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|||||||||| Journal: Effects, Doses, and Applicability of Gestrinone in Estrogen-Dependent Conditions and Post-Menopausal Women. (Pubmed Central) - Sep 29, 2024
Gestrinone appears to be effective compared to other progestins and may have some advantages in the treatment of estrogen-dependent pathologies. Future research must evaluate gestrinone's long-term safety and potential therapeutic indications.

|||||||||| Vaginorm (dehydroepiandrosterone) / Endoceutics, Bayer
Review, Journal: Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application. (Pubmed Central) - Sep 29, 2024
Future research must evaluate gestrinone's long-term safety and potential therapeutic indications. At present, the clinical use of dehydroepiandrosterone is limited by its Intrarosa

|||||||||| Journal: Identification of Osteosarcopenia by High-Resolution Peripheral Quantitative Computed Tomography. (Pubmed Central) - Sep 29, 2024
These findings demonstrated that HR-pQCT is a viable and effective screening method for differentiating osteosarcopenia from low bone mineral density alone without the need to carry out multiple assessments for osteosarcopenia, especially for case-finding purposes. This could facilitate the decision of a follow-up and the management of these frail older adults to ensure they receive timely therapeutic interventions to minimise the associated risks.

|||||||||| Review, Journal: Does Vitamin B6 Act as an Exercise Mimetic in Skeletal Muscle? (Pubmed Central) - Sep 29, 2024
Here, we provide several pieces of evidence supporting this hypothesis and discuss the potential mechanisms behind the similarities between the effects of B6 and exercise on muscle. This research, for the first time, provides insight into the exercise-mimetic roles of B6 in skeletal muscle.

|||||||||| Observational data, Journal: Association between Motoric Cognitive Risk Syndrome and Indicators of Reflecting Independent Living among Community-Dwelling Older Adults in Japan: A Cross-Sectional Study. (Pubmed Central) - Sep 29, 2024
In conclusion, MCR was found to be similarly associated with QMCOO and JST-IC as physical frailty. It is expected that the MCR will be used as an initial screening tool to identify signs of risk in community-dwelling older people, as it is easy to diagnose.

|||||||||| Journal: A Comparative Analysis of the SARC-F Questionnaire and the Malnutrition-Inflammation Score for Sarcopenia Risk Assessment and Negative Outcome Probability in Chronic Hemodialysis Patients. (Pubmed Central) - Sep 29, 2024
The SARC-F alone often did not correspond to an increased sarcopenia risk or clear clinical and biochemical indicators of PEW in HD patients. When assessing nutritional risk in this group, it is recommended to use more detailed tools, such as the MIS, to ensure the accurate identification of those at the highest risk for negative outcomes.

|||||||||| Biomarker, Journal, HEOR: Disease Activity, Inflammation Markers, and Quality of Life Are Associated with Muscle Strength in Croatian Rheumatoid Arthritis Patients-A National-Based Study. (Pubmed Central) - Sep 29, 2024
In the male RA participants, significant predictors of muscle strength are only weight, height, and anxiety/depression difficulties, according to the EQ5D. This study showed correlations between muscle strength and the parameters of disease activity, inflammation parameters, health-related quality of life, therapy, and exercise in the female RA participants in Croatia.

|||||||||| Review, Journal: Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions. (Pubmed Central) - Sep 29, 2024
This study emphasizes the complex interplay between vascular dysfunction, muscle degeneration, and cognitive decline, highlighting the necessity for multidisciplinary treatment approaches. Advances in this domain promise improved diagnostic accuracy, more effective therapeutic options, and enhanced preventive measures, all contributing to a higher quality of life for the elderly population.

|||||||||| Review, Journal: Cellular Senescence: The Driving Force of Musculoskeletal Diseases. (Pubmed Central) - Sep 29, 2024
Undoubtedly, targeting senescent cells and their secretory profiles could promote the development of integrated strategies, including regular exercise and a balanced diet or the use of senolytics and senomorphs, to improve the quality of life of the aging population. Therefore, our review aimed to highlight the role of cellular senescence in age-related musculoskeletal diseases, summarizing the main underlying mechanisms and potential anti-senescence strategies for the treatment of osteoporosis, sarcopenia, and osteoarthritis.

|||||||||| Journal: Challenging Sarcopenia: Exploring AdipoRon in Aging Skeletal Muscle as a Healthspan-Extending Shield. (Pubmed Central) - Sep 29, 2024
Finally, AR markedly curbed muscle fibrosis and mitigated local/systemic inflammation. Thus, a late three-month AR treatment successfully opposed sarcopenia and counteracted various hallmarks of aging, suggesting AR as a promising anti-aging therapy for skeletal muscles, potentially extending healthspan.

|||||||||| Lenvima (lenvatinib) / Eisai, Merck (MSD)
Journal, Metastases: The impact of lenvatinib on sarcopenia in patients with advanced unresectable hepatocellular carcinoma. (Pubmed Central) - Sep 28, 2024
However, despite progressive muscle loss, patients benefit from a therapy with lenvatinib in terms of OS and PFS without increased toxicity. However, assessment and prophylaxis of skeletal muscle status should be recommended during a therapy with lenvatinib.

|||||||||| Retrospective data, Journal: Evaluating Respiratory Muscle Strength in Sarcopenia Screening among Older Men in South Korea: A Retrospective Analysis. (Pubmed Central) - Sep 28, 2024
We suggest the screening cut-off values as 65.50 cmH2O for MIP and 84.50 cmH2O for MEP. Even when HGS and SMI measurements are not feasible, sarcopenia can be reasonably predicted based on respiratory muscle strength.

|||||||||| Journal: Grip Strength and Sarcopenia in Children With Cerebral Palsy: A Level Playing Field? (Pubmed Central) - Sep 28, 2024
Even when HGS and SMI measurements are not feasible, sarcopenia can be reasonably predicted based on respiratory muscle strength. No abstract available

|||||||||| Inter-observer agreement in the measurements of sarcopenia-related parameters (skeletal muscle and adiopse tissue area) with low-dose attenuation correction CT of 18F-FDG PET/CT in elderly hodgkin lymphoma (e-Poster Area) - Sep 27, 2024 - Abstract #EANM2024EANM_1814;
CT of PET/ CT is a safe, accurate and precise method for the measurements of skeletal muscle area, visceral and subcutaneous adipose tissue. Inter-observer agreement for the measurement of sarcopenia parameters assessed on low-dose CT of PET/CT was very good, except for IMAT.

|||||||||| Prediction of Treatment Response in HER-2 Positive Breast Cancer Patients Undergoing Neoadjuvant Treatment Using PET/CT Parameters and Body Composition Indices (e-Poster Area) - Sep 27, 2024 - Abstract #EANM2024EANM_1596;
In this study, an inverse relationship was found between the primary tumor MTV derived from PET/CT parameters and near-complete treatment response in HER-2 positive locally/locally advanced breast cancer patients. Additionally, for the prognostic value of sarcopenic indices obtained with CT component, larger series and prognostic studies are needed.

|||||||||| Development of a Deep Learning Model for Automated Measurement of Skeletal Muscle Mass in [18F]F-FDG PET/ CT Scans (Hall Y10-Y12) - Sep 27, 2024 - Abstract #EANM2024EANM_1411;
The study demonstrated that our 3D segmentation deep learning model could reasonably measure skeletal muscle mass from whole-body CT images in PET/CT scans. PET/CT is expected to become an increasingly important tool for personalized medicine, as it can acquire not only tumor accumulation values (SUVmax) from PET images, but also non-tumor parameters such as muscle mass that reflect individual patient characteristics from CT images.

|||||||||| PET/CT radiomics combined with clinical features in predicting sarcopenia and prognosis of diffuse large B-cell lymphoma (Hall Y4-Y9) - Sep 27, 2024 - Abstract #EANM2024EANM_997;
PET/CT is expected to become an increasingly important tool for personalized medicine, as it can acquire not only tumor accumulation values (SUVmax) from PET images, but also non-tumor parameters such as muscle mass that reflect individual patient characteristics from CT images. ML models incorporating clinical and PET/CT radiomics features could effectively predict the presence of sarcopenia and assess the prognosis in patients with DLBCL.

|||||||||| Journal, Surgery: Knowledge mapping of frailty and surgery: a bibliometric and visualized analysis. (Pubmed Central) - Sep 27, 2024
This study has identified the research hotspots and trends in perioperative frailty. Our findings will enable researchers to understand this field's knowledge structure better and identify future research directions.

|||||||||| Journal: Countermovement Jump Peak Power Changes with Age in Masters Weightlifters. (Pubmed Central) - Sep 27, 2024
Female weightlifters exhibited less age-related decline compared to normative data as well as the other Master athlete comparison cohorts (short and long-distance runners), whereas the males demonstrated similar age-related declines as the comparison cohorts. While the female weightlifters in the current study generally demonstrated the least age-related declines in CMJ peak power of the comparative literature, the male weightlifters showed similar age-related decline rates.

|||||||||| Diving into Health: Revolutionizing Parkinson's Disease Rehabilitation with Aquatic HIIT () - Sep 27, 2024 - Abstract #MDSCongress2024MDS_Congress_2062;
Balance scores increased by an average of 25% (p < 0.05), reflecting enhanced stability and a reduced risk of falls. Physical function scores also show 30% improvement (p < 0.01), highlighting the effectiveness of aquatic training.

|||||||||| Journal: Dietary selenium intake and sarcopenia in American adults. (Pubmed Central) - Sep 27, 2024
Furthermore, sensitivity analyses revealed a robust association between selenium intake and the prevalence of sarcopenia after further adjusting for blood selenium levels. The results suggest an inverse association between dietary selenium intake and the prevalence of sarcopenia among American adults.

|||||||||| Journal: Coexistence of high visceral fat area and sarcopenia and atherosclerotic markers in older patients with diabetes: Is there an association? (Pubmed Central) - Sep 27, 2024
The results suggest an inverse association between dietary selenium intake and the prevalence of sarcopenia among American adults. No abstract available

|||||||||| Journal: Sarcopenia Predicts the Development of Early Adjacent Segment Disease After Transforaminal Lumbar Interbody Fusion. (Pubmed Central) - Sep 26, 2024
Morphometric analysis of psoas size is a simple tool to identify patients at risk of developing ASD. This information can potentially guide preoperative and postoperative therapies, affect surgical decision making, and effectively counsel patients on risks of reoperation.

|||||||||| Retrospective data, Journal: Beyond body mass index: Body composition profiling for perioperative risk stratification in intrahepatic cholangiocarcinoma patients. (Pubmed Central) - Sep 26, 2024
Increased SAT and VAT were associated with the risk of perisurgical complications, prolonging hospitalization. Therefore, BCA derived from routine staging CT should be considered in the preoperative assessment of patients with iCC.

|||||||||| Journal: Weight-Specific Grip Strength as a Novel Indicator Associated with Cardiometabolic Risk in Children: The EMSNGS Study. (Pubmed Central) - Sep 26, 2024
This study established grip strength reference values for Chinese youth, introduced the concept of weight-specific HGS and RHGS, and demonstrated a dose-dependent relationship between weight-specific grip strength and cardiometabolic risk. These findings highlighted the association between low muscle strength and increased cardiometabolic risk.

|||||||||| Journal: Maccarone et al.'s comments on Cohort studies using 3D-CT are needed to assess whether "home Gym-Bed" exercises are beneficial against sarcopenia. (Pubmed Central) - Sep 26, 2024
The increase in daily muscular activity even through "Home In-Bed Gym" recovers at least in part the potential abilities progressively lost. Therefore, it is easy to rejuvenate the "lazy" population, that is, the vast majority of elderlies.[...].

|||||||||| Preclinical, Journal: Chronic whole-body heat treatment in obese insulin-resistant C57BL/6J mice. (Pubmed Central) - Sep 26, 2024
It also lowered the H-index of HSP70 balance, indicating improved immunoinflammatory status, and decreased activated caspase-1 and proliferative senescence in adipose tissue, both linked to insulin resistance. The findings suggest that even animals on a "control" diet but with insufficient physical activity and within their TNZ may experience impaired glycaemic homeostasis.

|||||||||| New trial: ZZ2024-158-02: Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Colorectal Cancer Patients (clinicaltrials.gov) - Sep 26, 2024
P=N/A, N=8000, Active, not recruiting, Sponsor: First Affiliated Hospital of Chongqing Medical University

|||||||||| Trial completion date, Trial primary completion date: Evaluation of Sarcopenia in Patients Receiving Home Health Care (clinicaltrials.gov) - Sep 26, 2024
P=N/A, N=120, Recruiting, Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
The findings suggest that even animals on a "control" diet but with insufficient physical activity and within their TNZ may experience impaired glycaemic homeostasis. Trial completion date: Feb 2024 --> Oct 2024 | Trial primary completion date: Feb 2024 --> Oct 2024

|||||||||| Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date: Abdominal Skeletal Muscle Compartments in Turkish Children (clinicaltrials.gov) - Sep 25, 2024
P=N/A, N=2300, Active, not recruiting, Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Trial completion date: Feb 2024 --> Oct 2024 | Trial primary completion date: Feb 2024 --> Oct 2024 Not yet recruiting --> Active, not recruiting | N=5000 --> 2300 | Trial completion date: Mar 2024 --> Oct 2024 | Trial primary completion date: Mar 2024 --> Oct 2024

|||||||||| Journal: Adverse plasma branched-chain amino acid profile mirrors fatty muscle degeneration in diabetic heart failure patients. (Pubmed Central) - Sep 25, 2024
Despite higher plasma BCAA levels in HF patients with diabetes, the prognostic value of low valine remained consistent regardless of diabetes status. However, low BCAAs were distinctly associated with fatty muscle degeneration in the extremities in diabetic patients, suggesting the importance of targeted interventions to prevent such tissue remodelling in this population.

|||||||||| Retrospective data, Review, Journal: The effects of exercise with or without dietary advice on muscle mass, muscle strength, and physical functioning among older cancer survivors: a meta-analysis of randomized controlled trials. (Pubmed Central) - Sep 25, 2024
However, low BCAAs were distinctly associated with fatty muscle degeneration in the extremities in diabetic patients, suggesting the importance of targeted interventions to prevent such tissue remodelling in this population. It is necessary for old cancer survivors to receive exercise and dietary support to improve physical functioning.

|||||||||| Journal: NCPD Tests: Undernutrition, Sarcopenia, Sarcopenic Obesity, and Sarcopenic Undernutrition: A Cross-sectional View on Patients Before Total Joint Arthroplasty. (Pubmed Central) - Sep 25, 2024
It is necessary for old cancer survivors to receive exercise and dietary support to improve physical functioning. No abstract available

|||||||||| Journal: Undernutrition, Sarcopenia, Sarcopenic Obesity, and Sarcopenic Undernutrition: A Cross-sectional View on Patients Before Total Joint Arthroplasty. (Pubmed Central) - Sep 25, 2024
Eating behaviors and leucocytes were the discriminating factors between malnourished and well-nourished. It remains to be established whether malnutrition affects outcome after surgery.

|||||||||| Journal: Liver transplant recipients have worse metabolic body phenotype compared with matched non-transplant controls. (Pubmed Central) - Sep 25, 2024
Using non-LT controls, the current study established the higher-than-expected adiposity burden among LT recipients, which is even higher among patients transplanted for MASH cirrhosis. These findings provide data needed to design future studies developing radiomics-based risk-stratification strategies in LT recipients.

|||||||||| Preclinical, Journal: Resveratrol as a potential therapeutic agent for sarcopenic obesity: Insights from in vivoperiments. (Pubmed Central) - Sep 25, 2024
The anti-inflammatory effects of RSV were confirmed in vivo in an SO mouse model. This study contributes to a more comprehensive understanding of the key mechanisms of the action of RSV against SO and provides new possibilities for drug development in the pathological process of SO.

|||||||||| Journal: Triad of Rehabilitation, Nutrition Support, and Oral Management improves Activities of Daily Living and Muscle Health in Hospitalized Patients after Stroke. (Pubmed Central) - Sep 25, 2024
The triad approach of intensive rehabilitation, personalized nutrition support, and oral management by dental professionals is strongly associated with improved ADL, muscle strength, and skeletal muscle mass in post-stroke rehabilitation patients. Implementing this multidisciplinary strategy may maximize functional and muscle health recovery.

|||||||||| Journal: Application of a New Definition of Sarcopenic Obesity in Middle-Aged and Older Adults and Association with Cognitive Function: Findings from the National Health and Nutrition Examination Survey 1999-2002. (Pubmed Central) - Sep 25, 2024
The new ESPEN-EASO definition of SO identified a high prevalence of SO cases. A significant association between SO and poor cognitive function in older individuals was observed.

|||||||||| Journal: Effect of the Japanese herbal medicine Hochuekkito for systemic inflammation, prognostic nutrition index, and body composition status in patients with gastrointestinal cancer. (Pubmed Central) - Sep 25, 2024
A significant association between SO and poor cognitive function in older individuals was observed. TJ-41 might be useful as part of multimodality therapy for gastrointestinal cancer, especially in patients with metastases.

|||||||||| Multimodal Ultrasound in the Assessment of Sarcopenia-related Muscle Involvement in Patients with Systemic Sclerosis: A Multicentric Study (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_3590;
TJ-41 might be useful as part of multimodality therapy for gastrointestinal cancer, especially in patients with metastases. Ultrasound could be a valuable method for investigating changes in muscle mass, quality, and stiffness indicative of sarcopenia-related muscle involvement in SSc patients.

|||||||||| Strengthening Fracture Risk Prediction in Rheumatoid Arthritis: Integrating a Self-report Sarcopenia Screening Tool (SARC-F) and Fracture Risk Assessment Tool (FRAX) Scores (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_3523;
A significant negative correlation exists between SARC-F score and femoral neck T-score, indicating that higher SARC-F scores are associated with lower bone mineral density. SARC-F may help identify patients at high risk of fractures, facilitating preventive interventions.

|||||||||| Increased Circulating Levels of Fatty Acid-binding Proteins as a Potential Biomarker of Disease Damage in Inflammatory Myopathies Patients (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2453;
SARC-F may help identify patients at high risk of fractures, facilitating preventive interventions. Increased circulating levels of FABP are candidate biomarkers of disease damage in IM similarly to that found in metabolic disorders3.

|||||||||| Association Between a Self-Report Screening Tool for Sarcopenia (SARC-F) and Disease Activity, Muscle Strength and Muscle Power Measures, Patient-Reported Outcomes and Body Composition in Patients with Spondyloarthritides (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2417;
Importantly, the SARC-F questionnaire did not differentiate between patients with and without sarcopenia based on the FNIH definition. Further research is needed to explore if this might be due to the small sample size of this study or if the SARC-F has limitations to screen for sarcopenia in patients with rheumatic diseases.

|||||||||| methotrexate / Generic mfg.
Kidney Function in Rheumatoid Arthritis: Estimating Glomerular Filtration Rate Using Creatinine versus Cystatin C in a Secondary Analysis of the TARGET Trial (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2382;
These results suggest eGFRcys may change in response to RA disease activity, possibly independent of a true change in GFR. We need further research with measured GFR to determine whether eGFRcr or eGFRcys is a better estimate of GFR.

|||||||||| Effects of Training with Blood Flow Restriction on Muscle Strength in Women with Rheumatoid Arthritis: A Randomized Clinical Trial (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2339;
Except for the knee extension, LIT-BFR was equivalent to the HIRT in improving muscle strength in RA women, demonstrating it to be a well-tolerated and effective tool for preventing and improving sarcopenia in these patients. Abbreviations: LIT-BFR, low-intensity training with blood flow restriction; HIRT, High-intensity resistance training; n, number; SD, standard deviation; kg, kilogram; kg/m

|||||||||| Evaluation of an Accelerated Physical Aging Phenotype in Newly Diagnosed Patients with Polymyalgia Rheumatica (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2072;
This study provides preliminary evidence for an accelerated physical aging phenotype in PMR. Further studies are needed to explore the role of inflammaging and immunosenescence in the pathophysiology of PMR.

|||||||||| Obesity Subtypes and Trajectories of Functional Change After 7-years of Follow-up: The Multicenter Osteoarthritis (MOST) Study (Room 146AB; In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_1002;
Individuals with obesity and concurrent low muscle mass or metabolic comorbidities have persistent, worse impairments in functional status over a 7-year period compared to those with obesity alone. Distinguishing these obesity subtypes through body composition and comorbidity assessments may be needed to enable personalized intervention and to avoid extended mobility disability.

|||||||||| Observational data, Journal: Evaluation of quadriceps muscle cross-sectional area using an ultrasonic diagnostic equipment with a wide field of view. (Pubmed Central) - Sep 24, 2024
The tested ultrasound device showed excellent measurement reproducibility and had good correlations with CT images. Further studies with an increased numbers of clinical cases and additional evaluations should allow the device to become a screening tool for diagnosing sarcopenia.

|||||||||| Retrospective data, Journal: Importance of hip capsular repair in total hip arthroplasty (THA) via the posterior lateral approach: a five year retrospective cohort study. (Pubmed Central) - Sep 24, 2024
Capsular repair during posterior-lateral THA improves postoperative hip function and mobility while reducing dislocation rates, blood loss, pain, inflammation, and economic burden. Patients with rheumatoid arthritis, epilepsy, or sarcopenia require individualized planning and enhanced postoperative care to minimize complications.

|||||||||| Review, Journal: MicroRNAs and their Modulatory Effect on the Hallmarks of Osteosarcopenia. (Pubmed Central) - Sep 24, 2024
activity, presenting it as a target for developing analogues that restore its function. Finally, microRNA-672 stands out for its ability to protect skeletal muscle and bone when expressed in the disease, highlighting its potential as a possible therapy for osteosarcopenia.



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