Sarcopenia
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  • ||||||||||  Biomarker, Journal:  Radiologic Features of T10 Paravertebral Muscle Sarcopenia: Prognostic Factors in COVID-19. (Pubmed Central) -  Aug 14, 2023   
    Easy to obtain and accurately calculated, radiologic features can provide a reliable alternative to laboratory methods for predicting survival in COVID-19. Thoracic muscles' CSA measurement in the level of the T10 vertebra, an acclaimed prognostic imaging assessment that relates directly to CT-SS and inflammatory markers in COVID-19 pneumonia, is a fairly specific tool for survival prognosis.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Characterization of gut microbiota in mouse models of aging and sarcopenia. (Pubmed Central) -  Aug 14, 2023   
    This study contained two experimental designs using the ICR mouse model for 1) determining the association between aging and gut microbiota (by analyzing murine fecal samples) and 2) determining the association between sarcopenia and gut microbiota in mice treated with microorganisms or dexamethasone...Although the sample size was small, these results point to similarities in the gut microbiota between aging and sarcopenia and to differences between young and old individuals. The results on gut microbiota obtained in this study form a basis for studying the development of sarcopenia in geriatric animal models in the future.
  • ||||||||||  Review, Journal:  Biological principles of adult degenerative scoliosis. (Pubmed Central) -  Aug 14, 2023   
    Here, we investigate the molecular mechanisms underlying ADS, with a focus on angiogenesis, inflammation, extracellular matrix remodeling, osteoporosis, sarcopenia, and biomechanical stress. We discuss current limitations and challenges in the field and highlight potential translational applications that may arise with a better understanding of these mechanisms.
  • ||||||||||  Biomarker, Retrospective data, Journal:  Identification of radiomic biomarkers in a set of four skeletal muscle groups on Dixon MRI of the NAKO MR study. (Pubmed Central) -  Aug 13, 2023   
    In addition, significant differences between subgroups of respective auxiliary targets as well as between both sexes were shown to be present within the ten lowest ranked features by means of Kruskal-Wallis H-tests and Mann-Whitney U-tests. The prediction performance for the selected features and the ranking scheme were verified on validation sets by a random forest based multi-class classification, with strong area under the curve (AUC) values of the receiver operator characteristic (ROC) of 73.03
  • ||||||||||  metformin / Generic mfg., galantamine hydrobromide / Generic mfg.
    Journal:  A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia. (Pubmed Central) -  Aug 12, 2023   
    RJx-01 improved muscle quality rather than quantity, indicating that the improvement in quality underlies the beneficial effects of the combination drug. The studies herein indicate synergistic beneficial effects of RJx-01 in the treatment of sarcopenia and support the pursuit of RJx-01 in a human clinical trial as a therapeutic intervention for sarcopenia.
  • ||||||||||  Geriatric Nutritional Risk Index and Sarcopenia in Patients Undergoing Cardiac Transplantation (Zone 2, Science and Technology Hall, Level 2) -  Aug 12, 2023 - Abstract #AHA2023AHA_4459;    
    Lower GNRI (higher nutritional risk) was associated with a greater prevalence of sarcopenia in patients undergoing cardiac transplantation. This index may represent a simple screening tool utilizing readily available data to ascertain sarcopenia in patients with advanced heart failure.
  • ||||||||||  The Association Between Preoperative Sarcopenia and Outcomes After Cardiac Transplantation (117) -  Aug 12, 2023 - Abstract #AHA2023AHA_2158;    
    Preoperative sarcopenia, diagnosed using pectoralis muscle area index, is an independent predictor of poor outcomes after cardiac transplant. This parameter is easily measurable from commonly obtained preoperative CT scans and may be considered in the transplant evaluation as a marker of risk.
  • ||||||||||  Journal:  Silver electroceutical technology to treat sarcopenia. (Pubmed Central) -  Aug 11, 2023   
    When applied to aged mice in vivo, specific ES conditions improved the prevalence and thickness of Type IIA fibers, along with biomechanical attributes, toward a younger skMC phenotype. This study is expected to pave the way toward an electroceutical treatment for sarcopenia with minimal side effects and help realize personalized bioelectronic medicine.
  • ||||||||||  Review, Journal:  Optimizing Nutritional Status of Patients Prior to Major Surgical Intervention. (Pubmed Central) -  Aug 11, 2023   
    We have reviewed the literature available and focused on the nutritional and metabolic aspects affecting surgical patients, with emphasis on the recommendations of enhanced recovery protocols. The implementation of enhanced recovery protocols and nutritional support guidelines focusing on the surgical patient as part of a multidisciplinary approach would improve the nutritional status of surgical patients at risk for negative outcomes.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Review, Journal:  Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota. (Pubmed Central) -  Aug 11, 2023   
    However, although these drugs are promising, they have not yet been investigated in randomized controlled trials specifically for the treatment and prevention of sarcopenia in patients with cirrhosis. No data exist on the effects of fecal transplantation on most links of gut-muscle axis in cirrhosis; however, the results of animal experimental studies are promising.
  • ||||||||||  Review, Journal:  Body Composition in Inflammatory Bowel Disease. (Pubmed Central) -  Aug 10, 2023   
    Disease activity, reduced nutrition intake, vitamin D deficiency, and intestinal dysbiosis are factors contributing to changed body composition. Early use of biological agents to induce remission is critical to improving body composition distribution in IBD patients, supplementation of vitamin D is also important, and moderate physical activity is recommended in IBD patients with clinical remission.
  • ||||||||||  Retrospective data, Review, Journal, Adverse events, Surgery:  Consensus-defined sarcopenia predicts adverse outcomes after elective abdominal surgery: meta-analysis. (Pubmed Central) -  Aug 10, 2023   
    Consensus-defined sarcopenia provides important prognostic information after elective abdominal surgery and can be appropriately measured in the preoperative setting. Development of targeted exercise-based interventions that minimize sarcopenia may improve outcomes for patients who are undergoing elective abdominal surgery.
  • ||||||||||  Preclinical, Journal:  The D -creatine dilution method non-invasively measures muscle mass in mice. (Pubmed Central) -  Aug 10, 2023   
    Overall, we provide evidence that the D Cr dilution method directly measures muscle mass in mice. Combined with its ease of use, accessibility, and non-invasive nature, the method may prove to more quickly advance development of preclinical therapies targeting sarcopenia.
  • ||||||||||  clindamycin phosphate / Generic mfg.
    Journal:  Suspected clinical toxoplasmosis in a 12-week-old puppy in Singapore. (Pubmed Central) -  Aug 9, 2023   
    While rare and undocumented, veterinary clinicians in Singapore are advised to also include toxoplasmosis infection as a differential diagnosis in dogs presenting with similar clinical signs. This is especially so for dogs which have access to the outdoors.
  • ||||||||||  Review, Journal:  Combined and intraoperative risk modelling for oesophagectomy: A systematic review. (Pubmed Central) -  Aug 9, 2023   
    This is especially so for dogs which have access to the outdoors. Despite the presence of some promising models in forecasting perioperative oesophagectomy outcomes, there is more research required to externally validate these models and demonstrate clinical benefit with the adoption of these models guiding postoperative care and allocating resources.
  • ||||||||||  Journal:  Myostatin is associated with the presence and development of acute-on-chronic liver failure. (Pubmed Central) -  Aug 9, 2023   
    In this study we show that myostatin levels are decreased in patients with cirrhosis, with lower levels in patients with acute decompensation and acute-on chronic liver failure (ACLF). Low myostatin levels in cirrhosis predict the development of ACLF and mortality independently of liver disease severity and sex.
  • ||||||||||  Trial initiation date:  Pennisetum Purpureum in Sarcopenia Patients (clinicaltrials.gov) -  Aug 9, 2023   
    P=N/A,  N=40, Not yet recruiting, 
    This may facilitate the prehabilitation of patients planned for surgery to reduce the risk of complications. Initiation date: Jun 2023 --> Sep 2023
  • ||||||||||  Journal:  Clinical considerations for sarcopenia in older Colombian Afro-descendant and mestizo women. (Pubmed Central) -  Aug 7, 2023   
    The role of alimentary interventions and exercises in improving body composition and thus postoperative outcome should be evaluated through prospective interventional studies. Compared with mestizos, CSS and PS were less frequent among Afro-descendants, who had 87% to 88% lower probability of CSS and 88% to 89% lower probability of PS.
  • ||||||||||  Journal:  Body composition and short-term mortality in patients critically ill with acute-on-chronic liver failure. (Pubmed Central) -  Aug 7, 2023   
    In a wider sense, besides the number and course of organ failures, the results recall the weight of the general condition of males with ACLF at admission to ICU. In females critically ill with ACLF, in analyses limited by the sample size, none of the body composition parameters was associated with short-term mortality independently of organ failures; this suggests that the number and course of organ failures are the main determinant of mortality in these patients.