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41 Companies |
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29 Products |
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29 Products |
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22 Mechanisms of Action |
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2 Trials |
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854 News |
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- Trial completion: A Phase I Study to Assess the Safety and Immunogenicity of ChAd63 ME-TRAP - MVA ME-TRAP Heterologous Prime-boost Vaccination Co-administered With EPI Vaccines in Gambian Infants (clinicaltrials.gov) - Dec 4, 2015
P1, N=65, Completed, Sponsor: University of Oxford
Active, not recruiting --> Completed
- Mosquirix (RTS,S) / GSK
Trial completion, Enrollment change: A Safety and Efficacy Study of Concomitant Administration of ChAd63/MVA ME-TRAP + RTS,S (clinicaltrials.gov) - Dec 4, 2015
P1/2, N=48, Completed, Sponsor: University of Oxford
Active, not recruiting --> Completed Active, not recruiting --> Completed | N=60 --> 48
- Trial completion: A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5 (clinicaltrials.gov) - Dec 4, 2015
P1, N=26, Completed, Sponsor: University of Oxford
Active, not recruiting --> Completed | N=60 --> 48 Active, not recruiting --> Completed
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi, Eurartesim (dihydroartemisinin/piperaquine) / Medicines for Malaria Venture, Leadiant Biosci
Trial completion, Combination therapy: Efficacy of Three ACTs for the Treatment of Falciparum Malaria in Maradi Niger (clinicaltrials.gov) - Nov 30, 2015
P4, N=663, Completed, Sponsor: Epicentre
Active, not recruiting --> Completed Recruiting --> Completed
- Trial completion, Trial primary completion date: Acute vs. Delayed Iron: Effect on Red Cell Iron Incorporation in Severe Malaria (clinicaltrials.gov) - Nov 30, 2015
P=N/A, N=100, Completed, Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting --> Completed Active, not recruiting --> Completed | Trial primary completion date: Aug 2015 --> May 2015
- Trial completion: Time to Become Negative of Three Rapid Diagnostic Tests for Malaria (clinicaltrials.gov) - Nov 30, 2015
P=N/A, N=424, Completed, Sponsor: Epicentre
Active, not recruiting --> Completed | Trial primary completion date: Aug 2015 --> May 2015 Recruiting --> Completed
- gentamicin sulfate / Generic mfg.
Enrollment closed: PAGELEC: WR 279,396 for the Treatment of Cutaneous Leishmaniasis (clinicaltrials.gov) - Nov 27, 2015
P2, N=30, Active, not recruiting, Sponsor: Assistance Publique - H
Recruiting --> Completed Recruiting --> Active, not recruiting
- Trial completion, Trial primary completion date: Safety, Attenuation and Immunogenicity of GAP3KO Administered Via A Stephensi Mosquitoes (clinicaltrials.gov) - Nov 19, 2015
P1, N=10, Completed, Sponsor: Seattle Biomedical Research Institute
Recruiting --> Active, not recruiting Active, not recruiting --> Completed | Trial primary completion date: Jul 2015 --> Feb 2015
- Trial completion: Phase II Efficacy Study of Artefenomel & Piperaquine in Adults & Children With P. Falciparum Malaria. (clinicaltrials.gov) - Nov 15, 2015
P2b, N=438, Completed, Sponsor: Medicines for Malaria Venture
Active, not recruiting --> Completed | Trial primary completion date: Jul 2015 --> Feb 2015 Active, not recruiting --> Completed
- || Trial primary completion date: Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis (clinicaltrials.gov) - Nov 9, 2015
P1, N=67, Recruiting, Sponsor: Sanaria Inc.
Active, not recruiting --> Completed Trial primary completion date: Jul 2015 --> Dec 2015
- ||| PfSPZ Vaccine / Sanaria
Trial completion, IO biomarker: A Clinical Trial of the PfSPZ Vaccine Administered by Direct Venous Inoculation in Healthy Malaria-Na (clinicaltrials.gov) - Nov 9, 2015
P1, N=67, Completed, Sponsor: Sanaria Inc.
Trial primary completion date: Jul 2015 --> Dec 2015 Recruiting --> Completed
- ||| PfSPZ Vaccine / Sanaria
Trial completion: Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Tanzanian Adults (clinicaltrials.gov) - Nov 9, 2015
P1, N=67, Completed, Sponsor: Sanaria Inc.
Recruiting --> Completed Recruiting --> Completed
- artemether/lumefantrine / Generic mfg.
Enrollment closed: Community-based Screening and Treatment of Malaria in Pregnancy: a Cluster-randomized Trial (clinicaltrials.gov) - Nov 5, 2015
P=N/A, N=5400, Active, not recruiting, Sponsor: Royal Tropical Institute
Recruiting --> Completed Recruiting --> Active, not recruiting
- chloroquine phosphate / Generic mfg.
Trial primary completion date: Chloroquine for Malaria in Pregnancy (clinicaltrials.gov) - Oct 29, 2015
P3, N=900, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Active, not recruiting Trial primary completion date: Jan 2015 --> Oct 2014
- | trimethoprim/sulfamethoxazole / Generic mfg.
Enrollment closed: Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE-BC2) (clinicaltrials.gov) - Oct 28, 2015
P3, N=200, Active, not recruiting, Sponsor: University of California, San Francisco
Trial primary completion date: Jan 2015 --> Oct 2014 Recruiting --> Active, not recruiting
- Trial completion, Trial primary completion date: Determination of Genetic Polymorphisms in Chronic Chagas Cardiomyopathy (clinicaltrials.gov) - Oct 13, 2015
P=N/A, N=55, Completed, Sponsor: Hospital Sao Rafael
Recruiting --> Active, not recruiting Not yet recruiting --> Completed | Trial primary completion date: Dec 2015 --> Jun 2015
- Biomarker, Trial completion, Trial primary completion date: Syndecan-4 as a Biomarker in Patients With Chagas Disease (clinicaltrials.gov) - Oct 13, 2015
P=N/A, N=60, Completed, Sponsor: Hospital Sao Rafael
Not yet recruiting --> Completed | Trial primary completion date: Dec 2015 --> Jun 2015 Recruiting --> Completed | Trial primary completion date: Jun 2013 --> Jun 2015
- Biomarker, Trial completion, Trial primary completion date: Galectin-3 as a Biomarker in Patients With Chagas Disease (clinicaltrials.gov) - Oct 13, 2015
P=N/A, N=60, Completed, Sponsor: Hospital Sao Rafael
Recruiting --> Completed | Trial primary completion date: Jun 2013 --> Jun 2015 Recruiting --> Completed | Trial primary completion date: Jun 2013 --> Jun 2015
- trimethoprim/sulfamethoxazole / Generic mfg.
Trial primary completion date: Impact of TMP-SMX Prophylaxis on Malaria Infection and Immunity in Children in Uganda (clinicaltrials.gov) - Sep 24, 2015
P=N/A, N=400, Not yet recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Completed | Trial primary completion date: Jun 2013 --> Jun 2015 Trial primary completion date: Aug 2015 --> Nov 2015
- Trial primary completion date: Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study (clinicaltrials.gov) - Sep 24, 2015
P3, N=72, Active, not recruiting, Sponsor: Institute of Tropical Medicine, Belgium
Trial primary completion date: Aug 2015 --> Nov 2015 Trial primary completion date: Aug 2015 --> Dec 2015
- Trial completion, Enrollment change: START-IPT: School-Based Treatment With ACT to Reduce Transmission (clinicaltrials.gov) - Sep 24, 2015
P4, N=10746, Completed, Sponsor: London School of Hygiene and Tropical Medicine
Trial primary completion date: Aug 2015 --> Dec 2015 Not yet recruiting --> Completed | N=25000 --> 10746
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi, Tivicay (dolutegravir) / ViiV Healthcare
Enrollment open, Trial initiation date, Trial primary completion date, Combination therapy: DolACT: Dolutegravir Interactions With Artemisinin-based Combination Therapies (clinicaltrials.gov) - Sep 24, 2015
P1, N=46, Recruiting, Sponsor: University of Liverpool
Not yet recruiting --> Completed | N=25000 --> 10746 Not yet recruiting --> Recruiting | Initiation date: Jan 2015 --> Jun 2015 | Trial primary completion date: Aug 2015 --> Dec 2015
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial completion, Trial primary completion date: KNUST-COMDIS: The Synergistic Effects of Home-management and Intermittent Preventive Treatment of Malaria in Children (clinicaltrials.gov) - Sep 18, 2015
P4, N=1490, Completed, Sponsor: Kwame Nkrumah University of Science and Technology
Not yet recruiting --> Recruiting | Initiation date: Jan 2015 --> Jun 2015 | Trial primary completion date: Aug 2015 --> Dec 2015 Recruiting --> Completed | Trial primary completion date: Nov 2008 --> May 2008
- Fexinidazole Winthrop (fexinidazole) / Sanofi
Enrollment change, Trial termination: Trial to Determine Efficacy of Fexinidazole in Visceral Leihmaniasis Patients in Sudan (clinicaltrials.gov) - Sep 18, 2015
P2, N=14, Terminated, Sponsor: Drugs for Neglected Diseases
Recruiting --> Completed | Trial primary completion date: Nov 2008 --> May 2008 N=66 --> 14 | Recruiting --> Terminated; Lack of efficacy
- | amphotericin b liposome / Generic mfg.
Enrollment closed, Combination therapy, Monotherapy: Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. (clinicaltrials.gov) - Sep 18, 2015
P3, N=132, Active, not recruiting, Sponsor: Drugs for Neglected Diseases
N=66 --> 14 | Recruiting --> Terminated; Lack of efficacy Recruiting --> Active, not recruiting
- amodiaquine hydrochloride / Generic mfg., sulfadoxine/pyrimethamine / Generic mfg., artemether/lumefantrine / Generic mfg.
Trial completion, Combination therapy: Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana (clinicaltrials.gov) - Sep 18, 2015
P4, N=2400, Completed, Sponsor: Centre for Global Health Research, Ghana
Recruiting --> Active, not recruiting Recruiting --> Completed
- Enrollment closed: Phase II Efficacy Study of Artefenomel & Piperaquine in Adults & Children With P. Falciparum Malaria. (clinicaltrials.gov) - Sep 16, 2015
P2b, N=495, Active, not recruiting, Sponsor: Medicines for Malaria Venture
Recruiting --> Completed Recruiting --> Active, not recruiting
- | Eurartesim (dihydroartemisinin/piperaquine) / Medicines for Malaria Venture, Leadiant Biosci
Enrollment closed: PRINOGAM: Primaquine's Gametocytocidal Efficacy in Malaria Asymptomatic Carriers (clinicaltrials.gov) - Sep 2, 2015
P3, N=1200, Active, not recruiting, Sponsor: Medical Research Council Unit, The Gambia
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- artemether/lumefantrine / Generic mfg.
Biomarker, Trial completion, Combination therapy: Artemisinin-based Combination Therapy for Treatment of Plasmodium Falciparum Malaria in North Sumatera, Indonesia (clinicaltrials.gov) - Sep 2, 2015
P4, N=338, Completed, Sponsor: London School of Hygiene and Tropical Medicine
Recruiting --> Active, not recruiting Recruiting --> Completed
- | primaquine / Generic mfg.
Trial completion: LOPRIM: Low Dose Primaquine for Clearance of Gametocytes (clinicaltrials.gov) - Sep 2, 2015
P2/3, N=360, Completed, Sponsor: London School of Hygiene and Tropical Medicine
Recruiting --> Completed Recruiting --> Completed
- |||| Trial completion, Trial primary completion date: MSP3-POC: Proof-of-Concept Study of MSP3-LSP Vaccine to Protect Against Malaria in Africa (clinicaltrials.gov) - Aug 31, 2015
P2b, N=800, Completed, Sponsor: Vac4All
Recruiting --> Completed Active, not recruiting --> Completed | Trial primary completion date: Jun 2013 --> Dec 2011
- ||||||| Trial completion, Enrollment change: Babesia Testing in Blood Donors (clinicaltrials.gov) - Aug 26, 2015
P3, N=90116, Completed, Sponsor: Imugen
Active, not recruiting --> Completed | Trial primary completion date: Jun 2013 --> Dec 2011 Recruiting --> Completed | N=26000 --> 90116
- Trial primary completion date: Phase 1 LEISH-F3 + SLA-SE Vaccine Trial in Healthy Adult Volunteers (clinicaltrials.gov) - Aug 25, 2015
P1, N=39, Active, not recruiting, Sponsor: IDRI
Recruiting --> Completed | N=26000 --> 90116 Trial primary completion date: Jun 2015 --> Dec 2015
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Enrollment change: ASAQ-MAL: Amodiaquine+Artesunate for Uncomplicated Malaria Treatment (clinicaltrials.gov) - Aug 12, 2015
P4, N=150, Completed, Sponsor: Centre Muraz
Trial primary completion date: Jun 2015 --> Dec 2015 N=50 --> 150
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial completion, Enrollment change, Trial primary completion date: AQUAMOD: ANC & Malaria Diagnostic in Pregnancy (clinicaltrials.gov) - Aug 12, 2015
P4, N=5254, Completed, Sponsor: Centre Muraz
N=50 --> 150 Recruiting --> Completed | N=7200 --> 5254 | Trial primary completion date: Dec 2013 --> Jul 2014
- Coarsucam (artesunate/amodiaquine) / Sanofi, DNDi
Trial completion, Trial primary completion date: Amodiaquine-Artesunate & Artemether-Lumefantrine Efficacy in Burkina Faso (clinicaltrials.gov) - Aug 12, 2015
P4, N=150, Completed, Sponsor: Centre Muraz
Recruiting --> Completed | N=7200 --> 5254 | Trial primary completion date: Dec 2013 --> Jul 2014 Active, not recruiting --> Completed | Trial primary completion date: Dec 2012 --> Sep 2014
- amodiaquine hydrochloride / Generic mfg.
Trial completion, Trial primary completion date: Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria (clinicaltrials.gov) - Aug 11, 2015
P2, N=70, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting --> Completed | Trial primary completion date: Dec 2012 --> Sep 2014 Recruiting --> Completed | Trial primary completion date: Mar 2016 --> Jul 2015
- Trial completion: Safety And Immunogenicity Of Novel Candidate Blood-Stage Malaria Vaccine P27A : Phase Ia/Ib (clinicaltrials.gov) - Aug 11, 2015
P1, N=56, Completed, Sponsor: Centre Hospitalier Universitaire Vaudois
Recruiting --> Completed | Trial primary completion date: Mar 2016 --> Jul 2015 Active, not recruiting --> Completed
- chloroquine phosphate / Generic mfg., atovaquone/proguanil / Generic mfg.
Trial completion: Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis (clinicaltrials.gov) - Aug 11, 2015
P=N/A, N=15, Completed, Sponsor: Radboud University
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Enrollment closed: Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Na (clinicaltrials.gov) - Jul 21, 2015
P1, N=36, Active, not recruiting, Sponsor: U.S. Army Medical Research and Materiel Command
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- Trial completion, Enrollment change: Differences in Malaria Infection Levels in HIV-infected Infants and Children Receiving PI- and NNRTI-based HAART (clinicaltrials.gov) - Jul 15, 2015
P0, N=105, Completed, Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Recruiting --> Active, not recruiting Active, not recruiting --> Completed | N=140 --> 105
- Eurartesim (dihydroartemisinin/piperaquine) / Medicines for Malaria Venture, Leadiant Biosci
Trial primary completion date: Eurartesim (clinicaltrials.gov) - Jul 9, 2015
P2, N=100, Recruiting, Sponsor: sigma-tau i.f.r. S.p.A.
Active, not recruiting --> Completed | N=140 --> 105 Trial primary completion date: Feb 2016 --> Dec 2016
- Euvax B (recombinant hepatitis B vaccine) / LG Chem, Menactra (Meningococcal-groups A, C, Y and W-135 polysaccharide diphtheria toxoid conjugate vaccine) / Sanofi
Trial primary completion date: Testing Pfs25-EPA/Alhydrogel as a Potential Malaria Transmission Blocking Vaccine (clinicaltrials.gov) - Jul 9, 2015
P1, N=350, Active, not recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Trial primary completion date: Feb 2016 --> Dec 2016 Trial primary completion date: Jun 2015 --> Jun 2016
- Eurartesim (dihydroartemisinin/piperaquine) / Medicines for Malaria Venture, Leadiant Biosci
Trial completion, Trial primary completion date: A Pharmacokinetic/Pharmacodynamic Study of Eurartesim Dispersible Formulation in Infants With P.Falciparum Malaria (clinicaltrials.gov) - Jul 9, 2015
P2, N=300, Completed, Sponsor: sigma-tau i.f.r. S.p.A.
Trial primary completion date: Jun 2015 --> Jun 2016 Recruiting --> Completed | Trial primary completion date: Feb 2015 --> Jul 2015
- acoziborole (SCYX-7158) / SCYNEXIS
Trial completion, Trial primary completion date: Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158 (clinicaltrials.gov) - Jun 25, 2015
P1, N=136, Completed, Sponsor: Drugs for Neglected Diseases
Recruiting --> Completed | Trial primary completion date: Feb 2015 --> Jul 2015 Recruiting --> Completed | Trial primary completion date: Feb 2013 --> Mar 2015
- levetiracetam / Generic mfg.
Trial completion: A Safety and Feasibility Study of Enteral LVT vs. Standard of Care for Seizure Control in Pediatric CM (clinicaltrials.gov) - Jun 22, 2015
P2, N=44, Completed, Sponsor: University of Rochester
Recruiting --> Completed | Trial primary completion date: Feb 2013 --> Mar 2015 Recruiting --> Completed
- Enrollment closed: A Phase I Study to Assess the Safety and Immunogenicity of ChAd63 ME-TRAP - MVA ME-TRAP Heterologous Prime-boost Vaccination Co-administered With EPI Vaccines in Gambian Infants (clinicaltrials.gov) - Jun 20, 2015
P1, N=65, Active, not recruiting, Sponsor: University of Oxford
Recruiting --> Completed Recruiting --> Active, not recruiting
- | Enrollment closed, Trial primary completion date: Comparison of Standard and Alternative Antimonial Dosage in Patients With American Cutaneous Leishmaniasis (clinicaltrials.gov) - Jun 20, 2015
P3, N=264, Active, not recruiting, Sponsor: Oswaldo Cruz Foundation
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2013 --> Dec 2015
- Trial completion, Enrollment change: Cepheid Rectal Sample Validation Study (clinicaltrials.gov) - Jun 20, 2015
P=N/A, N=402, Completed, Sponsor: University of Pittsburgh
Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2013 --> Dec 2015 Recruiting --> Completed | N=550 --> 402
- Trial primary completion date: Safety and Immunogenicity of Plant-Derived Pfs25 VLP-FhCMB Malaria Transmission Blocking Vaccine in Healthy Adults (clinicaltrials.gov) - Jun 18, 2015
P1, N=44, Active, not recruiting, Sponsor: Fraunhofer, Center for Molecular Biotechnology
Recruiting --> Completed | N=550 --> 402 Trial primary completion date: Mar 2015 --> Jun 2015