Sarcopenia
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  • ||||||||||  Preclinical, Journal:  Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice. (Pubmed Central) -  Dec 18, 2022   
    Mechanistically, structural modification of the NMJ is attributed to increased satellite cell activation and enhanced post-synaptic acetylcholine receptor (AChR) turnover upon 4EBP1 activation. Considering that loss of post-synaptic myonuclei and reduced NMJ turnover are features of aging, targeting 4EBP1 activation could induce NMJ renewal by expanding the pool of post-synaptic myonuclei as an alternative intervention to mitigate sarcopenia.
  • ||||||||||  Skeletal Muscle and Body Fat Mass: Are They the Culprit for Worse HCC Outcome? (1F Room 102) -  Dec 18, 2022 - Abstract #APASL2023APASL_256;    
    For unresectable HCC patients scheduled to receive TACE, the extent to which sarcopenia would affect the survival would be explored. Lastly, the metabolic alterations associated with sarcopenia/adiposity in HCC would be unveiled by metabolomic analysis.
  • ||||||||||  Sarcopenia in Hepatocellular Carcinoma (1F Room 102) -  Dec 18, 2022 - Abstract #APASL2023APASL_246;    
    It is not only associated with an increased risk of complications (hepatic encephalopathy and infection), hospitalization, higher healthcare costs, mortality, and poor survival in patients with HCC, and it is also a negative predictor of various HCC treatments. Furthermore, as well-preserved liver function is crucial to facilitate curative therapy and determines the sequential application of second-line systemic treatments for patients with HCC, the general assessment of the functional and nutritional status, such as sarcopenia, of patients have become an essential and key in the treatment of patients with HCC.
  • ||||||||||  Sarcopenia and Liver Fibrosis in Chronic Liver Diseases (1F Room 102) -  Dec 18, 2022 - Abstract #APASL2023APASL_245;    
    In the light of these results, we can conclude that there is a strong association between sarcopenia and NAFLD-related fibrosis. However, further longitudinal studies are needed to establish a direct causal relationship between both entities.
  • ||||||||||  Nutrition in Liver Cirrhosis: With a Focus on Critically I (1F Room 102) -  Dec 18, 2022 - Abstract #APASL2023APASL_201;    
    EASL and ESPEN guidelines recommend BCAA (0.25g/kg/d) in patients who can not achieve protein goals or are unable to tolerate protein, although further validation is needed. Until further data specific for liver cirrhosis with septic shock are available, nutrition intervention should be implemented in this clinical setting according to current guidelines for non-cirrhotic patients.
  • ||||||||||  Crucial Pathways for Progression of MAFLD/NASH Phenotypes (2F Room 201ABC) -  Dec 18, 2022 - Abstract #APASL2023APASL_72;    
    Lipotoxic stress, proinflammatory cytokines and chemokines, and the gut microbiome promote liver sinusoidal endothelial cell (LSEC), release of proinflammatory cytokines and chemokines and enhance the expression of adhesion molecules in NASH. In addition to liver disease progression, the increased incidence of CKD, HF and sarcopenia in NASH patients should be carefully evaluated in clinical practices.
  • ||||||||||  Clinical, Journal:  Relationship between food insecurity and geriatric syndromes in older adults: A multicenter study in Turkey. (Pubmed Central) -  Dec 16, 2022   
    While food insecurity is not associated with pre-frailty/frailty and sarcopenia risk, moderate and severe food insecurity is a modifiable risk factor for malnutrition risk and malnutrition. Thus, economic and social policies to eliminate food insecurity should be implemented, and efforts to prevent food insecurity should be planned through inter-sectoral cooperation.
  • ||||||||||  Retrospective data, Review, Journal:  Diagnostic test accuracy of ultrasound for sarcopenia diagnosis: A systematic review and meta-analysis. (Pubmed Central) -  Dec 16, 2022   
    Muscle ultrasound shows a low-to-moderate diagnostic test accuracy for sarcopenia diagnosis depending on different ultrasound parameters, measured muscles, reference standards and study populations. The combination of muscle quality indicators (e.g., EI) and muscle quantity indicators (e.g., MT) might provide better diagnostic test accuracy.
  • ||||||||||  Observational data, Journal:  Development of a nutritional risk screening tool for cancer patients undergoing outpatient treatment. (Pubmed Central) -  Dec 16, 2022   
    Given that abnormal body composition phenotypes detectable only via CT are associated with reduced survival, these should be more widely employed to identify patients at risk of poor prognosis, and allow potentially more effective, early intervention. The screening instrument developed in this study resulted in an equation for screening nutritional risk, which included the variables KPS and BMI with 84% assertiveness.
  • ||||||||||  Review, Journal:  The concept of aggressive nutrition therapy and clinical indication: A position paper. (Pubmed Central) -  Dec 16, 2022   
    A nutrition plan with the amount of energy accumulated should also be a vital issue. This position paper was authored by the Registered Dietitian Subcommittee of the Japanese Association of Rehabilitation Nutrition and was approved by the Japanese Association of Rehabilitation Nutrition.
  • ||||||||||  Journal:  MUSCLE DEPLETED OBESITY IN INDIVIDUALS SCREENED FOR COLORECTAL CÂNCER. (Pubmed Central) -  Dec 16, 2022   
    In this context, evidence shows the need to assess muscle composition in people with obesity, especially through other methods of assessing body composition. Our results add to the evidence on the importance of the population being guided about screening and adherence to healthy lifestyle recommendations, especially strategies aimed at weight control and the practice of physical activity.
  • ||||||||||  Journal:  Nutraceuticals and their role in promoting musculoskeletal healthy aging. (Pubmed Central) -  Dec 16, 2022   
    This paper highlights the key nutrients and phytochemicals of nutraceutical importance for the healthy aging of the elderly population. Although the scientific literature provides evidences of therapeutic effectiveness of nutraceuticals, more in-depth clinical investigations are needed.
  • ||||||||||  Biomarker, Journal:  Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence. (Pubmed Central) -  Dec 16, 2022   
    We also identified a small population of nuclei that express CDKN1A, present only in aged samples, consistent with p21-driven senescence in this subpopulation. Overall, our findings identify unique cellular subpopulations in aged and sarcopenic skeletal muscle, which will facilitate the development of new therapeutic strategies to combat age-related frailty.
  • ||||||||||  Review, Journal:  The inflammatory response, a mixed blessing for muscle homeostasis and plasticity. (Pubmed Central) -  Dec 13, 2022   
    We also summarize current perspectives suggesting that the inflammatory process in muscle homeostasis and repair is a double-edged sword. Lastly, we review recent therapeutic approaches for treating muscle wasting disorders, with a focus on the RANK/RANKL/OPG pathway and its involvement in muscle inflammation, protection and regeneration processes.
  • ||||||||||  Review, Journal:  Assessing the Effects of Dietary Protein Supplementation on Sarcopenia in Community-Dwelling Older Adults. (Pubmed Central) -  Dec 13, 2022   
    Greater dietary animal-based and soy-based protein diets can improve muscle mass in older adults. In conclusion, protein supplementation can improve muscle mass and reduce the risk of sarcopenia in sarcopenia and pre-frail older adults, while future studies should continue to investigate the effects of protein supplementation on indicators of sarcopenia in healthy older adults.