Sarcopenia
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  • ||||||||||  Review, Journal:  Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society? (Pubmed Central) -  Jul 18, 2023   
    Fractures in the elderly people are associated with bone fragility, which is influenced by diabetes and chronic kidney disease. Nutritional support for chronic disease patients and sarcopenic individuals with adequate energy and protein intake, vitamin D supplementation, blood glucose level management for individuals with diabetes, obesity prevention, nutritional education for healthy individuals, and the enlightenment of society could be crucial to solve the health-related problems in super-aging societies.
  • ||||||||||  Clinical guideline:  EASL Clinical Practice Guidelines on acute-on-chronic liver failure. (Pubmed Central) -  Jul 18, 2023   
    The recommendations are graded according to the Oxford Centre for Evidence-Based Medicine system and categorized as 'weak' or 'strong'. We aim to provide the best available evidence to aid the clinical decision-making process in the management of patients with ACLF.
  • ||||||||||  Journal:  Jump power predicts fracture risk in older adults independent of sarcopenia and FRAX. (Pubmed Central) -  Jul 18, 2023   
    When the definition of sarcopenia was modified with jump power measurement (step-up approach: no sarcopenia to possible sarcopenia; possible sarcopenia to sarcopenia when low jump power present), jump power-modified sarcopenia improved sensitivity (18% to 39.3%) to classify individuals who sustained MOF during follow-up to high risk compared to AWGS 2019 sarcopenia, while maintaining positive predictive value (22.3% to 20.6%). In summary, jump power predicted fracture risk in community-dwelling older adults independently of sarcopenia and FRAX MOF probabilities, suggesting potential contribution of complex motor function measurement in fracture risk assessment.
  • ||||||||||  Journal:  Breathlessness in older adults: What we know and what we still need to know. (Pubmed Central) -  Jul 18, 2023   
    Further research needs to investigate (1) the multi-factorial mechanisms of breathlessness in community-dwelling older adults including the role of respiratory sarcopenia; (2) the influence of affective and cognitive changes of older age on the perception and report of breathlessness; (3) the best way to assess and use breathlessness for risk prediction of adverse outcomes in general geriatric assessments; and (4) the most appropriate multi-modal rehabilitation interventions and their outcomes. Clinicians need to shift their approach to dyspnea from a disease symptom to a multifactorial geriatric condition that should be proactively searched for, as it identifies higher risk for adverse outcomes, and can be addressed with evidence-based interventions that can improve the quality of life and may reduce the risk of adverse outcomes in older adults.
  • ||||||||||  Impact Of Sarcopenia And Subcutaneous Adipopenia On Outcomes Following Cardiac Resynchronization Therapy (Exhibit Hall) -  Jul 18, 2023 - Abstract #HFSA2023HFSA_168;    
    Subcutaneous adipopenia was an independent predictor for higher mortality risk in patients undergoing CRT implantation. Despite being a well-known risk factor for poor prognosis, the presence of pre-CRT sarcopenia did not predict higher mortality, implying that cardiac processes leading to sarcopenia can be modified by CRT in eligible patients
  • ||||||||||  20: Scientific Sessions - Targeting Obesity to Treat Heart Failure (Ballroom A) -  Jul 18, 2023 - Abstract #HFSA2023HFSA_74;    
    Obesity is present in the majority of patients with HFpEF and also common in HFrEF. In order to understand and manage This growing population, there is a need to understand the mechanistic link between adiposity and heart failure, the overlap between obesity and sarcopenia in phenotypic presentations, new medications to treat obesity in heart failure, and non-pharmacologic modalities to manage obesity in heart failure.Learning Objectives:At the conclusion of This educational activity, the learner will be able to:Discuss objective measures of cardiovascular function in patients with obesity, comparing rest and exercise.Outline the potential role of epicardial fat in obesity and heart failure.Discuss new evidence for novel medications for weight loss in patients with concomitant obesity and heart failure.Review non-pharmacologic approaches to managing obesity in heart failure.Discuss the potential for early obesity interventions to prevent heart failure.
  • ||||||||||  Review, Journal:  Nutrition strategies to counteract sarcopenia: a focus on protein, LC n-3 PUFA, and precision nutrition. (Pubmed Central) -  Jul 17, 2023   
    In order to understand and manage This growing population, there is a need to understand the mechanistic link between adiposity and heart failure, the overlap between obesity and sarcopenia in phenotypic presentations, new medications to treat obesity in heart failure, and non-pharmacologic modalities to manage obesity in heart failure.Learning Objectives:At the conclusion of This educational activity, the learner will be able to:Discuss objective measures of cardiovascular function in patients with obesity, comparing rest and exercise.Outline the potential role of epicardial fat in obesity and heart failure.Discuss new evidence for novel medications for weight loss in patients with concomitant obesity and heart failure.Review non-pharmacologic approaches to managing obesity in heart failure.Discuss the potential for early obesity interventions to prevent heart failure. No abstract available
  • ||||||||||  Journal:  3D Body shape for regional and appendicular body composition estimation. (Pubmed Central) -  Jul 17, 2023   
    Compared to the vanilla linear regression model, our approach improves the RMSE by 17%. The experimental results suggest that the 3D body shape has the potential to be used to predict body composition, and in particular lean mass, for the whole body as well as specific regions of the body.
  • ||||||||||  Review, Journal:  Web-based nutrition: a useful resource for cancer patients? (Pubmed Central) -  Jul 17, 2023   
    Future research should evaluate (1) the differences in cost and coverage between face-to-face and web-based nutrition, (2) long-term outcomes, (3) cost-effectiveness, and last but not least, (4) the effectiveness of web-based nutrition in adolescents and children who suffer from cancer or who survived cancer, as nutritional status and body composition have a marked impact on clinical outcomes during and after treatment. The strength of this review lies in the large number of randomized controlled trials, which offer a guarantee of effectiveness and objectivity compared to cross-sectional studies.
  • ||||||||||  Preclinical, Journal:  Transcriptomic analysis the mechanisms of anti-osteoporosis of desert-living Cistanche herb in ovariectomized rats of postmenopausal osteoporosis. (Pubmed Central) -  Jul 17, 2023   
    A total of 269 genes were differentially expressed, including 201 genes that were downregulated and 68 genes that were upregulated between the model group and the PGC group. Bioinformation analysis results prompt the conclusion that PGC could promote the bone metabolism by muscle cell development, myofibril assembly, etc. In addition, our study also found that PGC has a good effect on osteoporosis complicated with cardiomyopathy, and it also provided evidence for the correlation between sarcopenia and osteoporosis.
  • ||||||||||  Review, Journal:  Masticatory Dysfunction in Older Adults: A Scoping Review. (Pubmed Central) -  Jul 17, 2023   
    This scoping review found that there was limited evidence for a causal link between each of the risk factors and masticatory dysfunction or the protective factors and the maintenance of masticatory ability in older adults. Establishing a standard method for measuring masticatory performance such as the commonly used chewing gum method and encouraging clinicians to routinely measure masticatory function will enable comparisons across multiple risk and protective factors, improving the evidence base and contributing to better patient care.
  • ||||||||||  Journal:  The Clinical Phenotype of Binge Eating Disorder among Postmenopausal Women: A Pilot Study. (Pubmed Central) -  Jul 15, 2023   
    Almost half of the sample presented with at least one mobility limitation; 85.7% had poor endurance. Evidence suggests that BED is highly comorbid with other chronic health conditions and may complicate treatment of these conditions, warranting further investigation and increased attention from healthcare providers serving postmenopausal women.
  • ||||||||||  Retrospective data, Review, Journal:  The Impact of Whey Protein Supplementation on Sarcopenia Progression among the Elderly: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Jul 15, 2023   
    The present meta-analysis demonstrated overall that whey supplementation does not improve any of the tested sarcopenia-linked parameters. However, we found that study duration (weeks) and age significantly affect the handgrip strength rate and the chair and stand test rate, respectively, so consideration should be given to oral supplementation combined with the age of participants and an appropriate physical activity as a form of sarcopenia prevention in the high-risk group.
  • ||||||||||  Review, Journal, Pre-transplantation, Post-transplantation:  Nutritional optimization in liver transplant patients: from the pre-transplant setting to post-transplant outcome. (Pubmed Central) -  Jul 14, 2023   
    we discuss here the results of the few available studies in the field and provide an expert opinion of the obstacles that have led, so far, to an absence of benefit of such specialized regimens as compared to standard nutritional support. In the next future, combining nutritional optimization with exercise and enhanced recovery after surgery (ERAS) protocols could help optimize outcomes following liver transplantation.
  • ||||||||||  Review, Journal:  Sarcopenia in end-stage liver disease and after liver transplantation. (Pubmed Central) -  Jul 14, 2023   
    Additionally, new pharmacological agents (e.g. myostatin inhibitors, testosterone supplements, and ammonia-lowering therapy) are under investigation in preclinical studies. Here, we present a narrative review of the definition, assessment, and management of sarcopenia in patients with end-stage liver disease prior to and after liver transplantation.
  • ||||||||||  Review, Journal:  The Potential Role of Spa Therapy in Managing Frailty in Rheumatic Patients: A Scoping Review. (Pubmed Central) -  Jul 14, 2023   
    Moreover, the health resort setting may offer potential resources to reduce risk factors, such as drug consumption, inactivity, and disease severity, and may serve as a setting for developing prevention protocols for frailty. Future research should explore innovative approaches, such as exercise training and early diagnostics, for the overall management of frailty in rheumatic patients in the spa setting.