Sarcopenia
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  • ||||||||||  Journal:  Frailty in Pancreas Transplantation. (Pubmed Central) -  Aug 14, 2021   
    Given the negative impact of frailty in solid organ transplants, we believe that frailty would have a similar or even worse impact in pancreas transplantation. Due to the paucity of data specifically among pancreas transplant recipients, here we include frailty data from patients with CKD, diabetes, and various solid organ transplant recipients.
  • ||||||||||  Clinical, Journal:  Nutraceutical correction in the complex non-drug treatment of metabolic syndrome (Pubmed Central) -  Aug 13, 2021   
    Due to weight loss and fat mass reduction a decrease in leptin expression by 29.85% and decrease in blood insulin levels by 11.2% were noted. Thus, LCD accompanied by nutraceutical correction of the gut microbiota and hepatic protection can be effectively used in combination with physical training in order to reduce the fat mass without pre-sarcopenia development that was confirmed by positive dynamics of volume indices, bioimpedance measurements and reduction in leptin and insulin expression.
  • ||||||||||  Enrollment closed:  The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy. (clinicaltrials.gov) -  Aug 12, 2021   
    P=N/A,  N=17, Active, not recruiting, 
    Furthermore, being overweight may be a protective factor for GS in older adults of both sexes. Recruiting --> Active, not recruiting
  • ||||||||||  Clinical, Review, Journal:  Body Composition Analysis of Computed Tomography Scans in Clinical Populations: The Role of Deep Learning. (Pubmed Central) -  Aug 11, 2021   
    Key Messages: The high accuracy and drastically improved speed of CT body composition analysis (<1 s/scan for neural networks vs. 15 min/scan for human analysis) suggest that neural networks may aid researchers and clinicians in better understanding the role of body composition in clinical populations by enabling cost-effective, large-scale research studies. As the role of body composition in clinical settings and the field of automated analysis advance, it will be critical to examine how clinicians interact with these systems and to evaluate whether these technologies are beneficial in improving treatment and health outcomes for patients.
  • ||||||||||  Journal:  Should we pay more attention to low creatinine levels? (Pubmed Central) -  Aug 11, 2021   
    A review is made of the basic aspects of creatine/creatinine metabolism and the close relationship between creatinine and muscle mass, which makes the former a biochemical marker of the latter. Emphasis is placed on the current prognostic value of both the low urinary excretion of creatinine and low serum creatinine levels in different clinical settings in which sarcopenia probably plays a significant role in morbidity and mortality.
  • ||||||||||  Journal:  Nutritional considerations for the management of the older person with hepato-pancreatico-biliary malignancy. (Pubmed Central) -  Aug 11, 2021   
    Prehabilitation aims to reduce the complications and side effects associated with treatment, aid recovery and improve quality of life, with the greatest benefits potentially being seen in high risk groups, such as people who are older and frail. Post-operatively, individualised nutritional support therapies targeting the preservation of weight and muscle indices are required to improve post-operative morbidity, and avoid delay or early cessation of any necessary adjuvant therapy.
  • ||||||||||  Clinical, Journal:  Irisin correlates positively with BMD in a cohort of older adult patients and downregulates the senescent marker p21 in osteoblasts. (Pubmed Central) -  Aug 11, 2021   
    Therefore, we investigated in vitro whether rec-irisin had a direct effect on this senescence marker, showing that p21 mRNA expression was significantly down-regulated in osteoblasts by the treatment with irisin. Overall, these results indicate that higher irisin levels are associated with a lower rate of age-related osteoporosis and that irisin could be effective in delaying the osteoblast aging process, suggesting a potential senolytic action of this myokine.
  • ||||||||||  Clinical, Journal:  Suboptimal Tongue Pressure Is Associated with Risk of Malnutrition in Community-Dwelling Older Individuals. (Pubmed Central) -  Aug 11, 2021   
    In conclusion, we found hints for an association between decreased tongue pressure and an increased risk of malnutrition in community-dwelling older individuals. Older people with suboptimal tongue pressure should undergo a thorough assessment of their nutritional status and swallowing function for the early identification of subclinical malnutrition and dysphagia.
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD)
    [VIRTUAL] Obesity is Associated With Greater Overall Survival in Patients With Metastatic NSCLC Receiving First - Line Pembrolizumab (ePoster Hall) -  Aug 9, 2021 - Abstract #IASLCWCLC2021IASLC_WCLC_883;    
    Further research on the relationship between obesity and NSCLC survival outcomes should examine possible biological mechanisms and further investigate other markers of body composition such as sarcopenia, peri-diagnosis weight loss, waist circumference and waist-to-hip ratio. It is likely that biomarkers of body composition will be more useful when utilised in conjunction with other prognostic biomarkers.
  • ||||||||||  Retrospective data, Review, Journal:  Sarcopenia and cognitive impairment: A systematic review and meta-analysis. (Pubmed Central) -  Aug 8, 2021   
    Sarcopenia is associated with an increased risk of cognitive impairment independent of study population, the definition of sarcopenia, and cognitive impairment. This suggests the importance of the early recognition of sarcopenia for the prevention of cognitive impairment in clinical practice.