Sarcopenia
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  • ||||||||||  Journal:  p21 induces a senescence program and skeletal muscle dysfunction. (Pubmed Central) -  Dec 13, 2022   
    Furthermore, p21OE mice exhibit manifestations of skeletal muscle pathology, such as atrophy, fibrosis, and impaired physical function when compared to age-matched controls. These findings suggest p21 alone is sufficient to drive a cellular senescence program and reveal a novel source of skeletal muscle loss and dysfunction.
  • ||||||||||  Journal:  Irisin ameliorates age-associated sarcopenia and metabolic dysfunction. (Pubmed Central) -  Dec 13, 2022   
    The present noninvasive and easy-to-use measurement and analysis method for detecting sarcopenia-induced changes in the arterial pulse transmission condition could aid the discrimination of possible sarcopenia. Together, this study revealed the importance of irisin in the maintenance of muscle physiology and systematic energy homeostasis during ageing and suggested a potent therapeutic strategy against age-associated metabolic diseases via irisin administration.
  • ||||||||||  Journal:  What Exactly Makes Age a Risk Factor for an Unfavorable Outcome after Mitral Valve Surgery? (Pubmed Central) -  Dec 12, 2022   
    It appears that elderly patients with advanced renal failure have a significantly higher risk of mortality, postoperative renal failure, need for dialysis, and possibly the development of pleural and pericardial effusions in mitral valve surgery. In addition, more frequent CIP/CIM with concomitant decrease in BMI in the most advanced age group indicate sarcopenia and thus an additional feature of frailty besides renal failure.
  • ||||||||||  ONX 0914 / Protalex
    Preclinical, Journal:  Immunoproteasome Inhibition Ameliorates Aged Dystrophic Mouse Muscle Environment. (Pubmed Central) -  Dec 12, 2022   
    These changes ultimately lead to a marked decrease of fibrosis and, potentially, to more controlled myofiber degeneration/regeneration cycles. Therefore, ONX-0914 is a promising molecule that may slow down muscle mass loss, with relatively low side effects, in dystrophic patients with moderate to advanced disease.
  • ||||||||||  Review, Journal:  MicroRNAs as the Sentinels of Redox and Hypertrophic Signalling. (Pubmed Central) -  Dec 12, 2022   
    We propose a hypothetical model of endurance exercise-induced microRNA "memory cloud" responsible for establishing a landscape conducive to aerobic as well as anabolic adaptation. We suggest that regular aerobic exercise, complimented by a healthy diet, in addition to promoting mitochondrial health and hypertrophic/insulin sensitivity, may also suppress the glycolytic phenotype and mTOR signalling through miRNAs which in turn promote systemic metabolic health.
  • ||||||||||  Review, Journal:  Inflammaging: Implications in Sarcopenia. (Pubmed Central) -  Dec 12, 2022   
    The use of melatonin, an antioxidant, ROS scavenger and immune and autophagy modulator, or senotherapeutic compounds targeting senescent cells could represent strategies to counteract inflammation. This review aims to present the many factors regulating skeletal muscle inflammaging and their major implications in order to understand the molecular mechanisms involved in sarcopenia.
  • ||||||||||  Preclinical, Review, Journal:  Zebrafish Models for Skeletal Muscle Senescence: Lessons from Cell Cultures and Rodent Models. (Pubmed Central) -  Dec 12, 2022   
    In rodents, several models have been reported that reflect the skeletal muscle aging phenotype or parts of it, including the accelerated aging models. Although there are fewer models of skeletal muscle aging in zebrafish than in mice, various models have been reported in recent years with the development of CRISPR/Cas9 technology, and further advancements in the field using zebrafish models are expected in the future.
  • ||||||||||  Journal:  Promoting Protein Intake in an Ageing Population: Product Design Implications for Protein Fortification. (Pubmed Central) -  Dec 12, 2022   
    Older adults are typically not consuming protein-fortified products; therefore, more importance should be placed on the consumption moment (breakfast or as snacks between meals) and on cereals, pasta, porridge, cakes, and biscuits. Older adults need increased awareness of, and more education on, the benefits of protein consumption, coupled with products tailored and designed to encourage intake.
  • ||||||||||  Journal:  Causal effects of homocysteine levels on the components of sarcopenia: A two-sample mendelian randomization study. (Pubmed Central) -  Dec 10, 2022   
    However, there were no significant associations of decreased plasma Hcy levels with grip strength (right: effect = 0.005, SE = 0.021, p = 0.82; left: effect = -0.006, SE = 0.014, p = 0.64), walking pace (effect = 0.01, 0.020, p = 0.61), or ALM (effect = -0.034, SE = 0.018, p = 0.06).The accuracy and robustness of these findings were confirmed by sensitivity tests. Increased circulating Hcy levels were associated with lower grip strength, slower walking pace, and decreased ALM.
  • ||||||||||  Biomarker, Review, Journal:  Anorexia of Aging: Metabolic Changes and Biomarker Discovery. (Pubmed Central) -  Dec 10, 2022   
    Here, we provide an overview on anorexia of aging in the context of age-related metabolic changes. A special focus is placed on candidate biomarkers that may be used to assist in the early identification of anorexia of aging and in the development of personalized nutritional counseling.
  • ||||||||||  Journal:  Respiratory sarcopenia: A position paper by four professional organizations. (Pubmed Central) -  Dec 9, 2022   
    It was jointly prepared by the representative authors and authorized by the Japanese Society for Respiratory Care and Rehabilitation, Japanese Association on Sarcopenia and Frailty, Japanese Society of Respiratory Physical Therapy and Japanese Association of Rehabilitation Nutrition. Geriatr Gerontol Int ••; ••: ••-•• Geriatr Gerontol Int 2022; ••: ••-••.
  • ||||||||||  goserelin acetate / Generic mfg.
    Trial completion date, Trial primary completion date:  Intramuscular Mechanisms of Androgen Deprivation-related Sarcopenia (clinicaltrials.gov) -  Dec 9, 2022   
    P=N/A,  N=60, Recruiting, 
    Geriatr Gerontol Int ••; ••: ••-•• Geriatr Gerontol Int 2022; ••: ••-••. Trial completion date: Aug 2022 --> Aug 2023 | Trial primary completion date: Aug 2022 --> Aug 2023
  • ||||||||||  Journal:  Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis. (Pubmed Central) -  Dec 7, 2022   
    Additionally, liver fibrosis was independently associated with sarcopenic obesity status (OR 4.69, 95% CI 1.95 to 11.29; OR 4.17, 95% CI 1.56 to 11.17; OR 3.80, 95% CI 0.86 to 16.75, respectively). These results demonstrated that sarcopenic obesity was independently associated with NAFLD and liver fibrosis and increased the risk of NAFLD and liver fibrosis more than obesity or sarcopenia alone.
  • ||||||||||  Teysuno (gimeracil/oteracil/tegafur) / Nordic Group, Otsuka
    Journal:  Negative prognostic impact of sarcopenia before and after neoadjuvant chemotherapy for pancreatic cancer. (Pubmed Central) -  Dec 7, 2022   
    Despite the similarity and shared criteria used for the identification of malnutrition, frailty and sarcopenia there is still a lack of cohesive thinking around the overlap of applied definitions and identification criteria. Sarcopenia before and after NAC for PC is suggested to be a poor prognostic factor, with a stronger impact before than after NAC.
  • ||||||||||  Review, Journal:  Acute Sarcopenia after Elective and Emergency Surgery. (Pubmed Central) -  Dec 6, 2022   
    The gaps in research found include the need for longitudinal studies looking in changes in muscle strength and quantity following surgery. Further work is needed to examine if biomarkers are replicated in other surgery to consolidate existing theories on the pathophysiology of muscle wasting.