Sarcopenia
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  • ||||||||||  Skeletal Muscle Extracellular Matrix in Patients on Hemodialysis (Room 4, Convention Center) -  Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_4693;    
    Alterations in ECM remodeling may play a role in sarcopenia in CKD. ECM not only provides structural support but also inhibits atrophic factors, such as myostatin inhibition by decorin.
  • ||||||||||  Exercise Mimetic Restores Muscle and Bone Outcomes in a Rat Model of CKD (Room 6D, Convention Center) -  Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_4565;    
    LAMZ administered for 5 weeks significantly improved both muscle strength and bone microarchitecture. The potential for an exercise mimetic is exciting for nephrologists and patients with CKD alike, as an alternative method to improve musculoskeletal health and quality of life.
  • ||||||||||  Journal:  Body mass index and sarcopenia and mortality risk among older hypertensive outpatients; the Nambu Cohort Study. (Pubmed Central) -  Oct 12, 2024   
    These findings demonstrate that weight reduction may deteriorate the mortality risk in older patients with hypertension, and new lifestyle modification strategies for improving ADL, quality of life, and prognosis are warranted for older patients with hypertension. We assessed the association between BMI, handgrip strength, and risk of all-cause mortality to evaluate the validity of weight reduction in older patients with hypertension.
  • ||||||||||  megestrol / Generic mfg.
    Clinical guideline, Journal:  SEOM clinical guidelines for cancer anorexia-cachexia syndrome (2023). (Pubmed Central) -  Oct 11, 2024   
    While pharmacological agents like megestrol acetate may be considered, their use requires careful evaluation of potential risks. At its core, this review underscores the imperative for a holistic and personalized approach to managing CACS, integrating nutritional interventions and pharmacological strategies based on a nuanced understanding of patient's condition.
  • ||||||||||  dichloroacetate topical / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
    Preclinical, Journal:  Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibility. (Pubmed Central) -  Oct 10, 2024   
    We use a model of inducible and reversible skeletal muscle SOD2 knockdown to demonstrate that elevated matrix superoxide reversibly impairs mitochondrial substrate flexibility characterized by impaired pyruvate oxidation. Despite the bioenergetic effect, the limited change in gene expression suggests that the elevated redox stress in this model is confined to the mitochondrial matrix.
  • ||||||||||  Preclinical, Journal:  Melatonin protects against sarcopenia in middle-aged mice. (Pubmed Central) -  Oct 10, 2024   
    Despite the bioenergetic effect, the limited change in gene expression suggests that the elevated redox stress in this model is confined to the mitochondrial matrix. MEL attenuates sarcopenia in middle-aged mice, and the mechanism may relate to mitochondria-induced oxidative stress and the PGC-1?/TFAM pathway.
  • ||||||||||  New trial:  Knee Replacement and Sarcopenia (clinicaltrials.gov) -  Oct 10, 2024   
    P=N/A,  N=31, Not yet recruiting, 
  • ||||||||||  Trial completion date, Trial primary completion date:  Enhancing Voluntary Motion in Broad Patient Populations with Modular Powered Orthoses (clinicaltrials.gov) -  Oct 10, 2024   
    P=N/A,  N=33, Recruiting, 
    MEL attenuates sarcopenia in middle-aged mice, and the mechanism may relate to mitochondria-induced oxidative stress and the PGC-1?/TFAM pathway. Trial completion date: Sep 2024 --> Sep 2025 | Trial primary completion date: Sep 2024 --> Sep 2025
  • ||||||||||  Review, Journal:  The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review. (Pubmed Central) -  Oct 9, 2024   
    By exploring targeted interventions, including the development of senotherapeutic drugs and probiotic therapies, this review aims to shed light on novel therapeutic avenues. These strategies leverage the connection between cellular senescence and gut microbiome alterations to advance aging research and development of interventions aimed at extending health span and improving the quality of life in the older population.
  • ||||||||||  Review, Journal:  Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies. (Pubmed Central) -  Oct 9, 2024   
    Notable therapeutic strategies such as Western medicine, traditional Chinese medicine, and other health-promotion interventions have been reported in several studies to hold promise in mitigating age-related gut disorders. This review highlights findings across various facets of gut aging with a focus on aging-associated changes of intestinal stem cells and their niche components, thus a deviation from the normal to repercussion, as well as essential therapeutic strategies to mitigate intestinal aging.
  • ||||||||||  Review, Journal:  Immunosuppression in adult liver transplant recipients: a 2024 update from the Italian Liver Transplant Working Group. (Pubmed Central) -  Oct 9, 2024   
    This review highlights findings across various facets of gut aging with a focus on aging-associated changes of intestinal stem cells and their niche components, thus a deviation from the normal to repercussion, as well as essential therapeutic strategies to mitigate intestinal aging. The updated consensus- and evidence-based 2024 recommendations for immunosuppression regimens in adult patients with ABO-compatible LT address a range of clinical variables that should be considered to optimize the choice of the immunosuppression treatment in clinical practice in Italy.
  • ||||||||||  Trial completion:  PWS: Ultrasound to Assess Sarcopenia in Prader Willi Syndrome (clinicaltrials.gov) -  Oct 9, 2024   
    P=N/A,  N=49, Completed, 
    Quantitative radiological measurement of sarcopenia, sarcopenic obesity, and body fat composition can be used as novel parameters in the prediction of disease prognosis in endometrial cancer. Recruiting --> Completed
  • ||||||||||  New trial:  BODI: Body Composition in Older Adults (clinicaltrials.gov) -  Oct 8, 2024   
    P=N/A,  N=30, Not yet recruiting, 
  • ||||||||||  Journal:  Interactions between muscle volume and body mass index on brain structure in the UK Biobank. (Pubmed Central) -  Oct 8, 2024   
    Greater thigh muscle volume correlates with better brain volumes at midlife in people without sarcopenia, but this relationship weakens with greater age and BMI. Further study is required to investigate the underlying mechanisms to understand which components of body composition are potentially modifiable risk factors for dementia.
  • ||||||||||  Trial primary completion date, Metastases:  Pulmonary Rehabilitation in Advanced Non-small Cell Lung Cancer Patients (clinicaltrials.gov) -  Oct 8, 2024   
    P=N/A,  N=94, Recruiting, 
    Further study is required to investigate the underlying mechanisms to understand which components of body composition are potentially modifiable risk factors for dementia. Trial primary completion date: Aug 2024 --> Dec 2024
  • ||||||||||  Review, Journal:  Individualized treatment of diabetes mellitus in older adults. (Pubmed Central) -  Oct 8, 2024   
    Treatment based on categorization and CGA by multidisciplinary professionals would be an individualized treatment for older adults with diabetes. Geriatr Gerontol Int 2024;