Sarcopenia
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  • ||||||||||  Journal:  The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity. (Pubmed Central) -  Jun 23, 2023   
    The correlations between lymphocyte subpopulations and metabolic, body composition, and clinical variables demonstrated the existence of a chronic, low-intensity inflammatory process in obesity. Therefore, measuring the immunometabolic profile by means of lymphocyte subpopulations in patients with severe obesity could be useful to determine the severity of the disease and the increased risk of presenting obesity-associated chronic degenerative diseases.
  • ||||||||||  Review, Journal:  Advances in the beneficial effects of nutrition on stroke-related Sarcopenia: A narrative review. (Pubmed Central) -  Jun 20, 2023   
    Mounting evidences showed that stroke-related sarcopenia might promote the occurrence and development of sarcopenia through various pathogenesis such as muscle atrophy, dysphagia, inflammation, and malnutrition, etc. At present, the main indicators used to assess malnutrition in patients with stroke-related sarcopenia include temporalis muscle thickness, calf circumference, phase angle, geriatric nutritional risk index and mini-nutritional assessment short-form, etc. Currently, there is no particularly effective method to curb its progression, but supplementation with essential amino acids, whey protein combined with vitamin D, high energy diet, avoiding Polypharmacy, as well as increasing physical activity level and reducing sedentary lifestyle may improve the malnutrition status of stroke patients, and increase the muscle mass and skeletal muscle index, further delay or even prevent the development of stroke-related sarcopenia. This article reviews the latest research progress on the characteristics, epidemiology, pathogenesis and the role of nutrition in stroke-related sarcopenia, so as to provide reference for the clinical treatment and rehabilitation of stroke-related sarcopenia.
  • ||||||||||  Journal, Surgery:  Bone turnover profile and muscular status in major orthopaedic surgery: a case series. (Pubmed Central) -  Jun 20, 2023   
    In major orthopedic surgery, bone integration and muscle status are both essential for achieving and lasting positive results. Considering the high incidence of district osteosarcopenia, an integrated surgical, pharmacological, and rehabilitative approach is desirable for the optimization of results, as well as more studies for the definition of the etiopathogenesis of this pathological condition.
  • ||||||||||  Journal:  Mechanisms of Skeletal Muscle Atrophy and Molecular Circuitry of Stem Cell Fate in Skeletal Muscle Regeneration and Aging. (Pubmed Central) -  Jun 20, 2023   
    Proof-of-concept studies in mice have demonstrated that reprogramming of this disrupted orchestration, resulting in the normalization of muscle function, may be possible using small molecules that target muscle macrophages. During aging, as well as in muscular dystrophies, disruptions in multiple signaling pathways and in the cross-talk between different cell populations contribute to the failure to properly repair and maintain muscle mass and function.
  • ||||||||||  Journal:  Maladaptive Immune Activation in Age-Related Decline of Muscle Function. (Pubmed Central) -  Jun 20, 2023   
    Where applicable, references are made to papers presented at the conference. We conclude by underscoring the need to incorporate age-related immune competency and inflammation when interpreting results from interventions that target specific pathways predicted to promote skeletal muscle function and tissue homeostasis.
  • ||||||||||  Journal:  Optimizing the Design of Clinical Trials to Evaluate the Efficacy of Function-Promoting Therapies. (Pubmed Central) -  Jun 20, 2023   
    We conclude by underscoring the need to incorporate age-related immune competency and inflammation when interpreting results from interventions that target specific pathways predicted to promote skeletal muscle function and tissue homeostasis. Collaborations among academic investigators, NIH, FDA, pharmaceutical industry, patients, and professional societies are needed to conduct well-designed trials of function-promoting pharmacological agents with and without multicomponent functional training.
  • ||||||||||  Journal:  Exercise and Behavior: Adjuncts to Pro-Myogenic Compounds for Enhancing Mobility in Older Adults. (Pubmed Central) -  Jun 20, 2023   
    We summarize here recent progress on biological mechanisms of exercise training, behavioral approaches to exercise participation, and the role task-specific exercise plays in synergy with pharmacologic therapies with a particular focus on older adults. Physical activity and exercise training in multiple settings should serve as the baseline standard of care around which other therapeutic interventions should be considered when the goal is restoring or increasing physical function.
  • ||||||||||  Journal:  Nutritional Interventions: Dietary Protein Needs and Influences on Skeletal Muscle of Older Adults. (Pubmed Central) -  Jun 20, 2023   
    Physical activity and exercise training in multiple settings should serve as the baseline standard of care around which other therapeutic interventions should be considered when the goal is restoring or increasing physical function. Quantity, quality, and patterning of dietary protein consumed by older adults with varied metabolic states, and hormonal and health status influence the nutritional needs and therapeutic use of protein to support muscle size and function.
  • ||||||||||  Review, Journal:  Diet, exercise, and pharmacotherapy for sarcopenia in people with diabetes. (Pubmed Central) -  Jun 20, 2023   
    In pharmacotherapy, certain classes of anti-diabetes compounds have possibility of preventing sarcopenia. However, much data on diet, exercise, and pharmacotherapy were obtained in obese and non-elderly patients with T2DM, demanding actual clinical data on non-obese and older patients with diabetes.
  • ||||||||||  Review, Journal:  Interplay of skeletal muscle and adipose tissue: sarcopenic obesity. (Pubmed Central) -  Jun 20, 2023   
    Numerous studies have attempted to demonstrate the pathophysiological interaction between sarcopenia and obesity, but the interwoven matrix of the relationship between myokines and adipokines has made it difficult for researchers to understand them. This review briefly describes updated information about the crosstalk between muscle and adipose tissue.
  • ||||||||||  Review, Journal:  Sarcopenia in youth. (Pubmed Central) -  Jun 20, 2023   
    This review summarizes the possible etiologies of sarcopenia in young populations, including metabolic syndrome, physical inactivity, inadequate nutrition, inherent and perinatal factors, vitamin D deficiency, endocrinopathy, an imbalance of gut microbiota, neuromuscular diseases, organ failure, malignancy, and other inflammatory disorders. This is the first review of the current knowledge on the importance, prevalence, diagnosis, and causes of sarcopenia in youth.
  • ||||||||||  Review, Journal:  Epidemiology of sarcopenia: Prevalence, risk factors, and consequences. (Pubmed Central) -  Jun 20, 2023   
    However, these associations were mainly based on non-cohort observational studies and need confirmation. High-quality cohort, omics, and Mendelian randomization studies are needed to deeply understand the etiological basis of sarcopenia.
  • ||||||||||  Journal:  Skeletal Muscle Mass and Surgical Morbidity After Laparoscopic Rectal Cancer Resection. (Pubmed Central) -  Jun 19, 2023   
    Skeletal muscle status in rectal cancer patients undergoing curative resection was not associated with overall postoperative morbidity, although there was a correlation between sarcopenia and more severe complications. Further studies in a larger cohort of patients are needed before conclusions can be drawn on the relationship between muscular depletion and surgical outcomes in rectal cancer patients.
  • ||||||||||  Retrospective data, Review, Journal:  Arthralgia of menopause - A retrospective review. (Pubmed Central) -  Jun 19, 2023   
    Joint synovium and cartilage interaction with estrogen is well documented. This article reviews the literature regarding the current approaches to treatment of arthralgia menopause.
  • ||||||||||  Journal:  Neural Mechanisms of Age-related Loss of Muscle Performance and Physical Function. (Pubmed Central) -  Jun 19, 2023   
    No abstract available Further research is needed to map putative neural mechanisms, determine the clinical relevance of age-related changes in neural activation to sarcopenia, and evaluate the effectiveness of various neurotherapeutic approaches to enhancing physical function.
  • ||||||||||  Journal:  Utilizing psoas muscle cross-sectional area to predict functional outcome. (Pubmed Central) -  Jun 19, 2023   
    For participants with an ISS <15, increased PMA was significantly associated with higher PCS at 3 (P?=?0.008), 6 (P?=?0.02), and 12 months (P?=?0.002), although this relationship was not statistically significant for ISS ?15 (P?=?0.85, 0.66, 0.61). For mild to moderately injured (but not seriously injured) patients, those with larger psoas muscles experience better functional outcomes after injury.