Sarcopenia
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  • ||||||||||  Trial completion date, Trial primary completion date:  Auto-regulated Resistance-training for Older Adults (clinicaltrials.gov) -  Jun 6, 2023   
    P=N/A,  N=30, Recruiting, 
    Deprescribing from polypharmacy on admission was positively associated with functional status at discharge and home discharge in older patients with sarcopenia after stroke. Trial completion date: Jan 2023 --> Aug 2023 | Trial primary completion date: Jan 2023 --> Aug 2023
  • ||||||||||  Enrollment open:  Strength-building Lifestyle-integrated Intervention (clinicaltrials.gov) -  Jun 6, 2023   
    P=N/A,  N=40, Recruiting, 
    Trial completion date: Jan 2023 --> Aug 2023 | Trial primary completion date: Jan 2023 --> Aug 2023 Not yet recruiting --> Recruiting
  • ||||||||||  Retrospective data, Review, Journal:  Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta?analysis. (Pubmed Central) -  Jun 5, 2023   
    In addition, the incidence rate in younger patients (46%) was found to be higher compared with the incidence rate in older patients (39%). In conclusion, the findings in the present systematic review revealed that a large number of patients with HCC suffer from sarcopenia, indicating the necessity of developing screening and intervention measures to improve the outcome in these patients.
  • ||||||||||  Review, Journal:  The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy. (Pubmed Central) -  Jun 5, 2023   
    However, the specific mechanism involved has not been thoroughly studied. Therefore, this review aims to explore the pathophysiology and therapeutic strategy related to sarcopenia and diabetes and provide insight for future investigations, which is of great significance for improving the quality of life in the elderly with diabetes and concurrently reducing the incidence of related complications.
  • ||||||||||  Review, Journal:  Sarcopenia in chronic liver diseases (Pubmed Central) -  Jun 5, 2023   
    This is an independent prognostic risk factor. Therefore, sarcopenia should be considered in the diagnostics and therapeutic approaches.
  • ||||||||||  Journal:  Evidence for inefficient contraction and abnormal mitochondrial activity in sarcopenia using magnetic resonance spectroscopy. (Pubmed Central) -  Jun 5, 2023   
    This study used P MRS to assess ATP utilization and resynthesis in sarcopenic muscle and demonstrated abnormal increases in the energy cost during exercise and perturbed mitochondrial energetics in recovery. Associations between mitochondrial complex activity and the fractional contribution to energy requirement during exercise indicate increased ability to generate energy oxidatively in those with better mitochondrial complex activity.
  • ||||||||||  Retrospective data, Review, Journal, HEOR:  Sarcopenia and health-related quality of life: A systematic review and meta-analysis. (Pubmed Central) -  Jun 5, 2023   
    This systematic review and meta-analysis combining 43 observational studies shows that HRQoL is significantly reduced in sarcopenic patients. The use of disease-specific HRQoL instruments may better discriminate sarcopenic patients with respect to their quality of life.
  • ||||||||||  Preclinical, Journal:  Milk protects against sarcopenic obesity due to increase in the genus Akkermansia in faeces of db/db mice. (Pubmed Central) -  Jun 5, 2023   
    The use of disease-specific HRQoL instruments may better discriminate sarcopenic patients with respect to their quality of life. The findings of this study suggest that besides increasing the intake of nutrients, such as amino acids, milk consumption also changes the intestinal environment, which might contribute to the mechanism of milk-induced improvement of sarcopenic obesity.
  • ||||||||||  Visken (pindolol) / Novartis
    Preclinical, Journal:  Effects of S-pindolol in mouse pancreatic and lung cancer cachexia models. (Pubmed Central) -  Jun 5, 2023   
    S-pindolol is an important candidate for clinical development in the treatment of cancer cachexia that strongly attenuates loss of body weight and lean body mass. This was also seen in the weight of individual muscles and resulted in higher grip strength.
  • ||||||||||  Biomarker, Journal:  Fatty acid amides as potential circulating biomarkers for sarcopenia. (Pubmed Central) -  Jun 5, 2023   
    DHA EA, in particular, strongly related to muscle mass and strength, can be a key metabolite to become a reliable metabolic biomarker for sarcopenia. Further research on fatty acid amides will provide insights into the metabolomic changes relevant to sarcopenia from an aging perspective.
  • ||||||||||  Review, Journal:  Post-translational regulation of muscle growth, muscle aging and sarcopenia. (Pubmed Central) -  Jun 5, 2023   
    To date, many studies have shown that numerous PTMs, such as phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, glycation, methylation, S-nitrosylation, carbonylation and S-glutathionylation, are involved in the regulation of muscle health and diseases. This article systematically summarizes the post-translational regulation of muscle growth and muscle atrophy and helps to understand the pathophysiology of muscle aging and develop effective strategies for diagnosing, preventing and treating sarcopenia.
  • ||||||||||  Retrospective data, Journal:  Interrelation between functional decline and dementia: The potential role of balance assessment. (Pubmed Central) -  Jun 5, 2023   
    BBS had a stronger correlation with cognitive performance compared with the traditional scales. The relationship between MoCA executive items and the BBS tests suggests the usefulness of targeted interventions involving cognitive stimulation to improve motor performance, and motor training to slow the progression of cognitive decline, particularly in MCI.
  • ||||||||||  Retrospective data, Review, Journal:  Exercise for sarcopenia in older people: A systematic review and network meta-analysis. (Pubmed Central) -  Jun 5, 2023   
    In older adults with sarcopenia, high or moderate certainty evidence showed that resistance exercise with or without nutrition and the combination of resistance exercise with aerobic and balance training were the most effective interventions for improving quality of life. Adding nutritional interventions to exercise had a larger effect on handgrip strength than exercise alone while showing a similar effect on other physical function measures.
  • ||||||||||  Sarconeos (BIO101) / Biophytis
    P1 data, PK/PD data, Clinical Trial,Phase I, Journal:  A Phase 1 study for safety and pharmacokinetics of BIO101 (20-hydroxyecdysone) in healthy young and older adults. (Pubmed Central) -  Jun 5, 2023   
    Adding nutritional interventions to exercise had a larger effect on handgrip strength than exercise alone while showing a similar effect on other physical function measures. BIO101 shows a good safety and pharmacokinetic profile that led to the selection of doses for the subsequent interventional clinical trials of Phase 2 in age-related sarcopenia (SARA-INT) and Phase 3 in Covid-19 (COVA).
  • ||||||||||  Journal:  Effects of exercise habits in adolescence and older age on sarcopenia risk in older adults: the Bunkyo Health Study. (Pubmed Central) -  Jun 5, 2023   
    BIO101 shows a good safety and pharmacokinetic profile that led to the selection of doses for the subsequent interventional clinical trials of Phase 2 in age-related sarcopenia (SARA-INT) and Phase 3 in Covid-19 (COVA). Older men with exercise habits in both adolescence and older age were at a lower risk of sarcopenia, low muscle mass and low muscle performance, whereas older women with exercise habits at both time periods were at a lower risk of low muscle performance.
  • ||||||||||  Retrospective data, Review, Journal:  Sarcopenia and cardiovascular diseases: A systematic review and meta-analysis. (Pubmed Central) -  Jun 5, 2023   
    With global aging, sarcopenia has brought a heavy burden to individuals and society. Therefore, it is important to identify the populations with high-risk or probable sarcopenia in order to do an early intervention, such as exercise, to counteract or slow down the progress of sarcopenia.
  • ||||||||||  New trial:  The Sarcopenia Study (clinicaltrials.gov) -  Jun 5, 2023   
    P=N/A,  N=80, Not yet recruiting, 
  • ||||||||||  Enrollment open:  Body Composition Ultrasound for Patients With Heart Failure (clinicaltrials.gov) -  Jun 5, 2023   
    P=N/A,  N=90, Recruiting, 
    These findings suggest a possible involvement of SeP-mediated reductive stress in physical inactivity-mediated sarcopenia, which may be a therapeutic target against sarcopenia. Suspended --> Recruiting
  • ||||||||||  Journal:  Research progress of sarcopenic obesity and chronic liver disease (Pubmed Central) -  Jun 3, 2023   
    At present, our understanding of the relationship between chronic liver disease and sarcopenic obesity is still poorly understood. In this paper, the research progress on chronic liver disease, sarcopenia, and sarcopenic obesity in recent years is reviewed so as to provide a theoretical basis for improving the clinical prognosis of patients with liver disease.
  • ||||||||||  Journal:  Managing the older adult with inflammatory bowel disease: is age just a number? (Pubmed Central) -  Jun 2, 2023   
    They are also more likely to have adverse outcomes despite having similar disease courses to younger adults with IBD. Focusing on biological age as opposed to chronological age can shift this trajectory and improve quality of care for this growing population of patients with IBD.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date:  ARMS-II: Detection and Treatment of Sarcopenia and Myosteatosis in Older African Americans (clinicaltrials.gov) -  Jun 2, 2023   
    P=N/A,  N=136, Active, not recruiting, 
    Focusing on biological age as opposed to chronological age can shift this trajectory and improve quality of care for this growing population of patients with IBD. Trial completion date: Dec 2022 --> Sep 2023