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|||||||||| Journal: GDF5 as a rejuvenating treatment for age-related neuromuscular failure. (Pubmed Central) - Nov 3, 2024
In addition, in human muscle biopsies, we found the same age-related alterations than those observed in mice and improved by GDF5 and reproduced its major effects on human cells, suggesting this treatment as efficient in humans. Overall, these data provide a foundation to examine the curative potential of GDF5 drug in clinical trials for sarcopenia and, eventually, other neuromuscular diseases.

|||||||||| Journal: Associations of serum sclerostin levels with body composition, pulmonary function, and exacerbations in COPD patients. (Pubmed Central) - Nov 3, 2024
SOST levels are associated with body composition and lung function in patients with COPD. Furthermore, lower SOST levels predict a higher risk of exacerbations and hospitalization.

|||||||||| Followed by panel discussion and Q&A including Sean Hill and Matthew Neve (Arena 1B) - Nov 3, 2024 - Abstract #COSA2024COSA_271;

|||||||||| Nutrition matters: exploring models of care and strategies to support patients with cancer-related malnutrition (Arena 1B) - Nov 3, 2024 - Abstract #COSA2024COSA_270;
Despite good progress in this space, a myriad of challenges exist. This presentation will explore different models of nutrition care, what core elements underpin these models, and pragmatic approaches that health services can take to develop, implement, and embed nutrition care across the cancer trajectory.

|||||||||| Improving delivery of exercise in oncology: an implementation science approach (Arena 1B) - Nov 3, 2024 - Abstract #COSA2024COSA_269;
Implementation science is the scientific study of strategies to promote the use of evidence-based practices in routine clinical care. I will explore common barriers to exercise delivery and provide implementation science-informed solutions for success.

|||||||||| Cancer-related malnutrition and sarcopenia: challenges and opportunities for improved care (Arena 1B) - Nov 3, 2024 - Abstract #COSA2024COSA_268;
The current challenges in identifying people at risk will be explored, including how and why we are missing people who would benefit from early access to care. Opportunities and resources to improve practice for better outcomes will be presented.

|||||||||| Plenary: Malnutrition and sarcopenia: exposing the reality about access to care (Arena 1B) - Nov 3, 2024 - Abstract #COSA2024COSA_267;

|||||||||| Review, Journal: Fermented Dairy Products, Musculoskeletal and Mental Health in Older Adults: is There Evidence to Support Benefits that go Beyond Those of Non-Fermented Dairy Products? (Pubmed Central) - Nov 2, 2024
Interventional studies reporting mental health outcomes are largely lacking for this age group (N?=?1). Given the very limited evidence for the effectiveness of fermented dairy products, future well-designed prospective and randomized controlled trials are needed to better understand their benefits (especially compared to those of non-fermented dairy foods), their characteristics and the quantities required to offer protection against musculoskeletal and/or mental health ageing.

|||||||||| Review, Journal: Experimental models as a tool for research on sarcopenia: a narrative review. (Pubmed Central) - Nov 2, 2024
We will summarize the literature and present relevant experimental models in terms of their advantages and disadvantages. All of the presented approaches could potentially contribute to the accurate and early diagnosis, follow-up, and possible treatment of sarcopenia.

|||||||||| Retrospective data, Review, Journal: The Evolving Landscape of Sarcopenia in Asia: A Systematic review and meta-analysis following the 2019 Asian working group for sarcopenia (AWGS) diagnostic criteria. (Pubmed Central) - Nov 2, 2024
All of the presented approaches could potentially contribute to the accurate and early diagnosis, follow-up, and possible treatment of sarcopenia. This comprehensive systematic review and meta-analysis highlights the substantial burden of sarcopenia among older adults in Asia, underscoring the need for early identification and intervention strategies to mitigate its adverse consequences on public health.

|||||||||| Retrospective data, Review, Journal: Sex difference, proteostasis and mitochondrial function impact stroke-related sarcopenia- a systematic review and meta-analysis. (Pubmed Central) - Nov 2, 2024
Sex difference, proteostasis, and mitochondrial function may impact the incidence of stroke-related sarcopenia. Understanding the underlying pathological mechanisms and potential therapeutic targets for this disease will provide new insights into disease treatment, prevention, and drug development.

|||||||||| Journal, Immune cell: Association between immune cells, inflammatory cytokines, and sarcopenia: Insights from a Mendelian randomization analysis. (Pubmed Central) - Nov 2, 2024
Understanding the underlying pathological mechanisms and potential therapeutic targets for this disease will provide new insights into disease treatment, prevention, and drug development. Our study reveals causal associations between specific immune phenotypes, inflammatory cytokines, and sarcopenia, providing insight into the development of sarcopenia and potential treatment strategies.

|||||||||| Biomarker, Retrospective data, Review, Journal: Effectiveness of resistance training on body composition, muscle strength, and biomarker in sarcopenic older adults: A meta-analysis of randomized controlled trials. (Pubmed Central) - Nov 2, 2024
Regarding biomarkers, RT had a medium effect size on insulin-like growth factor-1 (SMD = 0.70[0.10,1.30]), interleukin-10 (SMD = 0.61[0.09,1.13]), follistatin (SMD = 0.56[0.16,0.96]), but no effect on interleukin-6, tumor necrosis factor-alpha, and myostatin. It concludes that RT is an effective way to improve muscle strength and the level of synthetic hormones and anti-inflammatory factors in sarcopenic older adults, with a slight impact on body composition and no impact on pro-inflammatory factors.

|||||||||| Review, Journal: Sarcobesity: new paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise. (Pubmed Central) - Nov 2, 2024
For this reason, further studies are needed that encourage the support of therapeutic management. It is along these lines that we direct the reader to therapeutic approaches that demonstrate important, but still obscure, outcomes in the physiological conditions of sarcobesity, such as the role of taurine in modulating inflammatory and antioxidant mechanisms in muscle and adipose tissue, as well as the management of gut microbiota, able to systemically re-establish the structure and function of the gut-muscle axis, in addition to the merits of physical exercise as an instrument to improve muscular health and lifestyle quality.

|||||||||| Journal, Surgery: Role of sarcopenia in complex abdominal wall surgery: does it increase postoperative complications and mortality? (Pubmed Central) - Nov 1, 2024
Although sarcopenia does not seem to have an influence on hernia recurrence or the development of postoperative complications, whether local or systemic, in our study sarcopenia is associated with a higher risk of mortality after complex abdominal wall surgery. Nonetheless, with the results obtained in our study, we think that prehabilitation programs before complex AWS is advisable.

|||||||||| Journal: Efficacy of a Wearable Activity Tracker With Step-by-Step Goal-Setting on Older Adults' Physical Activity and Sarcopenia Indicators: Clustered Trial. (Pubmed Central) - Nov 1, 2024
A wearable activity tracker with gradual goal-setting is an efficient approach to improve older adults' physical activity and sarcopenia indicators. Smart wearable products with behavioral change techniques are recommended to prevent sarcopenia in older adult populations.

|||||||||| Journal, Checkpoint inhibition, Lymphopenia: Unraveling the Impact of Sarcopenia-Induced Lymphopenia on Treatment Response and Prognosis in Patients with Stage III Non-Small Cell Lung Cancer: Insights for Optimizing Chemoradiation and Immune Checkpoint Inhibitor. (Pubmed Central) - Nov 1, 2024
Our results demonstrated an association between pre-RT sarcopenia and poor survival, concurrent chemotherapy dose adjustments, and impaired lymphocyte recovery after definitive CCRT. Moreover, CCRT-induced lymphopenia not only contributed to poor prognosis but may have also impaired the therapeutic efficacy of subsequent maintenance ICI, ultimately worsening treatment outcomes.

|||||||||| Journal: Causal linkage of Graves' disease with aging: Mendelian randomization analysis of telomere length and age-related phenotypes. (Pubmed Central) - Nov 1, 2024
In contrast, there are no causal linkages between GD and facial aging, age-related macular degeneration, or Alzheimer's disease. Further experimental studies could be conducted to elucidate the mechanisms by which GD facilitates aging, which could help slow down the progress of aging.

|||||||||| Journal: Association between sarcopenic obesity and osteoarthritis: The potential mediating role of insulin resistance. (Pubmed Central) - Oct 31, 2024
Our findings suggest a significant correlation between insulin resistance, as measured by the TyG index, and elevated OA risk in individuals with sarcopenic obesity. Targeting insulin resistance through future research may be a promising avenue to lower OA risk in this population.

|||||||||| Retrospective data, Journal: Sarcopenic obesity in patients with head and neck cancer is predictive of critical weight loss during radiotherapy. (Pubmed Central) - Oct 31, 2024
Targeting insulin resistance through future research may be a promising avenue to lower OA risk in this population. SO was not found to impact on overall or cancer-specific survival; however, in patients with sarcopenia, those with SO had better overall survival (median 9

|||||||||| Journal: Predictors of the Disability in Activities of Daily Living in Nursing Home Residents: A Descriptive Study. (Pubmed Central) - Oct 31, 2024
This study found that malnutrition, immobility, and urinary incontinence considerably contributed to the disability profile of nursing home residents. Health professionals need to develop multi-dimensional care and prevention strategies, especially for geriatric syndromes such as malnutrition, immobility, and urinary incontinence.

|||||||||| Journal: Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China. (Pubmed Central) - Oct 31, 2024
Our study revealed that WHO grade and BMI demonstrated significant prognostic value for survival outcomes. Consequently, TMT does not appear to be a significant or applicable predictor in patients with high WHO grades.

|||||||||| Journal: Association of serum intact parathyroid hormone levels with sarcopenia in patients undergoing peritoneal dialysis. (Pubmed Central) - Oct 31, 2024
Among PD patients, elevated serum intact PTH levels are independently associated with sarcopenia. Further longitudinal studies are warranted to confirm their causal relationship.

|||||||||| Journal, Discordant: Unveiling a hidden burden: exploring sarcopenia in hospitalized older patients through concordance and cluster analysis. (Pubmed Central) - Oct 31, 2024
Further longitudinal studies are warranted to confirm their causal relationship. Sarcopenia is highly prevalent in hospitalized older adults, but the adjusted criteria and the inclusion of other parameters must be considered in the assessment.

|||||||||| Observational data, Journal: Prevalence and Risk Factors of Self-Reported Sarcopenia and Its Association With Multimorbidity in Community-Dwelling Older Adults: A Cross-Sectional Study. (Pubmed Central) - Oct 31, 2024
We also found that poor perceived health status was the strongest predictor of sarcopenia in older adults with multimorbidity, while oldest-old age (??85?years) was the strongest predictor of sarcopenia in those without multimorbidity. Large prospective cohort studies using objective sarcopenia screening tools are needed to demonstrate the synergistic effects of multimorbidity and sarcopenia on health outcomes among community-dwelling older adults.

|||||||||| Retrospective data, Review, Journal: Relationship between sarcopenia and metabolic dysfunction-associated steatotic liver disease (MASLD): A systematic review and meta-analysis. (Pubmed Central) - Oct 30, 2024
Sarcopenia increased MASLD's probability and was associated with a higher probability of liver fibrosis in MASLD patients. However, SMI had no predictive value of MASLD occurrence.

|||||||||| Preclinical, Journal: Cellular and transcriptomic changes by the supplementation of aged rat serum in human pluripotent stem cell-derived myogenic progenitors. (Pubmed Central) - Oct 30, 2024
Together, aged serum supplementation caused cellular and transcriptomic changes in human myogenic progenitors. The current data from our in vitro model possibly simulate non-cell autonomous contributions of blood composition to age-related processes in human skeletal muscle.

|||||||||| Journal: Risk of Sarcopenia, Hospitalization, and Mortality Among Malaysian Older Adults With Knee Pain: Five-Year Follow-up Study. (Pubmed Central) - Oct 30, 2024
Knee pain and knee OA symptoms were associated with increased risk of probable sarcopenia at five-year follow-up in an urban older population in Kuala Lumpur. Future studies should seek to identify modifiable risk factors for the development of sarcopenia in individuals with knee OA.

|||||||||| Observational data, Retrospective data, Journal: Prevalence and severity of sarcopenia in patients on maintenance hemodialysis: a cross-sectional study. (Pubmed Central) - Oct 30, 2024
The prevalence of probable or confirmed sarcopenia in patients on MHD is significant. Factors such as physical activity, body mass index, and inorganic phosphorus levels are independently associated the presence and severity of sarcopenia in this population.

|||||||||| Biomarker, Journal: Associations between serum cystatin C and fall reports in an Elderly population. (Pubmed Central) - Oct 30, 2024
In contrast, Cre and eGFR were not significant after adjustments; SI showed marginal significance (p?=?0.045). Cys C is significantly associated with fall risk in older adults, demonstrating a positive linear relationship with self-reported falls.

|||||||||| Journal, Adverse events, HEOR: Association between possible sarcopenia, all-cause mortality, and adverse health outcomes in community-dwelling older adults in China. (Pubmed Central) - Oct 30, 2024
In conclusion, in Chinese community-dwelling older adults, possible sarcopenia was associated with an increased risk of all-cause mortality, several chronic diseases, and functional dependence. Thus, alleviating or preventing possible sarcopenia may improve health outcomes and extend the lifespan of these individuals.

|||||||||| Preclinical, Journal: Age-related increase in the excitability of mouse layer V pyramidal neurons in the primary motor cortex is accompanied by an increased persistent inward current. (Pubmed Central) - Oct 30, 2024
The PIC amplitude was increased in old LVPN via increases in Na+ and Ca2+ PICs, in addition to being active across a wider voltage range. Given that LVPN function is integral to initiation of voluntary muscle contraction, altered LVPN excitability likely contributes to age-related impairment of physical function.

|||||||||| Journal: Sarcopenia in patients receiving TIPS is independently associated with increased risk of complications and mortality. (Pubmed Central) - Oct 29, 2024
Sarcopenia increases the risk of complications and mortality post-TIPS. Importantly, sarcopenia improves in patients receiving TIPS, particularly in those with severe sarcopenia at baseline and free of TIPS-related complications.

|||||||||| Journal: Commentary: Sarcopenia Predicts the Development of Early Adjacent Segment Disease Following Transforaminal Lumbar Interbody Fusion. (Pubmed Central) - Oct 29, 2024
Importantly, sarcopenia improves in patients receiving TIPS, particularly in those with severe sarcopenia at baseline and free of TIPS-related complications. No abstract available

|||||||||| Journal: Sarcopenia, dysphagia, and frailty in community-dwelling older adults: An analysis of mediation and moderated mediation models. (Pubmed Central) - Oct 29, 2024
Therefore, it is plausible to anticipate that if someone has taste and smell dysfunction in addition to sarcopenia, they are more likely to have dysphagia and, ultimately, frailty. These findings emphasize the importance of addressing sarcopenia, taste and smell dysfunction, and dysphagia concurrently in frailty management in older adults.

|||||||||| Review, Journal, Surgery: Prognostic value of body composition in oncological visceral surgery (Pubmed Central) - Oct 29, 2024
Rapidly growing evidence shows that body composition parameters, especially reduced muscle mass, are associated with adverse outcomes in cancer patients and have been reported to negatively affect overall survival (OS), disease-free survival (DFS), toxicity associated with chemotherapy and surgical complications. In this article, we summarize the recent literature and present the clinical influence of body composition in oncological visceral diseases.

|||||||||| Journal: Sarcopenia. (Pubmed Central) - Oct 29, 2024
In this article, we summarize the recent literature and present the clinical influence of body composition in oncological visceral diseases. No abstract available

|||||||||| Journal: Editorial: Molecular mechanisms underlying exercise-alleviated sarcopenic obesity. (Pubmed Central) - Oct 29, 2024
No abstract available No abstract available

|||||||||| Observational data, Journal: Associations of sarcopenia, obesity, and metabolic health with the risk of urinary incontinence in U.S. adult women: a population-based cross-sectional study. (Pubmed Central) - Oct 29, 2024
Metabolically unhealthy status, glycohemoglobin, vitamin D, and serum albumin levels were partial mediators of these associations. Our findings elucidated the complex interactions between sarcopenia, obesity, and metabolic health, underscoring the critical need for integrated therapeutic strategies that address both metabolic health and targeted nutritional interventions, aiming to enhance muscular health and effectively manage and prevent UI.

|||||||||| oltipraz (PMK-N01GI1) / Canopus BioPharma, Pharmaking
Journal: Heat exposure promotes sarcopenia via gut microbiota-derived metabolites. (Pubmed Central) - Oct 29, 2024
And Nrf2 activator (Oltipraz) supplementation alleviates muscle atrophy and dysfunction induced by heat exposure. Our findings reveal the detrimental effects of heat exposure on muscle function and provide new strategies for treating sarcopenia.

|||||||||| Journal: Ror2 signaling regulated by differential Wnt proteins determines pathological fate of muscle mesenchymal progenitors. (Pubmed Central) - Oct 29, 2024
We further found that both Wnts are abundant in degenerating muscle and synergistically stimulate Ror2, leading to unwanted MP proliferation and eventually intramuscular adipose tissue accumulation. These findings provide evidence that Ror2-mediated signaling elicited by differential Wnts plays a critical role in determining the pathological fate of MPs.

|||||||||| Clinical guideline, Journal: Physical activity and exercise in chronic kidney disease: consensus statements from the Physical Exercise Working Group of the Italian Society of Nephrology. (Pubmed Central) - Oct 29, 2024
Adopting a multidisciplinary team approach, which includes nephrologists, nurses, exercise professionals, and dietitians, is crucial for providing comprehensive rehabilitation for CKD patients. Integrating new technologies

|||||||||| Trial initiation date: The Foods & Oil to Repair, Correct and Enhance Strength (FORCES) Study (clinicaltrials.gov) - Oct 29, 2024
P=N/A, N=66, Not yet recruiting, Sponsor: Ohio State University
Integrating new technologies Initiation date: Aug 2024 --> Dec 2024

|||||||||| Review, Journal: Testosterone therapy for functional hypogonadism in middle-aged and elderly males: current evidence and future perspectives. (Pubmed Central) - Oct 28, 2024
Furthermore, there are numerous insightful studies suggesting additional benefits of TTh, for instance in cardio-renal-metabolic conditions. Specifically, future trials should investigate the role of TTh in improving symptoms and prognosis in various clinical contexts, including sarcopenia, frailty, dyslipidemia, arterial hypertension, diabetes mellitus, fracture risk, heart failure, stable angina, chronic kidney disease, mood disorders, and cognitive dysfunction.

|||||||||| Journal: Improving the functional detection of sarcopenic obesity: prevalence and handgrip scoring in the OBESAR cohort. (Pubmed Central) - Oct 28, 2024
Using adHGS through a scoring process considering age and sex may help to detect early signs of SO in a primary care setting in order to better prevent SO through a personalized approach in adults with obesity. A free online application, "GRip And Sarcopenia Prediction" (GRASP), is proposed to diagnose probable SO.

|||||||||| Journal: Tongue Pressure and Grip Strength as Indicators of Persistent Dysphagia After Acute Stroke. (Pubmed Central) - Oct 28, 2024
Older age, reduced tongue pressure, and reduced grip strength are strong predictors of persistent poststroke dysphagia at discharge. Thus, muscle strength is a more valuable parameter than muscle mass in predicting persistent poststroke dysphagia.

|||||||||| Observational data, Journal, Adverse events: Prognostic significance of eosinophil-to-platelet ratio and C-reactive protein in predicting adverse events during acute exacerbations of chronic obstructive pulmonary disease: A comprehensive observational study. (Pubmed Central) - Oct 28, 2024
EPR and CRP are useful prognostic markers of clinically significant in-hospital outcomes during COPD exacerbations. However, a multidimensional approach may further optimise risk prediction.

|||||||||| Journal: Indoor air pollution by solid fuel usages for cooking is longitudinally associated with possible sarcopenia in middle-aged Chinese population. (Pubmed Central) - Oct 28, 2024
Indoor air pollution from solid fuel usages for cooking was a modifiable risk factor for sarcopenia, especially in middle-aged female population. These findings provide a new prevention strategy to reduce the growing burden of sarcopenia, especially for middle-aged female individuals using solid fuels for cooking.

|||||||||| New trial: DS-BSSJ: Health Data from Well on My Legs Program (clinicaltrials.gov) - Oct 28, 2024
P=N/A, N=1600, Active, not recruiting, Sponsor: Hospices Civils de Lyon

|||||||||| Journal: Prevalence and Factors Associated with Sarcopenia in Post-Menopausal Women with Rheumatoid Arthritis. (Pubmed Central) - Oct 28, 2024
Sarcopenic RA patients had lower BMI, IPAQ, ASMI and handgrip strength. IGF-1 was the only parameter that was significantly lower in sarcopenic RA patients.



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