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41 Companies |
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29 Products |
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29 Products |
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22 Mechanisms of Action |
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2 Trials |
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854 News |
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- ||| PfSPZ Vaccine / Sanaria
New P1 trial, IO biomarker: A Clinical Trial of the PfSPZ Vaccine Administered by Direct Venous Inoculation in Healthy Malaria-Na (clinicaltrials.gov) - Aug 15, 2014
P1, N=69, Recruiting, Sponsor: Sanaria Inc.
- Enrollment open: A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5 (clinicaltrials.gov) - Aug 15, 2014
P1, N=24, Recruiting, Sponsor: University of Oxford
Not yet recruiting --> Recruiting
- Enrollment closed: A Phase I/IIa Study of the Safety, Immunogenicity and Efficacy of FMP2.1/AS01B, an Asexual Blood-Stage Vaccine for Plasmodium Falciparum Malaria (clinicaltrials.gov) - Aug 15, 2014
P1/2, N=30, Active, not recruiting, Sponsor: University of Oxford
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- vivax malaria vaccine (ChAd63 PvDBP/MVA PvDBP) / University of Oxford
Trial completion, Trial primary completion date: Phase Ia Study of ChAd63/MVA PvDBP (clinicaltrials.gov) - Aug 15, 2014
P1, N=24, Completed, Sponsor: University of Oxford
Recruiting --> Active, not recruiting Active, not recruiting --> Completed | Trial primary completion date: Apr 2014 --> Jul 2014
- ||| Enrollment open, Combination therapy: A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate (clinicaltrials.gov) - Aug 11, 2014
P1, N=120, Recruiting, Sponsor: GlaxoSmithKline
Active, not recruiting --> Completed | Trial primary completion date: Apr 2014 --> Jul 2014 Not yet recruiting --> Recruiting
- | ganaplacide (KAF156) / Novartis
Trial completion: Efficacy, Safety, Tolerability and Pharmacokinetics of KAF156 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection (clinicaltrials.gov) - Aug 8, 2014
P2, N=40, Completed, Sponsor: Novartis Pharmaceuticals
Not yet recruiting --> Recruiting Recruiting --> Completed
- || azithromycin / Generic mfg.
New P3 trial: SMCAZ: A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children (clinicaltrials.gov) - Aug 7, 2014
P3, N=19200, Not yet recruiting, Sponsor: London School of Hygiene and Tropical Medicine
- Enrollment closed: Safety and Immunogenicity of Plant-Derived Pfs25 VLP-FhCMB Malaria Transmission Blocking Vaccine in Healthy Adults (clinicaltrials.gov) - Aug 7, 2014
P1, N=44, Active, not recruiting, Sponsor: Fraunhofer, Center for Molecular Biotechnology
Recruiting --> Completed Recruiting --> Active, not recruiting
- Enrollment open, Trial initiation date: NIDIAGDigest: Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders (clinicaltrials.gov) - Aug 6, 2014
P=N/A, N=4000, Recruiting, Sponsor: Swiss Tropical & Public Health Institute
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting | Initiation date: Apr 2014 --> Jul 2014
- Trial completion: Study of Pharmacokinetics and Pharmacodynamics of Artesunate in Pregnant Women in the Democratic Republic of Congo (clinicaltrials.gov) - Aug 1, 2014
P1, N=51, Completed, Sponsor: NICHD Global Network for Women's and Children's Health
Not yet recruiting --> Recruiting | Initiation date: Apr 2014 --> Jul 2014 Recruiting --> Completed
- Licensing / partnership: Innovative Public-private Partnership to Target Subsidized Antimalarials in the Retail Sector (clinicaltrials.gov) - Jul 27, 2014
P=N/A, N=500, Not yet recruiting, Sponsor: Duke University
- Enrollment open: Phase II Efficacy Study of Artefenomel & Piperaquine in Adults & Children With P. Falciparum Malaria. (clinicaltrials.gov) - Jul 21, 2014
P2b, N=495, Recruiting, Sponsor: Medicines for Malaria Venture
Recruiting --> Completed Not yet recruiting --> Recruiting
- Trial completion, Trial initiation date: Bioavailability Study of Oral OZ439 Prototype Formulations Administered With Piperaquine Phosphate (PQP) (clinicaltrials.gov) - Jul 17, 2014
P1, N=22, Completed, Sponsor: Medicines for Malaria Venture
Not yet recruiting --> Recruiting Recruiting --> Completed | Initiation date: Apr 2014 --> Jul 2014
- levetiracetam / Generic mfg.
Trial primary completion date: A Safety and Feasibility Study of Enteral LVT vs. Standard of Care for Seizure Control in Pediatric CM (clinicaltrials.gov) - Jul 12, 2014
P2, N=0, Recruiting, Sponsor: University of Rochester
Recruiting --> Completed | Initiation date: Apr 2014 --> Jul 2014 Trial primary completion date: Aug 2014 --> Jun 2015
- Trial primary completion date: Replacement of Insecticides to Control Visceral Leishmaniasis (VL) (clinicaltrials.gov) - Jul 12, 2014
P3, N=3600, Recruiting, Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh
Trial primary completion date: Aug 2014 --> Jun 2015 Trial primary completion date: Dec 2013 --> Dec 2014
- | artemether/lumefantrine / Generic mfg.
Trial primary completion date: Efficacy, Safety and Pharmacokinetics of Artemether-lumefantrine Dispersible Tablet in the Treatment of Malaria in Infants < 5 kg (clinicaltrials.gov) - Jul 12, 2014
P2/3, N=40, Recruiting, Sponsor: Novartis Pharmaceuticals
Trial primary completion date: Dec 2013 --> Dec 2014 Trial primary completion date: Aug 2015 --> Jul 2014
- | amphotericin b liposome / Generic mfg.
Trial initiation date, Trial primary completion date, Combination therapy, Monotherapy: Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. (clinicaltrials.gov) - Jul 12, 2014
P3, N=132, Not yet recruiting, Sponsor: Drugs for Neglected Diseases
Trial primary completion date: Aug 2015 --> Jul 2014 Initiation date: Dec 2013 --> Jul 2014 | Trial primary completion date: Jun 2015 --> Jan 2016
- ||| New P1 trial, Combination therapy: A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate (clinicaltrials.gov) - Jul 10, 2014
P1, N=120, Not yet recruiting, Sponsor: GlaxoSmithKline
- Trial completion: Adenovirus Vaccine for Malaria (clinicaltrials.gov) - Jul 8, 2014
P1, N=75, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Initiation date: Dec 2013 --> Jul 2014 | Trial primary completion date: Jun 2015 --> Jan 2016 Active, not recruiting --> Completed
- New P1 trial: A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5 (clinicaltrials.gov) - Jul 4, 2014
P1, N=24, Not yet recruiting, Sponsor: University of Oxford
- chloroquine phosphate / Generic mfg., atovaquone/proguanil / Generic mfg.
Enrollment open: Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis (clinicaltrials.gov) - Jul 2, 2014
P=N/A, N=15, Recruiting, Sponsor: Radboud University
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- Trial primary completion date: DNA Clearance of Uncomplicated Trichomonas Vaginalis Infections in HIV Negative Women (clinicaltrials.gov) - Jun 27, 2014
P4, N=99, Completed, Sponsor: Tulane University Health Sciences Center
Not yet recruiting --> Recruiting Trial primary completion date: Dec 2016 --> Apr 2014
- Trial suspension: Trichomonas Vaginalis Repeat Infections Among HIV Negative Women (clinicaltrials.gov) - Jun 27, 2014
P3, N=1664, Suspended, Sponsor: Tulane University Health Sciences Center
Trial primary completion date: Dec 2016 --> Apr 2014 Recruiting --> Suspended
- Enrollment change: DNA Clearance of Uncomplicated Trichomonas Vaginalis Infections in HIV Negative Women (clinicaltrials.gov) - Jun 27, 2014
P4, N=99, Completed, Sponsor: Tulane University Health Sciences Center
Recruiting --> Suspended N=30 --> 99
- Enrollment change: Trichomonas Vaginalis Repeat Infections Among HIV Negative Women (clinicaltrials.gov) - Jun 27, 2014
P3, N=1664, Suspended, Sponsor: Tulane University Health Sciences Center
N=30 --> 99 N=2883 --> 1664
- Phase classification, Enrollment change, Trial suspension: Trichomonas Vaginalis Repeat Infections Among HIV Negative Women (clinicaltrials.gov) - Jun 27, 2014
P3, N=1664, Suspended, Sponsor: Tulane University Health Sciences Center
N=2883 --> 1664 Phase classification: P4 --> P3 | N=2883 --> 1664 | Recruiting --> Suspended
- New P1 trial: Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Na (clinicaltrials.gov) - Jun 27, 2014
P1, N=36, Not yet recruiting, Sponsor: U.S. Army Medical Research and Materiel Command
- Trial completion, Enrollment change, Trial primary completion date: DNA Clearance of Uncomplicated Trichomonas Vaginalis Infections in HIV Negative Women (clinicaltrials.gov) - Jun 27, 2014
P4, N=99, Completed, Sponsor: Tulane University Health Sciences Center
Phase classification: P4 --> P3 | N=2883 --> 1664 | Recruiting --> Suspended Recruiting --> Completed | N=30 --> 99 | Trial primary completion date: Dec 2016 --> Apr 2014
- || primaquine / Generic mfg., artemether/lumefantrine / Generic mfg.
New P2/3 trial, Combination therapy: Safety of Primaquine + Artemether-lumefantrine in G6PD Deficient Males With an Asymptomatic Malaria Infection (SAFEPRIM) (clinicaltrials.gov) - Jun 26, 2014
P2/3, N=70, Not yet recruiting, Sponsor: London School of Hygiene and Tropical Medicine
- Trial primary completion date: CINEBENZ: Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease (clinicaltrials.gov) - Jun 23, 2014
P4, N=52, Completed, Sponsor: Barcelona Centre for International Health Research
Recruiting --> Completed | N=30 --> 99 | Trial primary completion date: Dec 2016 --> Apr 2014 Trial primary completion date: Dec 2014 --> Nov 2013
- Trial completion, Trial primary completion date: CINEBENZ: Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease (clinicaltrials.gov) - Jun 23, 2014
P4, N=52, Completed, Sponsor: Barcelona Centre for International Health Research
Trial primary completion date: Dec 2014 --> Nov 2013 Active, not recruiting --> Completed | Trial primary completion date: Dec 2014 --> Nov 2013
- | Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
New P4 trial: MEFI: In Vivo Efficacy of Artemether-lumefantrine and Amodiaquine-artesunate in Mozambican Children (clinicaltrials.gov) - Jun 22, 2014
P4, N=700, Completed, Sponsor: Centro de Investigacao em Saude de Manhica
- gentamicin sulfate / Generic mfg.
Trial initiation date: PAGELEC: WR 279,396 for the Treatment of Cutaneous Leishmaniasis (clinicaltrials.gov) - Jun 17, 2014
P2, N=30, Recruiting, Sponsor: Assistance Publique - H
Active, not recruiting --> Completed | Trial primary completion date: Dec 2014 --> Nov 2013 Initiation date: Sep 2013 --> Jun 2014
- atovaquone/proguanil / Generic mfg., artemether/lumefantrine / Generic mfg.
Enrollment closed: Evaluation of the Riamet (clinicaltrials.gov) - Jun 17, 2014
P4, N=640, Active, not recruiting, Sponsor: Assistance Publique - H
Initiation date: Sep 2013 --> Jun 2014 Recruiting --> Active, not recruiting
- Trial primary completion date: Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia (clinicaltrials.gov) - Jun 13, 2014
P1/2, N=80, Recruiting, Sponsor: Drugs for Neglected Diseases
Recruiting --> Active, not recruiting Trial primary completion date: May 2014 --> Feb 2015
- primaquine / Generic mfg.
Trial primary completion date: LOPRIM: Low Dose Primaquine for Clearance of Gametocytes (clinicaltrials.gov) - Jun 8, 2014
P2/3, N=360, Recruiting, Sponsor: London School of Hygiene and Tropical Medicine
Trial primary completion date: May 2014 --> Feb 2015 Trial primary completion date: Dec 2013 --> Oct 2014
- Trial completion: Sustainable Financial Incentives To Improve Prescription Practices For Malaria (clinicaltrials.gov) - Jun 8, 2014
P=N/A, N=6084, Completed, Sponsor: Duke University
Trial primary completion date: Dec 2013 --> Oct 2014 Recruiting --> Completed
- Trial primary completion date: Malaria Transmission Studies in Mali (clinicaltrials.gov) - Jun 5, 2014
P=N/A, N=650, Recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Completed Trial primary completion date: May 2014 --> May 2016
- | Lampit (nifurtimox) / Bayer
Trial completion: Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients (clinicaltrials.gov) - Jun 5, 2014
P1, N=37, Completed, Sponsor: Bayer
Trial primary completion date: May 2014 --> May 2016 Recruiting --> Completed
- amphotericin b liposome / Generic mfg.
Trial primary completion date: LVBrasil: Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Brazil (clinicaltrials.gov) - Jun 3, 2014
P4, N=380, Terminated, Sponsor: University of Brasilia
Recruiting --> Completed Trial primary completion date: Jun 2014 --> Nov 2014
- amphotericin b liposome / Generic mfg.
Trial termination: LVBrasil: Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Brazil (clinicaltrials.gov) - Jun 3, 2014
P4, N=380, Terminated, Sponsor: University of Brasilia
Trial primary completion date: Jun 2014 --> Nov 2014 Recruiting --> Terminated; DSMB recommendation based on programmed interim analysis.
- Trial primary completion date, Viral vector: Adjuvanting Viral Vectored Malaria Vaccines With Matrix M (clinicaltrials.gov) - Jun 2, 2014
P1, N=22, Active, not recruiting, Sponsor: University of Oxford
Recruiting --> Terminated; DSMB recommendation based on programmed interim analysis. Trial primary completion date: Oct 2013 --> Jun 2014
- Enrollment open: A Phase I Study to Assess the Safety and Immunogenicity of ChAd63 ME-TRAP - MVA ME-TRAP Heterologous Prime-boost Vaccination Co-administered With EPI Vaccines in Gambian Infants (clinicaltrials.gov) - Jun 2, 2014
P1, N=65, Recruiting, Sponsor: University of Oxford
Trial primary completion date: Oct 2013 --> Jun 2014 Active, not recruiting --> Recruiting
- Mosquirix (RTS,S) / GSK
Enrollment closed: A Safety and Efficacy Study of ChAd63/MVA METRAP + RTS,S (clinicaltrials.gov) - Jun 2, 2014
P1/2, N=46, Active, not recruiting, Sponsor: University of Oxford
Active, not recruiting --> Recruiting Recruiting --> Active, not recruiting
- Enrollment closed, Viral vector: Adjuvanting Viral Vectored Malaria Vaccines With Matrix M (clinicaltrials.gov) - Jun 2, 2014
P1, N=22, Active, not recruiting, Sponsor: University of Oxford
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- Trial initiation date: Malaria in Early Life Study (clinicaltrials.gov) - May 30, 2014
P=N/A, N=756, Recruiting, Sponsor: Gadjah Mada University
Recruiting --> Active, not recruiting Initiation date: Jan 2014 --> May 2014
- Enrollment open: Malaria in Early Life Study (clinicaltrials.gov) - May 30, 2014
P=N/A, N=756, Recruiting, Sponsor: Gadjah Mada University
Initiation date: Jan 2014 --> May 2014 Not yet recruiting --> Recruiting
- trimethoprim/sulfamethoxazole / Generic mfg.
Trial completion: Home Management of Malaria and Pneumonia (clinicaltrials.gov) - May 28, 2014
P4, N=11500, Completed, Sponsor: World Health Organization
Not yet recruiting --> Recruiting Not yet recruiting --> Completed
- | trimethoprim/sulfamethoxazole / Generic mfg.
New P4 trial: Home Management of Malaria and Pneumonia (clinicaltrials.gov) - May 26, 2014
P4, N=11500, Completed, Sponsor: World Health Organization
- Enrollment closed: A Phase 1/2b Study of an Investigational Malaria Vaccination Strategy in 5-17 Month Old Infants and Children in Burkina Faso (clinicaltrials.gov) - May 26, 2014
P1/2, N=700, Active, not recruiting, Sponsor: University of Oxford
Not yet recruiting --> Completed Recruiting --> Active, not recruiting