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|||||||||| Review, Journal: Muscular Strength and Cardiovascular Disease: AN UPDATED STATE-OF-THE-ART NARRATIVE REVIEW. (Pubmed Central) - Oct 31, 2021
The majority of the studies investigating the role of MusS with cardiometabolic risk, however, are observational studies, not allowing to ultimately determine association versus causation. Importantly, MusS is also essential for the identification of nutritional status and body composition abnormalities, such as frailty and sarcopenia, which are major risk factors for CVD.

|||||||||| Journal: Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project. (Pubmed Central) - Oct 31, 2021
Inadequate intakes of nutrients are associated with FNIH-defined sarcopenia in older men, but not with the other two sarcopenia definitions. Further studies are required to understand these relationships.

|||||||||| Journal: The muscle biological clock (Pubmed Central) - Oct 31, 2021
Exercise capacity also displays a circadian rhythm. Alterations in biological rhythm, as in shift workers, alter muscle function and are associated with the development of sarcopenia.

|||||||||| Clinical, Review, Journal: Does sarcopenia affect outcomes in pediatric surgical patients? A scoping review. (Pubmed Central) - Oct 31, 2021
Despite studies showing an association between sarcopenia and negative outcomes in the adult surgical population, there remains a paucity of evidence regarding the impact of sarcopenia on the pediatric population. Future studies are needed to ascertain the relationship between muscle mass and outcomes in pediatric surgical patients.

|||||||||| Journal: The metabolic profiles and body composition of lean metabolic associated fatty liver disease. (Pubmed Central) - Oct 31, 2021
The prevalence of lean MAFLD was 16.5% in this study population and it was higher in elder age, especially of female subjects. Lean MAFLD patients had different metabolic profiles compared with lean healthy controls, but different body composition compared with non-lean MAFLD patients.

|||||||||| Clinical, Review, Journal: Prevalence and Nonpharmacological Interventions for Sarcopenia among Cirrhotic Patients. (Pubmed Central) - Oct 31, 2021
The exercise program is designed and carried out on a frequent basis within an extensive scheduled time aimed at improving functional performance, aerobic capacity, and healthy conditions. Finally, a combination of exercise training and therapeutic nutrition is powerfully recommended to control sarcopenia in cirrhosis.

|||||||||| Clinical, Review, Journal: Antineoplastic dosing in overweight and obese cancer patients: an Associazione Italiana Oncologia Medica (AIOM)/Associazione Medici Diabetologi (AMD)/Società Italiana Endocrinologia (SIE)/Società Italiana Farmacologia (SIF) multidisciplinary consensus position paper. (Pubmed Central) - Oct 31, 2021
Therefore, although the available findings point to the role of dose intensity in cancer treatment, and support full weight-based dosing, empirical dose capping often occurs in clinical practice in order to avoid toxicity. Thus a panel of experts of the Associazione Italiana Oncologia Medica (AIOM), Associazione Medici Diabetologi (AMD), Società Italiana Endocrinologia (SIE), and Società Italiana Farmacologia (SIF), provides here a consensus statement for appropriate cytotoxic chemotherapy and new biological cancer drug dosing in obese patients.

|||||||||| Preclinical, Journal: Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice. (Pubmed Central) - Oct 31, 2021
MAPK/ ERK1/2 was significantly increased in young and old Fgf2KO. We conclude that Fgf2KO, age-related decreased FGF2 in WT mice, and increased FGF21 in the setting of impaired Fgf2 expression likely contribute to impaired skeletal muscle function and sarcopenia in mice.

|||||||||| Journal: Diagnostic and therapeutic approach to sarcopenia (Pubmed Central) - Oct 31, 2021
In both cases, causes must be clarified and treatment should be initiated. To differentiate between acute and chronic sarcopenia it is necessary to assess disease progress after a certain period of time.

|||||||||| Journal: Hypothesizing Nutrigenomic-Based Precision Anti-Obesity Treatment and Prophylaxis: Should We Be Targeting Sarcopenia Induced Brain Dysfunction? (Pubmed Central) - Oct 31, 2021
Exercise seems to provide a significant benefit to overcome this obesity-promoting loss of muscle density. Utilization of proposed nutrigenomic formulae based on coupling genetic obesity risk testing promotes generalized anti-craving of carbohydrates and can inhibit carbohydrate bingeing, inducing significant healthy fat loss and relapse prevention.

|||||||||| The Impact of Low BMI on Surgical Outcomes Post Emergency Surgery in a Quaternary Centre in Australia (Channel 1 - ePosters [VIRTUAL]) - Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_879;
Further studies will be required to establish which co-morbid factors also associated with poor weight gain are associated with post-operative complications. We suggest that being underweight is an important and often overlooked factor associated with peri-operative morbidity.

|||||||||| Clinical, Journal: Computed Tomography Evaluation of Forearm and Hand Muscles in Patients With Distal Radius Fracture. (Pubmed Central) - Oct 30, 2021
These results support the opportunistic use of CT for evaluating bone fragility. Clinical usefulness of muscle HU measurement needs further studies.

|||||||||| Clinical, Journal: Association between anorexia of ageing and sarcopenia among Japanese older adults. (Pubmed Central) - Oct 30, 2021
Anorexia of ageing is associated with sarcopenia among Japanese elderly individuals. Further studies are needed to determine whether a causal association exists between anorexia and sarcopenia.

|||||||||| Clinical, Journal: Association between Skeletal Mass Indices and Metabolic Syndrome in Brazilian Adults. (Pubmed Central) - Oct 30, 2021
Further studies are needed to determine whether a causal association exists between anorexia and sarcopenia. In adults, the muscle mass assessed from the skeletal mass index adjusted for body weight and body mass index is inversely associated with metabolic syndrome in both sexes.

|||||||||| Clinical, Journal: Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients. (Pubmed Central) - Oct 30, 2021
In the first study to externally evaluate a commercially available software to assess body composition, automated segmentation of muscle and adipose tissues using ABACS was similar to manual analysis and associated with mortality after non-metastatic cancer. Automated methods will accelerate body composition research and, eventually, facilitate integration of body composition measures into clinical care.

|||||||||| Retrospective data, Review, Journal: Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta-analysis. (Pubmed Central) - Oct 30, 2021
This meta-analysis demonstrates that myosteatosis is associated with worse overall survival in patients with colorectal cancer. More investigation is needed to standardize the measurement protocol for myosteatosis and to further optimize its prognostic power for colorectal cancer patients.

|||||||||| Journal: A subset of microRNAs in the Dlk1-Dio3 cluster regulates age-associated muscle atrophy by targeting Atrogin-1. (Pubmed Central) - Oct 30, 2021
More investigation is needed to standardize the measurement protocol for myosteatosis and to further optimize its prognostic power for colorectal cancer patients. Our study suggests that genetic intervention using a muscle-directed miRNA delivery system has therapeutic efficacy in preventing Atrogin-1-mediated muscle atrophy in sarcopenia.

|||||||||| Journal: Association between muscle strength and advanced fibrosis in non-alcoholic fatty liver disease: a Korean nationwide survey. (Pubmed Central) - Oct 30, 2021
Low muscle strength is independently associated with NAFLD. The significant association between LMS and advanced fibrosis in NAFLD may be mediated through insulin resistance.

|||||||||| Clinical, Journal: Mortality in malnourished older adults diagnosed by ESPEN and GLIM criteria in the SarcoPhAge study. (Pubmed Central) - Oct 30, 2021
No association was found between malnutrition according to these two criteria and incidence of other health adverse consequences. GLIM criteria anticipate mortality and might guide interventions, with important implications for clinical practice and research.

|||||||||| Preclinical, Journal: Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice. (Pubmed Central) - Oct 30, 2021
GLIM criteria anticipate mortality and might guide interventions, with important implications for clinical practice and research. Our data provide a global view of age-associated neuromuscular changes in a mouse model of ageing and help to advance understanding of contributing pathways leading to development of sarcopenia.

|||||||||| Journal: Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration. (Pubmed Central) - Oct 30, 2021
Our data provide a global view of age-associated neuromuscular changes in a mouse model of ageing and help to advance understanding of contributing pathways leading to development of sarcopenia. Our study indicates that decline in IFN-γ response in a novel subset of macrophage contributes to satellite cells dysfunctions in aged skeletal muscles and demonstrates that this mechanism can be targeted to restore age-associated myogenesis.

|||||||||| Clinical, Journal: Sarcopenia and low muscle radiodensity associate with impaired FEV in allogeneic haematopoietic stem cell transplant recipients. (Pubmed Central) - Oct 30, 2021
Lumbar or thoracic CT images are useful for body composition assessment in this population and reveal high rates of sarcopenia, similar to those reported in very elderly patients. Reduced muscle mass and radiodensity associate with impaired FEV even after adjustment for clinical covariables including co-morbidities, performance status, disease risk, and mild intrinsic pulmonary disease (chronic obstructive pulmonary disease) defined by spirometry.

|||||||||| Clinical, Journal: Muscle wasting as an independent predictor of survival in patients with chronic heart failure. (Pubmed Central) - Oct 30, 2021
Muscle wasting is an independent predictor of death in ambulatory patients with heart failure. Clinical trials are needed to identify treatment approaches to this co-morbidity.

|||||||||| Retrospective data, Review, Journal: Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta-analysis. (Pubmed Central) - Oct 30, 2021
Sarcopenia is prevalent in a significant proportion of people with COPD and negatively impacts upon important clinical outcomes. Opportunities exist to optimize its early detection and management and to evaluate its impact on mortality in this patient group.

|||||||||| Journal: Osteoporosis in Parkinson's Disease: Relevance of Distal Radius Dual-Energy X-Ray Absorptiometry (DXA) and Sarcopenia. (Pubmed Central) - Oct 30, 2021
Distal radius DXA increased osteoporosis detection, especially in female PD patients, suggesting that diagnostic protocols for osteoporosis in PD could be optimized. A close association between osteoporosis and sarcopenia was documented for the first time in PD, which has important implications for clinical management and future research.

|||||||||| Preclinical, Journal: Cancer cachexia in a mouse model of oxidative stress. (Pubmed Central) - Oct 30, 2021
A close association between osteoporosis and sarcopenia was documented for the first time in PD, which has important implications for clinical management and future research. Oxidative stress does not exacerbate cancer-induced muscle loss; however, cancer cachexia may accelerate NMJ disruption.

|||||||||| Journal: Validation of a description of sarcopenic obesity defined as excess adiposity and low lean mass relative to adiposity. (Pubmed Central) - Oct 30, 2021
Oxidative stress does not exacerbate cancer-induced muscle loss; however, cancer cachexia may accelerate NMJ disruption. Body composition-defined measures of sarcopenic obesity defined as excess adiposity and lower-than-expected ALMI relative to FMI are associated with functional deficits and incident disability and overcome the limitations of using %BF in estimating obesity in this context.

|||||||||| Journal: The impact of different diagnostic criteria on the association of sarcopenia with injurious falls in the CLSA. (Pubmed Central) - Oct 30, 2021
In men, definitions including grip strength but not gait speed or the chair rise test, and adjusting lean mass for weight, BMI, or using the residual technique but not height , tended to be associated with injurious falls. In women, sarcopenia was generally not associated with injurious falls regardless of the definition used.

|||||||||| Clinical, Journal: Improving rehabilitation in sarcopenia: a randomized-controlled trial utilizing a muscle-targeted food for special medical purposes. (Pubmed Central) - Oct 30, 2021
P=N/A
In women, sarcopenia was generally not associated with injurious falls regardless of the definition used. In old adults with sarcopenia admitted to hospital for rehabilitation the consumption of a whey protein-based nutritional formula enriched with leucine and vitamin D improved physical performance and function, as well as muscle mass, and reduced the intensity and costs of care.

|||||||||| Preclinical, Journal: Differential effects of right and left heart failure on skeletal muscle in rats. (Pubmed Central) - Oct 30, 2021
Most of the catabolic changes were observed in soleus or gastrocnemius muscle rather than in the constantly active diaphragm. Mitochondrial dysfunction and up-regulation of myostatin were identified as the earliest signs of skeletal muscle impairment.

|||||||||| Clinical, Journal: Associations of combined genetic and epigenetic scores with muscle size and muscle strength: a pilot study in older women. (Pubmed Central) - Oct 30, 2021
Mitochondrial dysfunction and up-regulation of myostatin were identified as the earliest signs of skeletal muscle impairment. Our results improve the understanding of inter-individual variance in muscular characteristics of older women and suggest a possible application of a sarcopenia-driven methylation score to muscle strength estimation in older women while the combination with a genetic score still needs to be further studied.

|||||||||| Clinical, Journal: Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial. (Pubmed Central) - Oct 30, 2021
This HBex and dietary protein interventions did not change the physical performance (m-PPT) in community-dwelling older adults. Changes were observed in gait speed, PAL, muscle mass, strength, and dietary protein intake, in response to this combined intervention.

|||||||||| Clinical, Journal, Real-world evidence: Normative values of muscle strength across ages in a 'real world' population: results from the longevity check-up 7+ project. (Pubmed Central) - Oct 30, 2021
Our study established age-specific and gender-specific percentile reference values for handgrip strength and the 5 × STS test. The normative curves generated can be used to interpret the assessment of muscle strength in everyday practice for the early detection of individuals with or at risk of sarcopenia.

|||||||||| Clinical, Journal: Important determinants to take into account to optimize protein nutrition in the elderly: solutions to a complex equation. (Pubmed Central) - Oct 30, 2021
The normative curves generated can be used to interpret the assessment of muscle strength in everyday practice for the early detection of individuals with or at risk of sarcopenia. No abstract available

|||||||||| Clinical, Journal: The efficacy of essential amino acid supplementation for augmenting dietary protein intake in older adults: implications for skeletal muscle mass, strength and function. (Pubmed Central) - Oct 30, 2021
No abstract available No abstract available

|||||||||| Clinical, Journal: A comparison of sarcopenia prevalence between former Tokyo 1964 Olympic athletes and general community-dwelling older adults. (Pubmed Central) - Oct 30, 2021
Conversely, low physical function and higher musculoskeletal pain scores were more prevalent in former Olympic athletes, especially among athletes who competed in sports with physical contact. Our results warrant further promotion of exercise in adolescence and beyond as well as providing safety education, which is required to prevent the development of sarcopenia and musculoskeletal pain in old age.

|||||||||| Clinical, Journal: Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia. (Pubmed Central) - Oct 30, 2021
Poor performance in the 5-CST is increasingly common with age and is associated with a cluster of other factors that characterize risk for poor ageing such as physical inactivity, impaired cognition, and multimorbidity. We recommend a low threshold for performing the 5-CST in clinical settings and provide a protocol for its use.

|||||||||| BMP-7 / University of Central Florida
Journal, IO biomarker: Amelioration of diabetes-induced inflammation mediated pyroptosis, sarcopenia, and adverse muscle remodelling by bone morphogenetic protein-7. (Pubmed Central) - Oct 30, 2021
We also report that targeting pyroptosis with BMP-7 improves diabetic muscle pathophysiology and muscle function. These findings suggest that BMP-7 could be a potential therapeutic option to treat diabetic myopathy.

|||||||||| Clinical, Journal: The role of recipient myosteatosis in graft and patient survival after deceased donor liver transplantation. (Pubmed Central) - Oct 30, 2021
The prognostic value of myosteatosis seems to be particularly important in the early post-operative phase. Validation in prospective clinical trials is warranted.

|||||||||| Clinical, Journal: Effects of sarcopenia and malnutrition on morbidity and mortality in gynecologic cancer surgery: results of a prospective study. (Pubmed Central) - Oct 30, 2021
Validation in prospective clinical trials is warranted. We observed that preoperatively assessed ECOG status > 1, BMI > 25 kg, as well as phase angle alpha 1, hypoalbuminemia, phase angle < 4.5° as well as FIGO stage ≥ III A and severe postoperative complications within 30 days correlate significantly with poor overall survival.

|||||||||| Clinical, Reimbursement: Prevalence and Related Factors of Sarcopenia in Community-dwelling Elderly with Long-term Care Insurance. (Pubmed Central) - Oct 30, 2021
The prevalence of sarcopenia in the elderly in the long-term care insurance region was 36.4%, and age and body mass index were extracted as sarcopenia-related factors. The cut-off value of body mass index for sarcopenia was 22.6 kg/m2.

|||||||||| Journal: The composition of the gut microbiome differs among community dwelling older people with good and poor appetite. (Pubmed Central) - Oct 30, 2021
We found female individuals with reduced muscle strength had poor appetite compared with those with normal strength. These associations require further examination to understand causality and mechanisms of interaction, to inform potential strategies targeting the gut microbiota as a novel intervention for anorexia of ageing and sarcopenia.

|||||||||| Journal, HEOR: Evaluating quality of life in frailty: applicability and clinimetric properties of the SarQoL questionnaire. (Pubmed Central) - Oct 30, 2021
These associations require further examination to understand causality and mechanisms of interaction, to inform potential strategies targeting the gut microbiota as a novel intervention for anorexia of ageing and sarcopenia. The SarQoL questionnaire has adequate clinimetric properties for use with frail patients in clinical practice and trials and could provide data that are more appropriate and detailed than the generic questionnaires currently used.

|||||||||| deferiprone / Generic mfg.
Preclinical, Journal: Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage. (Pubmed Central) - Oct 30, 2021
Muscles from old mice have increased iron levels, which are associated with increased lipid peroxidation, increased susceptibility to IR injury, and impaired muscle regeneration. Our results suggest that iron is involved in effective muscle regeneration, highlighting the importance of iron homeostasis in muscle atrophy and muscle repair.

|||||||||| Journal: Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis. (Pubmed Central) - Oct 30, 2021
These data suggest MU characteristics differ according to depth within the VL which may be influenced by both ageing and exercise. A more homogenous distribution of MUP size and complexity across muscle depths in older athletes may be a result of a greater degree of age-related MU adaptations.

|||||||||| Journal: Impact of neutrophil-lymphocyte ratio, Glasgow Prognostic Score, and postoperative decrease in psoas muscle index on recurrence after curative gastrectomy. (Pubmed Central) - Oct 30, 2021
Invest. 68 : 119-124, February, 2021.

|||||||||| Clinical, Journal: Does renin-angiotensin system inhibition have impacts on muscle mass and bone mineral density in heart failure patients? (Pubmed Central) - Oct 30, 2021
68 : 119-124, February, 2021. Renin-angiotensin system inhibition is associated with a lower prevalence of muscle wasting in HF patients independently of established risk factors.

|||||||||| Journal: Micronutrients and sarcopenia: current perspectives. (Pubmed Central) - Oct 30, 2021
Renin-angiotensin system inhibition is associated with a lower prevalence of muscle wasting in HF patients independently of established risk factors. No abstract available

|||||||||| niclosamide / Generic mfg., dexamethasone / Generic mfg.
Journal: Investigation of niclosamide as a repurposing agent for skeletal muscle atrophy. (Pubmed Central) - Oct 30, 2021
Overall, these results suggest that niclosamide may not be a suitable repurposing drug for glucocorticoid-induced skeletal muscle atrophy or cancer cachexia. Nevertheless, niclosamide may be employed as a compound to study mechanisms regulating myogenesis and catabolic pathways in skeletal muscle.

|||||||||| Biomarker, Clinical, Journal: Clinical and biomarker assessment of frailty in liver transplantation. (Pubmed Central) - Oct 30, 2021
A comprehensive, validated algorithm for detecting and quantifying frailty specific to liver disease would allow for standardization and facile application in the clinical setting. Early diagnosis is key for timely intervention and improved patient outcomes.



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