Sarcopenia
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  • ||||||||||  Journal:  Role of adipokines in sarcopenia. (Pubmed Central) -  Aug 7, 2023   
    (PGC-1?) and sensitizing cells to insulin, thereby repressing atrophy-related genes (atrogin-1 and muscle RING finger 1 [MuRF1]) to prevent the loss of muscle mass. Here, we describe the effects on muscle of adipokines produced by adipose tissue, such as leptin, adiponectin, resistin, mucin and lipocalin-2, and discuss the importance of these adipokines for understanding the development of sarcopenia.
  • ||||||||||  Journal, Surgery:  A randomised controlled trial of prehabilitation in patients undergoing elective cardiac surgery. (Pubmed Central) -  Aug 7, 2023   
    The combination of exercise and inspiratory muscle training in a prehabilitation intervention before cardiac surgery was not superior to standard care in improving functional exercise capacity measured by six-minute walk test distance pre-operatively. Future trials should target patients living with sarcopenia and include inspiratory muscle strength training.
  • ||||||||||  Review, Journal:  Sarcopenic obesity: emerging mechanisms and therapeutic potential. (Pubmed Central) -  Aug 7, 2023   
    We review the available clinical evidence largely focused on diet, lifestyle, and behavioral interventions to improve quality of life in patients with sarcopenic obesity. Based upon available evidence, relieving consequences of energy burden such as oxidative stress, myosteatosis, and/or mitochondrial dysfunction is a promising area for therapeutic development in the treatment and management of sarcopenic obesity.
  • ||||||||||  Review, Journal:  "Diet for the prevention and management of sarcopenia". (Pubmed Central) -  Aug 7, 2023   
    Issues related to the design and implementation of effective nutritional strategies are discussed, with a focus on unanswered questions on the most appropriate timing of nutritional interventions to preserve muscle health and function into old age. A brief description is also provided on new technologies that can facilitate the development and implementation of personalized nutrition plans to contrast sarcopenia.
  • ||||||||||  Review, Journal:  Kidney function in cachexia and sarcopenia: Facts and numbers. (Pubmed Central) -  Aug 7, 2023   
    Future studies on cachexia and sarcopenia in patients with CKD are needed to report rigorously defined cachexia concerning kidney function. Moreover, in studies on sarcopenia with CKD, it is desirable to accumulate studies using cystatin C to accurately estimate kidney function.
  • ||||||||||  Journal:  A more accurate method to estimate muscle mass: A new estimation equation. (Pubmed Central) -  Aug 7, 2023   
    Early detection and treatment for muscle wasting might be crucial for reducing mortality risk and promoting healthy longevity. The estimated ASM equations are accurate and simple and can be routinely applied clinically to estimate ASM and thus assess sarcopenia.
  • ||||||||||  Journal:  Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle. (Pubmed Central) -  Aug 7, 2023   
    The CSMA of all muscles must be considered for evaluating cancer sarcopenia at L3. We provide for the first time a global transcriptomic profile of skeletal muscle in older people with and without obesity, demonstrating modulation of key genes and pathways implicated in the regulation of muscle function, changes in DNA methylation associated with such pathways and associations between genes within the modified pathways implicated in muscle regulation and changes in muscle fibre type.
  • ||||||||||  Journal:  Visceral obesity measured using computed tomography scans: No significant association with mortality in critically ill patients. (Pubmed Central) -  Aug 7, 2023   
    We provide for the first time a global transcriptomic profile of skeletal muscle in older people with and without obesity, demonstrating modulation of key genes and pathways implicated in the regulation of muscle function, changes in DNA methylation associated with such pathways and associations between genes within the modified pathways implicated in muscle regulation and changes in muscle fibre type. No significant association of visceral obesity and BMI with 90-day mortality was observed in critically ill patients, although obesity and visceral obesity tended to be associated with improved 90-day mortality.
  • ||||||||||  Review, Journal:  Incident sarcopenia in hospitalized older people: A systematic review. (Pubmed Central) -  Aug 6, 2023   
    Risk factors were older age, longer duration of bed rest, lower baseline body mass index, cognitive impairment and activities of daily living disability. None of the studies reported health outcomes associated with newly developed sarcopenia in hospital.
  • ||||||||||  Journal:  Grip strength cut-points from the Swiss DO-HEALTH population. (Pubmed Central) -  Aug 6, 2023   
    P3
    In generally healthy Swiss older adults, weakness defined by the median or the upper limit of the 1 GS quintile may serve as reference to identify clinically relevant weakness. Additional research is needed in less healthy populations in order to derive representative population-based cut-points.
  • ||||||||||  Journal:  Sarcopenia and type 2 diabetes: Pathophysiology and potential therapeutic lifestyle interventions. (Pubmed Central) -  Aug 6, 2023   
    Additional research is needed in less healthy populations in order to derive representative population-based cut-points. The purpose of this narrative review is: (1) discuss the pathophysiological link between age-related sarcopenia and T2D, and (2) discuss lifestyle interventions involving physical activity and nutrition that may counteract sarcopenia and T2D.
  • ||||||||||  Review, Journal:  The impact of age-related syndromes on ICU process and outcomes in very old patients. (Pubmed Central) -  Aug 5, 2023   
    A poor functional baseline reduces the chances of a successful outcome following ICU. This review emphasises the importance of using a geriatric assessment and considering the older patient as a whole, rather than the acute illness in isolation, when making decisions regarding intensive care treatment.
  • ||||||||||  Journal:  Sarcopenia in patients with rheumatic musculoskeletal diseases. (Pubmed Central) -  Aug 4, 2023   
    One-month hospitalization with high-dose glucocorticoid therapy is associated with sarcopenia progression in patients with RMDs. An early decrease in body weight can be used to predict muscle volume loss.
  • ||||||||||  Retrospective data, Review, Journal:  Sarcopenia increases mortality risk in liver transplantation: a systematic review and meta-analysis. (Pubmed Central) -  Aug 4, 2023   
    An early decrease in body weight can be used to predict muscle volume loss. Sarcopenia was significantly linked with an increased risk of mortality in patients listed, evaluated, and undergoing a liver transplantation, indicating the need of interventional studies in this special population with the main aim to reverse this potential reversible condition and decrease mortality risk.
  • ||||||||||  Journal:  Sex-specific alteration in human muscle transcriptome with age. (Pubmed Central) -  Aug 4, 2023   
    Gene Ontology (GO) enrichment revealed glucose catabolism, NAD metabolic processes, and muscle fiber transition pathways that are involved in aged female skeletal muscle, whereas replicative senescence, cytochrome C release, and muscle composition pathways are disrupted in aged male skeletal muscle. Targeting these novels, differentially regulated genes, and signaling pathways could serve as sex-specific therapeutic targets to combat the age-related onset of sarcopenia and promote healthy aging.
  • ||||||||||  Journal:  Strength gains after 12 (Pubmed Central) -  Aug 4, 2023   
    A significant positive correlation was found between ?PT knee extension and ?SM1 Glx/tCr, ?dlPFC Glx/tCr and between ?PT knee flexion and ?dlPFC mIns/tCr in the experimental group. Overall, findings suggest that resistance training seems to elicit alterations in various neurometabolites that correspond to exercise-induced "preservation" of brain health, while simultaneously having its beneficial effect on augmenting muscle functional characteristics in older adults.
  • ||||||||||  Journal:  Association among inflammaging, body composition, physical activity, and physical function tests in physically active women. (Pubmed Central) -  Aug 3, 2023   
    Interestingly, several significant negative and positive correlations between body composition, physical tests, and serum cytokine concentrations were found in the eutrophic and obese groups. While the eutrophic older women group showed a remarkable regulation of the systemic inflammatory status with positive associations in the physical parameters assessed, the overweight and obese groups presented impairment regulations of the inflammaging, which could be related to less weekly physical activity and higher body fat.
  • ||||||||||  Journal:  Skeletal Muscle and Fat Mass Reflect Chronic Pain in Older Adult. (Pubmed Central) -  Aug 3, 2023   
    When the MFR threshold related to chronic pain was calculated by sex, it was 2.984 for men and 1.867 for women. Evaluation of the body composition of elderly patients with non-specific chronic pain revealed that the MFR was useful as an index related to chronic pain.
  • ||||||||||  Trial completion date, Trial primary completion date:  Microbiome and Sarcopenia in Patients With Liver Cirrhosis (clinicaltrials.gov) -  Aug 3, 2023   
    P=N/A,  N=120, Recruiting, 
    Abstract is embargoed at this time. Trial completion date: Dec 2024 --> Dec 2026 | Trial primary completion date: Jul 2023 --> Dec 2026