Sarcopenia
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  • ||||||||||  Journal:  Mood and physical activity are associated with appetite in hospitalised older men and women. (Pubmed Central) -  Dec 30, 2022   
    In this group of older adults, better mood and higher habitual physical activity were independently associated with better appetite during hospital admission. These are potentially modifiable factors and could be targets for future research into interventions for the anorexia of ageing in the hospitalised older population.
  • ||||||||||  Journal:  Sarcopenia and menopause. (Pubmed Central) -  Dec 28, 2022   
    Further study is needed to determine the association between sarcopenia and ZFYVE27 known to be associated with spastic paraplegia. No abstract available
  • ||||||||||  Review, Journal:  Lipotoxicity-related sarcopenia: a review. (Pubmed Central) -  Dec 27, 2022   
    This suggests that appropriate lipotoxicity management should be considered the primary target for the prevention and/or treatment of chronic musculoskeletal and other aging-related disorders. Further advanced research is needed to understand the molecular details of lipotoxicity and its consequences for sarcopenia and sarcopenia-related comorbidities.
  • ||||||||||  Retrospective data, Journal:  Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study. (Pubmed Central) -  Dec 27, 2022   
    The donor SMI had no effect on the occurrence of SFSG syndrome and graft survival, while a high IMAC in both male and female donors was significantly correlated with the rate of SFSG syndrome [high vs low: (male donors) 15.8% vs. 2.5%, p = 0.0003; (female donors) 12.8% vs. 3.1%, p = 0.0234] and 6-month graft survival rates [(male donors) 87.7% vs 95.9%, p = 0.02; (female donors) 83.0% vs. 99.0%, p < 0.0001]. Multivariate analysis revealed that a high donor IMAC (HR; 5.42, CI; 2.13-13.8, p = 0.0004) was an independent risk factor for 6-month graft survival, and the donor IMAC is useful for donor selection for high-risk recipients.
  • ||||||||||  Review, Journal, Surgery:  Imaging based body composition profiling and outcomes after oncologic liver surgery. (Pubmed Central) -  Dec 27, 2022   
    Interest has recently grown in studying the effect of sarcopenic obesity, central obesity, or visceral fat amount, myosteatosis, and bone mineral density on -such patients. The objective of this review is to summarize the current evidence on whether imaging-based parameters of body composition have an impact on the outcome of patients undergoing liver surgery for each of the most frequent indications for liver resection in clinical practice: hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and colorectal liver metastases (CRLM).
  • ||||||||||  Review, Journal:  Uremic Sarcopenia. (Pubmed Central) -  Dec 27, 2022   
    Though some of these techniques have had beneficial results in animal experiments, human trials are still sparse. This review article relates to recent publications that describe the abnormalities in skeletal muscle that primarily leads to muscle wasting and its consequences in patients with CKD.
  • ||||||||||  Journal:  Calf circumference has a positive correlation with physical performance among community-dwelling middle-aged, older women. (Pubmed Central) -  Dec 27, 2022   
    On multivariate logistic regression, after adjusting for age, appendicular skeletal mass index, body mass index, exercise habits, income levels, and CC were positively correlated with physical performance as measured by both gait speed (β = 0.15, p = 0.01) and hand grip strength (β = 0.25, p < 0.001) in women, compared to only hand grip strength (β = 0.41, p < 0.001) in men. Lower calf circumference is an independent risk factor for poor physical performance, especially among women.
  • ||||||||||  Review, Journal:  Sarcopenia in pancreatic cancer: Effect on patient outcomes. (Pubmed Central) -  Dec 27, 2022   
    Theoretically, multimodal interventions may improve sarcopenia and clinical outcomes; however, no study has reported positive results. Further prospective studies are needed to confirm the prognostic role of sarcopenia and the effects of multimodal interventions in patients with pancreatic cancer.
  • ||||||||||  Trial primary completion date:  Sarcopenia and Outcomes of Neuroplasty in Lumbar Spinal Stenosis (clinicaltrials.gov) -  Dec 27, 2022   
    P=N/A,  N=79, Active, not recruiting, 
    our present trial demonstrated that a 6-month fish oil-derived n-3 PUFA supplementation could beneficially affect the body composition, muscle strength, physical performance and serum lipid profiles in older people, which could be into considerations when making strategies aiming to the primary prevention of sarcopenia. Trial primary completion date: Oct 2022 --> Apr 2023
  • ||||||||||  Prolia (denosumab) / Amgen, Daiichi Sankyo
    New P4 trial:  MITO: Muscle Impact of Treating Osteoporosis (clinicaltrials.gov) -  Dec 27, 2022   
    P4,  N=40, Not yet recruiting, 
  • ||||||||||  Review, Journal:  Prevalence of Sarcopenia in Heart Failure: A Systematic Review. (Pubmed Central) -  Dec 26, 2022   
    This review aims to summarize these mechanisms as well as potential therapeutic targets, independently of liver disease etiology. Sarcopenia is highly prevalent among those with HF (irrespective of type of HF) and is more commonly seen in males compared to females.
  • ||||||||||  Journal:  Impact of volume status on sarcopenia in non-dialysis chronic kidney disease patients. (Pubmed Central) -  Dec 25, 2022   
    However, considering the limitations of our study such as its small sample size, this association was not strong. Further studies that include volume-independent measurements, data on physical activity and diet, and a larger number of patients are warranted to overcome these limitations.
  • ||||||||||  Observational data, Journal:  Nutritional Status and Sarcopenia in Nursing Home Residents: A Cross-Sectional Study. (Pubmed Central) -  Dec 24, 2022   
    Age, number of children, sarcopenia, food intake, self-care status, dietary diversity and body composition were associated with malnutrition among nursing home residents. For vulnerable groups, researchers should focus on raising the body composition indicators, such as BMI, protein, BFM, SMI and TBW and measuring CC and UAC for initial screening.
  • ||||||||||  Journal:  Factors Associated with Dual-Fluency Walk Speed Improvement after Rehabilitation in Older Patients. (Pubmed Central) -  Dec 24, 2022   
    In multivariate analysis, the following factors were associated with an increase in dual-task walk speed: IADL (OR 2.50, 95% CI [1.26; 4.94], p = 0.009), vitamin D level (OR 0.83, 95% CI [0.72; 0.95], p = 0.008), severe sarcopenia (OR 0.00, 95% CI [0.00; 0.32], p = 0.016), depression (OR 15.85, 95% CI [1.32; 190.40], p = 0.029), number of drugs (OR 1.41, 95% CI [1.04; 1.92], p = 0.027), initial dual-fluency walk speed (OR 0.92, 95% CI [0.86; 0.98], p = 0.014) and time interval between initial and final assessments (OR 0.98, 95% CI [0.96; 1.00], p = 0.06). Identifying patients that are less resilient to rehabilitation may promote a centered-patient approach for an individualized and optimized rehabilitation care.
  • ||||||||||  Review, Journal:  Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults? (Pubmed Central) -  Dec 24, 2022   
    For instance, decades of studies in the field have demonstrated that in the older people, the clinical picture of sarcopenia remarkably overlaps (from a clinical and biological point of view) with that of frailty, primarily when referred to the physical function domain. Based on this premise, here we provide a deeper understanding of the biological mechanisms of sarcopenia and frailty, which in aging are often considered together, and how these converge with those observed in astronauts after space flight.
  • ||||||||||  Preclinical, Journal:  Cancer Cachexia and Dysregulated Phosphate Metabolism: Insights from Mutant p53 and Mutant Klotho Mouse Models. (Pubmed Central) -  Dec 24, 2022   
    Moreover, the hypothetical protection against phosphate toxicity afforded by tumorigenesis also provides an alternate explanation for putative tumor evasion of the immune system. Insights proposed in this perspective paper provide new directions for further research, with potential to develop novel interventions and clinical applications that modify dietary phosphate intake to reduce cachexia in cancer patients.
  • ||||||||||  Journal:  Association between Sarcopenia and Nutritional Status in Chilean Older People Aged 65 Years and Older. (Pubmed Central) -  Dec 24, 2022   
    Sarcopenia, as defined by the criteria of the EWGSOP2, depends on the nutritional status according to BMI in older people, with obese individuals being at greater risk of suffering from sarcopenia. Nearly 50% had probable sarcopenia, a condition that could be detected early with the purpose of taking preventive measures, such a nutritional approach.
  • ||||||||||  Journal:  The Risk of Sarcopenia among Adults with Normal-Weight Obesity in a Nutritional Management Setting. (Pubmed Central) -  Dec 24, 2022   
    Regression analysis showed that being in the NWO category increased the risk of sarcopenia 22-fold in males (RR = 22.27; 95%CI: 3.35-147.98) and 25-fold in females (RR = 25.22; 95%CI: 8.12-78.36), compared to those in the NWNO category. In a "real-world" nutritional setting, the assessment of body composition to identify NWO syndrome is vital since it is also associated with a higher risk of sarcopenia.
  • ||||||||||  Journal:  Dietary Inflammatory Index and Associations with Sarcopenia Symptomology in Community-Dwelling Older Adults. (Pubmed Central) -  Dec 24, 2022   
    More participants with a pro-inflammatory DII score had low muscle quantity than those with anti-inflammatory DII (3.4% vs. 6.4%, x = 4.537, p = 0.043) and DII was negatively associated with HGS (β = -0.157, p = 0.016) and ASM (β = -0.176, p = 0.002) which remained significant after adjusting for covariates. In this population, DII was associated with less favorable muscle strength, physical performance, and muscle quantity.
  • ||||||||||  Biomarker, Journal:  Dp-ucMGP as a Biomarker in Sarcopenia. (Pubmed Central) -  Dec 24, 2022   
    Persons in the lowest dp-ucMGP quartile have the highest risk for reduced muscle mass, decreasing with each quartile, whereas persons in the highest quartile have the highest risk of reduced muscle strength. Dp-ucMGP might be a good biomarker candidate in sarcopenia characterization.
  • ||||||||||  Review, Journal:  Muscle Delivery of Mitochondria-Targeted Drugs for the Treatment of Sarcopenia: Rationale and Perspectives. (Pubmed Central) -  Dec 24, 2022   
    Even though these mitochondria-delivered strategies demonstrate to be promising in preclinical models, their use needs to be promoted for clinical studies. Therefore, there is a compelling demand to further understand the mechanisms modulating mitochondrial homeostasis, to characterize powerful compounds that target muscle mitochondria to prevent sarcopenia in aged people.
  • ||||||||||  Review, Journal:  Exercise and mitochondrial mechanisms in patients with sarcopenia. (Pubmed Central) -  Dec 24, 2022   
    Activation of PGC1-ɑ also regulates transcription factors (such as TFAM, MEFs, and NRFs) and leads to the formation of new mitochondrial networks. Hence, moderate-intensity exercise can be used as a non-invasive treatment for sarcopenia by activating pathways that regulate the mitochondrial network in skeletal muscle.