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|||||||||| New trial: DS-BSSJ: Health Data from Well on My Legs Program (clinicaltrials.gov) - Oct 28, 2024
P=N/A, N=1600, Active, not recruiting, Sponsor: Hospices Civils de Lyon

|||||||||| Journal: Prevalence and Factors Associated with Sarcopenia in Post-Menopausal Women with Rheumatoid Arthritis. (Pubmed Central) - Oct 28, 2024
Sarcopenic RA patients had lower BMI, IPAQ, ASMI and handgrip strength. IGF-1 was the only parameter that was significantly lower in sarcopenic RA patients.

|||||||||| New trial: GrExID: Group Exercise Program Supported by Audiovisual Media During Hemodialysis (clinicaltrials.gov) - Oct 28, 2024
P=N/A, N=45, Not yet recruiting, Sponsor: Cardenal Herrera University

|||||||||| Journal: Clinical and imaging predictors for the development of diabetes mellitus following a single episode of acute pancreatitis in youth. (Pubmed Central) - Oct 27, 2024
IGF-1 was the only parameter that was significantly lower in sarcopenic RA patients. Development of preDM/DM following an index AP episode can be predicted by baseline AP severity, baseline CRP, IL-6 levels, and subcutaneous fat area.

|||||||||| Observational data, Journal: High serum 25-hydroxyvitamin D levels are associated with greater lean tissue mass and skeletal muscle mass:a cross-sectional study on young healthy Japanese women. (Pubmed Central) - Oct 27, 2024
Invest. 71 : 260-266, August, 2024.

|||||||||| Journal: The application of Chinese version of SARC-F and SARC-CalF in sarcopenia screening against five definitions: a diagnostic test accuracy study. (Pubmed Central) - Oct 27, 2024
Despite its low sensitivity, it proves to be a useful tool to identify severe cases in community taking advantage of its simplicity. SARC-CalF appears to be a more suitable screening tool for clinical use in detecting sarcopenia.

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Journal: Leptin as a surrogate immune-metabolic marker to predict impact of anti-cachectic therapy: results of a prospective randomized trial in multiple solid tumors. (Pubmed Central) - Oct 27, 2024
Leptin is a reliable predictive marker for multitargeted anti-cachectic treatment outcomes. Thus, it can be an ideal candidate for monitoring and predicting the effects of anti-cachectic treatment and a surrogate marker of the immune-metabolic actions of the selected drugs.

|||||||||| Review, Journal: Aging Skeletal Muscles: What Are the Mechanisms of Age-Related Loss of Strength and Muscle Mass, and Can We Impede Its Development and Progression? (Pubmed Central) - Oct 26, 2024
We conclude that although there are potential candidates and ongoing preclinical and clinical trials with drug treatments, the only evidence-based intervention today for humans is exercise. We present different exercise programmes and discuss to what extent the interindividual susceptibility to developing sarcopenia is due to our genetic predisposition or lifestyle factors.

|||||||||| Journal: Prognostic Value of Myosteatosis and Albumin-Bilirubin Grade for Survival in Hepatocellular Carcinoma Post Chemoembolization. (Pubmed Central) - Oct 26, 2024
The combination of preoperative CT-derived myosteatosis and ALBI grade enhances prognostication for patients with unresectable HCC undergoing TACE. The Myo-ALBI nomogram constructed in this study could support individualized prognosis prediction, assisting in treatment decision-making for HCC patients.

|||||||||| Journal: Multiparametric Approach to the Colorectal Cancer Phenotypes Integrating Morphofunctional Assessment and Computer Tomography. (Pubmed Central) - Oct 26, 2024
These methods complement each other in assessing muscle mass, fat distribution, and nutritional status in CCR. When CT is unavailable or bedside assessment is needed, HGS, BIVA, and NU provide an accurate assessment of body composition.

|||||||||| Review, Journal: Head and Neck Cancer and Sarcopenia: An Integrative Clinical and Functional Review. (Pubmed Central) - Oct 26, 2024
Interventions and management strategies for sarcopenia involve exercise interventions as a cornerstone; however, challenges arise due to patient-specific limitations during cancer treatment. A routine body composition analysis is proposed as a valuable addition to HNC patient management, with ongoing research required to refine preoperative exercise and nutrition programs for improved treatment outcomes and survival.

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Journal: Gintonin Stimulates Glucose Uptake in Myocytes: Involvement of Calcium and Extracellular Signal-Regulated Kinase Signaling. (Pubmed Central) - Oct 26, 2024
These results show that gintonin plays a role in glucose metabolism by increasing glucose uptake through transient calcium increases and ERK signaling pathways. Thus, gintonin may be beneficial for glucose metabolism control.

|||||||||| Journal: Development and validation of the sarcopenia disease risk perception scale for older adults. (Pubmed Central) - Oct 26, 2024
Thus, gintonin may be beneficial for glucose metabolism control. The Sarcopenia Disease Risk Perception Scale for Older Adults is reliable and valid, making it appropriate for assessing the risk perception level in the target population.

|||||||||| Clinical, Journal: The effect of unaffected side resistance training on upper limb function reconstruction and prevention of sarcopenia in stroke patients: a randomized controlled trial. (Pubmed Central) - Oct 26, 2024
Unilateral resistance training significantly mitigates muscle atrophy in stroke patients, preventing sarcopenia and enhancing upper limb function. It also ameliorates depressive symptoms, improving rehabilitation outcomes and overall quality of life.

|||||||||| Retrospective data, Journal: Impact of sarcopenia and fat distribution on outcomes in penile cancer. (Pubmed Central) - Oct 26, 2024
We showed that sarcopenia occurs in a relevant part of patients with penile cancer and is a significant risk factor for overall survival (p?=?0.032) and cancer specific survival (p?=?0.034) for patients with penile cancer. Regarding fat distribution further studies are needed to evaluate its impact on sarcopenia and survival.

|||||||||| Review, Journal: Ammonia-induced stress response in liver disease progression and hepatic encephalopathy. (Pubmed Central) - Oct 26, 2024
A clear causal relationship between ammonia-induced immune dysfunction and risk of infection has not yet been definitively proven. In this Review, we discuss the mechanisms by which ammonia produces its diverse deleterious effects and their clinical relevance in liver diseases, the importance of measuring ammonia levels for the diagnosis of hepatic encephalopathy, the prognosis of patients with cirrhosis and liver failure, and how our knowledge of inter-organ ammonia metabolism is leading to the development of novel therapeutic approaches.

|||||||||| Journal: Investigating the efficacy of AI-enhanced telerehabilitation in sarcopenic older individuals. (Pubmed Central) - Oct 25, 2024
AI-based telerehabilitation with 3D pose estimation is a viable and effective alternative for remote exercise interventions. It offers precise guidance and enhances the quality of rehabilitation training, demonstrating outcomes comparable to traditional and general online methods.

|||||||||| Journal: Running Plus Strength Training Positively Affects Muscle Strength and Quality in Both Younger (Below 50 Years Old) and Older (Above 50 Years Old) Women. (Pubmed Central) - Oct 25, 2024
It offers precise guidance and enhances the quality of rehabilitation training, demonstrating outcomes comparable to traditional and general online methods. In both age groups, active women had greater strength and higher muscle quality than inactive women, but the difference in strength, muscle mass, and muscle quality between younger and older women were the same among runners and inactive women.

|||||||||| Retrospective data, Journal, Surgery: Impact of Psoas Muscle Area Index on Short- and Mid-Term Mortality in Patients Undergoing Valve Surgery for Infective Endocarditis: A Retrospective Analysis. (Pubmed Central) - Oct 25, 2024
Routine radiological assessment of sarcopenia using PMAi could improve risk stratification and guide preoperative interventions. Tailored management strategies, especially in older women and patients with CKI, may enhance outcomes in this high-risk population.

|||||||||| Preclinical, Journal: Protective Effects of Cervus elaphus and Eucommia ulmoides Mixture (KGC01CE) on Muscle Loss and Function in Aged Rats. (Pubmed Central) - Oct 25, 2024
Furthermore, it was shown that KGC01CE activated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and inhibited the expression of muscle-degrading proteins MuRF, Atrogin-1, and myostatin. These results suggest that KGC01CE treatment may effectively prevent muscle loss and functional decline, providing a novel therapeutic strategy for sarcopenia.

|||||||||| Clinical, Journal: Optimizing muscle preservation during weight loss in patients with cirrhosis: A pilot study comparing continuous energy restriction to alternate-day modified fasting for weight loss in patients with obesity and non-alcoholic cirrhosis of the liver. (Pubmed Central) - Oct 25, 2024
P=N/A
Further research is needed to validate these findings in larger cohorts and to assess changes in muscle quality and visceral fat. ClinicalTrials.gov Identifier: NCT05367596.

|||||||||| Journal: Malnutrition and Obesity in Patients with COPD Exacerbation, Insights from the National Inpatient Sample. (Pubmed Central) - Oct 25, 2024
Malnourished patients had a lengthier hospital stay and a greater total charge. Malnutrition was identified as an independent risk factor associated with worse outcomes in obese patients admitted with COPD exacerbation.

|||||||||| Journal: Ischemic stroke and sarcopenia have an asymmetric bidirectional relationship based on a two-sample Mendelian randomization study. (Pubmed Central) - Oct 25, 2024
Conversely, our analysis suggests that CES can impact walking speed. Overall, these findings provide valuable insights into the prevention and treatment of these conditions.

|||||||||| Journal: Effects of Neuromuscular Training on Postural Balance and Physical Performance in Older Women: Randomized Controlled Trial. (Pubmed Central) - Oct 25, 2024
Handgrip strength showed no significant interactions (F = 3.216; p = 0.061; ?p2 = 0.127). These findings suggest that neuromuscular training is a promising intervention to mitigate the decline in balance and physical function associated with aging, offering a targeted approach to improve the quality of life in the elderly.

|||||||||| Preclinical, Review, Journal: Task-Based Eating and Drinking Interventions in Animal Models: A Narrative Review of Functional Improvements and Neuromuscular Adaptations in Age-Related Dysphagia. (Pubmed Central) - Oct 25, 2024
While these findings are promising, methodological concerns and potential biases were identified. Therefore, further research is necessary to refine the ACT-ING program, including both clinical studies in humans and preclinical studies in aging animal models that clearly define interventions targeting all aspects of ingestion-related skills within a motor learning and strength training framework.

|||||||||| Review, Journal, MRI: Sarcopenia in the foot on magnetic resonance imaging in patients with diabetes mellitus - a systematic review. (Pubmed Central) - Oct 25, 2024
Sarcopenic changes are evident on MRI of the foot in patients with diabetes and is profound in patients with diabetic neuropathy. The general extent and severity of sarcopenia seems to correlate with clinical scores to assess neuropathy and is implicated in the development of diabetic foot disease.

|||||||||| Journal, HEOR: Economic burden of sarcopenia-related disability in the elderly population: a study in Iran. (Pubmed Central) - Oct 25, 2024
The general extent and severity of sarcopenia seems to correlate with clinical scores to assess neuropathy and is implicated in the development of diabetic foot disease. The cumulative direct medical costs, direct non-medical costs, and indirect costs amounted to $215.1

|||||||||| Journal: Anthropometric equation has sufficient diagnostic capacity to identify sarcopenia in women with breast cancer. (Pubmed Central) - Oct 25, 2024
The cumulative direct medical costs, direct non-medical costs, and indirect costs amounted to $215.1 The anthropometric equation showed sufficient diagnostic capacity to be used as an alternative in identifying sarcopenia in women with breast cancer.

|||||||||| Journal: Relationship between different muscle mass indices and physical performance measures in Turkish older adults. (Pubmed Central) - Oct 25, 2024
The study indicates that ASMI adjusted for BMI shows stronger correlations with all physical performance parameters and is independently associated with dynapenia. Utilizing ASMI adjusted for BMI may improve sarcopenia diagnosis in Turkish older adults.

|||||||||| Clinical data, Retrospective data, Journal, Surgery: Effects of the Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls score on postoperative clinical outcomes following colorectal cancer surgery: a retrospective study. (Pubmed Central) - Oct 25, 2024
Utilizing ASMI adjusted for BMI may improve sarcopenia diagnosis in Turkish older adults. Preoperative SARC-F score was an independent risk factor associated with postoperative complications following colorectal cancer surgery.

|||||||||| Journal: Skeletal muscle size and quality in healthy kidney donors, normal range and clinical associations. (Pubmed Central) - Oct 25, 2024
Our study validates the normative values of psoas muscle mass and density in healthy individuals and suggests correlations with clinical parameters. We demonstrate the significance of measuring not only the mass of the muscle, but also its density, as it has a valid association with metabolic parameters, including BMI and lipid level, even in healthy individuals and in the normal range of the tests.

|||||||||| Retrospective data, Review, Journal: Establishment and validation of a risk prediction model for sarcopenia in gastrointestinal cancer patients: A systematic review and meta-analysis-based approach. (Pubmed Central) - Oct 24, 2024
The model of risk prediction developed through systematic review and meta-analysis demonstrates substantial for sarcopenia in patients with gastrointestinal cancers. Its clinical usability facilitates the screening of patients at high risk for sarcopenia.

|||||||||| Journal: Measurement of resting energy expenditure and its accuracy in women with breast cancer. (Pubmed Central) - Oct 24, 2024
None of the selected predictive equations provided accurate and precise REE estimates in this group. Although the Marra equation displayed the highest agreement, further studies are needed to evaluate REE variability and its prediction in women with BC.

|||||||||| Journal, Surgery: Association of Upper Gastrointestinal Surgery of Great Britain and Ireland (AUGIS)/perioperative quality initiative (POQI) consensus statement on prehabilitation in oesophagogastric surgery. (Pubmed Central) - Oct 24, 2024
Although the Marra equation displayed the highest agreement, further studies are needed to evaluate REE variability and its prediction in women with BC. Consensus statements encompassing the interventions and outcomes of prehabilitation services in oesophago-gastric cancer surgery have been developed to inform the implementation of programmes.

|||||||||| Review, Journal: Advancements in sarcopenia diagnosis: from imaging techniques to non-radiation assessments. (Pubmed Central) - Oct 24, 2024
Standardized protocols, such as those proposed by the Sarcopenia through Ultrasound (SARCUS) Working Group, are imperative for ensuring consistency across assessments. Future research should focus on refining these techniques and harnessing the potential of radiomics and artificial intelligence to enhance diagnostic accuracy and prognostic capabilities in sarcopenia.

|||||||||| Review, Journal: Relationship between Muscle Mass and Muscle Strength with Bone Density in Older Adults: A Systematic Review. (Pubmed Central) - Oct 24, 2024
However, the evidence quality was low due to inconsistency. The relationship between muscle mass, muscle strength, and bone density in older adults shows variability and inconsistent evidence.

|||||||||| Clinical, Clinical protocol, Journal: Efficacy of a combined exercise and nutrition intervention study for outpatients with possible sarcopenia in community-based primary care clinics (ENdSarC): study protocol for a multicenter single-blinded randomized controlled trial. (Pubmed Central) - Oct 24, 2024
P=N/A
To the best of our knowledge, this will be the first clinical trial to evaluate the efficacy of a combined exercise and nutritional supplementation intervention in older outpatients with possible sarcopenia in community-based primary care clinics. These findings will provide new insights to clinicians regarding the long-term usability for doctors and outpatients with possible sarcopenia in community-based primary care.

|||||||||| Review, Journal: Sarcopenia screening based on the assessment of gait with inertial measurement units: a systematic review. (Pubmed Central) - Oct 24, 2024
IMUs could be useful tools for sarcopenia screening based on gait analysis, specifically when artificial intelligence is used to process the recorded data. However, more development and research in this field is needed to provide an effective screening tool for doctors and health systems.

|||||||||| Journal: Among people on osteoporosis medication, loss of appendicular or total body lean mass is an independent risk factor for hip and major osteoporotic fractures. (Pubmed Central) - Oct 23, 2024
Loss of lean mass is associated with increased fracture risk among individuals on anti-osteoporosis medication. Patients should be encouraged to pursue strategies to prevent sarcopenia.

|||||||||| Journal: Sarcopenia definitions and their association with injurious falls in older Swedish women from the Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone fractures (SUPERB) study. (Pubmed Central) - Oct 23, 2024
Patients should be encouraged to pursue strategies to prevent sarcopenia. Sarcopenia definitions confined to muscle function and strength such as SDOC, rather than including DXA-determined ALMI (EWGSOP2 and AWGS), are associated with incident injurious falls with and without fractures in older women.

|||||||||| Journal: The influence of Muscle Wasting on Patient Outcomes among Burn Patients: A Burn Care Quality Platform Study. (Pubmed Central) - Oct 23, 2024
Muscle Wasting is an independent risk factor for several adverse outcomes in burn patients, but not mortality in the BCQP. Confidence in these findings would be improved with more accurate data collection, as the diagnosis of Muscle Wasting is likely under-reported, under-diagnosed, or both.

|||||||||| Retrospective data, Journal: Relationship between CT-derived cervical muscle mass and quality, systemic inflammation, and survival in symptomatic patients undergoing carotid endarterectomy. (Pubmed Central) - Oct 23, 2024
Confidence in these findings would be improved with more accurate data collection, as the diagnosis of Muscle Wasting is likely under-reported, under-diagnosed, or both. Cervical CT-derived muscle mass and density, and markers of systemic inflammation, such as systemic inflammatory grade, may be associated with an inferior long-term prognosis after carotid endarterectomy.

|||||||||| Journal, Metastases: Effects of sarcopenia and nutritional status on surgical outcomes for metastatic spinal tumors: In the perspective of peri-operative complications and performance improvement. (Pubmed Central) - Oct 23, 2024
Cervical CT-derived muscle mass and density, and markers of systemic inflammation, such as systemic inflammatory grade, may be associated with an inferior long-term prognosis after carotid endarterectomy. Preoperative nutritional status and sarcopenia are related factors in the outcome of surgical treatment for MST, and preoperative efforts to improve these may be a way to obtain better clinical results.

|||||||||| Review, Journal, Metastases: A short history of sarcopenia and frailty and their impact on advanced chronic liver disease. (Pubmed Central) - Oct 23, 2024
The prevalence of frailty in patients with advanced chronic liver disease is 27%. Given the high prevalence of sarcopenia and frailty in this population, early diagnosis and treatment are crucial to improving patient quality of life outcomes and reducing the strain on healthcare systems globally.

|||||||||| Observational data, Journal: Construction of frailty and risk prediction models in maintenance hemodialysis patients: a cross-sectional study. (Pubmed Central) - Oct 23, 2024
This survey shows that frailty was highly prevalent among Chinese hemodialysis patients. Medical staff and their families should make early judgments and carry out interventions on the risk of frailty.

|||||||||| Observational data, Journal: Association between sarcopenia and osteoporosis: the cross-sectional study from NHANES 1999-2020 and a bi-directions Mendelian randomization study. (Pubmed Central) - Oct 23, 2024
It suggests a potentially robust causal relationship between OP and sarcopenia. Notably, OP appears to be associated with a higher likelihood of losing ALM, and a significant loss of ALM may contribute to a decline in LS BMD.

|||||||||| Review, Journal: Body composition assessment in individuals with class II/III obesity: a narrative review. (Pubmed Central) - Oct 23, 2024
Muscle loss can cause sarcopenic obesity and other clinical complications, so understanding body composition is crucial. Assessing body composition can also help understand the impact of interventions on bones and avoid clinical complications.

|||||||||| New trial, HEOR: TRAIN-SARC: Effects of an Exercise Program in Women Over 60 yr. With HFpEF and Sarcopenia on Functional Capacity and Quality of Life (clinicaltrials.gov) - Oct 23, 2024
P=N/A, N=40, Not yet recruiting, Sponsor: Fundaci

|||||||||| Trial completion: HEROS: Oral Nutritional Supplementation With HMB Enhance Muscle Quality in Sarcopenic Surgical Patients (clinicaltrials.gov) - Oct 23, 2024
P=N/A, N=47, Completed, Sponsor: Sengkang General Hospital
Assessing body composition can also help understand the impact of interventions on bones and avoid clinical complications. Active, not recruiting --> Completed

|||||||||| New trial: Stress Urinary Incontinence and Sarcopenia in Postmenopausal Osteoporosis (clinicaltrials.gov) - Oct 22, 2024
P=N/A, N=100, Not yet recruiting, Sponsor: Beylikduzu State Hospital



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