Sarcopenia
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  • ||||||||||  Journal:  Use of the SARC-F Score as an Aid in Fragility Fractures Prevention. (Pubmed Central) -  Mar 28, 2023   
    A higher score on the SARC-F is determinant between having or not a fragility fracture, estimating that for each point in the score there is a 70% increase in the chance of a patient having a fracture, regardless of age, gender, and body mass index (BMI). Conclusion ?There was a direct correlation between a higher score on the SARC-F and an increase in the chance of fragility fracture.
  • ||||||||||  Review, Journal:  Research hotspots and trends of exercise for sarcopenia: A bibliometric analysis. (Pubmed Central) -  Mar 28, 2023   
    The keywords formed 6 clusters, namely "skeletal muscle," "muscle strength," "heart failure," "muscle protein synthesis," "insulin resistance" and "high-intensity interval training." In conclusion, this study demonstrates a new perspective on the current state of research and trends in exercise interventions for sarcopenia over the past 20 years via the visualization software CiteSpace. It may help researchers to identify potential collaborators and partner institutions, hotspots and research frontiers in the field of exercise interventions for sarcopenia.
  • ||||||||||  Journal:  Is Severe Neck Pain a Contraindication to Performing Laminoplasty in Patients With Cervical Spondylotic Myelopathy? (Pubmed Central) -  Mar 27, 2023   
    Patients with moderate and severe preoperative neck pain undergoing laminoplasty achieved equivalent PROMs at 6 months and 1 year as patients with mild preoperative neck pain. The results of this study highlight the multifactorial nature of neck pain in these patients and indicate that severe axial symptoms are not an absolute contraindication to performing laminoplasty in well-aligned patients with CSM.
  • ||||||||||  Journal:  Calf circumference predicts falls in older adults on hemodialysis. (Pubmed Central) -  Mar 27, 2023   
    CC measurement, an easy and nonexpensive tool, was able to predict falls in older patients on HD. Further studies should test the inclusion of CC in a fall risk assessment in older patients on hemodialysis.
  • ||||||||||  Journal:  Management of Sarcopenia in Primary Care Settings. (Pubmed Central) -  Mar 26, 2023   
    Previous studies reported that leucine, a branched-chain amino acid, is essential for protein synthesis in muscle, and a stimulator for skeletal muscle synthesis. A guideline conditionally recommends that diet or nutritional supplements should be combined with exercise intervention for older adults with sarcopenia.
  • ||||||||||  Journal:  Association between sarcopenia and kidney stones in United States adult population between 2011 and 2018. (Pubmed Central) -  Mar 25, 2023   
    After performing PSM, the aOR of the 95% in modal 4 for kidney stones in all participants and age <40?year were 2.365 (1.598-3.500) and 6.793 (2.619-17.6180), respectively (p?<?0.01), and especially the aOR in participants (age ?40) was 1.771(1.138-2.757) with p value being 0.011. Sarcopenia was positively related to the potential risk of kidney stones in the United States adult population.
  • ||||||||||  Clinical, Observational data, Journal:  "SARCOPENIA MEASURED BY ULTRASOUND IN HOSPITALIZED OLDER ADULTS" (ECOSARC): multi-centre, prospective observational study protocol. (Pubmed Central) -  Mar 25, 2023   
    P=N/A
    Considering that stroke is a potentially disabling event that can lead the affected individual to present with numerous sequelae, it is crucial to study the mechanisms of muscle mass loss and understand how adequate supplementation can help these patients to better recover. The results obtained will be of great interest to the scientific geriatric community to assess the utility and validity of ultrasound measurements for the detection and follow-up of sarcopenia in hospitalized older adults, and its association with adverse outcomes.
  • ||||||||||  BMP-7 / University of Central Florida, Iclusig (ponatinib) / Takeda, Otsuka, Incyte
    Journal:  PTEN-AKT pathway attenuates apoptosis and adverse remodeling in ponatinib-induced skeletal muscle toxicity following BMP-7 treatment. (Pubmed Central) -  Mar 25, 2023   
    Furthermore, BMP-7 treatment significantly (p?<?0.05) attenuated ponatinib-induced apoptosis, BAX/Bcl2 ratio, decreased PTEN, and increased cell survival protein AKT, decreased adverse muscle remodeling, and improved muscle function. Overall, we provide evidence that ponatinib-induces apoptosis leading to sarcopenia and muscle myopathy with decreased function which was attenuated by BMP-7.
  • ||||||||||  Clinical, Review, Journal:  Obesity and Aging. (Pubmed Central) -  Mar 25, 2023   
    Lifestyle interventions are generally recommended as initial therapy; however, these approaches have limitations in older adults. Similar benefits in older compared with younger adults are reported with pharmacotherapy, however, large randomized clinical trials in geriatric populations are lacking.
  • ||||||||||  Relationship of Sarcopenia and Frailty in Patients With Outcomes in Idiopathic Pulmonary Fibrosis (Walter E. Washington Convention Center, Room 209 A-C (Level 2)) -  Mar 25, 2023 - Abstract #ATS2023ATS_2107;    
    Frail IPF patients had an increased risk of mortality but this finding was not statistically significant (HR:1.5, P=0.3).Conclusions -Frailty is highly prevalent in this cohort of patients with IPF. Although FVC, DLCO, and 6MWD were not significantly associated with frailty or sarcopenia in IPF, future research will be directed at examining the relationships of genomic biomarkers of IPF disease severity with sarcopenia and frailty.
  • ||||||||||  Compound Sarcopenia in Hospitalized COPD Patients Worsens Outcomes in Relation to Age (Walter E. Washington Convention Center, Room 151 A (Street Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_1918;    
    MLP increased the odds for in-hospital mortality and decreased the odds for routine discharge comparing 50 years (Table 1).Conclusion. Muscle loss is more common in older patients with COPD and associated with adverse outcomes in relation to aging.
  • ||||||||||  Journal:  Mid-life cyclists preserve muscle mass and composition: a 3D MRI study. (Pubmed Central) -  Mar 25, 2023   
    These results suggest that cycling could help preserve muscle mass and composition in middle-aged men. Although more research is needed to support these results, this study adds new evidence to support public health efforts to promote cycling.
  • ||||||||||  Journal, Gene therapy:  AAV1.NT-3 gene therapy prevents age-related sarcopenia. (Pubmed Central) -  Mar 24, 2023   
    The molecular studies assessing the NT-3 effect on the oxidative state of distal hindlimb muscles, accompanied by western blot analyses for mTORC1 activation were in accordance with the histological findings. Considering the cost and quality of life to the individual, we believe our study has important implications for management of age-related sarcopenia.
  • ||||||||||  Review, Journal:  Nutritional ultrasound (Pubmed Central) -  Mar 24, 2023   
    Further, modulation of MCU activity may act as a potential pharmacological target in various conditions involving muscle loss. It is important to integrate nutritional ultrasound
  • ||||||||||  tamoxifen / Generic mfg.
    Preclinical, Journal:  Deletion of Sod1 in motor neurons exacerbates age-related changes in axons and neuromuscular junctions in mice. (Pubmed Central) -  Mar 24, 2023   
    Tamoxifen-induced deletion of neuronal Sod1 from two?months of age...The current study confirmed that a specific lack of Sod1 in the motor neuron causes significant alteration in axonal architecture and the neuromuscular junctions which can drive reduced muscle mass and function. Pinpointing early changes in motor neurons may provide therapeutic targets critical for maintaining muscle in the elderly.