Sarcopenia
Welcome,         Profile    Billing    Logout  
 46 Companies   12 Products   12 Products   17 Mechanisms of Action   756 Trials   22406 News 


«12...148149150151152153154155156157158...401402»
  • ||||||||||  Trial completion date, Trial primary completion date:  Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis (clinicaltrials.gov) -  Nov 17, 2022   
    P=N/A,  N=44, Not yet recruiting, 
    Trial completion date: May 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  Trial completion date, Trial primary completion date:  Electrical Stimulation of Human Myocytes in Microgravity (clinicaltrials.gov) -  Nov 17, 2022   
    P=N/A,  N=75, Active, not recruiting, 
    Trial completion date: May 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2023 Trial completion date: Sep 2022 --> Jun 2023 | Trial primary completion date: Sep 2022 --> Jun 2023
  • ||||||||||  Review, Journal:  Differential effects of vitamin D on upper and lower body fat-free mass: potential mechanisms. (Pubmed Central) -  Nov 16, 2022   
    Here we review the current literature on vitamin D, muscle mass and strength and discuss some potential mechanisms for the differing effects of vitamin D on upper and lower body FFM. In particular, differences in distribution of the vitamin D receptor as well as androgen receptors, in the upper and lower body musculature, will be discussed.
  • ||||||||||  Review, Journal:  Improving the prognosis before and after liver transplantation: Is muscle a game changer? (Pubmed Central) -  Nov 16, 2022   
    The bi-directional liver-muscle axis makes sense in this situation. Defining the best, easy to use in clinical practice tools to assess muscle quality, quantity, and function in this specific population and developing quality prospective studies to identify interventional strategies that could improve these parameters as well as evaluate the effect on mortality are among the important challenges of today.
  • ||||||||||  Journal:  Dietary Habits Are Related to Phase Angle in Male Patients with Non-Small-Cell Lung Cancer. (Pubmed Central) -  Nov 16, 2022   
    According to our results, a dietary pattern rich in potatoes and animal proteins (meat and poultry) was a significant determinant of PhA (B ± SE, p: 0.165 ± 0.08, p = 0.05) in multiple linear regression models after adjusting for age, smoking, lean tissue, and MedDietScore. In conclusion, dietary patterns may affect PhA, suggesting the crucial role of protein in cancer management and the prevention of sarcopenia.
  • ||||||||||  Review, Journal:  The anabolic applications of androgens in older adults with functional limitations. (Pubmed Central) -  Nov 16, 2022   
    Testosterone administration increases skeletal muscle mass, strength and power in older men with low or low normal testosterone levels, but the effects on performance-based measures of physical function have been inconsistent. Adequately powered randomized trials are needed to determine the long-term safety and efficacy of testosterone in improving physical function and quality of life in older adults with functional limitations.
  • ||||||||||  Journal:  Sarcopenia, obesity, and diabetes - The metabolic conundrum trifecta. (Pubmed Central) -  Nov 16, 2022   
    Adequately powered randomized trials are needed to determine the long-term safety and efficacy of testosterone in improving physical function and quality of life in older adults with functional limitations. No abstract available
  • ||||||||||  Review, Journal:  Osteosarcopenia in Patients with Chronic Obstructive Pulmonary Diseases: Which Pathophysiologic Implications for Rehabilitation? (Pubmed Central) -  Nov 16, 2022   
    Taken together, our results summarized the currently available evidence about the multilevel interactions between osteosarcopenia and COPD to pave the way for a comprehensive approach targeting the most common risk factors of these pathological conditions. Further studies are needed to clarify the role of modern clinical strategies and telemedicine solutions to optimize healthcare delivery in patients with COPD, including osteopenia, osteoporosis, and sarcopenia screening in these subjects.
  • ||||||||||  Biomarker, Review, Journal:  Sarcopenia and Frailty in Heart Failure: Is There a Biomarker Signature? (Pubmed Central) -  Nov 16, 2022   
    This review outlines the current knowledge of biomarkers that are considered promising for diagnosing sarcopenia and frailty in HF. The listed biomarkers might support the diagnosis, prognosis, and therapeutic decisions for sarcopenia and frailty in HF patients.
  • ||||||||||  Preclinical, Journal:  Connexin 43 Channels in Osteocytes Are Necessary for Bone Mass and Skeletal Muscle Function in Aged Male Mice. (Pubmed Central) -  Nov 16, 2022   
    In vitro, the impairment of Cx43 HCs in osteocytes from aged mice also promoted muscle collagen synthesis through activation of TGFβ/smad2/3 signaling because of reduced PGE levels in the PO CM. These findings indicate that the enhancement of Cx43 HCs while GJs are inhibited reduces bone mass, and the impairment of Cx43 HCs inhibits PGE level in osteocytes and this reduction promotes muscle collagen synthesis in skeletal muscle through activation of TGFβ/smad2/3 signaling, which together with increased ROS level contributes to reduced muscle force in aged mice.
  • ||||||||||  Journal:  Uremic Myopathy and Mitochondrial Dysfunction in Kidney Disease. (Pubmed Central) -  Nov 16, 2022   
    In conclusion, mice with adenine-induced CKD developed sarcopenia and with increased glycolytic metabolism but without gross changes in fiber structure. In vitro models of uremic myopathy suggest fatty acid utilization is preserved compared to decreased glucose utilization.
  • ||||||||||  Journal:  Significance of Temporal Muscle Thickness in Chronic Subdural Hematoma. (Pubmed Central) -  Nov 16, 2022   
    (4) While total appendicular skeletal muscle mass is important to prevent MetS, it is necessary to maintain an optimal ratio of muscle mass between the upper and lower appendicular skeletal muscle mass. TMT may represent an objective prognostic parameter and assist the identification of vulnerable CSDH patients.
  • ||||||||||  Retrospective data, Review, Journal:  The Relationship between Sarcopenia and Injury Events: A Systematic Review and Meta-Analysis of 98,754 Older Adults. (Pubmed Central) -  Nov 16, 2022   
    This study followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and collected a total of 38 prospective studies, and the results showed that, when compared to robust individuals, the risk of injury events for older individuals with sarcopenia was significantly higher for fractures (HR = 9.66, CI: 5.07-18.38), hospital admissions (HR = 11.80, CI: 4.86-28.65), and death (HR = 9.57, CI: 3.17-28.94). In consideration of the negative impact of sarcopenia on the subsequent health of older adults, professional nursing personnel should assess older adults for sarcopenia as early as possible and propose relevant care policies to further reduce negative health impacts.
  • ||||||||||  Review, Journal:  The Role of Hypoxia-Inducible Factor-1 Alpha in Renal Disease. (Pubmed Central) -  Nov 16, 2022   
    In renal diseases, the critical characteristic of HIF-1α is protective, but it also has a negative effect, such as in sarcopenia. This review summarizes the mechanisms of HIF-1α regulation in renal disease.