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- | Observational data, Journal: Comment on Cancello et al. Sarcopenia Prevalence Among Hospitalized Patients with Severe Obesity: An Observational Study. J. Clin. Med. 2024, 13, 2880. (Pubmed Central) - Nov 27, 2024
The exploration of this important topic is highly commendable; however, we would like to highlight a critical issue that has not been fully addressed in this study. Specifically, the study does not fully adhere to the consensus definition of sarcopenic obesity (SO) as outlined by the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO), as we will explain below.
- | Biomarker, Journal: Low Serum Beta-2 Microglobulin Level: A Possible Biomarker for Sarcopenia in the Elderly Population. (Pubmed Central) - Nov 27, 2024
Individuals who had beta-2 microglobulin levels below 2.26 mcg/mL were found to have a 10.75 times higher risk of sarcopenia. A low serum beta-2 microglobulin level has the potential to be an important candidate biomarker for the diagnosis of sarcopenia.
- | Journal: Association Between Sarcopenia and Acupressure Testing in Older Adults Requiring Long-Term Care. (Pubmed Central) - Nov 27, 2024
In older adult patients requiring long-term care, sarcopenia is associated with an increased number of tender points throughout the body, with the supraspinatus and lower cervical regions potentially being specific tender points. Acupressure testing for tenderness may be a useful assessment parameter in sarcopenia patients.
- | Biomarker, Journal: Identifying the Shared Metabolite Biomarkers and Potential Intervention Targets for Multiple Sarcopenia-Related Phenotypes. (Pubmed Central) - Nov 27, 2024
We identified 27 metabolite biomarkers with robust causal evidence for sarcopenia-related phenotypes, highlighting 13 metabolites with a cross-sarcopenia effect, and prioritized several metabolites as the potential interventional targets of lifestyle changes. Our study provided new insight into the etiology and prevention of sarcopenia.
- | Journal: Textbook outcome and nomogram-guided approaches for enhancing surgical success in elderly HCC patients: Deciphering the influence of sarcopenia. (Pubmed Central) - Nov 27, 2024
Sarcopenia emerges as a prognostic factor for LR outcomes in elderly HCC patients. Postoperative complications in sarcopenic patients may compromise oncological outcomes.
- | Journal: Sex-Specific Association of Low Muscle Mass with Depression Status in Asymptomatic Adults: A Population-Based Study. (Pubmed Central) - Nov 27, 2024
Decreased muscle mass was independently associated with increased chances of depression and severe depression in both sexes, with a significantly stronger association in men compared to women. This highlights the potential significance of LMM as a predictor of depression, particularly in men.
- || Review, Journal: Alzheimer's Disease: Understanding Motor Impairments. (Pubmed Central) - Nov 27, 2024
This review provides an in-depth analysis of motor symptoms in AD, discussing its progression, potential mechanisms, and therapeutic strategies. Addressing motor symptoms alongside cognitive decline may enhance patient functionality, improve quality of life, and support more comprehensive disease management strategies.
- | Journal: Factors Influencing the Attrition Rate of a 10-Week Multimodal Rehabilitation Program in Patients After Lung Transplant: A Neural Network Analysis. (Pubmed Central) - Nov 27, 2024
The prevalence of high attrition rate in LT recipients is high. The profile of patients with a high probability of attrition includes those with chronic obstructive pulmonary disease, low BMI and handgrip strength, and reduced HRQoL.
- || Review, Journal: Potential Vitamin E Signaling Mediators in Skeletal Muscle. (Pubmed Central) - Nov 27, 2024
In this review, we focus on the actual knowledge of Vit E forms in SkM functions and new potential signaling effectors (i.e., bioactive sphingolipids and myokines). The possible advantages of Vit E supplementation in counteracting SkM dysfunctions in sarcopenia and under microgravity will also be discussed.
- || Review, Journal: Myokines and Their Potential Protective Role Against Oxidative Stress in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). (Pubmed Central) - Nov 27, 2024
Finally, we underscore the therapeutic potential of exercise as a non-pharmacological intervention to enhance myokine release, thereby preventing the progression of MASD through improved hepatic antioxidant defenses. This review represents a comprehensive perspective on the intersection of exercise, myokine biology, and liver health.
- | Journal: Validation of Ultrasound Measurement of Vastus Lateralis for Appendicular Skeletal Muscle Mass in Chronic Kidney Disease Patients with Hemodialysis. (Pubmed Central) - Nov 27, 2024
The ASM adjusted with BMI demonstrated superior performance in diagnosing sarcopenia compared to the ASM adjusted with height. Ultrasound provides a cost-effective bedside tool for evaluating muscle conditions in HD patients.
- | Journal, HEOR: Depression and Quality of Life in Patients With Chronic Kidney Disease: A Mediation Analysis of Handgrip Strength and Demoralization. (Pubmed Central) - Nov 27, 2024
Therefore, nurses should better appreciate the importance of handgrip strength for patients with CKD and evaluate handgrip strength. Nurses should also develop physical and mental interventions to increase handgrip strength and decrease demoralization.
- || Retrospective data, Review, Journal, HEOR: To nap or not? Evidence from a meta-analysis of cohort studies of habitual daytime napping and health outcomes. (Pubmed Central) - Nov 26, 2024
No significant differences in napping and health risks were observed for napping frequency, percentage of nappers, sample size, sex, age, body mass index, follow-up years, or comorbidity status. These findings indicate that individuals with a long napping duration should consider shortening their daily nap duration to 30
- Observational data, Retrospective data, Journal: Correlation of Sarcopenia with Coronary Artery Disease Severity and Pericoronary Adipose Tissue Attenuation: A Coronary CT Study. (Pubmed Central) - Nov 26, 2024
This study demonstrated weak associations between the sarcopenia indicators and the cardiovascular risk, as assessed by the CAD severity and pCAT inflammation. However, these correlations were not strong predictors of CAD severity, as age and traditional cardiovascular risk factors overshadowed the impact of sarcopenia in the cardiovascular risk assessment.
- || Review, Journal: Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms. (Pubmed Central) - Nov 26, 2024
A better understanding of these interactions could inform more comprehensive obesity management approaches by addressing both central nervous system influences on behavior and peripheral metabolic regulation. This review synthesizes recent insights into these roles, highlighting potential therapeutic strategies targeting both systems for more effective obesity interventions.
- | Biomarker, Journal: Beyond the Obesity Paradox: Analysis of New Prognostic Factors in Transcatheter Aortic Valve Implantation Procedure. (Pubmed Central) - Nov 26, 2024
We confirm that overweight and obesity are good prognostic factors, and sarcopenia is a poor prognostic factor for outcomes following the TAVI procedure. We focused on the scientific validation of an easy and fast way to measure fat and skeletal muscle mass using CT to better predict the outcomes of patients undergoing TAVI.
- | Retrospective data, Journal, Metastases: Prognostic Value of Sarcopenia in Elderly Patients with Metastatic Non-Small-Cell Lung Cancer Undergoing Radiotherapy. (Pubmed Central) - Nov 26, 2024
These findings suggest that psoas muscle size is a valuable prognostic marker for elderly NSCLC patients, potentially guiding treatment decisions and patient management. Further research is needed to validate these results and refine prognostic models for this population.
- ||| Review, Journal, Adverse events: Definitions and adverse outcomes of sarcopenia in older patients in orthopedic and trauma care: A scoping review on current evidence. (Pubmed Central) - Nov 26, 2024
This scoping review suggests that sarcopenia may be associated with prolonged length of stay, higher rates of non-home discharge, and increased mortality among older patients in orthopedic and trauma care. However, prospective studies are necessary to establish the relationship between sarcopenia and refractures, falls, and functional outcome/quality of life among older patients in orthopedic and trauma care.
- || Review, Journal: Scientific landscape of oxidative stress in sarcopenia: from bibliometric analysis to hotspots review. (Pubmed Central) - Nov 26, 2024
Given the expectation that research on OS in sarcopenia will remain a prominent area of interest in the future, this article could serve as a valuable resource for scholars seeking to shape future studies through an understanding of influential scholarly contributions and key research findings. https://www.crd.york.ac.uk, identifier CRD42024528628.
- | Journal: Low geriatric nutritional risk index is associated with osteosarcopenia in older patients with type 2 diabetes mellitus. (Pubmed Central) - Nov 26, 2024
Low GNRI was associated with an increased risk of osteosarcopenia in older adults with T2DM. Comprehensive clinical evaluation of nutritional status by a simple tool such as GNRI might be helpful for early identification of those at high risk for osteosarcopenia in older diabetic individuals.
- | Retrospective data, Journal, Metastases: Sarcopenia's Role in Neoadjuvant Chemotherapy Outcomes for Locally Advanced Breast Cancer: A Retrospective Analysis. (Pubmed Central) - Nov 26, 2024
CONCLUSIONS Sarcopenia significantly increases after NAC but does not independently impact pathological response, recurrence, or survival in locally advanced breast cancer. Obesity and comorbid conditions are key factors influencing sarcopenia, highlighting the need for comprehensive management to mitigate treatment-related sarcopenia.
- | Enrollment open, Trial initiation date, Trial primary completion date: Myomachia: Comparison of Serum Myokine Dosages and Imaging Methods in the Evaluation of Sarcopenia in Patients With Hepatocellular Carcinoma (clinicaltrials.gov) - Nov 26, 2024
P=N/A, N=139, Recruiting, Sponsor: CHU de Reims
Obesity and comorbid conditions are key factors influencing sarcopenia, highlighting the need for comprehensive management to mitigate treatment-related sarcopenia. Not yet recruiting --> Recruiting | Initiation date: Aug 2024 --> Nov 2024 | Trial primary completion date: Jul 2025 --> Nov 2025
- | Journal: Letter to the editor: High-density lipoprotein cholesterol level and risk of muscle strength decline and sarcopenia in older adults. (Pubmed Central) - Nov 25, 2024
Not yet recruiting --> Recruiting | Initiation date: Aug 2024 --> Nov 2024 | Trial primary completion date: Jul 2025 --> Nov 2025 No abstract available
- || Review, Journal: The Prevalence of Sarcopenia in Patients with Solid Tumors Differs Across Regions: A Systematic Review. (Pubmed Central) - Nov 25, 2024
European studies demonstrate high prevalence rates for both settings. There is need for regional harmonization of sarcopenia definitions.
- || Clinical data, Journal: Association Between Sarcopenia, Clinical Outcomes, and Survival in Patients with Extensive-Stage Small Cell Lung Cancer Treated with First-Line Immunochemotherapy: A Prospective Cohort Study. (Pubmed Central) - Nov 25, 2024
Patients with Extensive SCLC and sarcopenia had worse clinical outcomes and shorter OS. Sarcopenia is a prognostic factor affecting first-line treatment efficacy and long-term survival of patients with SCLC in the era of immunotherapy.
- | Preclinical, Journal: The Non-Linear Profile of Aging: U-Shaped Expression of Myostatin, Follistatin and Intermediate Signals in a Longitudinal In Vitro Murine Cell Sarcopenia Model. (Pubmed Central) - Nov 25, 2024
Our work demonstrates a U-shape tendency for myostatin and follistatin and for the signaling pathway regulators. These results could be of the utmost importance when designing further research on seeking molecular biomarkers and/or targets for sarcopenia.
- | Journal: MRI-Based Phenotyping for Osteosarcopenic Adiposity in Subjects from a Population-Based Cohort. (Pubmed Central) - Nov 25, 2024
The highest prevalence of an impaired glucose tolerance as well as significantly higher blood pressure, blood dyslipidemia, and hepatic steatosis was found in the OSA subgroup (all p < 0.005). MR biomarkers of bone, skeletal muscle and fat are feasible for body composition phenotyping and may allow for targeted risk stratification in suspected OSA syndrome.
- | Journal: Reliability and Validity of Measuring the Strength of the Chin-Tuck Maneuver in Community-Dwelling Older Adults as a Means of Evaluating Swallowing-Related Muscle Strength. (Pubmed Central) - Nov 25, 2024
Chin-tuck strength was significantly associated with maximum tongue pressure, grip strength, knee extension strength, and TUGT. This study suggests that chin-tuck strength is a reliable and valid assessment of swallowing-related muscle strength.
- | Observational data, Journal: The Prevalence of Malnutrition and Sarcopenia and the Relationship with Inflammation and Anemia Among Community-Dwelling Older Adults: A Preliminary Cross-Sectional Study. (Pubmed Central) - Nov 25, 2024
The association between sarcopenia, malnutrition status, and anemia might overlap in clinical manifestation. In addition, future research directions regarding the utility of routine CBC testing should focus on sarcopenia and malnutrition status.
- || Retrospective data, Review, Journal: The Impact of Exercise and Protein Intake on Inflammaging: A Meta-Analysis and Systematic Review of Randomized Controlled Trials. (Pubmed Central) - Nov 25, 2024
These findings highlight the importance of combined interventions against muscle wasting. Future studies and meta-analyses should further address the effects of Ex and Pro and Ex-Pro on inflammatory markers of older adults, considering specific conditions and larger sample sizes to identify optimal strategies for the aging population.
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Journal: Managing Dosage Adjustments in Pseudo-Hypocreatinemia: Insights from Vancomycin-Induced Nephrotoxicity in a Sarcopenic Patient. (Pubmed Central) - Nov 25, 2024
This case underscores the need for careful interpretation of creatinine-based assessments. We propose strategies to optimize medication dosing, particularly in patients with sarcopenia, to mitigate such risks.
- | Retrospective data, Journal: The impact of appendicular skeletal muscle index and trunk muscle index on stress urinary incontinence risk in female adults: a retrospective study. (Pubmed Central) - Nov 25, 2024
Our study results showed that there was no association between ASMI and the risk of SUI, while a high TMI reduced the risk of SUI. This suggested that the ratio of muscle mass and BMI in different body regions has varying effects on SUI.
- | Observational data, Journal: Association of dietary inflammatory index with sarcopenia in patients with Metabolic dysfunction-associated fatty liver disease: a cross-sectional study. (Pubmed Central) - Nov 25, 2024
DII was significantly associated with the risk of sarcopenia in female patients with MAFLD, with higher DII scores related to a higher risk of sarcopenia. Higher DII scores related to a higher risk of sarcopenia in men with significant fibrosis.
- | Journal: The ability of GLIM and MNA-FF to diagnose malnutrition and predict sarcopenia and frailty in hospitalized adults over 60?years of age. (Pubmed Central) - Nov 25, 2024
It is possible to verify that divergent conceptual frameworks are used to understand malnutrition by the MNA-FF and GLIM and that the GLIM obtained a greater number of malnutrition diagnoses. Both the GLIM ANTHRO and the MNA-FF associated malnutrition with frailty and sarcopenia, with higher hazard ratios for the MNA-FF.
- || Review, Journal: Frailty in kidney transplant recipients. (Pubmed Central) - Nov 25, 2024
Frailty at the time of transplantation is associated with complications after kidney transplantation such as delayed graft function, longer hospital stays, rehospitalizations, immunosuppression intolerance, surgical complications, and death. Nevertheless, kidney transplantation can be a viable intervention for frailty in dialysis patients.
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Preclinical, Journal: Perindopril erbumine-entrapped ultradeformable liposomes alleviate sarcopenia via effective skin delivery in muscle atrophy mouse model. (Pubmed Central) - Nov 23, 2024
PE-UDLs also increased the expression of myosin heavy chain (MHC) protein and reduced the expression of muscle atrophy F-box (Atrogin-1) and muscle ring-finger protein-1 (MuRF1), thereby improving muscles atrophy. In conclusion, these results demonstrate the therapeutic potential of PE-UDLs against sarcopenia.
- | Journal: Unrecognized association between autonomous cortisol secretion and myosteatosis in patients with aldosterone-producing adenoma. (Pubmed Central) - Nov 23, 2024
In conclusion, these results demonstrate the therapeutic potential of PE-UDLs against sarcopenia. No abstract available
- | Journal, Surgery: The use of the psoas-to-lumbar vertebrae index and modified frailty index in predicting postoperative complications in degenerative spine surgery: can sarcopenia or frailty be underestimated? (Pubmed Central) - Nov 23, 2024
Frailty is a robust predictor of postoperative complications in DSD surgeries, while sarcopenia, appears to play a lesser role. The findings suggest that frailty alone provide a more comprehensive assessment of risk than sarcopenia.
- | Observational data, Retrospective data, Journal: Association of Skeletal Muscle Mass and Muscle Quality at Diagnosis With Survival in Young Women With Breast Cancer: Retrospective Observational Study. (Pubmed Central) - Nov 23, 2024
Poor muscle quality at diagnosis was associated with shorter progression-free survival in young women with breast cancer. Future research should determine the significance of changes in muscle quality throughout treatment.
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Journal, Metastases: Skeletal muscle is independently associated with grade 3-4 toxicity in advanced stage pancreatic ductal adenocarcinoma patients receiving chemotherapy. (Pubmed Central) - Nov 23, 2024
Future research should determine the significance of changes in muscle quality throughout treatment. Sarcopenia and early muscle and fat wasting during FOLFIRINOX treatment were associated with treatment-related toxicity, warranting exploration of body composition guided personalized dosing of chemotherapeutics to limit DLTs.
- | Observational data, Journal, Real-world evidence, Real-world: Global Leadership Initiative in Sarcopenia (GLIS)-defined sarcopenia increases the mortality of esophageal cancer patients after esophagectomy: A Chinese real-world cohort study. (Pubmed Central) - Nov 23, 2024
GLIS-defined sarcopenia is prevalent among Chinese EC patients and is linked to increased mortality risk postesophagectomy. This finding offers compelling evidence and serves as a valuable reference for the establishment of an operational definition of GLIS sarcopenia.
- | Retrospective data, Journal: Sarcopenia and osteoporosis in patients with psoriatic arthritis: A single-center retrospective study. (Pubmed Central) - Nov 23, 2024
Osteoporosis rates for males and females were 5.7% and 7.5%, respectively. SMI, T-score, and BMI are significantly correlated with each other and should be considered in clinical practice.
- | Journal: Prevalence of dehydration in older hospitalized patients with oropharyngeal dysphagia. (Pubmed Central) - Nov 22, 2024
Dehydration is a highly prevalent condition among hospitalized older patients with OD. Assessment of hydration status, and promotion and monitoring of safe fluid intake with multimodal hydration interventions, is mandatory in patients with OD.
- | Journal, Metabolomic study: Clinically relevant body composition phenotypes are associated with distinct circulating cytokine and metabolomic milieus in epithelial ovarian cancer patients. (Pubmed Central) - Nov 22, 2024
In this pilot study, we identified several significantly differentially abundant metabolites according to body composition phenotypes, confirming that clinically significant joint-exposure body composition phenotypes are also biologically distinct. Although we observed evidence that at-risk phenotypes were associated with increased abundance of immuno-metabolic biomarkers indicated in immune suppression, additional confirmatory studies focused on defining the link between body composition and immune cell composition and spatial relationships in the EOC tumor microenvironment are warranted.
- | Journal: Assessment and Rehabilitation in Sarcopenic Patients. (Pubmed Central) - Nov 22, 2024
Patients assessment (lab tests, gait analysis, VAS and the Clinical Frailty Scale) was made on two levels-first (T1-inpatient assessment), and after 6 months (T2-outpatient assessment). The rehabilitation program based on the kinetic program brought positive improvements in physical performance and locomotion (gait speed and walking cadence) in sarcopenic patients.
- | Journal: Temporal Muscle Thickness Predicts Mortality and Disability in Older Adults Diagnosed with Mild Dementia. (Pubmed Central) - Nov 22, 2024
TMT emerges as a cost-efficient measure of muscle mass indicating clinical relevance and utility in healthcare settings. Implementing TMT assessment could improve patient care and aid in identifying individuals at risk of adverse outcomes in mild dementia.
- || Clinical, Retrospective data, Review, Journal: Polyphenol Supplementation and Sarcopenia: A Systematic Review and Meta-Analysis of Clinical Trials. (Pubmed Central) - Nov 22, 2024
Based on the available data, this study provides pooled evidence that treatment with polyphenols may have a beneficial effect on muscle mass in sarcopenic subjects. However, further studies with larger sample sizes are required to substantiate this effect and draw more accurate conclusions.
- Observational data, Retrospective data, Journal: Evaluation of Handgrip Strength Asymmetry to Assess Sarcopenia in Older Patients with Chronic Low Back Pain: A Retrospective Cross-Sectional Study. (Pubmed Central) - Nov 22, 2024
However, further studies with larger sample sizes are required to substantiate this effect and draw more accurate conclusions. Severe HGS asymmetry was associated with poor physical performance and a higher proportion of sarcopenia in older female patients with CLBP.
- || Clinical, Journal: Five-Time Sit-To-Stand Lower Limb Muscle Power in Older Women: An Explorative, Descriptive and Comparative Analysis. (Pubmed Central) - Nov 22, 2024
Severe HGS asymmetry was associated with poor physical performance and a higher proportion of sarcopenia in older female patients with CLBP. Findings of the present study suggest that 5STS biomechanical aspects might contribute to discriminating older women with high and low physical performance.
- | Journal, HEOR: Muscle Mass, Strength, Power and Physical Performance and Their Association with Quality of Life in Older Adults, the Study of Muscle, Mobility and Aging (SOMMA). (Pubmed Central) - Nov 22, 2024
Poor performance, lower fitness and lower strength are related to worse quality of life, particularly pain, in older adults. Future studies should quantify these relationships longitudinally.