Sarcopenia
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  • ||||||||||  Trial completion date, Trial primary completion date:  ENHANce: Exercise and Nutrition for Healthy AgeiNg (clinicaltrials.gov) -  Aug 18, 2021   
    P=N/A,  N=180, Recruiting, 
    Trial completion date: Jul 2021 --> Jul 2022 Trial completion date: Jun 2020 --> Jun 2024 | Trial primary completion date: Mar 2020 --> Jan 2023
  • ||||||||||  Trial completion date, Trial primary completion date:  iFRAIL: Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients (clinicaltrials.gov) -  Aug 18, 2021   
    P=N/A,  N=200, Recruiting, 
    Trial completion date: Jun 2020 --> Jun 2024 | Trial primary completion date: Mar 2020 --> Jan 2023 Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
  • ||||||||||  Clinical, Journal:  Prognostic value of a rapid sarcopenia measure in acutely ill older adults. (Pubmed Central) -  Aug 18, 2021   
    Sarcopenia was a strong predictor of 1-year adverse outcomes among acutely ill older outpatients. Combining handgrip strength with calf circumference may be a practical and efficient approach to screen for sarcopenia, and thereby identify high-risk older adults in busy clinical settings.
  • ||||||||||  Clinical, Journal:  From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study. (Pubmed Central) -  Aug 18, 2021   
    Given the lack of equivalence from individual muscle groups, we recommend that further work be undertaken to investigate which muscle group, or indeed whether the gold standard of whole L3 skeletal muscle, provides the best correlation with clinical outcomes. Overall, our findings show that sustaining nutritional support might be clinically relevant in increasing physical performance in elderly malnourished patients and that the use of specific BCAAem might ameliorate also cognitive performance thanks to an amelioration of mitochondria bioenergetics.
  • ||||||||||  Clinical, Journal:  Automated body composition analysis of clinically acquired computed tomography scans using neural networks. (Pubmed Central) -  Aug 18, 2021   
    Both sarcopenia and visceral obesity were associated with adverse outcomes in severe CD patients whereas usual nutritional assessment was not. Our network displayed excellent ability to analyze diverse body composition phenotypes and clinical cohorts, which will create feasible opportunities to advance our capacity to predict health outcomes in clinical populations.
  • ||||||||||  Clinical, Review, Journal:  Nonalcoholic Fatty Liver Disease and Implications for Older Adults with Diabetes. (Pubmed Central) -  Aug 18, 2021   
    For this reason, appropriate identification and management of NAFLD are clinically relevant particularly in the group of older patients with type 2 diabetes. In this regard, clinicians should consider the peculiar characteristics of elderly patients, such as frailty, multimorbidity, and polypharmacy.
  • ||||||||||  Preclinical, Journal:  Measuring Exercise Capacity and Physical Function in Adult and Older Mice. (Pubmed Central) -  Aug 18, 2021   
    We found that there was an overall age-related significant decline (p&0.05) in all measurements, and the CFAB score demonstrated that some individual mice (the upper quartile) retained the functional capacity of average mice one cohort younger. We conclude that the CFAB is a powerful, repeatable and non-invasive tool to assess and compare physical function and assess complex motor task ability in mice, which will enable researchers to easily track performance at the individual mouse level.
  • ||||||||||  Journal:  Comment on: OSTEOSARCOPENIA: WHERE OSTEOPOROSIS AND SARCOPENIA COLLIDE. (Pubmed Central) -  Aug 18, 2021   
    We conclude that the CFAB is a powerful, repeatable and non-invasive tool to assess and compare physical function and assess complex motor task ability in mice, which will enable researchers to easily track performance at the individual mouse level. No abstract available
  • ||||||||||  Journal:  Neuroprotective effects of exercise on the aging human neuromuscular system. (Pubmed Central) -  Aug 18, 2021   
    Although there is some discrepancy across studies of masters athletes, if one considers all experimental limitations as well as the available literature in animals, there is compelling evidence of a protective effect of chronic physical training on human MUs. Our tenet is that high-levels of physical activity can mitigate the natural trajectory of loss of quantity and quality of MUs in old age.
  • ||||||||||  Trial completion:  SPISAR: Efficacy of the Consumption of a Spinach Extract on Muscle Function in Subjects Over 50 Years of Age (clinicaltrials.gov) -  Aug 18, 2021   
    P=N/A,  N=50, Completed, 
    The high frequency of overestimated renal function in Japanese patients suggests that indicators of renal function should be carefully considered; furthermore, monitoring and interventions for both renal function and sarcopenia are needed in patients with CLD. Active, not recruiting --> Completed
  • ||||||||||  Journal:  Association of X-ray Absorptiometry Body Composition Measurements with Basic Anthropometrics and Mortality Hazard. (Pubmed Central) -  Aug 15, 2021   
    Whole-body composition did not substantially improve mortality prediction compared to basic anthropometrics alone, but regional composition did, with high trunk fat-free mass and low limb fat-free mass both associated with elevated mortality risk. These findings illustrate how DEXA body composition could guide health assessment in conjunction with the more widely employed simple anthropometrics.