Sarcopenia
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  • ||||||||||  Journal:  Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1-Arih2 axis. (Pubmed Central) -  Dec 24, 2022   
    Flexibility exercises and monitoring the dynamic change of flexibility might be helpful in preventing sarcopenia among adults aged 50 years or over. The comprehensive results show that PDHB plays a sarcoprotective role by suppressing the FoxP1-Arih2 axis and may serve as a therapeutic target in sarcopenia.
  • ||||||||||  Journal:  Prevalence and associated factors of sarcopenia in community-dwelling older adults at risk of malnutrition. (Pubmed Central) -  Dec 24, 2022   
    P=N/A
    In community-dwelling older adults at risk of malnutrition, there is a high prevalence of sarcopenia and severe sarcopenia. As such, screening positive for either malnutrition risk or sarcopenia in older adults should prompt screening for the other risk factor, to allow early institution of disease modifying interventions to forestall adverse outcomes for both malnutrition and sarcopenia.
  • ||||||||||  Journal, Metastases:  Deep learning-based assessment of body composition and liver tumour burden for survival modelling in advanced colorectal cancer. (Pubmed Central) -  Dec 23, 2022   
    As such, screening positive for either malnutrition risk or sarcopenia in older adults should prompt screening for the other risk factor, to allow early institution of disease modifying interventions to forestall adverse outcomes for both malnutrition and sarcopenia. Automated segmentation enables to extract prognostic parameters from routine imaging data for personalized survival modelling in advanced colorectal cancer patients.
  • ||||||||||  Review, Journal:  Research progress on the correlation between sarcopenia and osteoarthritis (Pubmed Central) -  Dec 23, 2022   
    Clinical studies show that sarcopenia can affect the rehabilitation effect and increase the risk of postoperative complications after total joint arthroplasty in many ways. Current research results show that sarcopenia and OA are related and can be mutually affected in the above 5 aspects, but more studies are needed to further clarify the relationship between them, so as to provide more theoretical basis for the understanding, prevention, diagnosis, and treatments of the two diseases.
  • ||||||||||  Journal:  Malnutrition management of hospitalized patients with diabetes/hyperglycemia and sarcopenia (Pubmed Central) -  Dec 23, 2022   
    Both sarcopenia and malnutrition are conditions amenable to intervention to improve clinical prognosis. This document describes the results of the expert consensus and the responses of the panelists on the nutritional management in routine clinical practice of patients with diabetes/hyperglycemia hospitalized (non-critically ill) with sarcopenia.
  • ||||||||||  Journal:  Malnutrition management of hospitalized patients with diabetes/hyperglycemia and hip fracture (Pubmed Central) -  Dec 23, 2022   
    The prevalence of malnutrition in patients with hip fracture is also high, due to their advanced age, and the acute injury itself provokes catabolic and inflammatory responses that result in disease-related malnutrition and sarcopenia, which aggravates the patient's clinical condition. This document describes the results of the expert consensus and the responses of the panelists on the nutritional management in routine clinical practice of patients with diabetes/hyperglycemia hospitalized (non-critically ill) with hip fracture.
  • ||||||||||  FEASIBILITY OF A NURSE AND DIETITIAN-LED IBD SURGICAL PREHABILITATION PROGRAM (Exhibit/Poster Hall (Aurora Halls 1/2) - Gaylord Resort) -  Dec 23, 2022 - Abstract #CCCongress2023CCCongress_365;    
    We hypothesize that low compliance with post-operative IN was due to formula not being available for inpatients at our facility; the impact of IN on post-operative outcomes should be evaluated in future studies. Further evaluation of outcomes associated with structured, multidisciplinary prehabilitation in IBD relative to usual care is warranted.
  • ||||||||||  miglustat / Generic mfg.
    Journal:  Nutritional Management In Late Onset Tay-Sachs Disease: A Case Report. (Pubmed Central) -  Dec 23, 2022   
    The treatment for such disorders commonly includes the use of miglustat, a medication that may cause several side effects (e.g., diarrhea and weight loss) that can contribute to the development of malnutrition...In response to the nutrition intervention, the patient progressed with diarrhea cessation, weight recovery, and improvement in physical function measured by the dynamometer. As patients undergoing treatment for Tay-Sachs disease quickly progress to malnutrition, and given the lack of guidelines to inform healthcare providers on nutritional recommendations for this cohort, the description of a case that had positive progression may inform healthcare providers and help to initiate a discussion on the need to conduct research in this field for the development of therapeutic protocols and nutrition recommendations.
  • ||||||||||  Journal:  The value of dietary plant protein in older people. (Pubmed Central) -  Dec 22, 2022   
    Recent literature highlights several health benefits associated with increased consumption of vegetable foods. However, their efficiency on postprandial muscle protein synthesis remains to be evaluated and long-term studies are needed.
  • ||||||||||  Clinical, Journal:  Sarcopenia, biological age and treatment eligibility in patients with cancer. (Pubmed Central) -  Dec 22, 2022   
    However, their efficiency on postprandial muscle protein synthesis remains to be evaluated and long-term studies are needed. Integration of sarcopenia measures within scores of allostatic load may further increase the clinical relevance of changes of body composition, highlight its sensitivity to early nutritional intervention leading to mitigation of accelerated ageing, and contribute to wide delivery of precision oncology.
  • ||||||||||  Trial completion date, Trial primary completion date:  M&M: Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer (clinicaltrials.gov) -  Dec 22, 2022   
    P=N/A,  N=300, Recruiting, 
    The overall accuracy of CC was better than SARC-Calf for sarcopenia screening. Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  Journal:  Sarcopenia-related gut microbial changes are associated with the risk of complications in people with cirrhosis. (Pubmed Central) -  Dec 21, 2022   
    Those with a sarcopenia-related poor microbial signature, in which Ruminococcus 2 and Anaerostipes were both depleted, had significantly more infectious and non-infectious complications, as well as more hospitalizations. These findings highlight the therapeutic potential of modifying the gut microbiota of individuals with sarcopenic cirrhosis to improve their clinical outcomes.
  • ||||||||||  Review, Journal:  Muscle ultrasound and its application to point-of-care ultrasonography: a narrative review. (Pubmed Central) -  Dec 21, 2022   
    Recommended methods for muscle ultrasound was published recently, and the results of future studies are expected to be comparable. Although several challenging issues with muscle ultrasound remain, if it could be incorporated into educational programmes such as POCUS training, more clinicians may be able to use ultrasound for skeletal muscle assessment in the future.KEY MESSAGESThe evolution of hand-held ultrasound devices enables physicians to perform ultrasound at the bedside as part of regular medical examinations.Muscle ultrasound is considered an effective tool for evaluating muscle size and quality, and has been studied in various settings.More clinicians may be able to evaluate skeletal muscle assessment with the development of educational programmes on muscle ultrasound in the future.
  • ||||||||||  Journal:  Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway. (Pubmed Central) -  Dec 21, 2022   
    Mechanistically, irisin or FNDC5 overexpression attenuated D-gal-induced senescence, redox imbalance, and fibrosis by regulating the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Overall, irisin might be a promising therapeutic candidate for age-related skeletal muscle fibrosis.
  • ||||||||||  Journal:  Global trends and hotspots in research on osteoporosis rehabilitation: A bibliometric study and visualization analysis. (Pubmed Central) -  Dec 20, 2022   
    At present, "physical activity," "weight bearing exercise," "muscle strength," "whole body vibration," "postmenopausal women," "older women," children, men are the noteworthy research hot topics. Future research that focus on the major modes and parameters of physical activity/exercise for osteoporosis (including whole body vibration, weight bearing exercises, resistance training), targeted multicomponent training regimens, rehabilitation therapy for postmenopausal women, older women, children and men, osteoporosis related-sarcopenia and fractures, and mesenchymal stem cells are becoming frontiers and focus on the health topics related to osteoporosis rehabilitation in the upcoming years, which are worthy of further exploration.
  • ||||||||||  methotrexate / Generic mfg.
    Review, Journal:  Time to Deal with Rheumatoid Cachexia: Prevalence, Diagnostic Criteria, Treatment Effects and Evidence for Management. (Pubmed Central) -  Dec 20, 2022   
    The use of corticosteroids and tumour necrosis factor α (TNF-α) inhibitors tend to increase fat accumulation, whereas other disease-modifying antirheumatic drugs (DMARDs) appear to induce increments in fat-free mass. The present review presents all information regarding the prevalence of RC, diagnostic criteria, and comorbidities, as well as the effects of pharmacotherapy and medical nutrition therapy on body composition of patients with RA.
  • ||||||||||  Journal:  A nomogram for screening sarcopenia in Chinese type 2 diabetes mellitus patients. (Pubmed Central) -  Dec 20, 2022   
    Age, sex, BMI, WHR, and heart rate were used to detect sarcopenia in patients with type 2 diabetes mellitus. The novel screening model is an accurate, easy-to-implement and low-cost tool for early identification of sarcopenia in Chinese patients with type 2 diabetes mellitus.
  • ||||||||||  Trial completion:  How COVID-19 Effects to Muscle Mass Change ?n ICU? (clinicaltrials.gov) -  Dec 20, 2022   
    P=N/A,  N=25, Completed, 
    Recruiting --> Active, not recruiting | N=48 --> 30 Active, not recruiting --> Completed