-day readmission rates, 30-day re-operation rates, rate of discharge to a facility, and longer LOS among patients undergoing complex revision thoracolumbar spine surgery.
  • ||||||||||  [VIRTUAL] Sarcopenia prevalence in recovered of COVID-19 patients. () -  Jul 29, 2021 - Abstract #ERS2021ERS_4320;    
    Although OSK-0028 did not attenuate inflammatory response after esophagectomy, it prevented postoperative bodyweight loss. Higher sarcopenia prevalence were shown in patients who required IMV, which impose a worse prognosis for the patients.
  • ||||||||||  [VIRTUAL] Research priorities for airway diseases in "long COVID" () -  Jul 29, 2021 - Abstract #ERS2021ERS_1831;    
    High scores were also assigned to validating tools for remote monitoring of symptoms; determining the incidence and risk factors of new-onset airway diseases using lung function and imaging; studying effectiveness of exercise rehabilitation; and investigating risk of venous thrombotic events including the role of anticoagulants both newly administered, or previously prescribed. This exercise brings much-needed clarity to clinicians, academics, funders and policymakers on research priorities for airway diseases post COVID-19.
  • ||||||||||  [VIRTUAL] RISK FACTORS FOR THE DEVELOPMENT OF SARCOPENIA IN PATIENTS WITH COVID-19 (Channel 2) -  Jul 29, 2021 - Abstract #ERS2021ERS_1324;    
    This exercise brings much-needed clarity to clinicians, academics, funders and policymakers on research priorities for airway diseases post COVID-19. The main risk factors for sarcopenia development are age, invasive mechanical ventilation, hypertension, diabetes, and COPD, probably implying a worse prognosis.
  • ||||||||||  Review, Journal:  Molecular and Neural Mechanism of Dysphagia Due to Cancer. (Pubmed Central) -  Jul 29, 2021   
    Taste and smell disorders that contribute to swallowing can worsen or develop because of pharmacotherapy or radiation therapy; metabolic or central nervous system damage due to cachexia, sarcopenia, or inflammation can also cause dysphagia. As the causes of eating disorders in cancer patients are complex and involve multiple factors, cancer patients require a multifaceted and long-term approach by the medical care team.
  • ||||||||||  Journal:  Assessment of the performance of the SarQoL questionnaire in screening for sarcopenia in older people. (Pubmed Central) -  Jul 29, 2021   
    As the causes of eating disorders in cancer patients are complex and involve multiple factors, cancer patients require a multifaceted and long-term approach by the medical care team. This exploratory study showed that the SarQoL could potentially be applied in a screening strategy, with the added benefit of providing a measure of QoL at the same time.
  • ||||||||||  Spinraza (nusinersen) / Biogen, Ionis
    Clinical, Observational data, Journal:  The endocrine manifestations of spinal muscular atrophy, a real-life observational study. (Pubmed Central) -  Jul 28, 2021   
    The introduction of nusinersen, the first therapeutic modality for Spinal Muscular Atrophy (SMA) patients has raised hopes and led to construction of a multi-professional medical SMA service, including pediatric endocrinology...Most of the young women had normal pubertal development and regular menses, regardless of degree of obesity. Our findings suggest that isolated precocious pubarche is associated with early-onset insulin resistance linked to severity of muscular atrophy.
  • ||||||||||  Clinical, Journal:  Perceived Neighborhood Environment Associated with Sarcopenia in Urban-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study (KFACS). (Pubmed Central) -  Jul 28, 2021   
    These neighborhood environmental characteristics were linked with an increased likelihood of sarcopenia: no public transportation access (OR = 2.04; 95% CI = 1.19-3.48), poor recreational facilities access (OR = 1.39; 95% CI = 1.01-1.90), absence of destination (OR = 1.53; 95% CI = 1.06-2.20), many hill hazards (OR = 1.36; 95% CI = 1.03-1.78), and lack of traffic safety (OR = 1.35; 95% CI = 1.02-1.78). Thus, better neighborhood environmental strategies may help prevent sarcopenia among urban-dwelling older adults.
  • ||||||||||  Clinical, Review, Journal:  Uremic Toxins and Frailty in Patients with Chronic Kidney Disease: A Molecular Insight. (Pubmed Central) -  Jul 28, 2021   
    Uremic toxin lowering strategies may bear the potential of improving patients' outcomes and restoring their quality of life, through frailty attenuation. Pathogenic molecule-targeted therapeutics potentially disconnect the association between uremic toxins and frailty, additionally serving as an outcome-modifying approach in the future.