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17 Mechanisms of Action |
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- || Review, Journal: Sarcopenia and bone health: new acquisitions for a firm liaison. (Pubmed Central) - Dec 6, 2022
New therapeutic strategies that simultaneously target bone and muscle tissue are limited, but recently new targets for the development of dual-action drug therapies have been identified. This narrative review aims to provide an overview of the latest scientific evidence associated with OS, a complex disorder that will pave the way for future research aimed at understanding the bone-muscle-associated pathogenetic mechanisms.
- | Journal: Ginsenoside Rb1 Prevents Oxidative Stress-Induced Apoptosis and Mitochondrial Dysfunction in Muscle Stem Cells via NF-κB Pathway. (Pubmed Central) - Dec 6, 2022
Mechanistically, it was proven that Rb1 exerted its antioxidant effects and avoided the apoptosis of myoblasts by targeting the core regulator of the nuclear factor-kappa B (NF-κB) signal pathway. Therefore, these findings suggest that Rb1 may have a beneficial role in the prevention and treatment of MuSC exhaustion-related diseases like sarcopenia.
- || Clinical data, Journal: Impact of low skeletal muscle mass and quality on clinical outcomes in patients with head and neck cancer undergoing (chemo)radiation. (Pubmed Central) - Dec 6, 2022
PT-IMAT was a significant risk factor only in the case of CSS (HR for one cm increase 1.02; 95% CI = 1.00-1.03; p = 0.046). In conclusion, pre-treatment low muscle quality is a strong prognostic indicator of death risk in patients affected by HNC and undergoing (chemo)radiotherapy with curative intent.
- | Journal: Editorial: Muscle mass and function in COVID-19. (Pubmed Central) - Dec 6, 2022
In conclusion, pre-treatment low muscle quality is a strong prognostic indicator of death risk in patients affected by HNC and undergoing (chemo)radiotherapy with curative intent. No abstract available
- | Journal: Dual-Energy X-Ray Absorptiometry and Anthropometry for Assessment of Nutritional Status at Diagnosis in Children with Cancer: A Single-Center Experience from India. (Pubmed Central) - Dec 6, 2022
Conclusion Our study reports undernutrition among two-fifths of newly diagnosed patients of childhood cancer associated with high prevalence of sarcopenia and adiposity. These findings are of utmost clinical relevance in planning interventional strategies.
- || Review, Journal: Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient. (Pubmed Central) - Dec 6, 2022
Finally, the evaluation of nutrition risk and status is essential to predict and mitigate surgical outcomes. Nascent to novel approaches are the future of objectively identifying patients at perioperative nutrition risk and guiding therapy toward optimal perioperative standards of care.
- | Journal: Sarcopenia: the 'hidden' marker of surgical outcome. (Pubmed Central) - Dec 6, 2022
Nascent to novel approaches are the future of objectively identifying patients at perioperative nutrition risk and guiding therapy toward optimal perioperative standards of care. No abstract available
- | Journal: Effect of sarcopenia on survival outcomes in patients with nasopharyngeal and sinonasal cancer. (Pubmed Central) - Dec 6, 2022
No abstract available No abstract available
- | Journal: Body composition in sarcopenia in middle-aged individuals (Pubmed Central) - Dec 6, 2022
No abstract available the introduction of bioimpedancemetry and dynamometry into early screening for muscle mass reduction will allow timely start of therapeutic and preventive measures even in middle age, which will lead to a decrease in the progression of sarcopenia in the elderly, as well as improve the quality of life.
- | Journal: Response letter to "sarcopenia, osteoporosis and fractures: what we see". (Pubmed Central) - Dec 6, 2022
the introduction of bioimpedancemetry and dynamometry into early screening for muscle mass reduction will allow timely start of therapeutic and preventive measures even in middle age, which will lead to a decrease in the progression of sarcopenia in the elderly, as well as improve the quality of life. No abstract available
- | Journal: Sarcopenia, osteoporosis, and fractures: what we see mainly depends on how we look? (Pubmed Central) - Dec 6, 2022
No abstract available No abstract available
- | Journal: The causal association of sarcopenia with osteoporosis and obesity: a Mendelian randomization analysis. (Pubmed Central) - Dec 6, 2022
No abstract available No abstract available
- | Journal: Association between dietary diversity and sarcopenia in community-dwelling older adults. (Pubmed Central) - Dec 6, 2022
This cross-sectional study revealed that poor dietary diversity was associated with sarcopenia among older adults. Ingestion of low-protein foods and high-protein foods is infrequently associated with sarcopenia and ingestion of high-protein foods.
- | Journal: C-reactive protein and muscle-related measures over 14 years in Chinese community-dwelling older adults. (Pubmed Central) - Dec 6, 2022
Ingestion of low-protein foods and high-protein foods is infrequently associated with sarcopenia and ingestion of high-protein foods. This prospective study suggests that, among Chinese community-dwelling older adults, baseline inflammatory state as measured by hsCRP was not associated with the decline in muscle-related measures over a long period of time.
- | Observational data, Journal: Association between sarcopenia and oral functions in community-dwelling older adults: A cross-sectional study. (Pubmed Central) - Dec 6, 2022
The potential decline in oral functions in older adults with sarcopenia may have been overlooked until now. This study indicates the need for dental perspectives in intervening with older adults with sarcopenia and the need to encourage them to see dental professionals.
- | New trial: Effects of Obesity on Rectus Femoris Muscle Thickness, Sarcopenia, Gait and Balance in Women (clinicaltrials.gov) - Dec 6, 2022
P=N/A, N=1, Enrolling by invitation, Sponsor: Kutahya Health Sciences University
- | New trial: INTOMOB: An INtervention TO Improve MOBility of Older Hospitalized Patients (clinicaltrials.gov) - Dec 6, 2022
P=N/A, N=294, Not yet recruiting, Sponsor: University Hospital Inselspital, Berne
- | Journal: Association of high body mass index, waist circumference, and body fat percentage with sarcopenia in older women. (Pubmed Central) - Dec 6, 2022
However, obesity parameters including BMI, WC, and PBF were positively correlated with a lower incidence of sarcopenia only in women. Obesity in older women may have a protective effect in reducing ASMI and the incidence of sarcopenia.
- | New trial: SARCO_CARE: Fish Protein Supplementation and Sarcopenia Outcomes in Carehomes (clinicaltrials.gov) - Dec 5, 2022
P=N/A, N=184, Not yet recruiting, Sponsor: University of Ulster
- | Enrollment open: VD2O: Vegan Diets: the Short-term Effects on Daily Muscle Protein Synthesis Rates as Compared to Omnivorous Diets in Older Adults Assessed by D2O. (clinicaltrials.gov) - Dec 5, 2022
P=N/A, N=35, Recruiting, Sponsor: Wageningen University
Obesity in older women may have a protective effect in reducing ASMI and the incidence of sarcopenia. Not yet recruiting --> Recruiting
- | Journal: Diagnostic Value of Sarcopenia Computed Tomography Metrics for Elderly Patients with or without Cancers with Gastrointestinal Disorders. (Pubmed Central) - Dec 5, 2022
Not yet recruiting --> Recruiting L3SMG covers all features of sarcopenia with more diagnostic value than other metrics, allowing a complete sarcopenia assessment with CT alone and not just in populations with cancer.
- | Journal: Laparoscopic liver resection is associated with less significant muscle loss than the conventional open approach. (Pubmed Central) - Dec 5, 2022
LLR for HCC was associated with less significant muscle loss than OLR. Since significant muscle loss was a predictive factor for early tumor recurrence and associated with impaired liver metabolism, LLR may subsequently result in a more favorable outcome.
- | Journal: A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle. (Pubmed Central) - Dec 4, 2022
report on alterations in CD47 and THBS1 expression and function in aged muscle stem cells that disrupt their regeneration capacity. Targeting THBS1-CD47 cross-signaling is sufficient to reverse sarcopenia and restore muscle mass and function in aged mice.
- | Journal: Effects of a Pedometer-Based Walking Home Program Plus Resistance Training on Inflammatory Cytokines and Depression in Thai Older People with Sarcopenia: A Three-Arm Randomized Controlled Trial. (Pubmed Central) - Dec 4, 2022
Older people with sarcopenia who accumulated >7,500 steps/day, 5 days/week plus resistive elastic band twice /week show improvements in inflammation and depressive symptoms. Encourage physical activity had a positive effect on reducing inflammation and depression among older people with sarcopenia.
- | Journal: Frail patients dropping out of neoadjuvant treatment: what should we do? (Pubmed Central) - Dec 4, 2022
Even though not significant, survival rates for patients who interrupted treatment in the whole trial were lower (5-year OS completed 64.6 vs. interrupted 41.8 p 0.07). Promptness in giving patient support for gastrointestinal symptoms, careful evaluation of anemia and patient nutritional status, and psychological programs from the beginning of the oncologic treatment may improve the final results.
- | Journal: Combined assessment of muscle quality and quantity predicts oncological outcome in patients with esophageal cancer. (Pubmed Central) - Dec 4, 2022
Promptness in giving patient support for gastrointestinal symptoms, careful evaluation of anemia and patient nutritional status, and psychological programs from the beginning of the oncologic treatment may improve the final results. Combined assessment between preoperative PMI and mIMAC could stratify risk for oncological outcomes, and preoperative mIMAC might be surrogate marker for aging and nutritional status in esophageal cancer patients.
- | Journal: Chest X-ray-based opportunistic screening of sarcopenia using deep learning. (Pubmed Central) - Dec 3, 2022
Combined assessment between preoperative PMI and mIMAC could stratify risk for oncological outcomes, and preoperative mIMAC might be surrogate marker for aging and nutritional status in esophageal cancer patients. Chest X-ray-based deep leaning model improved detection of sarcopenia, which merits further investigation.
- | Preclinical, Journal, IO biomarker: MicroRNA profiling of different exercise interventions for alleviating skeletal muscle atrophy in naturally aging rats. (Pubmed Central) - Dec 3, 2022
Chest X-ray-based deep leaning model improved detection of sarcopenia, which merits further investigation. These findings are closely correlated with the progression of sarcopenia and could act as potential biomarkers for the diagnosis and interventional monitoring of aging-induced skeletal muscle atrophy.
- | Journal: The combination of phase angle and age has a good diagnostic value for sarcopenia in continuous ambulatory peritoneal dialysis patients. (Pubmed Central) - Dec 3, 2022
Phase angle can act as a predictor of sarcopenia in those patients. But the combination of age and phase angle is more valuable in diagnosing sarcopenia.
- | Preclinical, Journal: Effects of an exogenous ketone ester using multi-omics in skeletal muscle of aging C57BL/6J male mice. (Pubmed Central) - Dec 3, 2022
In conclusion, 72-week-old male mice consuming the exogenous KE, BD-AcAc, had lower age-related gains in body weight and FM compared to CON mice. Furthermore, transcriptional and proteomics data suggest a signature in skeletal muscle of KE-treated mice consistent with markers of improved skeletal muscle regeneration, improved electron transport chain utilization, and increased insulin sensitivity.
- ||| Clinical: Frequency of Sarcopenia, Sarcopenic Obesity, and Changes in Physical Function in Surgical Oncology Patients Referre… https://t.co/1AQWToA7Hy (Twitter) - Dec 3, 2022
- | Journal: Risk of Malnutrition and Insufficient Protein Intake among Older People Living at Home: Baseline Findings of the Power Meals Study. (Pubmed Central) - Dec 3, 2022
In conclusion, a third of older people living at home were at risk of malnutrition or malnourished. Multiple physical, psychological and social factors in older adults were associated with nutritional status and protein intake.
- | Journal: Screening of osteoporosis and sarcopenia in individuals aged 50 years and older at different altitudes in Yunnan province: Protocol of a longitudinal cohort study. (Pubmed Central) - Dec 2, 2022
Results will be disseminated through scientific conferences and peer-reviewed publications, as well as meetings with stakeholders. http://www.chictr.org.cn/index.aspx, identifier ChiCTR2100052153.
- || Sarcopenia and sarcopenic obesity in oncology and beyond! So many great talks @UNCGeriOnc @ShacharMD @chefaleixomd @corp_UNC (Twitter) - Dec 2, 2022
- | Journal: Nutritional assessment and intervention in hospitalized cancer patients at risk of or with malnutrition: evaluation of the effect on anthropometric and body composition parameters (Pubmed Central) - Dec 2, 2022
http://www.chictr.org.cn/index.aspx, identifier ChiCTR2100052153. the implementation of a protocol for assessment and nutritional support at admission in cancer patients may help prevent or delay the worsening of their nutritional status during hospital stay.
- | Journal: Association between premorbid sarcopenia and neurological deterioration in patients with acute ischemic stroke. (Pubmed Central) - Dec 2, 2022
Premorbid sarcopenia is independently associated with ND in patients with acute ischemic stroke. Therefore, it is necessary to detect premorbid sarcopenia to predict ND in these patients.
- | Journal: TIPS placement as the first-line therapy to prevent variceal rebleeding in patients with cirrhosis and sarcopenia. (Pubmed Central) - Dec 2, 2022
Therefore, it is necessary to detect premorbid sarcopenia to predict ND in these patients. For patients treated with TIPS as the first-line treatment for prevention of rebleeding, baseline sarcopenia did not increase the risk of post-TIPS mortality and overt HE.
- | Preclinical, Journal: The roles of sclerostin and irisin on bone and muscle of orchiectomized rats. (Pubmed Central) - Dec 2, 2022
Reduced BMD, impaired bone microarchitecture, weak strength of bone and muscle, and thin myofibers were induced by androgen deficiency of ORX rats. Serum sclerostin and irisin levels were significantly changed after ORX, which might be closely correlated with the occurrence of osteoporosis and sarcopenia in ORX rats.
- | Journal: Lower body muscle strength, dynapenic obesity and risk of type 2 diabetes -longitudinal results on the chair-stand test from the Survey of Health, Ageing and Retirement in Europe (SHARE). (Pubmed Central) - Dec 2, 2022
Poor results in the CST-5 were associated with an increased risk of diabetes. Among obese persons, the risk of diabetes was not modified by results of the CST-5.
- | Journal: Is pectoralis muscle index a risk factor for mortality in left ventricular assist device patients? (Pubmed Central) - Dec 1, 2022
Among obese persons, the risk of diabetes was not modified by results of the CST-5. Sarcopenia defined by low pectoralis muscle index increases the risk for 2-year mortality in left ventricular assist device patients.
- || Biomarker, Retrospective data, Review, Journal: Sarcopenia as a predictor of outcome after transcatheter aortic valve implantation: protocol for systematic review and meta-analysis. (Pubmed Central) - Dec 1, 2022
The results will be disseminated in a peer-reviewed journal. CRD42022349525.
- | bardoxolone methyl (RTA 402) / Kyowa Kirin, Reata
Journal: Oxidized Albumin: Evaluation of Oxidative Stress as a Marker for the Progression of Kidney Disease. (Pubmed Central) - Dec 1, 2022
Bardoxolone methyl, a nuclear factor-erythroid 2-related factor 2 (Nrf2) activator with anti-oxidative and inflammatory modulation effects, has been reported to improve renal function in clinical trials...Oxidized albumin is not only a marker for kidney disease but also a nephrotoxic substance. This suggests that measuring the levels of oxidized albumin could be a biomarker for diagnosing the progression of and complications associated with renal disease in addition to evaluating the efficacy of therapeutic drugs.
- | Journal: Muscle Strength, but Not Muscle Mass, Is Associated with Left Ventricular Diastolic Function during Aging in Chinese. (Pubmed Central) - Dec 1, 2022
No significant correlation was observed between RASM, grip strength and left ventricular mass, left ventricular ejection fraction or left ventricular fractional shortening. Higher grip strength is independently associated with better left ventricular diastolic function in Chinese during aging.
- |||| Clinical: Thank you @JournalCancer for publishing our interesting article on the impact of sarcopenia on patients with MM. This would not have been possible without the support of my mentors Dr. Wilson Gonsalves and @myelomaMD at @MayoClinic (Twitter) - Nov 30, 2022
- || Retrospective data, Review, Journal: Deciphering the "obesity paradox" in the elderly: A systematic review and meta-analysis of sarcopenic obesity. (Pubmed Central) - Nov 30, 2022
Apart from unifying the diagnosis of SO, more research is needed to subphenotype people with obesity and sarcopenia for individualized treatment. Meanwhile, the maintenance of proper body composition of muscle and fat may delay or attenuate the adverse outcomes of aging.
- | Journal: Sarcopenia and echocardiographic parameters for prediction of cardiovascular events and mortality in patients undergoing maintenance hemodialysis. (Pubmed Central) - Nov 30, 2022
Sarcopenia was a significant predictor of CVE (HR, 10.96; 95% CI [1.14-105.10]; P = 0.038). Our findings demonstrated that sarcopenia is associated with LVDD and LVH, and is associated with a higher probability of death and CVE.
- | Observational data, Journal: Impact of osteoporosis on physical performance parameters of middle-aged and elderly individuals-a cross-sectional study (Pubmed Central) - Nov 30, 2022
In a subgroup of OP patients with VFs, there is a close relationship between bone and muscle with an increasing deterioration of the musculoskeletal system. For prophylaxis of osteosarcopenia, early training seems reasonable.
- || Review, Journal: Prevention of post-tips hepatic encephalopathy: The search of the ideal candidate. (Pubmed Central) - Nov 30, 2022
However, the shunt of the portal blood into the systemic circulation is the cause of one of the major complications of the procedure: the post-TIPS hepatic encephalopathy (HE). To date, few pharmacological treatment has been proven effective to prevent this complication and thus, the identification of patients at high risk of post-TIPS hepatic encephalopathy and the patients' carefully selection is the only way to prevent this frequent complication.
- | Journal: Defining terms commonly used in sarcopenia research: a glossary proposed by the Global Leadership in Sarcopenia (GLIS) Steering Committee. (Pubmed Central) - Nov 30, 2022
Our goal is to promote this common language to describe sarcopenia and its components in clinical and research settings in order to increase clinical awareness and research interest in this important condition. We hope that the use of common terminology in sarcopenia research will increase understanding of the concept and improve communication around this important age-related condition.