Sarcopenia News - LARVOL Sigma

Sarcopenia	Welcome, Profile Billing Logout

«1 2...119 120 121 122 123124125 126 127 128 129...401 402 »

|||||||||| Journal: Obesity and type (Pubmed Central) - May 1, 2023
The importance of modern GLP?1 agonists and dual GLP?1 GIP agonists increases since these drugs target obesity and type

|||||||||| New trial: Leucine-enriched Formulas in Patients With Tumor-induced Sarcopenia (clinicaltrials.gov) - May 1, 2023
P=N/A, N=48, Completed, Sponsor: Maim

|||||||||| Review, Journal: Toward the recognition and management of sarcopenia in routine clinical care. (Pubmed Central) - May 1, 2023
The management decision process of sarcopenia warrants an evaluation of risk factors such as a sedentary lifestyle, inadequate exercise, poor nutritional intake, smoking, depression and living circumstances. Herein, we provide an evidence-based update of the prevention and management of sarcopenia and propose practical information to facilitate the disease's adoption into routine care.

|||||||||| Journal: Preoperative Rapid Weight Loss as a Prognostic Predictor After Surgical Resection for Pancreatic Cancer. (Pubmed Central) - Apr 30, 2023
Herein, we provide an evidence-based update of the prevention and management of sarcopenia and propose practical information to facilitate the disease's adoption into routine care. Preoperative rapid BW loss ?1.34% per month was an independent predictor of worse survival of patients with PDAC.

|||||||||| Clinical: Frequency of Sarcopenia, Sarcopenic Obesity, and Changes in Physical Function in Surgical Oncology Patients Referre… https://t.co/1AQWToiwQ0 (Twitter) - Apr 30, 2023

|||||||||| To the best of my knowledge, frailty is a #geriatricsyndrome characterized by an increased vulnerability to stressors. There are many ways to evaluate it, including SPPB which is mentioned in some papers. However, SARC-F is a screening tool specifically designed for sarcopenia (Twitter) - Apr 30, 2023

|||||||||| #Sphingolipids accumulate in aged #muscle, and their reduction counteracts #sarcopenia @NatureAging @mackinprof @GGouspillou @NKLeBRASSEUR @MVFranchi @darrencandow https://t.co/Ruy7EAns5S (Twitter) - Apr 29, 2023

|||||||||| Connecting Sarcopenia, Brain Structure, and Cognitive Performance: Large-Scale Evidence From the UK Biobank (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_723;
The brainstem and cerebellum white matter volumes mediate the link between sarcopenia and cognitive performance (p<1e-06). Conclusions Our findings suggest that understanding the link between probable sarcopenia and brain structure alterations and cognition is necessary to disentangle the sarcopenia-dementia connection.

|||||||||| Journal, Adverse events: The Role of Frailty and Sarcopenia in Predicting Major Adverse Events, Length of Stay and Reoperation Following En Bloc Resection of Primary Tumours of the Spine. (Pubmed Central) - Apr 29, 2023
The STFI was only associated with unplanned reoperation for SSI on unadjusted analysis, while the mFI and sarcopenia were not predictive of any outcome. Further studies are needed to investigate the relationship between frailty, sarcopenia and perioperative outcomes following en bloc resection of primary spinal tumors.

|||||||||| Journal: Lean non-alcoholic fatty liver disease: Age-dependent differences in pathology, prognosis, and liver-related events. (Pubmed Central) - Apr 29, 2023
Age is an important consideration in patients with lean NAFLD. Compared with non-lean NAFLD, lean NAFLD was associated with a worse prognosis and higher risk of complications in patients aged ?60 years.

|||||||||| Journal: Evaluation of muscle strength and quality in North African patients with chronic hepatitis B: A pilot case control study. (Pubmed Central) - Apr 29, 2023
One NC-CHB participant had a confirmed sarcopenia.To conclude, both controls and NC-CHB patients had similar HGS values. Only one NC-CHB patient had a confirmed sarcopenia.

|||||||||| Journal: Sarcopenia is an independent risk factor for all-cause mortality rate in patients with diabetic foot ulcers. (Pubmed Central) - Apr 28, 2023
Sarcopenia is an independent risk factor for all-cause mortality of patients with DFUs and hence an important prognostic factor for patients with DFUs. Active prevention and improvement of sarcopenia can potentially improve the survival outcomes of this patient population.

|||||||||| Journal: A Novel Neutrophil-to-Lymphocyte Ratio and Sarcopenia Based TACE-Predict Model of Hepatocellular Carcinoma Patients. (Pubmed Central) - Apr 28, 2023
The C-indexes of the nomogram for OS were 0.782/0.728 in the training and validation cohorts, outperforming other currently available models. A novel nomogram based on NLR and sarcopenia may be useful to predict the prognosis of HCC patients who underwent TACE across BCLC A-C stage patients.

|||||||||| Journal: Editorial: Muscle plasticity: Regulation of adaptive changes in muscles and mitochondrial dynamics. (Pubmed Central) - Apr 28, 2023
A novel nomogram based on NLR and sarcopenia may be useful to predict the prognosis of HCC patients who underwent TACE across BCLC A-C stage patients. No abstract available

|||||||||| thyroxine / Generic mfg.
Observational data, Journal: Higher thyroid hormone has a negative association with lower limb lean body mass in euthyroid older adults: Analysis from the Baltimore Longitudinal study of aging. (Pubmed Central) - Apr 28, 2023
In euthyroid older adults, higher FT4 is associated with lower leg lean mass and higher odds of sarcopenia. Understanding the relationship between thyroid hormone and sarcopenia is needed to improve clinical decision-making and avoid functional decline from excess thyroid hormone use in older adults.

|||||||||| Zolinza (vorinostat) / Merck (MSD)
Journal: Repurposing Approved Drugs for Sarcopenia Based on Transcriptomics Data in Humans. (Pubmed Central) - Apr 28, 2023
Vorinostat, the top-ranking drug, was also validated in an in vitro study, which demonstrated its efficacy in promoting muscle fiber formation. Although still requiring further validation in animal models and human clinical trials, these results suggest a promising drug repurposing prospect in the treatment and prevention of sarcopenia.

|||||||||| Journal, Machine learning: A Machine-Learning Approach to Target Clinical and Biological Features Associated with Sarcopenia: Findings from Northern and Southern Italian Aging Populations. (Pubmed Central) - Apr 28, 2023
Albumin, CRP, vitamin D, and serum folate should not be neglected in screening for sarcopenia in the aging population. Better preventive medicine settings in geriatrics are urgently needed to lessen the impact of sarcopenia on the general health, quality of life, and medical care delivery of the aging population.

|||||||||| Journal: Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies. (Pubmed Central) - Apr 28, 2023
These findings suggest that different types of frailty may be characterized by distinct metabolic perturbations. Amino acid profiling may therefore serve as a valuable tool for frailty biomarker discovery.

|||||||||| Review, Journal: Exercise Improves the Coordination of the Mitochondrial Unfolded Protein Response and Mitophagy in Aging Skeletal Muscle. (Pubmed Central) - Apr 28, 2023
Furthermore, the bidirectional regulation of reactive oxygen species (ROS) and AMPK in modulating this mechanism is discussed. The hierarchical surveillance network of MQC can be targeted by exercise-derived ROS to attenuate aging, which offers a molecular basis for potential therapeutic interventions for sarcopenia.

|||||||||| Preclinical, Journal: Effects of Turmeric Extract on Age-Related Skeletal Muscle Atrophy in Senescence-Accelerated Mice. (Pubmed Central) - Apr 28, 2023
Moreover, TE may have reduced mitochondrial damage and maintained cell growth and division by downregulating the mRNA expression of the genes mfn2 and tsc2. Thus, the results indicated TE's potential for preventing age-related muscle atrophy and sarcopenia.

|||||||||| Observational data, Journal: Nutritional Care Practices in Geriatric Rehabilitation Facilities across Europe: A Cross-Sectional Study. (Pubmed Central) - Apr 28, 2023
Thus, the results indicated TE's potential for preventing age-related muscle atrophy and sarcopenia. As malnutrition, sarcopenia, and frailty are often present in patients admitted to GR, in addition to being interrelated, it is recommended to develop an integrated approach to screening and treatment of all three clinical problems.

|||||||||| Journal: Engagement in Aerobic Exercise Is Associated with a Reduced Prevalence of Sarcopenia and Severe Sarcopenia in Italian Older Adults. (Pubmed Central) - Apr 28, 2023
The results of the binary regression showed negative associations between RS and the presence of STS-based sarcopenia in women, and between RS and STS-based severe sarcopenia in men. Collectively, these findings indicate that RS is negatively associated with the presence of sarcopenia in large sample of relatively unselected Italian older adults.

|||||||||| Review, Journal: Redox Signaling in Chronic Kidney Disease-Associated Cachexia. (Pubmed Central) - Apr 28, 2023
The importance of oxidative stress has been shown by experimental studies in which antioxidant therapies ameliorated CKD and its associated complications in the 5/6 nephrectomy model. Treatment of CKD-associated cachexia is a challenge and further studies are necessary to investigate potential therapies involving antioxidant therapy.

|||||||||| Review, Journal: Overcoming barriers to timely recognition and treatment of cancer cachexia: Sharing Progress in Cancer Care Task Force Position Paper and Call to Action. (Pubmed Central) - Apr 28, 2023
In June 2020, Sharing Progress in Cancer Care (SPCC) convened a multidisciplinary task force of medical experts and patient advocates to examine the barriers preventing the timely recognition of cancer cachexia, and provide practical recommendations to improve clinical care. This position paper summarises the key points and highlights available resources to support the integration of structured nutrition care pathways.

|||||||||| Retrospective data, Review, Journal, Surgery: Perioperative nutritional assessment and interventions in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): A systematic review. (Pubmed Central) - Apr 28, 2023
Preoperative nutritional assessment tools, including SGA and objective sarcopaenia measures, have a role in predicting nutritional status for CRS-HIPEC patients. Optimisation of nutrition is important for preventing complications.

|||||||||| Journal: Sarcopenia - Definition, Radiological Diagnosis, Clinical Significance. (Pubmed Central) - Apr 28, 2023

|||||||||| Journal: The significance of the osteosarcopenia as a predictor of the long-term outcomes in hepatocellular carcinoma after hepatic resection. (Pubmed Central) - Apr 28, 2023
Preoperative osteosarcopenia may be a prognostic factor in patients with hepatocellular carcinoma after hepatic resection. Our results suggests that the preoperative maintenance of skeletal muscle and bone density may potentially improve prognosis.

|||||||||| Clinical: More exciting ideas on aging and #bmtsm from @sghmd. Conditioning and the early stage of transplant seems to be so debilitating to many elderly pts (let alone later admissions for complications)—can that early sarcopenia be drugable when pts struggle to exercise? #msktoxtct (Twitter) - Apr 28, 2023

|||||||||| Trial completion, Enrollment change, Trial completion date, Trial primary completion date: REALPA: Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health (clinicaltrials.gov) - Apr 28, 2023
P=N/A, N=23, Completed, Sponsor: Louisiana State University and A&M College
Our results suggests that the preoperative maintenance of skeletal muscle and bone density may potentially improve prognosis. Recruiting --> Completed | N=45 --> 23 | Trial completion date: Jun 2023 --> Feb 2023 | Trial primary completion date: Jun 2023 --> Feb 2023

|||||||||| Review, Journal: Annual review of capillary electrophoresis technology in 2022 (Pubmed Central) - Apr 27, 2023
A comprehensive overview of representative CE works published in Journal of Chromatography A, Electrophoresis, and important Chinese core journals (Peking University) with IFs<5.0 is also provided. Based on IFs, this review introduces representative works on CE to facilitate readers' understanding of important research advances in CE technology over the last year.

|||||||||| Journal: Early Feasibility of an Activity-Based Intervention for Improving Ingestive Functions in Older Adults with Oropharyngeal Dysphagia. (Pubmed Central) - Apr 27, 2023
Three putative mediators of change (experienced autonomy support, in-therapy engagement, and perceived improvement in swallowing capacity) appeared to have been best accomplished in participants with slight to moderate dysphagia. The ACT-ING program showed preliminary evidence of early feasibility, warranting further early-phase dose articulation and proof-of-concept trials.

|||||||||| acetylcysteine solution / Generic mfg.
Review, Journal: Nutritional Support During Long COVID: A Systematic Scoping Review. (Pubmed Central) - Apr 27, 2023
Current gaps in the literature include a potential role for anti-inflammatory nutrients such as the omega 3 fatty acids, which are currently undergoing clinical trials, glutathione-boosting treatments such as N-acetylcysteine, alpha-lipoic acid, or liposomal glutathione in long COVID, and a possible adjunctive role for anti-inflammatory dietary interventions...Clinical trials of single nutrients are currently being conducted, and future systematic reviews could focus on single nutrient or dietary interventions to identify their nuanced mechanisms of action. Further clinical studies incorporating complex nutritional interventions are also warranted to strengthen the evidence base for using nutrition as a useful adjunctive treatment for people living with long COVID.

|||||||||| Journal: Sarcopenia Predicts Disease Progression in Patients with T1 High-grade Non-muscle-invasive Bladder Cancer Treated with Adjuvant Intravesical Bacillus Calmette-Gu (Pubmed Central) - Apr 27, 2023
We looked at the role of loss of skeletal muscle (sarcopenia) as a factor in predicting prognosis for stage T1 high-grade non-muscle-invasive bladder cancer. We found that sarcopenia is a ready-to-use, cost-free marker that could be used to guide treatment and follow-up in this disease, although the results need to be confirmed in other studies.

|||||||||| New trial: SARCO-GYN: Prospective Study of Detection of Sarcopenia in Clinical Practice for Patient With Ovarian or Endometrial Cancer (clinicaltrials.gov) - Apr 27, 2023
P=N/A, N=75, Recruiting, Sponsor: Centre Hospitalier Metropole Savoie

|||||||||| Observational data, Journal: Anxiety, depression and post-traumatic stress disorder in patients on hemodialysis in the setting of the pandemic, inflation, and the Beirut blast: a cross-sectional study. (Pubmed Central) - Apr 27, 2023
Psychiatric disorders were found to be compounded with increased prevalence of malnutrition, frailty, and sarcopenia. These findings urge healthcare providers to implement early diagnostic and intervention strategies to improve both mental and physical wellbeing of this vulnerable population, in similar settings.

|||||||||| Preclinical, Journal: Adult and elderly in vitro digestibility patterns of proteins and carbohydrates as affected by different commercial bread types. (Pubmed Central) - Apr 27, 2023
These findings urge healthcare providers to implement early diagnostic and intervention strategies to improve both mental and physical wellbeing of this vulnerable population, in similar settings. The extent of differences under different physiological settings varied depending on the bread type, without significant changes for soft wheat bread (?GI

|||||||||| The sit to stand test in cancer patients and survivors. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_6846;
Stage 4 cancer patients and overweight/obese patients were at especially high risk of having an impaired STS-30. Clinicians should utilize the STS-30 to screen cancer patients and survivors and if scores are impaired, further assess for presence of sarcopenia and introduce interventions to address it.

|||||||||| Alecensa (alectinib) / Roche
Analysis of significant weight gain in patients using alectinib for ALK-positive lung cancer. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_6497;
This may lead to serious metabolic disturbances in long-surviving patients. >Numeric variables are reported as mean

|||||||||| Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
Sarcopenia vs body mass index (BMI) as a prognostic biomarker in patients with metastatic clear cell renal cell carcinoma (mCCRCC) in the era of first line immune checkpoint inhibitors (ICIs). () - Apr 26, 2023 - Abstract #ASCO2023ASCO_5315;
This finding is consistent with the literature suggesting that muscle mass measurement provides an important prognostic biomarker for patients with mCCRCC. SMI could inform treatment selection and adoption of muscle measures when risk-stratifying this population should be considered.

|||||||||| oxaliplatin / Generic mfg.
Sex difference in tolerability of adjuvant oxaliplatin-based chemotherapy for colorectal cancer and changes in diagnostic components of sarcopenia: A prospective study. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_4975;
SMI could inform treatment selection and adoption of muscle measures when risk-stratifying this population should be considered. It is suggested that adjuvant CAPOX has negative impact on postoperative recovery of psychological and physical components in female patients.

|||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Retrospective analysis of digital biomarker predictability of immune checkpoint inhibitor therapy outcomes in patients with NSCLC. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_4718;
This may be especially important for ICI therapy as skeletal muscle effects the immune function through myokines. Sarcopenia has been associated with immune senescence and thus may play a significant role in decreasing response to ICI therapy.

|||||||||| Effect of a digital biopsychometric risk profile of patients with cancer on the delivery of risk-stratified personalised prehabilitation. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_4459;
Bio-psychometric profiling highlights modifiable risk factors and provides a focus for prehabilitation to be personalised. The findings also highlighted the importance of psychological wellbeing as high levels of emotional distress were associated with lower reported quality of life.

|||||||||| Body composition measures as predictors of toxicity in patients with metastatic breast cancer receiving PARP inhibitors. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_4242;
Skeletal muscle mass and adipose tissue may be taken into consideration in PARPi treatment and dosing decisions. A larger study is needed to further examine this hypothesis.

|||||||||| Evaluating the impact of exercise in women living with indolent metastatic breast cancer: The EMBody trial. (On Demand | Hall A; Poster Bd # 506b) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3734;
P2
Patients will be followed post- intervention for sustained behavior change and survival trajectory. Clinical trial information: NCT05468034.

|||||||||| Nutritional program among patients with prostate cancer receiving androgen deprivation therapy (ADT). (On Demand | Hall A; Poster Bd # 440) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3667;
Future studies should validate the benefit of this program in randomized trial with a longer follow-up assessment (6 and 12 months after treatment initiation). >

|||||||||| Associations between sarcopenia and clinical outcomes in men with metastatic castrate-resistant prostate cancer. (On Demand | Hall A; Poster Bd # 424) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3652;
Additionally, sarcopenia predicts radiographic progression and overall mortality regardless of treatment type in men with mCRPC. Confirmation is needed from large-scale studies.

|||||||||| Racial differences in muscle measures and survival among older adults with GI malignancies. (On Demand | Hall A; Poster Bd # 412) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3640;
Muscle measures may differ by race and have different associations with survival by racial group. Therefore, it is essential to develop cut points for muscle measures incorporating race.

|||||||||| Association of sarcopenia and treatment tolerability in older adults with advanced cancer: Secondary analysis of a nationwide NCI Community Oncology Research Program (NCORP) randomized clinical trial. (Available On Demand; Poster Bd # 406) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3634;
P=N/A
Furthermore, those with severe sarc had significantly worse survival. Evaluation for sarc before initiating treatment in older adults could help oncologists identify pts at higher risk of toxicity and poor survival.

|||||||||| Biologic profile to predict overall survival in non-metastatic breast cancer: A latent class analysis on aging biomarkers. (On Demand | Hall A; Poster Bd # 405) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3633;
The strong correlation between markers argues for a unique underlying biological pathway. Noteworthy, high IGF1, usually considered as a risk factor for breast cancer progression, was associated with a better prognosis.

|||||||||| resatorvid (TAK-242) / Takeda, Akaza Bioscience
Preclinical, Journal, IO biomarker: Sulforaphane reduces lipopolysaccharide-induced inflammation and enhances myogenic differentiation of mouse embryonic myoblasts via the toll-like receptor 4 and NLRP3 pathways. (Pubmed Central) - Apr 26, 2023
Noteworthy, high IGF1, usually considered as a risk factor for breast cancer progression, was associated with a better prognosis. Sulforaphane can reduce sepsis-induced inflammatory responses and enhance myogenic differentiation by regulating the TLR4 and NLRP3 inflammasome pathways.



	Diseases Companies Products Productz Mechanisms of Action Sites