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|||||||||| COMPOUND SARCOPENIA AND PHYSICAL FRAILTY ADVERSELY IMPACT OUTCOMES IN HOSPITALIZED PATIENTS WITH HEPATOCELLULAR CARCINOMA IN AN AGE DEPENDENT MANNER () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2601;
PF without/with MLP/compound sarcopenia is more frequent with increasing age and adversely impacts hospitalization outcomes in HCC patients including cost of stay and decreases the likelihood of discharge to home. Compound sarcopenia/MLP alone adversely affected only LOS and discharge disposition in hospitalized patients with HCC.

|||||||||| REAL-WORLD STUDY OF ADJUVANT THERAPY AFTER COMPLETE RESECTION OF EARLY-STAGE HEPATOCELLULAR CARCINOMA () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2554;
Compound sarcopenia/MLP alone adversely affected only LOS and discharge disposition in hospitalized patients with HCC. Following complete surgical resection of early-stage liver cancer, patients categorized as low-risk based on SMD may not require postoperative adjuvant therapy.

|||||||||| NO IMPACT OF SARCOPENIA ON PROGNOSIS OF TRANSARTERIAL CHEMOEMBOLIZATION FOR HEPATOCELLULAR CARCINOMA () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2490;
Following complete surgical resection of early-stage liver cancer, patients categorized as low-risk based on SMD may not require postoperative adjuvant therapy. Our data suggest that sarcopenia has no impact on the prognosis of TACE for intermediate-stage HCC.

|||||||||| LIVER FRAILTY INDEX, NOT SIX-MINUTE WALK DISTANCE, IS ASSOCIATED WITH LIVER TRANSPLANT WAITLIST DROPOUT () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2476;
LFI, not 6MWD, is significantly associated with waitlist dropout in liver transplant candidates, independent of MELDNa. A graded relationship was seen with rising LFI and increased waitlist dropout, death on the waitlist, and decreased survival to transplant.

|||||||||| ACTIVITY METRICS MEASURED BY WEARABLE TECHNOLOGY CORRELATES WITH PATIENT-REPORTED WELLBEING IN CIRRHOSIS () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2374;
Even in a relatively-well group of patients with cirrhosis, more than half reported low HRQoL associated with wearable-measured activity metrics reflecting fewer steps and more inactive time. Further work can help establish the probable bidirectional relationship, whereby worse wellbeing results in less activity, worsening wellbeing/outcomes.

|||||||||| Victoza (liraglutide) / Novo Nordisk
THE IMPACT OF LIRAGLUTIDE ON PATIENTS WITH METABOLIC DYSFUNCTION ASSOCIATED FATTY LIVER DISEASE () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2318;
These findings suggest that liraglutide may be a beneficial therapeutic option for managing MASLD, particularly in patients with obesity and metabolic syndrome. Further long-term studies are needed to confirm these benefits and assess the effects on liver-related morbidity and mortality.

|||||||||| ETHANOL INDUCED SKELETAL MUSCLE SENESCENCE CONTRIBUTES TO SARCOPENIA IN ALCOHOL RELATED LIVER DISEASE () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2199;
Further long-term studies are needed to confirm these benefits and assess the effects on liver-related morbidity and mortality. Multiomics directed experimental studies show that ethanol and ALD result in post-mitotic senescence that is caused by lower redox ratio but not mitochondrial free radical generation.

|||||||||| GLOBAL LANDSCAPE OF SKELETAL MUSCLE MITOCHONDRIAL FUNCTIONAL AND STRUCTURAL PERTURBATIONS IN SARCOPENIA OF ALCOHOL RELATED LIVER DISEASE () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2180;
Multiomics directed experimental studies show that ethanol and ALD result in post-mitotic senescence that is caused by lower redox ratio but not mitochondrial free radical generation. Integrated multiomics analyses showed perturbations in skeletal muscle mitochondrial function and structure with stabilization of HIF1a and myostatin

|||||||||| INCORPORATING SARCOPENIA TO ENHANCE MORTALITY PREDICTION IN SEVERE ALCOHOLIC HEPATITIS () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2168;
These findings suggest that routine assessment of sarcopenia via cross-sectional imaging could improve risk stratification and early management decisions, including considerations for liver transplantation and goals of care planning. Further external validation is warranted.

|||||||||| PROGNOSTIC SIGNIFICANCE OF SKELETAL MUSCLE MASS IN PATIENTS WITH ALCOHOLIC CIRRHOSIS () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2164;
Reduced SMI is associated with an increased risk of mortality in group AC. However, reduced HGS is associated with an increased risk of mortality in group NAC.

|||||||||| BODY MASS INDEX INFLUENCES LIVER-RELATED MORTALITY AFTER THE FIRST DECOMPENSATION EVENT IN PATIENTS WITH ALCOHOL-RELATED LIVER DISEASE () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2155;
However, reduced HGS is associated with an increased risk of mortality in group NAC. BMI, T-Bil and post-discharge drinking behavior influence post-discharge prognosis in ALD patients with decompensation events.

|||||||||| FRAILTY AND SARCOPENIA PREDICT PERI-OPERATIVE OUTCOMES IN PATIENTS UNDERGOING LIVER TRANSPLANTATION: ANALYSIS OF NATIONAL INPATIENT SAMPLE 2016-2020 () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2126;
Patients with frailty and sarcopenia independently or in combination, have significantly worse outcomes. Formally assessing sarcopenia and frailty pre-LT and utilizing them as objective prognostication tools can aid with risk stratification of patients who would benefit from more intensive nutritional supplementation, aggressive physical therapy programs pre-operatively.

|||||||||| MYOSTEATOSIS AND MUSCLE LOSS IMPACT LIVER TRANSPLANT OUTCOMES IN MALE PATIENTS WITH HEPATOCELLULAR CARCINOMA () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2123;
Pre-transplant myosteatosis aggravated the adverse impact of sarcopenia on liver transplant outcomes in male HCC patients. Post-transplant muscle loss might assist in prognostic stratification of recipients without pre-existing sarcopenia, intriguing new insights into individualized management.

|||||||||| IMPACT OF SARCOPENIA, FRAILTY, AND MUSCLE FAT INFILTRATION ON MORTALITY IN PATIENTS UNDERGOING LIVER TRANSPLANT EVALUATION () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2100;
Additionally we found patients with intermediate PDFF (5-10%) have the best survival outcomes, suggesting PDFF as a valuable survival predictor. Larger studies are needed to further explore the correlation between PDFF and outcomes in this patient population, potentially enhancing pre-transplant evaluation and risk stratification.

|||||||||| ANALYSIS OF THE IMPACT OF FEMALE SEX AND SARCOPENIA ON SERUM CREATININE AND WAITLIST PRIORITY FOR LIVER TRANSPLANTATION () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1999;
Larger studies are needed to further explore the correlation between PDFF and outcomes in this patient population, potentially enhancing pre-transplant evaluation and risk stratification. The higher waitlist mortality seen in females is unlikely due to lower serum creatinine, and other factors need to be further investigated

|||||||||| CYSTATIN C VS. CREATININE: WHO WINS IN CIRRHOSIS? () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1979;
We found no significant difference between SCr and CysC eGFR in predicting adverse renal outcomes post-transplant despite a large difference in median eGFR (16.9 mL/min). Factors known to contribute to kidney disease (i.e. diabetes or hypertension) were not associated with these outcomes.

|||||||||| MUSCLE STEATOSIS SIGNIFICANTLY INCREASES THE RISK OF DEATH IN PATIENTS WITH CIRRHOSIS - A RETROSPECTIVE COHORT STUDY () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1951;
Factors known to contribute to kidney disease (i.e. diabetes or hypertension) were not associated with these outcomes. Muscle steatosis significantly increases the risk of death from cirrhosis.

|||||||||| INCIDENCE OF CIRRHOSIS AND EXTRAHEPATIC MANIFESTATIONS AMONG LEAN AND NON-LEAN INDIVIDUALS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1823;
Lean patients also had lower cirrhosis incidence but higher LRE suggesting they have worse outcomes when they develop cirrhosis, likely from sarcopenia effect. These findings also suggest that cardiac risk assessments are essential in MASLD, particularly in lean individuals.

|||||||||| ADVERSE SOCIAL DETERMINANTS OF HEALTH CONTRIBUTE TO WORSE CLINICAL OUTCOMES IN SARCOPENIC PATIENTS WITH CIRRHOSIS () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1658;
MLP and SDOH were both independently associated with adverse outcomes in cirrhotic patients, in regards to length of stay in the hospital, and number of concurrent diagnoses at discharge. Patients with MLP also had higher healthcare costs, higher in-hospital mortality, and were less likely to be discharged to home.

|||||||||| TARGETING LOWER SERUM ALBUMIN WITH LONG TERM ALBUMIN ADMINISTRATION IMPROVES OUTCOMES OF RECURRENT ASCITES IN PATIENTS WITH DECOMPENSATED CIRRHOSIS- FINAL RESULTS OF THE RANDOMISED CONTROLLED TRIAL () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1437;
P=N/A
Patients with MLP also had higher healthcare costs, higher in-hospital mortality, and were less likely to be discharged to home. An Alb3.0 long-term strategy effectively reduces infections, adverse renal and liver-related outcomes, better ascites control, and improves frailty and long-term survival in patients with recurrent ascites.

|||||||||| ENDURANCE EXERCISE PROMOTES FAVORABLE GUT MICROBIOME COMPOSITION DURING HYPERAMMONEMIA () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1409;
An Alb3.0 long-term strategy effectively reduces infections, adverse renal and liver-related outcomes, better ascites control, and improves frailty and long-term survival in patients with recurrent ascites. A proinflammatory/pathogenic GMB during hyperammonemia is replaced by SCFA generating bacteria suggesting beneficial effects of EE on the GMB in liver disease.

|||||||||| NUTRITION CARE IN ACUTE ON CHRONIC LIVER FAILURE IN THE INTENSIVE CARE UNIT () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1384;
Our data shows that current nutritional practices in the critical care setting do not meet nutrition guidelines for the care of cirrhosis patients. Further analyses are required to assess nutrition adequacy in this vulnerable population, and to assess the impact of nutritional factors on morbidity and mortality in the ICU and hospital setting.

|||||||||| MALNUTRITION IMPACT ON PATIENTS WITH CIRRHOSIS; A NATIONWIDE ANALYSIS () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1357;
In this study, cirrhotic patients with malnutrition had an increased chance of in-hospital mortality. Moreover, they had higher chances for decompensation including HE and ascites, and other in-hospital complications such as AKI, HRS and RF, which can lead to increased LOS and increased financial burden.

|||||||||| DIABETES IS A RISK FACTOR FOR SARCOPENIA OF PATIENTS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS-DRIVEN CIRRHOSIS () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1323;
In individuals with MASH associated liver cirrhosis, the presence of DM increased the risk of mortality caused by sarcopenia. DM can be thus used as a new additional diagnostic criterion to identify patients with poor prognosis in MASH associated cirrhotic patients.

|||||||||| ENHANCED MUSCLE MASS MITIGATES MASLD IN MYOSTATIN KNOCKOUT MICE WITHOUT IMPACTING EXERCISE PERFORMANCE () - Oct 15, 2024 - Abstract #AASLD2024AASLD_869;
Our findings suggest that increased muscle mass, independent of exercise performance, can significantly ameliorate MASLD histology. Mstn-KO mice serve as a valuable model for exploring and harnessing muscle-liver crosstalk in liver diseases, indicating potential pathways for treatment that do not rely on exercise enhancement.

|||||||||| Visken (pindolol) / Novartis
UNLOCKING S-PINDOLOL'S POTENTIAL FOR MASLD: BENEFICIAL EFFECTS ON MUSCLE MASS AND FUNCTION AND LIVER HISTOLOGY IN WESTERN-DIET FED MICE () - Oct 15, 2024 - Abstract #AASLD2024AASLD_866;
It may be hypothesized that pindolol's positive effects on muscle mass and function could play a role on its beneficial effects on MASLD through improvement of secretion of various salutary myokines. The present data underscore S-pindolol's therapeutic potential in MASLD.

|||||||||| MUSCLE MASS, FRAILTY AND CARDIOPULMONARY EXERCISE TESTING: CORRELATIONS AND IMPACT ON LIVER TRANSPLANT OUTCOMES () - Oct 15, 2024 - Abstract #AASLD2024AASLD_768;
Sarcopenia or frailty did not impact waitlist mortality and post LT survival. Sarcopenic patients can have successful LT outcomes with personalized physiotherapy and nutritional interventions.

|||||||||| STEATOTIC AND FIBROTIC LIVER-DERIVED TNF-ALPHA EXACERBATES SKELETAL MUSCLE ATROPHY IN SENESCENCE-ACCELERATED MICE () - Oct 15, 2024 - Abstract #AASLD2024AASLD_739;
The present study indicated that senescent liver is susceptible to steatosis and fibrosis due to enhanced oxidative stress, and that TNF-alpha released from steatotic and fibrotic liver might induce MASH-associated skeletal muscle atrophy. The findings revealed an aspect of liver-muscle interaction, which might be a potential target for prevention and treatment of sarcopenia associated with liver diseases.

|||||||||| Journal: Interprofessional Management of (Risk of) Malnutrition and Sarcopenia: A Grounded Theory Study from the Perspective of Professionals. (Pubmed Central) - Oct 15, 2024
Based on insights from professionals, interprofessional collaboration requires synergy between professionals, infrastructure, and older adults. Professionals need both infrastructure elements and the engagement of older adults for successful interprofessional collaboration.

|||||||||| Journal: Verification of grip strength as an evaluation tool for locomotive syndrome in rheumatoid arthritis. (Pubmed Central) - Oct 15, 2024
LS was significantly associated with grip strength, even after adjusting for the presence of finger and wrist joint inflammation. We recommend adopting grip strength measurement as a screening tool for evaluating LS and guiding interventions.

|||||||||| Journal: The cross-sectional area of gluteal muscle on multiaxial CT scan as a predictor for diagnosing sarcopenia in patients with degenerative lumbar disease. (Pubmed Central) - Oct 15, 2024
The GMI serves as a reliable predictor of sarcopenia in elderly patients undergoing lumbar spine surgery for DLD, suggesting a significant role of gluteal muscles in diagnosing sarcopenia. Incorporating GMI into clinical assessments is critical to better manage and diagnose sarcopenia in this population.

|||||||||| Trial completion date, Trial primary completion date: Effects of Different Dietary Interventions on Abdominal Fat Components, Quadriceps Muscles and Cardiometabolic Parameters (clinicaltrials.gov) - Oct 15, 2024
P=N/A, N=100, Enrolling by invitation, Sponsor: University of Pernambuco
Incorporating GMI into clinical assessments is critical to better manage and diagnose sarcopenia in this population. Trial completion date: Aug 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Mar 2025

||||||||||  Nebido (testosterone undecanoate depot injection) / Grunenthal
Enrollment open:  Does Human Skeletal Muscle Possess an Epigenetic Memory of Testosterone? (clinicaltrials.gov) -  Oct 15, 2024
P2/3, N=40, Recruiting,  Sponsor: Norwegian School of Sport Sciences
Trial completion date: Aug 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Mar 2025 Not yet recruiting --> Recruiting

|||||||||| Review, Journal: Muscle Mass and Glucagon-Like Peptide-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss? (Pubmed Central) - Oct 14, 2024
Several pharmacologic treatments to maintain or improve muscle mass designed in combination with GLP-1-based therapies are under development. For future development of GLP-1-based therapies (and other therapies) designed for weight loss, as well as for patient-centered treatment optimization, the introduction of more objective and comprehensive ways of assessing muscle health (including accurate and meaningful assessments of muscle quantity, composition, function, mobility, and strength) is important for the substantial numbers of patients who will likely be taking these medications well into the future.

|||||||||| Biomarker, Retrospective data, Journal: CT-based body composition analysis and pulmonary fat attenuation volume as biomarkers to predict overall survival in patients with non-specific interstitial pneumonia. (Pubmed Central) - Oct 14, 2024
A single-center analysis of 71 patients with board-certified diagnosis of NSIP is presented Indices related to muscle, mediastinal fat, and pulmonary fat attenuation volume were significantly associated with survival at univariate analysis. CT pulmonary fat attenuation volume, normalized by lung volume, resulted as an independent predictor for death.

|||||||||| Review, Journal: Nutritional strategies for improving sarcopenia outcomes in older adults: A narrative review. (Pubmed Central) - Oct 14, 2024
However, the impact of other supplements (e.g., branched-chain amino acids, isolated amino acids, and omega-3) on sarcopenia and related outcomes remain unclear. This narrative review will discuss the evidence of the impact of these nutritional strategies on sarcopenia outcomes in older adults.

|||||||||| Journal: Editorial: Clinical management of older persons with sarcopenia: current status and future directions. (Pubmed Central) - Oct 14, 2024
This narrative review will discuss the evidence of the impact of these nutritional strategies on sarcopenia outcomes in older adults. No abstract available

|||||||||| Retrospective data, Review, Journal: Exploring the relationship between ultrasound parameters and muscle strength in older adults: a meta-analysis of sarcopenia-related exercise performance. (Pubmed Central) - Oct 14, 2024
To enhance the accuracy of sarcopenia diagnosis and the effectiveness of management strategies, there is a need for larger, longitudinal studies that evaluate a comprehensive range of ultrasonographic parameters. https://inplasy.com, identifier INPLASY202410086.

|||||||||| Journal: Relationship of Handgrip Strength and Asymmetry with Walking Ability in Older Adults with Excess Adiposity. (Pubmed Central) - Oct 14, 2024
HGS asymmetry is only correlated to gait speed (r = 0.31) and there are no differences in physical function between those with and without asymmetry. Maximal HGS tests should continue to be used to screen for functional decline and disability.

|||||||||| Journal: Masseter muscle thickness is predictive of cancer cachexia in patients with head and neck cancer. (Pubmed Central) - Oct 14, 2024
Maximal HGS tests should continue to be used to screen for functional decline and disability. Compared with SMI, MT is a good alternative prognostic biomarker to determine CA-CX status in HNC patients.

|||||||||| Journal: Sarcopenic obesity and reduced BMD in young men living with HIV: body composition and sex steroids interplay. (Pubmed Central) - Oct 14, 2024
This is among the first studies investigating the distribution of obesity phenotypes and the prevalence of SO among MLWH showing that SO is present in 11-12% of enrolled MLWH regardless of the definition used. However, deep differences emerged using two different diagnostic definitions.

|||||||||| Observational data, Retrospective data, Journal: Low skeletal muscle mass index is independently associated with low bone mineral density in kidney transplant recipients: a retrospective observational cohort study. (Pubmed Central) - Oct 14, 2024
However, deep differences emerged using two different diagnostic definitions. In kidney transplant recipients, an independent association between lower bone mineral density and skeletal muscle mass index was observed in both sexes.

|||||||||| Clinical, Retrospective data, Review, Journal: Impact of Cachexia on Chemotherapy Efficacy and Survival in Pancreatic Cancer: A Systematic Review and Meta-Analysis. (Pubmed Central) - Oct 14, 2024
Recognition and management of cachexia are crucial for optimizing treatment outcomes and improving patient survival. Future research should focus on prospective studies to better understand the impact of cachexia on treatment response and develop tailored interventions to mitigate its adverse effects.

|||||||||| Journal: Development and Validation of a Prediction Model for Dysphagia in Community-Dwelling Older Adults. (Pubmed Central) - Oct 14, 2024
The prediction model established in this study was of a certain predictive value for the risk of dysphagia in community-dwelling older adults. By estimating the likelihood of future outcomes or the onset of certain diseases, it can assist medical personnel in formulating preventive strategies, lessening the workload of nurses, and also diminishing the financial burden on patients, thereby enhancing their overall quality of life.

|||||||||| Journal: Response to "Utility of SARC-F for screening for sarcopenia in ulcerative colitis". (Pubmed Central) - Oct 13, 2024
By estimating the likelihood of future outcomes or the onset of certain diseases, it can assist medical personnel in formulating preventive strategies, lessening the workload of nurses, and also diminishing the financial burden on patients, thereby enhancing their overall quality of life. No abstract available

|||||||||| Journal: Utility of SARC-F for screening for sarcopenia in ulcerative colitis. (Pubmed Central) - Oct 13, 2024
No abstract available No abstract available

|||||||||| Impact of nutritional status on short-term and oncological outcomes in retroperitoneal sarcoma (Gorilla 1) - Oct 13, 2024 - Abstract #ESSO2024ESSO_196;
While the SMI correlates linearly with OS, the existing cut-offs values appear inadequate for RPS. This suggests a need for tumor-specific SMI thresholds.

|||||||||| Fall risk factors and fall prevention in patients with multiple myeloma: first results of the MYFALL study (Lima) - Oct 13, 2024 - Abstract #DGHO2024DGHO_1282;
Advanced age, peripheral neuropathy, fear of falling, sarcopenia and reduced mobility are contributing factors. Of note, the incidence of musculoskeletal pain was particulary high in these patients, which is a known risk factor for falls.

|||||||||| Rituxan (rituximab) / Roche
Sarcopenia in patients with mantle cell lymphoma (MCL) - A retrospective analysis of the European Mantle Cell Lymphoma Registry (Geneva 1-2) - Oct 13, 2024 - Abstract #DGHO2024DGHO_570;
However, these results need to be interpreted with care, as wide variability exists in the cutoff values of muscle mass for defining sarcopenia. This is only a small and retrospective cohort, but our data highlight the importance of a general awareness of sarcopenia and the relevance of prevention.

|||||||||| Assessment of sarcopenia using artificial intelligence-based 3D muscle segmentation in whole-body computed tomography in patients with multiple myeloma (Osaka/Samarkand) - Oct 13, 2024 - Abstract #DGHO2024DGHO_128;
Loss of MV and increase of IMAT were reliably detectable and associated with changes in BMI. Loss of MV was highest in muscles with more type 2 muscle fibers (fast-twitch, high energy) whereas muscles with predominantely type 1 fibers (slow-twitch, postural control) were less affected.



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