Sarcopenia
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  • ||||||||||  Clinical data, Journal:  Long-Term Clinical Outcomes of Patients with Chronic Obstructive Pulmonary Disease with Sarcopenia. (Pubmed Central) -  Aug 26, 2023   
    Sarcopenia is associated with clinical prognosis, pneumonia occurrence, and the acute exacerbation of COPD requiring intensive care in patients with COPD. Therefore, it is important to carefully monitor sarcopenia development as well as recommend appropriate exercise and nutritional supplementation in patients with COPD.
  • ||||||||||  Review, Journal:  Impact of Sarcopenia on Spinal Spondylosis: A Literature Review. (Pubmed Central) -  Aug 26, 2023   
    This review identified several problems in the literature, including the limited number of studies examining CSM, adult spinal deformity (ASD) and scoliosis, and the retrospective study design of most reports. The further accumulation of quality research is needed to clarify the relationship between SS and sarcopenia.
  • ||||||||||  Clinical, Review, Journal:  Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence. (Pubmed Central) -  Aug 26, 2023   
    This narrative review aims to highlight the importance of assessing frailty as an aid to guide therapeutic decision-making and tailor CAD management to the specific needs of older adults, taking into account age-related pharmacokinetic and pharmacodynamic changes, polypharmacy, and potential drug interactions. We also discuss gaps in the evidence and offer perspectives on how best in the future to optimize the global strategy of CAD management in older adults.
  • ||||||||||  Review, Journal:  Role of Body Composition in the Prediction of Skeletal Fragility Induced by Hormone Deprivation Therapies in Cancer Patients. (Pubmed Central) -  Aug 25, 2023   
    Current clinical guidelines for the prevention of treatment-induced osteoporosis focus on bone mineral density (BMD) as a main predictive factor for fracture risk; however, the pathophysiology underlying HDT-induced bone fragility differs from that of primary and postmenopausal osteoporosis, suggesting a prevalent role for bone quality alterations. Focusing on available data from clinical trials, in our review we suggest osteosarcopenic obesity as a common target for the prevention and treatment of HDTs-related metabolic and skeletal complications, beyond a BMD-centred approach.
  • ||||||||||  Journal:  Comparison of strategies for assessment of rate of torque development in older and younger adults. (Pubmed Central) -  Aug 25, 2023   
    P=N/A
    These RTD indices showed significant association with the majority of mobility tests, but there was no clear advantage among them. Thus, voluntary RTD normalized to pkT was ill-suited for use in OAs, while results suggests that voluntary RTD normalized to stimulated torque parameters may be useful for identifying central mechanisms of RTD impairment in OAs.Clinical trial registration number NCT02505529; date of registration 07/22/2015.
  • ||||||||||  Observational data, Journal:  Frailty and sarcopenia in older kidney transplant recipients: a cross-sectional study. (Pubmed Central) -  Aug 25, 2023   
    Furthermore, the KCL was verified as a useful tool for frailty screening in these patient. Easy identification of patients with frailty, which is reversible, can help clinicians institute appropriate corrective measures for kidney transplant recipients to improve transplant outcomes.
  • ||||||||||  Review, Journal:  Role of nutrition in patients with coexisting chronic obstructive pulmonary disease and sarcopenia. (Pubmed Central) -  Aug 24, 2023   
    In recent years, studies have found that oral supplementation with protein, micronutrients, fat, or a combination of nutritional supplements can improve the muscle strength and physical performance of these patients; some studies have also elucidated the possible underlying mechanisms. This review aimed to elucidate the role of nutrition among patients with coexisting COPD and sarcopenia.
  • ||||||||||  Enrollment change, Metastases:  ACCESS-ESLD: Relevance of Sarcopenia in Advanced Liver Disease (clinicaltrials.gov) -  Aug 24, 2023   
    P=N/A,  N=150, Recruiting, 
    Our results suggest that Ast-Dio treatment may alleviate sarcopenia in mice with senile type 2 diabetes mellitus through its effects on the Rab5a/mTOR pathway and mitochondrial quality control. N=100 --> 150
  • ||||||||||  Journal:  Nutrition-related parameters of maintenance haemodialysis patients. (Pubmed Central) -  Aug 24, 2023   
    Vitamin D deficiency or insufficiency was 91.2% and electrolyte abnormalities were very common; 57.9% had hypocalcaemia, 61.4% had hyperphosphatemia and all patients had hyperkalaemia. Muscle mass was preserved in most patients in this population, but the muscle power was significantly low, along with a high prevalence of hypoalbuminaemia, anaemia, vitamin D deficiency or insufficiency, hypocalcaemia, hyperphospatemia and hyperkalaemia.
  • ||||||||||  Journal:  Sarcopenia: clinical consequences and management. (Pubmed Central) -  Aug 24, 2023   
    Muscle mass was preserved in most patients in this population, but the muscle power was significantly low, along with a high prevalence of hypoalbuminaemia, anaemia, vitamin D deficiency or insufficiency, hypocalcaemia, hyperphospatemia and hyperkalaemia. No abstract available
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD)
    Sarcopenia as a Predictor of Neoadjuvant Therapy-Related Toxicity in Esophageal Squamous Cell Carcinoma Patients (Hall B2; In Person Only; Screen: 34) -  Aug 22, 2023 - Abstract #ASTRO2023ASTRO_1390;    
    This algorithm is positioned for prospective testing to determine if use will inform HNC management. Materials/ A retrospective analysis was performed using a prospectively collected patient cohort of an academic cancer center diagnosed with cT2-4N0-3M0 ESCC between 2019-2022 and treated with neoadjuvant chemoradiotherapy
  • ||||||||||  Imfinzi (durvalumab) / AstraZeneca
    AI-Derived CT Body Composition in Advanced Non-Small Cell Lung Cancer: A Multicohort Study (Hall B2; In Person Only; Screen: 5) -  Aug 22, 2023 - Abstract #ASTRO2023ASTRO_338;    
    SAT density changes are also strongly associated with prognosis, particularly in female patients. Automated CT-derived BC measurements should be considered along with other risk factors in determining lung cancer prognosis and ability to tolerate oncologic treatments.
  • ||||||||||  Journal:  Impact of Quantitative Computed Tomography-Based Analysis of Abdominal Adipose Tissue in Patients with Lymphoma. (Pubmed Central) -  Aug 22, 2023   
    Opportunistic analysis of body composition on computed tomography (CT) images might contribute to the improvement of patient management and clinical outcomes together with implementation of targeted patient-tailored therapies. The purpose of this literature review is to describe the role of CT to evaluate abdominal adipose tissue quantity and distribution in patients with lymphoma.
  • ||||||||||  Journal:  Cycle exercise training and muscle mass: A preliminary investigation of 17 lower limb muscles in older men. (Pubmed Central) -  Aug 22, 2023   
    This new evidence related to cycle exercise training in older individuals clarifies the specific upper leg muscles that are highly impacted, while revealing all the lower leg muscles do not appear responsive, in the context of muscle mass and sarcopenia. This study provides information for exercise program development in older individuals, suggesting other specific exercises are needed for the rectus femoris and adductors, certain hamstrings, and the anterior and posterior lower leg muscles to augment the beneficial effects of cycling exercise for older adults.
  • ||||||||||  New trial:  MASK: Middle Age muScle Krill Study (clinicaltrials.gov) -  Aug 22, 2023   
    P=N/A,  N=92, Not yet recruiting,