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|||||||||| Clinical, Journal: Recruitment strategies and design considerations in a trial of resistance training to prevent dose-limiting toxicities in colon cancer patients undergoing chemotherapy. (Pubmed Central) - Sep 26, 2021
Control patients at the end of the study receive a consult with a FORCE exercise trainer, an online exercise RT training program and a set of resistance bands. Results of this trial will provide information on the benefit of resistance exercise as a treatment to increase RDI.

|||||||||| L-ornithine-L-aspartate / Generic mfg.
Review, Journal: Nutraceuticals for the treatment of sarcopenia in chronic liver disease. (Pubmed Central) - Sep 26, 2021
Nutraceuticals offer a promising and likely safe adjunct to standard care for sarcopenia in cirrhosis. While there is most evidence to support the use of BCAA and l-carnitine supplementation, further well-designed clinical trials are needed to elucidate their efficacy as a therapy for muscle loss in this population.

|||||||||| Clinical, Journal: Protein Recommendation to Increase Muscle (PRIMe): Study protocol for a randomized controlled pilot trial investigating the feasibility of a high protein diet to halt loss of muscle mass in patients with colorectal cancer. (Pubmed Central) - Sep 26, 2021
This evidence-based study investigates the feasibility of increasing protein intake following a diagnosis of cancer on clinical outcomes during treatment for colorectal cancer. This study will inform larger trials assessing the impact of increasing protein intake in cancer to determine their importance and integration into standard clinical care for people with cancer.

|||||||||| Clinical, Journal: Skeletal muscle anabolic and insulin sensitivity responses to a mixed meal in adult patients with active Crohn's disease. (Pubmed Central) - Sep 26, 2021
Combining these results with our previous findings in paediatric patients suggests that age of onset and/or disease burden over time, as well as daily protein intake, may be significant in the development of sarcopenia in CD. Longitudinal studies investigating these factors are required.

|||||||||| Clinical, Review, Journal: Prevalence, diagnostic criteria, and factors associated with sarcopenic obesity in older adults from a low middle income country: A systematic review. (Pubmed Central) - Sep 26, 2021
Epidemiological studies conducted so far in Brazil are heterogeneous, which limits the possibility of comparison between prevalence and distribution of sarcopenic obesity among older adults. Further studies with representative samples of the population are required to understand the magnitude of SO in this group.

|||||||||| Clinical, Journal: Preoperative skeletal muscle index and visceral-to-subcutaneous fat area ratio are associated with long-term outcomes of elderly gastric cancer patients after gastrectomy. (Pubmed Central) - Sep 26, 2021
Further studies with representative samples of the population are required to understand the magnitude of SO in this group. Preoperative SMI and VSR were prognostic factors for the overall survival of elderly patients with gastric cancer after gastrectomy.

|||||||||| Journal: A significant association of non-obese non-alcoholic fatty liver disease with osteosarcopenic obesity in females 50 years and older. (Pubmed Central) - Sep 26, 2021
Non-obese NAFLD had a significant association with OSO in females, independent of plausible confounders. These results suggest that non-obese NAFLD might be an independent risk factor for OSO.

|||||||||| Clinical, Journal: Prevalence, associated factors, and prognostic value of sarcopenia in patients with acute exacerbated chronic obstructive pulmonary disease: A cohort study. (Pubmed Central) - Sep 26, 2021
Malnutrition and advanced Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage were associated with increased chances of this condition in AECOPD patients. Reduced HSG combined with low CC may be an alternative when FFMI not be obtained for sarcopenia diagnosis.

|||||||||| Clinical, Journal: Both muscle quantity and quality are predictors of waiting list mortality in patients with end-stage liver disease. (Pubmed Central) - Sep 26, 2021
Reduced HSG combined with low CC may be an alternative when FFMI not be obtained for sarcopenia diagnosis. Both low muscle quantity and quality, and not nutritional intake, were independent risk factors for mortality in patients with ESLD.

|||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Clinical, Journal: Body Composition as a Predictor of Toxicity and Prognosis in Patients with Diffuse Large B-Cell Lymphoma Receiving R-CHOP Immunochemotherapy. (Pubmed Central) - Sep 26, 2021
SMG was an innovative and valuable indicator of immunochemotherapy toxicity and other adverse outcomes. Additionally, it can be used to individualize antineoplastic drug dosing.

|||||||||| Clinical, Review, Journal: Impact of body composition, nutritional and inflammatory status on outcome of non-small cell lung cancer patients treated with immunotherapy. (Pubmed Central) - Sep 26, 2021
Additionally, it can be used to individualize antineoplastic drug dosing. A multimodal approach based on nutrition assessment and physical exercise should be evaluated to improve aspects of the immune response against cancer and to propose the best treatment to every patient.

|||||||||| Retrospective data, Review, Journal: The effects of amino acid/protein supplementation in patients undergoing hemodialysis: A systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) - Sep 26, 2021
We confirmed the positive effect of amino acid/protein supplementation on physical function in people undergoing hemodialysis. However, there is still insufficient evidence, and more rigorously designed randomized controlled trials with high quality are needed.

|||||||||| sirolimus / Generic mfg.
Review, Journal: The effects of glucagon and the target of rapamycin (TOR) on skeletal muscle protein synthesis and age-dependent sarcopenia in humans. (Pubmed Central) - Sep 26, 2021
However, there is still insufficient evidence, and more rigorously designed randomized controlled trials with high quality are needed. Human TOR participates in the pathogenesis of sarcopenia and arterial stiffness, although its effects remain to be fully elucidated.

|||||||||| Clinical, Journal: Evaluation of techniques used to assess skeletal muscle quantity in patients with cirrhosis. (Pubmed Central) - Sep 26, 2021
The use of USMT over other bedside skeletal muscle mass estimates was not supported by our results. Further studies evaluating novel bedside skeletal muscle mass estimation techniques in cirrhosis patients are required.

|||||||||| Clinical, Observational data, Journal: Muscle mass evaluation using psoas muscle mass index by computed tomography imaging in hemodialysis patients. (Pubmed Central) - Sep 26, 2021
PMI assessed with CT positively correlated with SMI measured using BIA. PMI might be one of the methods for evaluating the muscle mass in HD patients, when CT scans are taken as part of routine care.

|||||||||| Clinical, Journal: Measurement of body composition: Agreement between methods of measurement by bioimpedance and computed tomography in patients with non-small cell lung cancer. (Pubmed Central) - Sep 26, 2021
Bias was reduced and LoA narrowed in the subgroup analysis however not to acceptable levels. This study finds it possible that patients with low physical performance are liable to larger overestimations of MM with BIA than those with normal physical performance.

|||||||||| Clinical, Retrospective data, Review, Journal: Long-term changes in nutritional status and body composition in patients with malignant pancreatic disease - A systematic review. (Pubmed Central) - Sep 26, 2021
There is a paucity of data regarding nutritional intervention in pancreatic cancer. Future work should include the use of validated functional and clinical assessment tools to further explore the impact of nutritional intervention, and the relationship between nutritional status and outcome.

|||||||||| Very similar to what happens with sarcopenia, an equivalent of 9-10 extra points of MELD or MELD-Na. I believe that sarcopenia is a more objective measure and perhaps less biased in the setting of decompensated cirrhosis or aclf. (Twitter) - Sep 25, 2021

|||||||||| Clinical, Journal: Prevalence and factors associated with recurrent falls among middle-aged community-dwelling women. (Pubmed Central) - Sep 25, 2021
The prevalence of falls among middle-aged women was considerably high. Falls were associated with advanced age, low muscle mass and muscle strength.

|||||||||| Clinical, Journal: Using accelerometers in the assessment of sarcopenia in older adults attending a day hospital service in Ireland. (Pubmed Central) - Sep 25, 2021
Accelerometer data can be used in an older day hospital population to track physical activity levels and sedentary behaviours. The assessment tool used to assess muscle strength and the cut-off criteria for physical activity behaviour influences the association with sarcopenia.

|||||||||| Journal: Detecting a valid screening method for sarcopenia in acute care setting. (Pubmed Central) - Sep 25, 2021
SARC-F and Ishii equation could be used as a valid simple screening tool in acute hospital setting. Combing these two screening tools resulted in better diagnostic accuracy with higher sensitivity and specificity.

|||||||||| Journal: Communications to the International Sarcopenia Translational Research Conference 2021. (Pubmed Central) - Sep 25, 2021
Combing these two screening tools resulted in better diagnostic accuracy with higher sensitivity and specificity. No abstract available

|||||||||| [VIRTUAL] Effects of branched-chain amino acid-rich supplementation on EWGSOP2 criteria for sarcopenia in older adults: a systematic review and meta-analysis () - Sep 25, 2021 - Abstract #ACRM2021ACRM_948;
BCAA-rich supplements may exert beneficial effects on muscle strength and mass of older people. However, owing to high heterogeneity, inferences from the results must be made with caution.

|||||||||| [VIRTUAL] Association of Different Muscle Mass Indices, Strength, and Physical Performance with Falling in Elderly: Results from the Korean Frailty and Aging Cohort Study () - Sep 25, 2021 - Abstract #ACRM2021ACRM_897;
The predictive value of individual measures of sarcopenia vary by genders. Poor physical performance was significantly associated with incidence of falls in females, but there was no significant associations between muscle mass indices, strength, and physical performance and falling in males.

|||||||||| [VIRTUAL] Impact of COVID-19 on frailty, sarcopenia, and functionality after hospital discharge () - Sep 25, 2021 - Abstract #ACRM2021ACRM_751;
Despite functionality returning to baseline after 4 months, sarcopenia and frailty remained deficient when compared to the pre-hospitalization period. Therefore, a long-term follow-up is necessary for evaluation and rehabilitation after hospitalization by COVID-19

|||||||||| [VIRTUAL] Effect of Branched Chain Amino Acid Supplementation on Prevention of Sarcopenia after Stroke () - Sep 25, 2021 - Abstract #ACRM2021ACRM_705;
We also found that nutritional support helps functional improvement on neurologic recovery. Stroke leads to complex systemic metabolic changes, thus loss of muscle mass and malnutrition frequently occurs after stroke.

|||||||||| Opdivo (nivolumab) / Ono Pharma, BMS, Cdactin-O (CBM-588) / Osel, Miyarisan, Yervoy (ipilimumab) / Ono Pharma, BMS
A masterful presentation by @LuisMezaco @cityofhope recapping the #microbiome in #kidneycancer & re-capping his presentation from @ASCO #ASCO21 re: nivo/ipi +/- CBM588 & @ZeynepZengin's data on sarcopenia & microbiome from @myESMO #ESMO21. Fantastic mtg hosted by @manuelmaiamd. (Twitter) - Sep 25, 2021

|||||||||| 5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
Clinical, Journal: The impact of sarcopenia and decrease in skeletal muscle mass in patients with advanced pancreatic cancer during FOLFIRINOX therapy. (Pubmed Central) - Sep 25, 2021
In conclusion, decrease in SMM within 2 months after the initiation of chemotherapy had significantly shorter OS, although sarcopenia at diagnosis did not affect OS. Therefore, it might be important to maintain SMM during chemotherapy for a better prognosis.

|||||||||| rivaroxaban / Generic mfg., apixaban / Generic mfg.
Clinical, Journal: Muscle Mass and Direct Oral Anticoagulant Activity in Older Adults With Atrial Fibrillation. (Pubmed Central) - Sep 25, 2021
Our proof-of-concept study has identified an association between ALM and DOAC levels in older adults with AF. Further research is needed to determine the impact of ALM on bleeding complications and the potential role of ALM-guided dosing for sarcopenic patients.

|||||||||| Journal: Developing a UK sarcopenia registry: recruitment and baseline characteristics of the SarcNet pilot. (Pubmed Central) - Sep 25, 2021
Further research is needed to determine the impact of ALM on bleeding complications and the potential role of ALM-guided dosing for sarcopenic patients. recruitment to a multisite UK sarcopenia registry is feasible, with high levels of consent for recontact.

|||||||||| Clinical, Review, Journal: Type 2 diabetes mellitus in older adults: clinical considerations and management. (Pubmed Central) - Sep 25, 2021
We then evaluate new evidence relating particularly to the effects of frailty and sarcopenia, the clinical difficulties of age-associated comorbidities, and the implications for existing guidelines and therapeutic options. Our conclusions will focus on the effect of T2DM on an ageing society.

|||||||||| Biomarker, Clinical, Journal: Relationship between Serum Alkaline Phosphatase and Low Muscle Mass Index Among Korean Adults: A Nationwide Population-Based Study. (Pubmed Central) - Sep 25, 2021
On the receiver operating characteristic curve analysis, the predictive power was significantly higher for ALP levels than for white blood cell count in women (p < 0.001), whereas the difference was not significant in men (p = 0.515). Our findings suggest the potential use of serum ALP as an inflammatory marker and a predictor of sarcopenia.

|||||||||| Clinical, Review, Journal: The Utility of Body Composition Assessment in Nutrition and Clinical Practice: An Overview of Current Methodology. (Pubmed Central) - Sep 25, 2021
Though weight tracking and calculation of BMI are used commonly by clinicians and dietitians, these measures do not provide insight on the relative contributions of fat mass and fat-free mass or the changes in these compartments that may reflect disease risk. Therefore, it is important that healthcare professionals have a critical understanding of body composition assessment and the strengths and limitations of the methods available.

|||||||||| Clinical, Journal: Malnutrition as a risk factor of adverse postoperative outcomes in patients undergoing hepatic resection: analysis of US hospitals. (Pubmed Central) - Sep 24, 2021
In multivariate, malnutrition was associated with higher mortality (p<0.028, aOR 1.3 95%CI 1.03-1.65). Thus, we conclude that malnutrition is an independent risk factor of postoperative mortality in patients undergoing hepatectomy.

|||||||||| Review, Journal: Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics. (Pubmed Central) - Sep 24, 2021
We also discuss how senescence of muscle stem cells and muscle-resident fibro-adipogenic progenitors affects muscle pathologies or regeneration, and consider the possibility that immunosenescence leads to muscle pathogenesis. Finally, we explore senotherapy, the therapeutic targeting of senescence to treat age-related disease, from the standpoint of improving muscle regeneration.

|||||||||| Review, Journal: Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management. (Pubmed Central) - Sep 24, 2021
In this review, we focused on the impact of CR on frailty and aimed to identify potential associated mechanisms. Although CR may help prevent frailty, further studies are required to determine the underlying mechanisms and specific CR regimens suitable for use in humans.

|||||||||| Review, Journal: Advances in research on pharmacotherapy of sarcopenia. (Pubmed Central) - Sep 24, 2021
Clinical trials of new drugs targeting multiple molecules are ongoing. This article focuses on the latest progress in pharmacotherapeutic approaches of sarcopenia in recent years by comprehensively reviewing the clinical outcomes of the existing and emerging pharmacotherapies as well as the molecular mechanisms underlying their therapeutic benefits and side effects.

|||||||||| Retrospective data, Review, Journal: Missing puzzle pieces of time-restricted-eating (TRE) as a long-term weight-loss strategy in overweight and obese people? A systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) - Sep 24, 2021
Favorable effect of TRE was observed on glucose metabolism but not on lipid profiles independent of weight loss. Hence TRE shall be administered with caution to overweight and obese people who have comorbidities such as dyslipidemia and sarcopenia.

|||||||||| This is great, thank you! I have been inspired by various #BariatricSurgery researchers along with some in the field of #SarcopenicObesity to imagine future research. (Twitter) - Sep 24, 2021

|||||||||| [VIRTUAL] Fam210a Maintains Cardiac Mitochondrial Homeostasis by Promoting Ca2+ Efflux (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_1291;
Our evidence suggests that FAM210A is a novel mitochondrial Ca2+ efflux regulator required for maintaining cardiac mitochondrial homeostasis and offers new targets for treating mitochondrial disease. This work uncovers important interplay among mitochondrial Ca2+ signaling, metabolic reprogramming, and translational control in cardiac health and disease.

|||||||||| [VIRTUAL] Association of Fried's Frailty Score and Sarcopenia with Outcomes After Left Ventricular Assist Device Implantation (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_811;
The addition of sarcopenia assessment allows for higher sensitivity in identifying patients with frailty who are at risk for poor outcomes. Larger studies are needed to validate these findings.

|||||||||| [VIRTUAL] Subclinical Renal Impairment and Inflammation in Cognitive Frailty in Older Adults (Tanushimaru Cohort Study) (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_649;
Larger studies are needed to validate these findings. RI and inflammation were associated with cognitive frailty, especially inflammation was strongly associated with frailty.

|||||||||| BMP-7 / University of Central Florida
[VIRTUAL] Bmp-7 Ameliorates Lipid Accumulation Induced, Hmgb1 Initiated Pyroptosis Leading To Sarcopenia, Muscle Deterioration And Adverse Muscle Remodeling In Diabetes (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_297;
Targeting pyroptosis and lipid accumulation in muscle cells, with BMP-7 improves diabetic muscle pathophysiology and muscle function. These findings shows BMP-7 as a potential therapeutic option to treat diabetic myopathy.

|||||||||| [VIRTUAL] Sarcopenia in psoriatic patients treated at a reference center () - Sep 24, 2021 - Abstract #EADV2021EADV_2815;

|||||||||| Clinical, Journal: Testosterone Replacement Therapy added to Intensive Lifestyle Intervention in Older Men with Obesity and Hypogonadism. (Pubmed Central) - Sep 24, 2021
In older, obese hypogonadal men, adding testosterone for six months to lifestyle therapy does not further improve overall physical function. However, our findings suggest that testosterone may attenuate the weight loss-induced reduction in muscle mass and hip BMD and may further improve aerobic capacity.

|||||||||| Journal: Skeletal muscle fat quantification by dual-energy computed tomography in comparison with 3T MR imaging. (Pubmed Central) - Sep 24, 2021
• Virtual non-contrast-enhanced dual-energy CT HU values allow to differentiate between high and low native skeletal muscle mean radiation attenuation in contrast-enhanced DECT scans. • Measuring muscle fat by dual-energy computed tomography is a new approach for the determination of muscle quality, an important parameter for the diagnostic confirmation of sarcopenia as a comorbidity associated with poor clinical outcome.

|||||||||| Journal: Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors and macrophages from human skeletal muscle biopsies. (Pubmed Central) - Sep 24, 2021
Finally, in vitro validation of the cellular phenotype of muscle stem cells, fibro-adipogenic progenitors, and macrophages confirms population specific traits. This study demonstrates that mononuclear cell populations can be quantified and subsequently analyzed from needle biopsy material and opens the perspective for future clinical studies of cellular mechanisms in muscle wasting.

|||||||||| Journal: Intramuscular pressure of human tibialis anterior muscle detects age-related changes in muscle performance. (Pubmed Central) - Sep 24, 2021
Surprisingly, the EMD did not exhibit any difference between young and older adults and the IMPD was consistent with the EMD. Data supporting the hypotheses suggest that IMP measurement is an indicator of muscle performance in older adults.

|||||||||| Clinical, Review, Journal: Pathogenesis of Musculoskeletal Deficits in Children and Adults with Inflammatory Bowel Disease. (Pubmed Central) - Sep 24, 2021
In paediatric IBD, these factors may contribute to suboptimal bone and muscle accrual. This review evaluates the main pathogenic factors associated with musculoskeletal deficits in children and adults with IBD and summarises the current literature and understanding of the musculoskeletal phenotype in these patients.

|||||||||| CAN WE PREDICT INCISIONAL HERNIA AFTER KIDNEY TRANSPLANTATION? () - Sep 23, 2021 - Abstract #ESOT2021ESOT_1903;
This review evaluates the main pathogenic factors associated with musculoskeletal deficits in children and adults with IBD and summarises the current literature and understanding of the musculoskeletal phenotype in these patients. By using a set of clinical predictors including age at KT, time in RRT, gender and SMRA, we believe the risk of IH can be predicted with much higher accuracy than any currently available IH tool.



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