Sarcopenia
Welcome,         Profile    Billing    Logout  
 46 Companies   12 Products   12 Products   17 Mechanisms of Action   756 Trials   22406 News 


«12...102103104105106107108109110111112...401402»
  • ||||||||||  Review, Journal:  The Influence of the Mediterranean Dietary Pattern on Osteoporosis and Sarcopenia. (Pubmed Central) -  Aug 2, 2023   
    However, there is doubt about the interaction between the MedDiet, strength and fracture risk. Perhaps the amount of EVOO (extra virgin olive oil), fruits, vegetables and fish rich in anti-inflammatory and antioxidant nutrients ingested has an influence, though the results remain controversial.
  • ||||||||||  Journal:  Longitudinal Association between Uric Acid and Incident Sarcopenia. (Pubmed Central) -  Aug 2, 2023   
    This review explores the causes of muscle loss in CKD and how it can be influenced by nutritional strategies aimed at improving muscle mass and muscle strength. Our findings indicated that UA was negatively associated with incident sarcopenia in males but not in females among middle-aged and older Chinese.
  • ||||||||||  givinostat (ITF2357) / Italfarmaco
    Journal:  Chemokine/ITGA4 Interaction Directs iPSC-Derived Myogenic Progenitor Migration to Injury Sites in Aging Muscle for Regeneration. (Pubmed Central) -  Aug 2, 2023   
    We recently generated muscle progenitor cells (MPCs) from human-induced pluripotent stem-cell (iPSC) cell lines using small molecules, CHIR99021 and Givinostat (Givi-MPCs) sequentially...MPCs expressing ITGA4 sensed chemokines secreted by endothelial cells at the injury site as a chemoattracting signal to migrate to the injured muscle. The mobilization of Givi-MPCs was mediated by the ligand-receptor interaction, which facilitated their engraftment for repairing the sarcopenic muscle with injury.
  • ||||||||||  Review, Journal:  Evolutionary overview of sarcopenia - bibliometric study on the Web of science: A review. (Pubmed Central) -  Aug 1, 2023   
    The development trend of this research field is promising. The mature and stable professional topics such as "RESISTANCE EXERCISE" and "SURVIVAL" that appeared in the late stage belong to the core topics, while newly emerging topics like "FRACTURES" and "PROTEIN" belong to the marginal topics, indicating that the research on muscle and bone metabolism in the field of sarcopenia has yet to be further in-depth, and the "CANCER" topic is a highly promising research topic with strong development potential.
  • ||||||||||  sirolimus / Generic mfg.
    Review, Journal:  The Effect of Omega-3 Fatty Acids on Sarcopenia: Mechanism of Action and Potential Efficacy. (Pubmed Central) -  Aug 1, 2023   
    augmented expression of mechanistic target of rapamycin complex 1 (mTORC1) pathway, 3...In conclusion, n-3 PUFAs likely improve musculoskeletal health related to sarcopenia, with suggestive effect on muscle mass, strength, physical performance, and muscle protein synthesis. However, the interpretation of the findings is limited by the small number of participants, heterogeneity of supplementation regimens, and different measuring protocols.
  • ||||||||||  Body Composition Testing with Bioimpedance Spectroscopy in Oncologic Care: Using Personalized Data to Guide Treatment (306) -  Aug 1, 2023 - Abstract #ACRM2023ACRM_442;    
    We will present the growing body of evidence that concludes there is a need for timely, noninvasive techniques that can screen and provide early detection of symptoms that cannot otherwise be detected by physical exam. The format will include case studies, body composition testing with interactive role-play for the interpretation of results, along with the basics of program development to integrate (BIS) technology into the cancer care continuum.
  • ||||||||||  Review, Journal:  Resistance Training and Weight Loss in Older Adults: A Scoping Review. (Pubmed Central) -  Aug 1, 2023   
    However, it is important to note that only one study, showing questionably reproducible findings, found a significant lean body mass gain. The lack of abundant high-quality evidence demonstrating combined RT and a healthy diet can lead to significant fat loss and lean body mass gain, coupled with high attrition rates observed in many of the studies reviewed, highlight the need for further rigorous research.
  • ||||||||||  Trial completion date, Trial primary completion date:  Optimal Protein Supplementation and Early Exercise In Mechanically Ventilated Patients (clinicaltrials.gov) -  Aug 1, 2023   
    P=N/A,  N=150, Recruiting, 
    The lack of abundant high-quality evidence demonstrating combined RT and a healthy diet can lead to significant fat loss and lean body mass gain, coupled with high attrition rates observed in many of the studies reviewed, highlight the need for further rigorous research. Trial completion date: Mar 2023 --> Sep 2023 | Trial primary completion date: Mar 2023 --> Sep 2023
  • ||||||||||  Enrollment open:  Sternocleidomastoid Thickness in Sarcopenia (clinicaltrials.gov) -  Aug 1, 2023   
    P=N/A,  N=80, Recruiting, 
    Trial completion date: Mar 2023 --> Sep 2023 | Trial primary completion date: Mar 2023 --> Sep 2023 Not yet recruiting --> Recruiting
  • ||||||||||  Enrollment closed:  Identifying Therapeutic Targets of Accelerated Sarcopenia (clinicaltrials.gov) -  Aug 1, 2023   
    P=N/A,  N=95, Active, not recruiting, 
    Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
  • ||||||||||  Review, Journal:  Oxidative stress: roles in skeletal muscle atrophy. (Pubmed Central) -  Aug 1, 2023   
    Finally, this review proposes the alleviation oxidative stress using antioxidants, Chinese herbal extracts, stem cell and extracellular vesicles as a promising therapeutic strategy for muscle atrophy. This review will aid in the development of novel therapeutic strategies and drugs for muscle atrophy.
  • ||||||||||  Review, Journal:  Energy metabolism of the immune system : Consequences in chronic inflammation (Pubmed Central) -  Jul 31, 2023   
    This decrease in ER may be associated with a functional abnormality in mitochondria and the decrease in hormonal receptors may be associated with sarcopenia in orbicularis oculi muscle fibers. Based on the energy changes mentioned, novel treatment suggestions can be made in addition to those already known in energy metabolism.
  • ||||||||||  Review, Journal:  Minerals and Sarcopenia in Older Adults: An Updated Systematic Review. (Pubmed Central) -  Jul 31, 2023   
    This systematic review shows a potential role for selenium and magnesium on the prevention and treatment of sarcopenia in older adults. More randomized controlled trials are warranted to determine the impact of minerals on sarcopenia in older adults.
  • ||||||||||  Journal:  Cognitive Impairment Predicts Sarcopenia 9 Years Later Among Older Adults. (Pubmed Central) -  Jul 31, 2023   
    Cognitive impairment may predict sarcopenia in Brazilian older adults. More studies are necessary to identify the main mechanisms shared by sarcopenia and cognitive decline, which could support the development of prevention interventions.
  • ||||||||||  Review, Journal:  Slow or fast: implications of myofibre type and associated differences for manifestation of neuromuscular disorders. (Pubmed Central) -  Jul 31, 2023   
    Equally, understanding the different responses of slow and fast myofibres due to intrinsic and extrinsic factors can provide deep insight into the precise molecular mechanisms that initiate and exacerbate various neuromuscular disorders. This focus on the influence of different myofibre types is of fundamental importance to enhance translation for clinical management and therapies for many skeletal muscle disorders.
  • ||||||||||  Review, Journal:  Cell-Based Therapies for Degenerative Musculoskeletal Diseases. (Pubmed Central) -  Jul 31, 2023   
    In this review, current experimental attempts to use cell-based therapies for DMDs are highlighted, and the modes of action of different cell types and their derivatives, such as exosomes, are generalized. In addition, the latest findings from state-of-the-art clinical trials are reviewed, approaches to improve the efficiency of cell-based therapies are summarized, and unresolved questions and potential future research directions for the translation of cell-based therapies are identified.
  • ||||||||||  Journal:  Muscle Injuries Induce a Prostacyclin-PPAR?/PGC1a-FAO Spike That Boosts Regeneration. (Pubmed Central) -  Jul 31, 2023   
    Functional experiments demonstrate that the prostacyclin-PPAR?/PGC1a-FAO spike is necessary and sufficient to promote both young and aged muscle regeneration, and that prostacyclin can synergize with PPAR?/PGC1a-FAO signaling to restore aged muscles' regeneration and physical function. Given that the post-injury prostacyclin-PPAR?-FAO spike can be modulated pharmacologically and via post-exercise nutrition, this work has implications for how prostacyclin-PPAR?-FAO might be fine-tuned to promote regeneration and treat muscle diseases of aging.
  • ||||||||||  Observational data, Journal:  Sarcopenic Obesity and Risk of Disability in Community-Dwelling Japanese Older Adults: A 5-year Longitudinal Study. (Pubmed Central) -  Jul 31, 2023   
    Given that the post-injury prostacyclin-PPAR?-FAO spike can be modulated pharmacologically and via post-exercise nutrition, this work has implications for how prostacyclin-PPAR?-FAO might be fine-tuned to promote regeneration and treat muscle diseases of aging. The risk of disability onset because of sarcopenic obesity was exceedingly higher compared with sarcopenia alone among community-dwelling older adults in Japan The health providers should consider assessing the co-existence of sarcopenia and obesity to screen for the risk of disability onset in the community-dwelling population.
  • ||||||||||  Retrospective data, Review, Journal:  Prevalence of Sarcopenia in Liver Cirrhosis: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Jul 31, 2023   
    Poor management of muscle mass loss plays a role in the prognosis of death and quality of life of patients with LC. Clinicians in the field are recommended, when screening for sarcopenia, to pay close attention by carefully assessing body composition as part of the monitoring scheme.