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17 Mechanisms of Action |
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756 Trials |
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- || Retrospective data, Review, Journal: Effects of whey and soy protein supplementation on inflammatory cytokines in older adults: a systematic review and meta-analysis. (Pubmed Central) - Mar 2, 2023
levels, respectively. This effect may be enhanced by soy isoflavones and may be more prominent in individuals with sarcopenia.
- || Review, Journal: Sarcopenia-a (Pubmed Central) - Mar 2, 2023
For diagnostic criteria, physical parameters (muscle mass measurement) and functional aspects (muscle strength, gait speed, physical performance) are required. In routine clinical care, screening patients using the SARC?F questionnaire is recommended by recent guidelines of the European Workgroup for Sarcopenia.
- | Journal: Relationship between asthma and sarcopenia in the elderly: a nationwide study from the KNHANES. (Pubmed Central) - Mar 2, 2023
Our findings suggest that decreased muscle mass and physical activity levels contribute to reduced lung function in elderly asthmatics. Furthermore, sarcopenic asthma was associated with aging, low BMI, and reduced lung function in the elderly.
- || Clinical, Journal: Brain ?-amyloid links the association of change in BMI with cognitive decline in community-dwelling older adults. (Pubmed Central) - Mar 2, 2023
Changes in BMI and cognitive decline in older adults may be affected by similar mechanisms underlying the accumulation of brain pathologies like ?-amyloid in aging brains. Elucidating the molecular mechanisms underlying these associations may provide novel targets for developing interventions that maintain brain health and metabolic homeostasis in old age.
- | Trial completion date, Trial primary completion date: Evaluation of Sarcopenia-Related Malnutrition in Older Adults (clinicaltrials.gov) - Mar 2, 2023
P=N/A, N=300, Recruiting, Sponsor: Istanbul Medeniyet University
Elucidating the molecular mechanisms underlying these associations may provide novel targets for developing interventions that maintain brain health and metabolic homeostasis in old age. Trial completion date: Oct 2022 --> May 2023 | Trial primary completion date: Oct 2022 --> May 2023
- | New trial: Foot Core Exercise Program on Balance Control and Walking in Aged Sarcopenia (clinicaltrials.gov) - Mar 2, 2023
P=N/A, N=60, Recruiting, Sponsor: Buddhist Tzu Chi General Hospital
- | Trial completion, Trial completion date: Feasibility and Impact of Resistance Training for Sarcopenic Dysphagia (clinicaltrials.gov) - Mar 2, 2023
P=N/A, N=11, Completed, Sponsor: Hvidovre University Hospital
Trial completion date: Oct 2022 --> May 2023 | Trial primary completion date: Oct 2022 --> May 2023 Recruiting --> Completed | Trial completion date: Aug 2023 --> Feb 2023
- | Journal: COVID-19 in older adult residents in nursing homes: factors associated with mortality and impact on functional capacity. (Pubmed Central) - Mar 1, 2023
Although the null hypothesis analysis did not find significant differences between the groups, the effect size suggests that older adults residing in nursing homes who died from COVID-19 had lower handgrip strength. In the survivors, the isolation period after COVID-19 infection only negatively impacted the sit-to-stand performance.
- |||| Clinical, MRI: New Tech Report | Novel Use for Pelvic Magnetic Resonance Imaging Scans to Estimate Lean BM + Screen Sarcopenia in Patients w/ #RectalCancer- https://t.co/NmmNMDOKMS @AlexaMelucci @livlynch18 @apl2018 @kmustian @DrR_DUNNE @FergaljFleming @ShoreUrmc @URochesterSurg @WilmotCancer (Twitter) - Mar 1, 2023
- | Journal, Stroma: CT-based assessment of sarcopenia for differentiating wild-type from mutant-type gastrointestinal stromal tumor. (Pubmed Central) - Feb 28, 2023
The additional gene sequencing analysis based on both our data and the external data demonstrated aberrant signal pathways being closely associated with sarcopenia in the wt-GIST. Our study supported the use of CT-based assessment of sarcopenia in differentiating the wt-GIST from the mu-GIST preoperatively.
- | Journal: Effect of total knee replacement on skeletal muscle mass measurements using dual energy X-ray absorptiometry. (Pubmed Central) - Feb 28, 2023
Only one participant was classified as having low muscle mass without AMD processing, but this came to four after AMD processing. LM assessment in individuals who had TKR could be significantly different according to the use of AMD.
- Clinical protocol, Journal: Protocol for a randomised, placebo-controlled, double-blinded clinical trial on the effect of oestrogen replacement on physical performance to muscle resistance exercise for older women with osteoarthritis of knee joint: the EPOK trial. (Pubmed Central) - Feb 28, 2023
Japan Registry of Clinical Trials: jRCTs061210062. Registered 17th December 2021, https://jrct.niph.go.jp/en-latest-detail/jRCTs061210062 .
- | Journal, HEOR, Cost-effectiveness, Cost effectiveness: AI-based opportunistic CT screening of incidental cardiovascular disease, osteoporosis, and sarcopenia: cost-effectiveness analysis. (Pubmed Central) - Feb 28, 2023
Registered 17th December 2021, https://jrct.niph.go.jp/en-latest-detail/jRCTs061210062 . AI-assisted CT-based opportunistic screening appears to be a highly cost-effective and clinically efficacious strategy across a broad array of input assumptions, and was cost saving in most scenarios.
- ||| Clinical, Review: An elusive consensus definition of sarcopenia impedes research and clinical treatment: A narrative review (Coletta & @mackinprof 2023) https://t.co/S8C1edu6eB (Twitter) - Feb 28, 2023
- | Journal: The Impact of Persistent Low Weight Status on the Occurrence of Vertebral Fractures: A Nationwide Population-Based Cohort Study. (Pubmed Central) - Feb 27, 2023
Low weight is a risk factor for VFs in the general population. Given the significant correlation between cumulative periods of low weight and the risk of VFs, it is necessary to treat underweight patients before a VF to prevent its development and other osteoporotic fractures.
- | Journal: A preliminary study on degenerate characteristics of lumbar and abdominal muscles in middle-aged and elderly people with varying bone mass. (Pubmed Central) - Feb 27, 2023
The changes of SMIs of the lumbar and abdominal muscles in patients with varying bone mass are asynchronous. SMI of RA is expected to be a promising imaging marker for predicting abnormal bone mass.
- || Review, Journal: Non-pharmacological interventions for possible sarcopenia or sarcopenia in community-dwelling older adults: a scoping review protocol. (Pubmed Central) - Feb 27, 2023
The results will be published in peer-reviewed scientific journals and also disseminated in relevant disease support groups and conferences. The planned scoping review will help us identify the current status of research and gaps in the literature, so as to develop a future research agenda.
- | Journal: Role of preoperative sarcopenia in predicting postoperative complications and survival after pancreatoduodenectomy for pancreatic cancer. (Pubmed Central) - Feb 27, 2023
In our study, sarcopenia was associated with postoperative complications and in particular with pancreatic fistula. Further studies will need to demonstrated that sarcopenia can be considered an objective measure of patient frailty and strongly associated with short- and long-term outcomes.
- | Journal: CT-determined sarcopenia is associated with neutropenia in patients undergoing hyperthermic intraperitoneal chemotherapy for gastrointestinal cancer. (Pubmed Central) - Feb 27, 2023
Further studies will need to demonstrated that sarcopenia can be considered an objective measure of patient frailty and strongly associated with short- and long-term outcomes. Sarcopenia and low albumin level were significantly associated with an increased rate of delayed neutropenia after HIPEC in that disease setting and could be the preoperative risk predictors.
- | Observational data, Journal: Menopause hormone therapy and sarcodynapenia: the Canadian Longitudinal Study on Aging. (Pubmed Central) - Feb 27, 2023
Menopause hormone therapy for 5 years or less is associated with a lower prevalence of sarcodynapenia among physically active women and with a higher prevalence of sarcodynapenia in those less active. Strategies to promote an active lifestyle in all postmenopausal women, including MHT users, are needed to attain benefits for musculoskeletal health.
- | Journal: Muscle fiber type grouping does not change in response to prolonged resistance exercise training in healthy older men. (Pubmed Central) - Feb 27, 2023
Muscle fiber type grouping is not associated with lower body strength or muscle mass in healthy, older men. In addition, twelve weeks of resistance exercise training results in type II muscle fiber specific hypertrophy but does not affect fiber type grouping.
- | Journal: Normative cutoffs of muscle mass, muscle strength, and frailty for healthy Indian population. (Pubmed Central) - Feb 27, 2023
In addition, twelve weeks of resistance exercise training results in type II muscle fiber specific hypertrophy but does not affect fiber type grouping. We derived gender-specific cutoffs for SMI, HGS, CSUT, and LFI from healthy adult Indian population, which can be used to detect sarcopenia and frailty among patients with liver diseases, as well as other conditions.
- | Retrospective data, Journal: Study of Post-Kidney Transplantation Parietal Complications and Presarcopenia. (Pubmed Central) - Feb 27, 2023
Muscle fat infiltration appears to influence the outcome of renal transplantation. The management of sarcopenia in pretransplantation should be a subject of further research.
- | Retrospective data, Journal, Checkpoint inhibition: Sarcopenia as a Determinant of the Efficacy of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: A Meta-Analysis. (Pubmed Central) - Feb 27, 2023
Sarcopenia reduced the overall response rate (OR = 2.22, 95% CI, 1.01-4.84, P?=?0.02), with I= 56%, P?=?0.02, and disease control rate (OR = 3.15, 95% CI, 2.10-4.72, P?<?0.0001) with I = 33%, P?=?0.18. Pre-immunotherapy sarcopenia was associated with poor clinical outcomes in patients with advanced NSCLC who received ICIs.
- || Review, Journal: Markers of sarcopenia increase 30-day mortality following emergency laparotomy: A systematic review. (Pubmed Central) - Feb 27, 2023
The existing literature is limited, however it indicates that low psoas muscle mass and quality markers are associated with increased 30-day mortality rates after emergency laparotomy. Therefore, muscle markers can be used as a new feasible tool to identify most at risk patients requiring further interventions.
- | Journal: Comparison of Skeletal Muscle Changes at Three Vertebral Levels Following Radiotherapy in Patients With Oropharyngeal Carcinoma. (Pubmed Central) - Feb 27, 2023
No difference was found in the percentage change of T2-CSA with L3-CSA (mean -2.2%, SD 10.6, 95%CI -6.0 to 1.6, and p?=?0.240), however, was significantly different to C3-CSA (mean 13.2%, SD 11.6, 95%CI 9.1 to 17.3, and p?<?0.001). Results suggest SM at C3 does not change proportionately and may not be a reliable representation of whole-body SM change over time.
- | Journal: Sarcopenia at CT and Poor Outcomes after Liver Transplant. (Pubmed Central) - Feb 27, 2023
Results suggest SM at C3 does not change proportionately and may not be a reliable representation of whole-body SM change over time. No abstract available
- | Journal, Post-transplantation: Association between Abdominal CT Measurements of Body Composition before Deceased Donor Liver Transplant with Posttransplant Outcomes. (Pubmed Central) - Feb 27, 2023
No abstract available Conclusions Sarcopenia, as assessed on routine pre-liver transplant (LT) abdominal CT scans, was the only factor significantly associated with post-LT mortality.
- | Journal: Muscle mass ratio in male gastric cancer patients as an independent predictor of postoperative complications after minimally invasive distal gastrectomy. (Pubmed Central) - Feb 27, 2023
Conclusions Sarcopenia, as assessed on routine pre-liver transplant (LT) abdominal CT scans, was the only factor significantly associated with post-LT mortality. The MMR calculated using bioelectrical impedance analysis can be a useful predictor for postoperative complications after MIDG in male GC patients.
- | Journal: Pylorus-preserving versus Pylorus-resecting: Impact on dynamic changes of nutrition and body composition in pancreatic cancer patients before and after pancreatoduodenectomy. (Pubmed Central) - Feb 27, 2023
PPPD may contribute to better maintaining visceral fat mass and blood ALB levels. CT quantification can be an objective and effective method to evaluate the nutritional status of pancreatic cancer patients during the pre- and postoperative period and can provide a useful objective basis for guiding clinical treatment.
- | Journal: Muscle Health Patterns and Brain MRI Indices: A Cluster Analysis. (Pubmed Central) - Feb 27, 2023
Clinicians should raise awareness on the brain MRI findings in clinical settings. Because these patients mostly had central nervous system conditions or other critical illnesses, the risk of sarcopenia as a comorbidity will substantially affect the prognosis and medical care.
- | Journal, HEOR: Preventing Osteoporosis, Sarcopenia and Obesity to care about Quality of Life. (Pubmed Central) - Feb 27, 2023
Because these patients mostly had central nervous system conditions or other critical illnesses, the risk of sarcopenia as a comorbidity will substantially affect the prognosis and medical care. No abstract available
- | Biomarker, Journal: Skeletal muscle area predicts the outcomes of non-small-cell lung cancer after trimodality therapy. (Pubmed Central) - Feb 27, 2023
No abstract available Pre-NACRT SMAI correlates with poor prognosis; therefore, assessing sarcopenia based on pre-NACRT SMAI may help determine optimal treatment strategies and suitable nutritional and exercise interventions.
- || Review, Journal, Surgery: Perioperative nutrition for gastrointestinal surgery: On the cutting edge. (Pubmed Central) - Feb 27, 2023
There has also been a recent emergence in randomized studies evaluating the use of ?-3 fatty acids, amino acids, and immunonutrition. Meta-analyses have reported favorable outcomes for these supplements, though individual studies are small and with significant methodological limitations and risk of bias, emphasizing the need for high-quality randomized studies to guide clinical practice.
- || Review, Journal: Nutritional Problems Related to Oropharyngeal and Esophageal Changes in Aging: A Narrative Review. (Pubmed Central) - Feb 27, 2023
Our increasing knowledge on this subject will contribute to healthcare professionals in the prevention and treatment of health problems such as malnutrition that may occur during the aging process. In this review, a literature search was conducted with the keywords "older" or "elderly" or "geriatrics" and "nutrition" or "malnutrition" and "oropharyngeal functions" or "esophageal functions" in PubMed, ScienceDirect, and Google Scholar electronic databases.KEY TEACHING POINTSSome changes may occur in oropharyngeal and esophageal functions with aging.Sensory and physiological changes in the aging process affect oral food intake and nutritional status.Impairments in oral food intake in elderly individuals can lead to malnutrition and sarcopenia.Age-related changes affecting oral food intake increase the importance of nutritionists with the increase in the elderly population.
- | Enrollment closed: Starting a Testosterone and Exercise Program After Hip Injury (clinicaltrials.gov) - Feb 27, 2023
P3, N=129, Active, not recruiting, Sponsor: Washington University School of Medicine
In this review, a literature search was conducted with the keywords "older" or "elderly" or "geriatrics" and "nutrition" or "malnutrition" and "oropharyngeal functions" or "esophageal functions" in PubMed, ScienceDirect, and Google Scholar electronic databases.KEY TEACHING POINTSSome changes may occur in oropharyngeal and esophageal functions with aging.Sensory and physiological changes in the aging process affect oral food intake and nutritional status.Impairments in oral food intake in elderly individuals can lead to malnutrition and sarcopenia.Age-related changes affecting oral food intake increase the importance of nutritionists with the increase in the elderly population. Recruiting --> Active, not recruiting
- ||| Thank you Philipp! 🤝 Sure! This is how the data are. Sarcopenia is - not surprisingly again - an adverse factor also in cancer immunotherapy. So, do physical exercise!😎 (Twitter) - Feb 26, 2023
- || Review, Journal: Musculoskeletal exercise: Its role in promoting health and longevity. (Pubmed Central) - Feb 26, 2023
Accordingly, health providers should screen for PI, lack of RT, and mobility risks using short screening questions, and employ simple functional tests, when indicated, to evaluate patients for impairment in gait, muscle strength, flexibility, and balance. This review also provides general principles for initiating and conducting RT and provides general and specific examples of resistance training programs, which should be individualized for patients through the evaluation and guidance by appropriate health providers, physical therapists, and certified trainers.
- | Journal: Impact of sarcopenic obesity on functional outcomes. (Pubmed Central) - Feb 26, 2023
This review also provides general principles for initiating and conducting RT and provides general and specific examples of resistance training programs, which should be individualized for patients through the evaluation and guidance by appropriate health providers, physical therapists, and certified trainers. No abstract available
- | Journal: Dynapenia, Muscle Quality, and Hepatic Steatosis in Patients with Obesity and Sarcopenic Obesity. (Pubmed Central) - Feb 26, 2023
Similar findings emerged when including liver enzyme levels in place of hepatic steatosis. Muscle quality was positively associated with ?-cell function corrected for insulin resistance among patients with obesity and sarcopenic obesity, irrespective of the presence of fatty liver disease.
- || Review, Journal: Aging, Physical Exercise, Telomeres, and Sarcopenia: A Narrative Review. (Pubmed Central) - Feb 26, 2023
Higher levels of physical activity are associated with an apparent increase in telomere length. This review aims to present the current state of the art of knowledge on the effect of physical exercise on telomeric maintenance and activation of repair mechanisms in sarcopenia.
- | Journal: Associations of Total Body Fat Mass and Skeletal Muscle Index with All-Cause and Cancer-Specific Mortality in Cancer Survivors. (Pubmed Central) - Feb 26, 2023
Our findings show the opposing relations of fat mass and appendicular skeletal muscle mass index with mortality in a national sample of cancer survivors, and that the relationships may differ by race. These results emphasize the importance of maintaining a healthy body composition among cancer survivors.
- | Journal, IO biomarker, Metastases: Effect of Cancer-Related Cachexia and Associated Changes in Nutritional Status, Inflammatory Status, and Muscle Mass on Immunotherapy Efficacy and Survival in Patients with Advanced Non-Small Cell Lung Cancer. (Pubmed Central) - Feb 26, 2023
In conclusion, our study supports the evidence that cachexia, with its related changes in inflammatory, body composition, and nutritional parameters, is a key prognostic and predictive factor for ICIs. Further larger studies are needed to confirm these findings and to explore the potential benefit of counteracting cachexia to improve immunotherapy efficacy.
- | Journal: Body Composition and Metabolic Dysfunction Really Matter for the Achievement of Better Outcomes in High-Grade Serous Ovarian Cancer. (Pubmed Central) - Feb 26, 2023
We have demonstrated the relevance of BC and metabolism disorders as determinants of outcomes in HGSOC. We have shone a spotlight on the relevance of incorporating corrective measures addressing these disorders to obtain better results.
- || Clinical data, Journal: Association of Thoracic Skeletal Muscle Index with Clinical Outcome and Response to Nutritional Interventions in Patients at Risk of Malnutrition-Secondary Analysis of a Randomized Trial. (Pubmed Central) - Feb 25, 2023
We have shone a spotlight on the relevance of incorporating corrective measures addressing these disorders to obtain better results. Within medical patients at risk for malnutrition, SMI at thoracic vertebra provided low prognostic information regarding clinical outcomes and nutritional treatment response.
- || Review, Journal: Creatine Supplementation to Improve Sarcopenia in Chronic Liver Disease: Facts and Perspectives. (Pubmed Central) - Feb 25, 2023
Creatine supplementation could address several critical points of chronic liver disease and its complications. Further studies are needed to support the clinical burden of this hypothesis.
- || Review, Journal: Impact of Sarcopenia on Non-Alcoholic Fatty Liver Disease. (Pubmed Central) - Feb 25, 2023
However, inadequate oral intake may lead to further loss of muscle mass. Aerobic and resistance exercise should also be used appropriately.
- || Review, Journal: Nutritional Strategies to Manage Malnutrition and Sarcopenia following Liver Transplantation: A Narrative Review. (Pubmed Central) - Feb 25, 2023
In conclusion, nutritional intervention after LT has different beneficial effects on malnutrition, sarcopenia, and other advert outcomes. Additional large and well-constructed RCTs using validated tools to assess nutritional status and sarcopenia are warranted to ensure more robust conclusions.