Sarcopenia
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  • ||||||||||  Observational data, Journal:  Sarcopenia parameters in active older adults - an eight-year longitudinal study. (Pubmed Central) -  May 24, 2023   
    P=N/A
    Despite expected lower scores on tests of sarcopenia parameters due to age-related decline, participants performed better on motor tests than reported in similar studies. Nevertheless, the prevalence of sarcopenia was consistent with most of the published literature.
  • ||||||||||  Review, Journal:  Liver transplantation in the patient with physical frailty. (Pubmed Central) -  May 24, 2023   
    In addition to physical frailty, there is recognition that a global evaluation including a multidisciplinary approach to other components of frailty (e.g., cognition, emotional, psychosocial) also need to be addressed in patients on the transplant waitlist. Recent advances in our understanding of the underlying mechanisms of sarcopenia and contractile dysfunction have helped identify novel therapeutic targets.
  • ||||||||||  Retrospective data, Journal:  Effects of antiresorptive agents on body composition: a case-control retrospective study. (Pubmed Central) -  May 24, 2023   
    Bisphosphonates treatment did not modify lean tissues, however a significant reduction of A/G ratio in BP group was documented. Thus the BPs seems to act on patients body composition and extra-skeletal tissues but larger prospective studies are needed to evaluate whether these modifications have clinical relevance.
  • ||||||||||  Journal:  Evaluation of functional parameters of the foot and ankle in elderly with sarcopenia. (Pubmed Central) -  May 24, 2023   
    Thus the BPs seems to act on patients body composition and extra-skeletal tissues but larger prospective studies are needed to evaluate whether these modifications have clinical relevance. The SARC-F score and the handgrip strength test are easy to apply in the screening of sarcopenia, and the functional parameters of the foot and ankle were shown to be altered in the studied group.
  • ||||||||||  Review, Journal:  Challenges in the Vaccination of the Elderly and Strategies for Improvement. (Pubmed Central) -  May 23, 2023   
    Included also are several publications on senolytic medications under investigation to boost the immune system and vaccine response in the elderly. With all those in regard, the currently recommended vaccines for the elderly are presented.
  • ||||||||||  Prolia (denosumab) / Amgen, Daiichi Sankyo
    Trial completion date, Trial primary completion date:  MITO: Muscle Impact of Treating Osteoporosis (clinicaltrials.gov) -  May 23, 2023   
    P4,  N=40, Recruiting, 
    In conclusion, AP muscle strength was found to have a greater impact on single-leg standing balance compared with KE muscle strength. Trial completion date: Jul 2024 --> Jul 2026 | Trial primary completion date: Jul 2024 --> Jul 2025
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Beyond its psychiatric use: the benefits of low dose lithium supplementation. (Pubmed Central) -  May 22, 2023   
    Although lithium's actions have been widely studied in the brain, the study of the potential benefits of lithium, particularly at a low dose is still relatively novel. Therefore, this review aims to provide possible mechanistic insights for future research in this field.
  • ||||||||||  Review, Journal:  Role of Nutritional Supplements on Gut-Muscle Axis Across Age: a Mini-Review. (Pubmed Central) -  May 20, 2023   
    In addition, a combination of resistance exercise and supplementation has been shown to have a more significant beneficial effect on anthropometric and muscle function parameters, leading to a decrease in sarcopenic state. Thus, understanding the relationship between the gut microbiome and muscle metabolism is crucial for developing new treatments for sarcopenia across age groups.
  • ||||||||||  Review, Journal:  Sarcopenia and Cardiovascular Diseases. (Pubmed Central) -  May 19, 2023   
    Relying on body mass index is not useful for screening because many patients will have sarcopenic obesity, a particularly important phenotype among older cardiac patients. In this review, we aimed to: (1) provide a definition of sarcopenia within the context of muscle wasting disorders; (2) summarize the associations between sarcopenia and different cardiovascular diseases; (3) highlight an approach for a diagnostic evaluation; (4) discuss management strategies for sarcopenia; and (5) outline key gaps in knowledge with implications for the future of the field.
  • ||||||||||  Journal:  Butyrate promotes C2C12 myoblast proliferation by activating ERK/MAPK pathway. (Pubmed Central) -  May 19, 2023   
    In addition, the above proliferative phenotypes could be suppressed by the combination of ERK/MAPK inhibitor. A combined transcriptomic and metabolomic approach was applied in our study to investigate the potential effect of microbiota-derived butyrate yield on muscular proliferation which may indicate a protective effect of nutritional supplements.
  • ||||||||||  CAN OSTEOARTHRITIS, SARCOPENIA AND BODY COMPOSITION PREDICT LOSS OF FUNCTION? () -  May 19, 2023 - Abstract #EULAR2023EULAR_4559;    
    Clinicians could provide real-world evidence that being underweight carries the risk of vertebral fractures. A multiple linear regression was carried out to see if having OA, Sarcopenia and percentage of fat free mass can predict LEFS, once all were significantly different within groups, creating a statistically significant model [Z(3,233)=155,957; p< 0,001:R 2 =0,668] were with having OA (
  • ||||||||||  BODY COMPOSITION IN POSTMENOPAUSAL WOMEN WITH CHRONIC KNEE PAIN () -  May 19, 2023 - Abstract #EULAR2023EULAR_4547;    
    Conclusion Women with severe chronic knee pain have significantly higher BW, BMI, ALM, and fat mass than females with mild pain. Despite the absence of differences in sarcopenia frequency, the subjects with severe knee pain have not only an increased frequency of obesity but also high sarcopenic obesity.
  • ||||||||||  BODY COMPOSITION ASSESSMENT IN PATIENTS WITH SYSTEMIC SCLERODERMA () -  May 19, 2023 - Abstract #EULAR2023EULAR_4546;    
    Conclusion The results of the pilot study showed that 50% of patients with SS were obese, 33.3% - SP and 4.7% sarcopenic obesity. Thus, 12% of patients with SS had SP, which requires further study of this problem in order to identify specific risk factors for SP and develop methods for its prevention in patients with SJS.
  • ||||||||||  ASSESSMENT OF THE PREVALENCE OF SARCOPENIA IN ADULT WITH JUVENILE IDIOPATHIC ARTHRITIS () -  May 19, 2023 - Abstract #EULAR2023EULAR_4466;    
    The definition of sarcopenia by the EWGSOP does not seem to be adapted to a younger population, with a low sensitivity screening of sarcopenia in this population by the SARC-F score and an underestimation of low muscle strength by the grip test. Further studies with a larger population and a control population are needed to clarify these results.
  • ||||||||||  UROLITHIN A AND B ACCELERATE MYOCYTE FUSION INTO MYOTUBES () -  May 19, 2023 - Abstract #EULAR2023EULAR_4398;    
    In parallel, urolithins present anti-inflammatory properties, mainly by reducing CYP1B1 expression and the PGE2 synthesis via PTGS1, but also for UA by increasing LIF. Our data provide a better understanding of urolithin activities and highlight their potential in the treatment of muscle disorders such as sarcopenia.