Sarcopenia
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  • ||||||||||  Review, Journal:  The contradictory role of branched-chain amino acids in lifespan and insulin resistance. (Pubmed Central) -  Jul 6, 2023   
    However, the negative effects of BCAAs on longevity and insulin resistance were mostly observed in high-fat diet-fed subjects or obese individuals, while the effects in other diseases still need to be studied further. In conclusion, there is still no definite conclusion on the specific conditions under which BCAAs and insulin resistance extend life, shorten life, or do not change lifespan, and there is still no credible and comprehensive explanation for the different effects of BCAAs and insulin resistance on lifespan.
  • ||||||||||  Phase classification:  OsteoPreP: Food Supplements for Postmenopausal Bone Health (clinicaltrials.gov) -  Jul 6, 2023   
    P4,  N=160, Recruiting, 
    In conclusion, there is still no definite conclusion on the specific conditions under which BCAAs and insulin resistance extend life, shorten life, or do not change lifespan, and there is still no credible and comprehensive explanation for the different effects of BCAAs and insulin resistance on lifespan. Phase classification: P1/2 --> P4
  • ||||||||||  Review, Journal:  Sarcopenia, osteoporosis and frailty. (Pubmed Central) -  Jul 5, 2023   
    The most promising results have been obtained in preclinical models where common drug targets have been identified to treat these conditions simultaneously. In this narrative review, we critically summarize the current understanding of the definitions, epidemiology, pathophysiology, and treatment of osteosarcopenia as part of an integrative approach to musculoskeletal frailty.
  • ||||||||||  Review, Journal:  Mechanisms of sarcopenia in liver cirrhosis and the role of myokines. (Pubmed Central) -  Jul 3, 2023   
    In this review, we focused on the mechanisms of cirrhosis-related sarcopenia and the role of myokines that have already been studied in the literature, either as markers helping in the diagnostic evaluation of sarcopenia, or as prognostic factors of survival. Standard therapeutic options to prevent or treat sarcopenia in LC are also being reported, as well as the possible therapeutic implication of myokines.
  • ||||||||||  New trial:  C-Protein in Fatigue and Aging (clinicaltrials.gov) -  Jul 3, 2023   
    P=N/A,  N=24, Recruiting, 
  • ||||||||||  Preclinical, Journal:  A chronic high-fat diet does not exacerbate muscle atrophy in fast-twitch skeletal muscle of aged mice. (Pubmed Central) -  Jul 3, 2023   
    The cross-sectional area and myofibre diameter were lower in both groups of aged mice (after 20 months of LFD or HFD) compared with young mice (after 4 months of the diets), but there were no differences between mice fed LFD or HFD for 20 months. These data suggest that long-term feeding of HFD does not aggravate muscle wasting in fast-twitch EDL muscle of male mice.
  • ||||||||||  Observational data, Retrospective data, Journal:  Sarcopenic Dysphagia Revisited: A Cross-Sectional Study in Hospitalized Geriatric Patients. (Pubmed Central) -  Jul 2, 2023   
    Considering these results, both the association between sarcopenia and OD and pure sarcopenic dysphagia appear questionable. Further prospective studies are needed to elucidate if sarcopenia is merely an epiphenomenon of severe disease or whether it plays a causative role in the development of OD.
  • ||||||||||  Review, Journal:  Polyamines and Physical Activity in Musculoskeletal Diseases: A Potential Therapeutic Challenge. (Pubmed Central) -  Jul 2, 2023   
    We hope these findings, with caution, can encourage researchers to continue investigating in this direction. In particular, if these novel insights could be confirmed in further in vivo and clinical studies, and the two synergic treatments could be optimized in terms of dose and duration, then polyamine supplementation and physical exercise might have a clinical potential in sarcopenia, and more importantly, implications for a healthy lifestyle in the elderly population.
  • ||||||||||  Journal:  Association of Gene Variants with Seasonal Variation in Muscle Strength and Aerobic Capacity in Elite Skiers. (Pubmed Central) -  Jul 2, 2023   
    Genotype associations for the variability in changes of aerobic metabolism-associated power output during exhaustive exercise and anaerobic peak power over the preparation and competition period motivate personalized training regimes. This may help to predict and maximize the benefit of physical conditioning of elite skiers based on chronological characteristics and the polymorphisms of the ACTN3, ACE, and TNC genes investigated here.
  • ||||||||||  Journal:  Association of hyperuricemia combined with sarcopenia on ASCVD risk. (Pubmed Central) -  Jul 2, 2023   
    This may help to predict and maximize the benefit of physical conditioning of elite skiers based on chronological characteristics and the polymorphisms of the ACTN3, ACE, and TNC genes investigated here. Hyperuricemia is independently associated with high-risk ASCVD; Sarcopenia and high-risk ASCVD did not show an independent relationship, but there was a synergistic effect of the two on ASCVD risk, which may imply that managing both hyperuricemia and sarcopenia may have a greater cardiovascular benefit.