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|||||||||| Journal: Components of frailty, sarcopenia and their association with vitamin D deficiency. Cross-sectional, analytical study. (Pubmed Central) - Jan 20, 2023
The frail and pre-frail phenotypes, as well as exhaustion, are associated with vitamin D insufficiency.

|||||||||| Journal: Appetite loss and associated factors at 1 year after intensive care unit elder survivors in a secondary analysis of the SMAP-HoPe study. (Pubmed Central) - Jan 20, 2023
High severity of depression was associated with a high probability of appetite loss (odds ratio, 1.2; 95%CI, 1.14-1.28; p = 0.00). Poor appetite is common 12 months after intensive care and is associated with the severity of depression.

|||||||||| Journal: Sarcopenia: investigation of metabolic changes and its associated mechanisms. (Pubmed Central) - Jan 20, 2023
We observed a difference in the plasma metabolic profile in association with different measures of sarcopenia, which identifies very long-chain fatty acids, Carn.DC and citrulline as key variables associated with the disease severity. These findings point to a potential link between sarcopenia and mitochondrial dysfunction and portraits a number of possible biochemical pathways which might be involved in the disease pathogenesis.

|||||||||| Impact of Anthropometric Parameters on Clinical Outcomes in Asians with Metabolic DysfunctionAssociated Fatty Liver Disease (4F Joy Lounge) - Jan 20, 2023 - Abstract #APASL2023APASL_379;
Visceral adiposity was an independent predictor of advanced fibrosis. 626

|||||||||| Impact of Anthropometric Parameters on Clinical Outcomes in Asians with Metabolic DysfunctionAssociated Fatty Liver Disease (2F Room 201ABC) - Jan 20, 2023 - Abstract #APASL2023APASL_355;
Visceral adiposity was an independent predictor of advanced fibrosis. 736

|||||||||| Journal: Association of Dental Caries with Muscle Mass, Muscle Strength, and Sarcopenia: A Community-Based Study. (Pubmed Central) - Jan 19, 2023
Significant differences were observed in gut microbiota composition both in severe dental caries and sarcopenia, and there was an overlap of the genera features. Future longitudinal studies are needed to clarify causal relationships.

|||||||||| Journal: Linolenic acid ameliorates sarcopenia in C. elegans by promoting mitophagy and fighting oxidative stress. (Pubmed Central) - Jan 19, 2023
This included the increase of the expression of the mitophagy gene pink-1 and DAF-16/FOXO transcription factors, respectively, by linolenic acid. This study could provide some evidence for the application of n-3 PUFA in improving sarcopenia.

|||||||||| New trial: ReFit: Reducing Falls With Progressive Resistance Training for the Oldest Old Adults With Sarcopenia (clinicaltrials.gov) - Jan 19, 2023
P=N/A, N=240, Not yet recruiting, Sponsor: Norwegian University of Science and Technology

|||||||||| Trial completion, Trial primary completion date: The Effect of Tai Chi Exercise Among Elders With Sarcopenia (clinicaltrials.gov) - Jan 19, 2023
P=N/A, N=60, Completed, Sponsor: China Medical University Hospital
This study could provide some evidence for the application of n-3 PUFA in improving sarcopenia. Recruiting --> Completed | Trial primary completion date: Jul 2022 --> Apr 2022

|||||||||| Skeletal #Muscle Mass = ☠️Predictor among Nonagenarians and Centenarians #aging #health #exercise #sarcopenia @darrencandow @mackinprof @GGouspillou @DavidScottPhD https://t.co/jH49NAVI8e (Twitter) - Jan 18, 2023

|||||||||| “strength begins to decline ~1% annually after the age of 40 and accelerates in later years. The age-related declines in muscle strength, which coincide with losses in muscle mass, are known as sarcopenia.” https://t.co/l88lghawXG (Twitter) - Jan 18, 2023

|||||||||| You may find this consensus on sarcopenia from 2018 interesting https://t.co/uSIGGPtZ4M (Twitter) - Jan 18, 2023

|||||||||| Journal: Relationships of Fall Risk With Frailty, Sarcopenia, and Balance Disturbances in Mild-to-Moderate Alzheimer's Disease. (Pubmed Central) - Jan 18, 2023
We found that falls were not influenced by AD stage. Both physical and cumulative frailty were strongly associated with falls in patients with mild-to-moderate AD.

|||||||||| Review, Journal: Sarcopenia in the Cirrhotic Patient: Current Knowledge and Future Directions. (Pubmed Central) - Jan 18, 2023
This highlights the importance of identification of at-risk individuals with early nutritional, therapeutic and physical therapy intervention. This manuscript summarizes literature relevant to sarcopenia in cirrhosis, describes current knowledge, and elucidates possible future directions.

|||||||||| Trial completion date, Trial primary completion date: GoMob-in: Goal-directed Mobilization of Medical Inpatients (clinicaltrials.gov) - Jan 18, 2023
P=N/A, N=160, Recruiting, Sponsor: University Hospital Inselspital, Berne
This manuscript summarizes literature relevant to sarcopenia in cirrhosis, describes current knowledge, and elucidates possible future directions. Trial completion date: Dec 2022 --> May 2023 | Trial primary completion date: Sep 2022 --> Feb 2023

|||||||||| New trial: HRS: Effect of Technology-assisted Physical Therapy for Patient With High Risk of Sarcopenia (clinicaltrials.gov) - Jan 18, 2023
P=N/A, N=100, Not yet recruiting, Sponsor: National Taiwan University Hospital

|||||||||| New trial: Prevalence and Associated Factors of Sarcopenia Among Elderly Patients in Osteoporosis Clinic (clinicaltrials.gov) - Jan 18, 2023
P=N/A, N=94, Active, not recruiting, Sponsor: Kowloon Hospital, Hong Kong

|||||||||| New trial: POWER: Protein Supplement and Exercise Training for the Treatment of Sarcopenia Risk in Older Adults (clinicaltrials.gov) - Jan 18, 2023
P=N/A, N=40, Not yet recruiting, Sponsor: University College Dublin

|||||||||| Journal, MRI: A Novel Use for Pelvic Magnetic Resonance Imaging Scans to Estimate Lean Body Mass and Screen for Sarcopenia in Patients with Rectal Cancer. (Pubmed Central) - Jan 18, 2023
Trial completion date: Dec 2022 --> May 2023 | Trial primary completion date: Sep 2022 --> Feb 2023 Future studies may evaluate changes in lean body mass on serial pelvic magnetic resonance imaging studies among patients with rectal cancer.

|||||||||| Journal: Usefulness of muscle ultrasound in appendicular skeletal muscle mass estimation for sarcopenia assessment. (Pubmed Central) - Jan 18, 2023
In addition, multiple logistic regression analysis revealed that the ratios of EI to MT in the BF and RF muscles in men and MT in the BB muscle in women could be valuable parameters for sarcopenia screening. Therefore, our study suggests that muscle ultrasound could be an effective tool for estimating ASM and screening sarcopenia.

|||||||||| Clinical data, Retrospective data, Journal: Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis. (Pubmed Central) - Jan 18, 2023
In addition, cirrhosis and poor liver functional reserve increase the danger of sarcopenia. OS was more impaired in HCC patients with sarcopenia at early stage of tumor than at other tumor stages.

|||||||||| Review, Journal: Frailty and surgical outcomes in gastrointestinal cancer: Integration of geriatric assessment and prehabilitation into surgical practice for vulnerable patients. (Pubmed Central) - Jan 17, 2023
In addition, improving preoperative vulnerability and preventing functional decline after surgery is important in providing favorable long-term survival in patients with gastrointestinal cancer. Further clinical trials are needed to examine the effects of minimally invasive surgery, and chemotherapy in frail patients with gastrointestinal cancer.

|||||||||| Journal: Differences in prognosis and underuse of adjuvant chemotherapy between elderly and non-elderly patients in stage III colorectal cancer. (Pubmed Central) - Jan 17, 2023
Elderly patients did not show a benefit of adjuvant chemotherapy regardless of whether they had completed adjuvant chemotherapy, unlike non-elderly patients. Moreover, the evaluation of preoperative sarcopenia in elderly colorectal cancer patients may be useful in determining the indication for adjuvant chemotherapy.

|||||||||| Journal: Brachial-Ankle Pulse Wave Velocity Mediates the Association between Increased Age and Risk of Sarcopenia among Chinese Patients with Type 2 Diabetes Mellitus. (Pubmed Central) - Jan 17, 2023
baPWV mediated 20.5% of the positive relationship between increased age and the prevalence of sarcopenia. Elevated baPWV partially mediates the association of age and sarcopenia among patients with T2DM.

|||||||||| Journal: Targeting mitochondria to extend physically active lifespan. (Pubmed Central) - Jan 17, 2023
Elevated baPWV partially mediates the association of age and sarcopenia among patients with T2DM. No abstract available

|||||||||| Journal: Oxylipin status, before and after LC n-3 PUFA supplementation, has little relationship with skeletal muscle biology in older adults at risk of sarcopenia. (Pubmed Central) - Jan 17, 2023
An independent cohort validation is needed to explore baseline correlations further. Further research is warranted to assess other biological mechanisms by which LC n-3 PUFA might affect muscle biology.

|||||||||| New trial: Muscular Deficits of Diabetic Myopathy (clinicaltrials.gov) - Jan 17, 2023
P=N/A, N=108, Recruiting, Sponsor: University of Aarhus

|||||||||| Clinical, Surgery: @ASPEN_nutrition @berkeleydoc @drdawnbeaulieu 41/90 of patients with IBD were sarcopenic. Of these, 19.5% were overweight/obese and 41.5% had a normal BMI! Sarcopenia was the only significant predictor of need fr surgery in overweight/obese patients. https://t.co/3OjENNKH7F (Twitter) - Jan 17, 2023

|||||||||| Great point @BeniwalPatelMD about obesity & sarcopenia in #IBD - & nutritional support - tagging #GastroRD @GIdietitian @DawnaMughalPhD @ThereziaRD @KateScarlata_RD (Twitter) - Jan 17, 2023

|||||||||| Clinical, Clinical data: A tangent but fun to discuss: sarcopenic obesity is a real problem in our IBD patients with poor clinical outcomes. What do you use to assess nutrition status? BMI doesn't correlate well to body composition. When do you use oral enteral nutrition? (Twitter) - Jan 17, 2023

|||||||||| Journal, HEOR, Surgery: Muscle strength trajectories and their association with postoperative health-related quality of life in patients undergoing coronary artery bypass grafting surgery: a prospective cohort study. (Pubmed Central) - Jan 17, 2023
P=N/A
Future research should focus on female patients, reacting potentially different on CABG and/or rehabilitation treatment. Trial registration NCT03774342, 12-12-2018.

|||||||||| Journal: Comparison of CT derived body composition at the thoracic T4 and T12 with lumbar L3 vertebral levels and their utility in patients with rectal cancer. (Pubmed Central) - Jan 17, 2023
Trial registration NCT03774342, 12-12-2018. Quantifying skeletal muscle mass at the T4 vertebral level is comparable to measures achieved at L3 in patients with rectal cancer, notwithstanding annotation time for T4 measurements are longer.

|||||||||| GLIM (global leadership initiate on malnutrition) has been proposed to dx malnutrition. BMI is flawed and doesn’t speak to body composition. Handgrip strength is first step in identifying sarcopenia, and if low we can use imaging (CT @L3) to measure muscle mass, dx sarcopenia (Twitter) - Jan 17, 2023

|||||||||| Clinical, HEOR: Why do pts with low serum urate levels have worse health outcomes? Drs. Baker, George, @MikulsTed @Tuhina_Neogi @davidryan09 et al - risk of early mortality partly explained by higher rates of sarcopenia. May help promote more aggressive mgmt of gout! https://t.co/xo1cSzUbjc (Twitter) - Jan 16, 2023

|||||||||| Retrospective data: significant results in healthy adults not performing weightlifting exercises, this is still an open question since there are not many published studies testing people in these conditions. #sarcopenia #agingwell #aging #muscle #musclebuilding #musclegain #metaanalysis (Twitter) - Jan 16, 2023

|||||||||| questions of our study published in the Journal of Cachexia, Sarcopenia and Muscle @JCSM_cachexia in April 2022: https://t.co/aOPsOOIkSG Conducted by @nunesea and a fantastic team To seek answers, we searched four scientific databases and screened more than 8900 studies. (Twitter) - Jan 16, 2023

|||||||||| Journal: Correction for: Endothelin-1-mediated miR-let-7g-5p triggers interlukin-6 and TNF-α to cause myopathy and chronic adipose inflammation in elderly patients with diabetes mellitus. (Pubmed Central) - Jan 16, 2023
Quantifying skeletal muscle mass at the T4 vertebral level is comparable to measures achieved at L3 in patients with rectal cancer, notwithstanding annotation time for T4 measurements are longer. No abstract available

|||||||||| Sarcopenia? Muscle wasting. lack of muscle. small muscles? #sarcopenia #musclewasting #atrophy (Twitter) - Jan 15, 2023

||||||||||  Prolia (denosumab) / Amgen, Daiichi Sankyo
Trial completion date, Trial primary completion date:  MITO: Muscle Impact of Treating Osteoporosis (clinicaltrials.gov) -  Jan 14, 2023
P4, N=40, Not yet recruiting,  Sponsor: Nami Safai Haeri
No abstract available Trial completion date: Jul 2023 --> Jul 2024 | Trial primary completion date: Jul 2023 --> Jul 2024

|||||||||| Journal: Sarcopenic Obesity, the Possible Culprit for Nonalcoholic Fatty Liver Disease or Fibrosis. (Pubmed Central) - Jan 14, 2023
Trial completion date: Jul 2023 --> Jul 2024 | Trial primary completion date: Jul 2023 --> Jul 2024 No abstract available

|||||||||| Journal: The body mass index change is associated with death or hemodialysis transfer in Japanese patients initiating peritoneal dialysis. (Pubmed Central) - Jan 14, 2023
The risk was not significantly higher in patients with the highest tertile (T3, BMI change: >0.67%) than those in the T2 group (HR: 1.18; 95% CI: 0.66-2.11). A decreased BMI over time is independently associated with HD transfer or all-cause mortality among patients initiating PD, which highlights the importance of the 6-month BMI change as a novel prognostic marker.

|||||||||| Preclinical, Journal: Lespedeza bicolor extract supplementation reduced hyperglycemia-induced skeletal muscle damage by regulation of AMPK/SIRT/PGC1α-related energy metabolism in type 2 diabetic mice. (Pubmed Central) - Jan 14, 2023
Meanwhile, LBE supplementation reduced oxidative stress and inflammation in mice with T2DM. Taken together, the current study suggested that LBE could be a potential therapeutic to prevent skeletal muscle damage by regulation AMPK/SIRT/PGC1α-related energy metabolism in T2DM.

|||||||||| Glad to see mom happy but her gait is slower since pandemic as she avoids going out. Get her a bike to combat sarcopenia for the New Year. Hope she gain more strength next time I see her. (Twitter) - Jan 14, 2023

|||||||||| Journal: Relationship between healthy eating index and sarcopenia in elderly people. (Pubmed Central) - Jan 14, 2023
In conclusion, healthy eating was inversely associated with odds of sarcopenia among women, but not in men. Further studies with a large sample size and prospective design are needed to examine this association.

|||||||||| Preclinical, Journal: Omega-3 fatty acid and menaquinone-7 combination are helpful for aortic calcification prevention, reducing osteoclast area of bone and Fox0 expression of muscle in uremic rats. (Pubmed Central) - Jan 13, 2023
Furthermore, decreased mammalian target of rapamycin and increased Forkhead box protein 1 expression was significantly restored by combined supplementation. Combined nutrients supplementation with omega-3 FA and MK-7 may be helpful for aortic VC prevention, reducing osteoclast activation and improving sarcopenia-related molecules in adenine and low-protein diet induced uremic rats.

|||||||||| Journal: Low muscle strength vs. low muscle mass for screening sarcopenia in patients undergoing hemodialysis. (Pubmed Central) - Jan 13, 2023
Combined nutrients supplementation with omega-3 FA and MK-7 may be helpful for aortic VC prevention, reducing osteoclast activation and improving sarcopenia-related molecules in adenine and low-protein diet induced uremic rats. No abstract available

|||||||||| Review, Journal: Biochemical Markers of Musculoskeletal Health and Aging to be Assessed in Clinical Trials of Drugs Aiming at the Treatment of Sarcopenia: Consensus Paper from an Expert Group Meeting Organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Académique de Recherche et d'Expérimentation en Santé (CARES SPRL), Under the Auspices of the World Health Organization Collaborating Center for the Epidemiology of Musculoskeletal Conditions and Aging. (Pubmed Central) - Jan 13, 2023
The group also proposed optional biochemical markers that may provide insights into the mode of action of pharmacological therapies. Further research and development of new methods for biochemical marker assays may lead to the evolution of these recommendations.

|||||||||| Journal: Improvement in sarcopenia is positively associated with recovery of independence in urination and defecation in patients undergoing rehabilitation after a stroke. (Pubmed Central) - Jan 13, 2023
Improvement in HGS (OR: 4.33; 95% CI, 0.99-18.90; P = 0.048) was independently associated with FIM-Bowel at the time of discharge Improvement in sarcopenia and muscle strength during hospitalization may have a positive effect on urinary independence in stroke patients undergoing convalescent rehabilitation, and improvement in muscle strength may have a positive effect on defecation independence. Multidisciplinary sarcopenia treatment should be implemented in addition to conventional rehabilitation for these patients.

|||||||||| Journal: Parameters of body composition and creeping fat are associated with activity of Crohn's disease. (Pubmed Central) - Jan 13, 2023
Multidisciplinary sarcopenia treatment should be implemented in addition to conventional rehabilitation for these patients. CrF is significantly associated with CD activity.

|||||||||| PURPLE translational registry: A novel multi-sided platform approach to accelerate research in pancreatic cancer () - Jan 13, 2023 - Abstract #LCC2023LCC_68;
This multi-sided platform is designed to address the needs of clinicians, researcher and patients. We plan to expand this platform to incorporate greater data analytic capacity, development of scalable pipelines, and streamline identification and access to molecularly targeted clinical trials in pancreatic cancer.



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