Sarcopenia
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  • ||||||||||  Journal:  Osteosarcopenia in chronic pancreatitis (Pubmed Central) -  Oct 29, 2022   
    The development of osteopenia and sarcopenia syndromes in CP is interrelated and associated with both traditional risk factors and an increased concentration of cytokines in the in the colon mucosa.
  • ||||||||||  Journal:  Roles of active forms of vitamin D in supporting innate immune systems and in reducing excess inflammation in COVID-19 (Pubmed Central) -  Oct 29, 2022   
    Vitamin D supplementation stimulates the synthesis of antibacterial peptides and is important for weakening the cytokine storm, reducing excessive acute and chronic inflammation, and also for compensating for chronic comorbid pathologies. Active forms of vitamin D (alfacalcidol, etc.) are of particular importance for compensating for vitamin D deficiency in elderly patients, endocrine-immune dysfunction, sarcopenia, chronic renal failure (in which the metabolism of vitamin D in the kidneys is disturbed).
  • ||||||||||  Journal:  Exploration of mitochondrial defects in sarcopenic hip fracture patients. (Pubmed Central) -  Oct 29, 2022   
    Primary myoblast cultures gained from the same muscle biopsies did not show significant mitochondrial defects. We hypothesize that a sum of external consequences, including vitamin D deficiency and iron deficiency caused by disturbances in the iron metabolism, result in complex I deficiency, which in turn affects the TCA and contributes to muscle weakness and loss.
  • ||||||||||  Journal:  Osteocytes regulate senescence of bone and bone marrow. (Pubmed Central) -  Oct 29, 2022   
    The acquisition of a senescence-associated secretory phenotype (SASP) in both osteoprogenic and myeloid lineage cells was the underlying cause. Together, we showed that osteocytes play critical roles in regulation of lineage cell specifications in bone and bone marrow through mediation of senescence.
  • ||||||||||  Review, Journal:  Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities. (Pubmed Central) -  Oct 29, 2022   
    Besides the therapies targeting the signaling pathways mentioned above, such as AdipoRon and elamipretide, we further summarize other potential pharmacological approaches like inhibitors of sodium-glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase-4 (DPP-4), as well as some natural products, which may have the beneficial effects on improving the skeletal muscle mitochondrial function of HF. Targeting myocyte mitochondrial biogenesis, oxidative metabolism, oxidative phosphorylation, and reduction of oxidative stress injury are promising future opportunities for the prevention and management of skeletal muscle myopathy in HF.
  • ||||||||||  Journal, HEOR:  Validation of the Persian version of the sarcopenia-specific quality of life questionnaire (SarQoL-IR). (Pubmed Central) -  Oct 29, 2022   
    Targeting myocyte mitochondrial biogenesis, oxidative metabolism, oxidative phosphorylation, and reduction of oxidative stress injury are promising future opportunities for the prevention and management of skeletal muscle myopathy in HF. This is the first study to confirm the reliability and validity of the Persian version of the SarQoL for the measurement of quality of life among Iranian sarcopenic older adults.
  • ||||||||||  Review, Journal:  Role of Matrix Metalloproteinases in Musculoskeletal Diseases. (Pubmed Central) -  Oct 29, 2022   
    By modulating ECM reconstruction, cellular migration, and differentiation, MMPs preserve myofiber integrity and homeostasis. In this review, the role of MMPs in skeletal muscle function, muscle injury and repair, skeletal muscle inflammation, and muscular dystrophy and future approaches for MMP-based therapies in musculoskeletal disorders are discussed at the cellular and molecule level.
  • ||||||||||  Preclinical, Journal:  Potential Effects of Resistant Exercise on Cognitive and Muscle Functions Mediated by Myokines in Sarcopenic Obese Mice. (Pubmed Central) -  Oct 29, 2022   
    Interestingly, the protein level of brain-derived neurotrophic factor (BDNF) in EX was simultaneously increased in all tissues including muscle, plasma, and hippocampus compared to that in OB. In conclusion, modulation of muscle-derived cognitive function-related myokines in various pathological conditions via a resistant exercise could be a possible way of relieving muscle and cognitive dysfunction.
  • ||||||||||  Journal:  Diagnostic Value of Inflammatory Markers in Elderly Arab Women with Sarcopenia. (Pubmed Central) -  Oct 28, 2022   
    In conclusion, elevated levels of TNF-α are significantly associated with the risk of sarcopenia, while variations perceived in circulating CRP can be explained by changes in the muscle mass indices only among individuals with sarcopenia. The present findings, while promising, need further investigations on a larger scale to determine whether inflammatory markers hold any diagnostic value in assessing sarcopenia among elderly Arab women.
  • ||||||||||  Observational data, Journal:  Association of Micronutrients and Handgrip Strength in Korean Older Population: A Cross-Sectional Study. (Pubmed Central) -  Oct 28, 2022   
    Among micronutrients, insufficient potassium intake showed a significant association with low handgrip strength for men (OR: 3.159, 95% CI: 1.164-8.578) and women (OR: 2.793, 95% CI: 1.380-5.654) aged ≥65 years, respectively (p = 0.005 for men, p = 0.024 for women), as a result of adjusting for all confounding factors that could affect low handgrip strength. In conclusion, potassium intake among micronutrients in Korean older populations with low handgrip strength might need continuous monitoring for the intervention or prevention of dynapenia or sarcopenia.
  • ||||||||||  Journal:  Impact of Low Skeletal Muscle Mass and Obesity on Hearing Loss in Asymptomatic Individuals: A Population-Based Study. (Pubmed Central) -  Oct 28, 2022   
    In multivariable-adjusted models, the risk of hearing loss was the highest in the pre-sarcopenic obesity group (odds ratio: 1.30 [95% confidence interval: 1.10-1.56]), followed by the obesity alone (1.20 [1.12-1.28]) and pre-sarcopenia alone (1.19 [1.06-1.34]) group compared with the control group (p < 0.001). Pre-sarcopenic obesity was independently associated with a higher prevalence of hearing loss, supporting pre-sarcopenic obesity itself as a risk for the decline in hearing function.
  • ||||||||||  Review, Journal:  Approaching Sarcopenic Obesity in Young and Middle-Aged Female Adults in Weight Management Settings: A Narrative Review. (Pubmed Central) -  Oct 28, 2022   
    Finally, patients with SO have a reduced baseline resting energy expenditure and more sedentary behaviors, which seem to account for the relationship between SO and poorer weight management outcomes, such as a higher early dropout rate and major later difficulties in weight loss maintenance. Therefore, specific strategies for personalized weight management programs for patients with SO should be incorporated to determine a successful management of this phenotype.
  • ||||||||||  Review, Journal:  Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review. (Pubmed Central) -  Oct 28, 2022   
    In the world's aging society, TRT can be a tool for preventing the onset of sarcopenia in older-adult men. This narrative review aims to show the relationship between the decline in testosterone with age, sarcopenia, and frailty, as well as the effects of testosterone replacement therapy on muscle mass and strength.
  • ||||||||||  Review, Journal:  Bronchial Asthma and Sarcopenia: An Upcoming Potential Interaction. (Pubmed Central) -  Oct 28, 2022   
    This narrative review aims to show the relationship between the decline in testosterone with age, sarcopenia, and frailty, as well as the effects of testosterone replacement therapy on muscle mass and strength. Emerging data support that pulmonologists should be aware of the sarcopenia concept and be prepared to evaluate the existence of low muscle mass in their asthmatic patients.
  • ||||||||||  Retrospective data, Journal:  Polypharmacy and Its Association with Dysphagia and Malnutrition among Stroke Patients with Sarcopenia. (Pubmed Central) -  Oct 28, 2022   
    Polypharmacy is associated with dysphagia and malnutrition in post-stroke patients with sarcopenia. In addition to the combination of nutritional and exercise therapies, review and optimization of prescription medications may be warranted to treat sarcopenia in order to maximize improvement in outcomes for these patients.
  • ||||||||||  Journal:  Trends in Nutrition Research for Sarcopenia: A Bibliometric Analysis. (Pubmed Central) -  Oct 28, 2022   
    Our analysis suggested that global nutrition and sarcopenia-related research increased rapidly from 2001 to 2021, demonstrating that this was a promising area of future research that could benefit from continued advances. Future research may focus on the effects of age and sex as well as intervention effectiveness, particularly exercise and nutrition supplementation.
  • ||||||||||  Biomarker, Review, Journal:  Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease. (Pubmed Central) -  Oct 28, 2022   
    In this article, we will explore currently available nutritional-inflammatory biomarkers in distinct CKD populations (hemodialysis, peritoneal dialysis, transplantation) with a view to evaluating their efficacy as predictors of malnutrition and their involvement in the common proinflammatory process. Although there is a direct relationship between inflammatory-nutritional status, signs and symptoms [e.g., protein-energy wasting (PEW), anorexia], and comorbidities (e.g., atheromatosis, atherosclerosis), we are in need of clearly standardized markers for nutritional-inflammatory assessment to improve their performance and design appropriate bidirectional interventions.
  • ||||||||||  Preclinical, Journal:  Effects of Whey Peptide Supplementation on Sarcopenic Obesity in High-Fat Diet-Fed Mice. (Pubmed Central) -  Oct 28, 2022   
    In skeletal muscle, WP supplementation regardless of RE alleviated energy metabolism dysregulation and resulted in down-regulated protein degradation (Atrogin-1 (p = 0.003), MuRF1 (p = 0.006)) and apoptosis (Bax) (p = 0.004). Taken together, the current study elucidated that WP supplementation regardless of RE has potential anti-obesity and anti-sarcopenic effects in sarcopenic obesity.
  • ||||||||||  Enrollment change, Trial completion date, Trial termination:  Evaluation of a Screening Strategy for Sarcopenia: a Monocentric Prospective Cohort Study (STRAS) (clinicaltrials.gov) -  Oct 28, 2022   
    P=N/A,  N=15, Terminated, 
    Future work will need to delineate the molecular details of these processes. N=300 --> 15 | Trial completion date: Mar 2023 --> Sep 2022 | Recruiting --> Terminated; insufficient recruitment to meet the objectives in time
  • ||||||||||  Journal:  When the Pandemic Will Be Over: Lots of Hope and Some Concerns. (Pubmed Central) -  Oct 27, 2022   
    Accordingly, the pandemic is negatively impacting the accumulation of the functional reserves of each individual, starting from early life. With the long-term effects of the pandemic to be seen in the coming years, clinicians must be prepared to manage such high clinical complexity of people they encounter, through the implementation of multidimensional and multidisciplinary interventions.
  • ||||||||||  Review, Journal:  Use of bioelectrical impedance analysis in centenarians: a systematic review. (Pubmed Central) -  Oct 27, 2022   
    With the long-term effects of the pandemic to be seen in the coming years, clinicians must be prepared to manage such high clinical complexity of people they encounter, through the implementation of multidimensional and multidisciplinary interventions. BIA may be used for assessing body composition in centenarians, but research is limited to a few studies suggesting the need of future research in this area.
  • ||||||||||  Journal:  Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation. (Pubmed Central) -  Oct 27, 2022   
    Loss of muscle strength occurs in both models, potentially because of reduced membrane excitability with altered NKA signaling and RyR stability, decreased fiber Ca sensitivity and suppressed SERCA activity via modification of the Cys residue, dysregulated SR and cytosolic Ca homeostasis, and impaired mitochondrial Ca buffering and respiration. Our results provide a better understanding of the specific impacts of aging and oxidative stress on mechanisms related to muscle weakness that may point to future interventions for countering muscle weakness.