Sarcopenia
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  • ||||||||||  Biomarker, Journal:  Subphenotypes of frailty in lung transplant candidates. (Pubmed Central) -  Apr 10, 2023   
    In this early phase study, we identified biological frailty subphenotypes in lung transplant candidates. A hyperinflammatory, sarcopenic subphenotype appears to be associated with worse clinical outcomes.
  • ||||||||||  Biomarker, Review, Journal:  Protein Biomarkers in Blood Reflect the Interrelationships Between Stroke Outcome, Inflammation, Coagulation, Adhesion, Senescence and Cancer. (Pubmed Central) -  Apr 10, 2023   
    Moreover, the processes that underlie inflammation, hypercoagulation and cellular senescence connect stroke to cancer, and biomarkers of cancer-associated thromboembolism, as well as of sarcopenia, overlap strongly with the biomarkers discussed here. Finally, we demonstrate that most of the outcome-predicting protein biomarkers form a close-meshed functional interaction network, suggesting that the outcome after stroke is partially determined by an interplay of molecular processes relating to inflammation, coagulation, cell adhesion and cellular senescence.
  • ||||||||||  Journal:  Fat and fat-free mass as important determinants of body composition assessment in relation to sarcopenic obesity. (Pubmed Central) -  Apr 8, 2023   
    FM/FFM correlates excellently with FM and VFA and can be implemented to diagnose obesity. In order to comprehensively evaluate the state of health and body composition, the proportionality of not only fat, but also fat-free/muscle mass should be analyzed, because it turns out that a negative impact on health and survival is associated not only with an excessive amount of adipose tissue, but also with a lower muscle mass.
  • ||||||||||  Journal:  Hyperuricemia may be associated with muscle wellness in older adults. (Pubmed Central) -  Apr 8, 2023   
    In order to comprehensively evaluate the state of health and body composition, the proportionality of not only fat, but also fat-free/muscle mass should be analyzed, because it turns out that a negative impact on health and survival is associated not only with an excessive amount of adipose tissue, but also with a lower muscle mass. Considering the positive effect of hyperuricemia on sarcopenia, avoiding aggressive uric acid-lowering therapy may be a good option in older adults with asymptomatic hyperuricemia.
  • ||||||||||  Review, Journal:  Muscle strength and physical performance contribute to and improve fracture risk prediction in older people: A narrative review. (Pubmed Central) -  Apr 8, 2023   
    Most of the included publications showed that muscle mass is not a good predictor of fracture risk, while poor muscle strength and performance are associated with an increased risk of fracture, particularly in men, independent of age, BMD, and other risk factors for fractures. Muscle strength and performance can potentially improve the predictive accuracy in men beyond that obtained by the fracture risk assessment tools, Garvan FRC and FRAX.
  • ||||||||||  Journal:  Lipid hydroperoxides promote sarcopenia through carbonyl stress. (Pubmed Central) -  Apr 7, 2023   
    In young and old mice, genetic and pharmacologic neutralization of LOOH or their secondary reactive lipid aldehydes robustly prevented muscle atrophy and weakness, indicating that LOOH-derived carbonyl stress mediates age- and disuse-induced muscle dysfunction. Our findings provide novel insights for the role of LOOH in sarcopenia including a therapeutic implication by pharmacologic suppression.
  • ||||||||||  Clinical data, Journal:  Gut microbiota in relation to frailty and clinical outcomes. (Pubmed Central) -  Apr 7, 2023   
    Then, we specifically focus on the relationship between gut microbiota and frailty syndrome, that is one of the major age-related burdens. Finally, examples of microbiome-based precision interventions, mainly dietary, prebiotic and probiotic ones, are discussed as tools to ameliorate the symptoms of frailty and its overlapping conditions (e.g. sarcopenia), with the ultimate goal of actually contributing to healthy ageing and hopefully promoting longevity.
  • ||||||||||  Journal:  Functional impact on adults and older people after hospitalization by Covid-19. (Pubmed Central) -  Apr 7, 2023   
    This trial was registered at clinicaltrials.gov as NCT03637855 (https://clinicaltrials.gov/ct2/show/NCT03637855), NCT05217524 (https://clinicaltrials.gov/ct2/show/NCT05217524), and NCT03771417 (https://clinicaltrials.gov/ct2/show/NCT03771417). Hospitalization by Covid-19 impacts functional capacity after 1
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Trial completion date, Trial primary completion date:  PRIMe: Protein Recommendation to Increase Muscle (clinicaltrials.gov) -  Apr 6, 2023   
    P=N/A,  N=50, Completed, 
    Hospitalization by Covid-19 impacts functional capacity after 1 Active, not recruiting --> Completed | Trial completion date: Feb 2023 --> Apr 2022 | Trial primary completion date: Feb 2023 --> Apr 2022
  • ||||||||||  Review, Journal:  Sarcopenia and Frailty in Cirrhosis: Assessment and Management. (Pubmed Central) -  Apr 5, 2023   
    To manage sarcopenia/frailty, a multidisciplinary team should develop a personalized comprehensive care plan that includes patient education, protein/calorie intake goals, late evening meals, exercise programs, and micronutrient replenishment. In selected patients, branched-chain amino acid and testosterone supplements may also be beneficial.
  • ||||||||||  Trial completion date, Trial termination:  EAMA9+: EAMA Sarcopenia in Acute Care Patients in 9+European Countries (clinicaltrials.gov) -  Apr 5, 2023   
    P=N/A,  N=366, Terminated, 
    The IFPI score could improve patient survival prediction. Trial completion date: Mar 2021 --> Apr 2023 | Unknown status --> Terminated; COVID-19 pandemic and lack of funding necessary for continuation
  • ||||||||||  Review, Journal:  Muscle Quality in Older Adults: A Scoping Review. (Pubmed Central) -  Apr 4, 2023   
    Herein, we propose a standardized definition of muscle quality to include terminology, domain, and assessment methods (tests, tools, and body sites). Such standardization may help researchers, clinicians, and decision makers use muscle quality as a potential marker of "skeletal muscle health" in older adults.
  • ||||||||||  Journal:  A Nomogram for Optimizing Sarcopenia Screening in Community-dwelling Older Adults: AB3C Model. (Pubmed Central) -  Apr 4, 2023   
    Such standardization may help researchers, clinicians, and decision makers use muscle quality as a potential marker of "skeletal muscle health" in older adults. AB3C model, an easy-to-apply and cost-effective nomogram, was developed to predict the risk of sarcopenia, which may contribute to optimizing sarcopenia screening in community settings.
  • ||||||||||  Journal:  Impact of osteosarcopenia on disability and mortality among Japanese older adults. (Pubmed Central) -  Apr 4, 2023   
    Among older adults, OS identified by bioimpedance and quantitative ultrasound assessments was associated with an increased risk of disability and mortality. Further research is needed to implement these findings in community health activities, such as setting precise cut-off values and constructing accurate disability and mortality prediction models.
  • ||||||||||  Preclinical, Review, Journal:  Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models. (Pubmed Central) -  Apr 4, 2023   
    We also put a special focus on cellular alterations occurring in COPD, a chronic and highly prevalent respiratory disease mainly linked to tobacco smoke exposure, where muscle wasting is strongly associated with increased mortality, and discuss the pros and cons of animal models versus human studies in this context. Finally, we discuss resident cells metabolism and present future promising leads for research, including the use of muscle organoids.
  • ||||||||||  Retrospective data, Review, Journal:  Sarcopenia is associated with a greater risk of polypharmacy and number of medications: a systematic review and meta-analysis. (Pubmed Central) -  Apr 4, 2023   
    This systematic review and meta-analysis reported a significantly increased risk of polypharmacy and higher number of medications in people with sarcopenia compared with individuals without this condition. Future research should clarify whether the specificity and number of medications is a direct contributor in accelerating the progression of muscle wasting and dysfunction contributing to sarcopenia in older adults.
  • ||||||||||  Biomarker, Review, Journal:  C-terminal agrin fragment as a biomarker of muscle wasting and weakness: a narrative review. (Pubmed Central) -  Apr 4, 2023   
    CAF seems a reliable marker to assess muscle wasting in ageing and disease, also correlating with measurements of appendicular lean mass and muscle function. Future research should aim at enlarging sample size and accurately reporting the medical history of each patient, to normalize for any condition, including chronic kidney disease, that may influence the circulating concentration of this biomarker.
  • ||||||||||  Journal:  Recognising, reducing and preventing deconditioning in hospitalised older people. (Pubmed Central) -  Apr 4, 2023   
    Hospital-associated deconditioning can be reduced or prevented through mobilisation strategies such as those promoted by the #EndPJparalysis campaign. This article explains the importance of reducing or preventing hospital-associated deconditioning and nurses' role in this.
  • ||||||||||  Journal:  Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function. (Pubmed Central) -  Apr 4, 2023   
    Consensus should be reached on standardized cut-off values for defining sarcopenia in patients with ovarian cancer. The present findings suggest that our 2-year mixed aerobic, strength and balance training seemed effective for preventing the age and sarcopenia-related increases in CAF concentration, preserving NMJ stability as well as muscle structure (PA and Lf) and improving physical performance in sarcopenic older individuals.
  • ||||||||||  Journal:  Effect of the GERAS DANcing for Cognition and Exercise Program on Physical Function in Older Adults. (Pubmed Central) -  Apr 4, 2023   
    Individuals with baseline SPPB ?8 points (n = 38)-indicative of sarcopenia and physical frailty-had the most marked improvement (SPPB total: +1.45, SD = 1.97, p < .001; balance: +0.65, SD = 1.27, p = .006; chair stands: +0.68, SD = 0.97, p < .001). GERAS DANcing for Cognition and Exercise may be a promising rehabilitation intervention to improve daily physical function.